Improvements in heart rate variability with exercise therapy

Canadian Journal of Cardiology

Volumn 26, Issue 6, 2010, Pages 303-312

  Routledge, Faye S ^a,b   Campbell, Tavis S ^c   McFetridge Durdle, Judith A ^a,d   Bacon, Simon L ^e  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d FUTURE Program for Cardiovascular Nurse Scientists   (Canada)

^e Gina Cody School of Engineering and Computer Science   (Canada)

Author keywords

Autonomic nervous system; Exercise therapy; Heart rate variability; Prognostic

Indexed keywords

AUTONOMIC NERVOUS SYSTEM; CORONARY ARTERY BYPASS GRAFT; DIABETES MELLITUS; HEART FAILURE; HEART INFARCTION; HEART RATE VARIABILITY; HUMAN; KINESIOTHERAPY; PROGNOSIS; REVASCULARIZATION; REVIEW; SYMPATHETIC TONE; UNSTABLE ANGINA PECTORIS; VAGUS TONE;

EID: 77953407299     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0828-282X(10)70395-0     Document Type: Review

References (89)

1. Hon EH, Lee ST. The fetal electrocardiogram. 3. Display techniques. Am J Obstet Gynecol 1965;91:56-60.
2. Weber F, Schneider H, von Arnim T, Urbaszek W. Heart rate variability and ischaemia in patients with coronary heart disease and stable angina pectoris; influence of drug therapy and prognostic value. TIBBS investigators group. Total ischemic burden bisoprolol study. Eur Heart J 1999;20:38-50.
3. Konrady AO, Rudomanov OG, Yacovleva OI, Shlyakhto EV. Power spectral components of heart rate variability in different types of cardiac remodelling in hypertensive patients. Med Sci Monit 2001;7:58-63.
4. Scalvini S, Volterrani M, Zanelli E, et al. Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure? Assessment of autonomic modulation with heart rate variability. Int J Cardiol 1998;67:9-17. (Pubitemid 28559241)
5. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996;17:354-81.
6. Lanza GA, Sgueglia GA, Cianflone D, et al. Relation of heart rate variability to serum levels of C-reactive protein in patients with unstable angina pectoris. Am J Cardiol 2006;97:1702-6. (Pubitemid 43817853)
7. Macfarlane PW, Norrie J, WOSCOPS Executive Committee. The value of the electrocardiogram in risk assessment in primary prevention: Experience from the West of Scotland Coronary Prevention study. J Electrocardiol 2007;40:101-9. (Pubitemid 44958596)
8. Stein PK, Domitrovich PP, Huikuri HV, Kleiger RE; CAST Investigators. Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction. J Cardiovasc Electrophysiol 2005;16:13-20.
9. Whang W, Bigger JT Jr. Comparison of the prognostic value of RR-interval variability after acute myocardial infarction in patients with versus those without diabetes mellitus. Am J Cardiol 2003;92:247-51. (Pubitemid 36897703)
10. Reed MJ, Robertson CE, Addison PS. Heart rate variability measurements and the prediction of ventricular arrhythmias. QJM 2005;98:87-95.
11. McMillan DE. Interpreting heart rate variability sleep/wake patterns in cardiac patients. J Cardiovasc Nurs 2002;17:69-81.
12. Freeman JV, Dewey FE, Hadley DM, Myers J, Froelicher VF. Autonomic nervous system interaction with the cardiovascular system during exercise. Prog Cardiovasc Dis 2006;48:342-62. (Pubitemid 44313773)
13. Achten J, Jeukendrup AE. Heart rate monitoring: Applications and limitations. Sports Med 2003;33:517-38. (Pubitemid 36718348)
14. Kleiger RE, Stein PK, Bigger JT Jr. Heart rate variability: Measurement and clinical utility. Ann Noninvasive Electrocardiol 2005;10:88-101. (Pubitemid 40476672)
15. Tapanainen JM, Thomsen PE, Kober L, et al. Fractal analysis of heart rate variability and mortality after an acute myocardial infarction. Am J Cardiol 2002;90:347-52.
16. Lahiri MK, Kannankeril PJ, Goldberger JJ. Assessment of autonomic function in cardiovascular disease: Physiological basis and prognostic implications. J Am Coll Cardiol 2008;51:1725-33.
17. Seely AJ, Macklem PT. Complex systems and the technology of variability analysis. Crit Care 2004;8:R367-84.
18. Stein PK, Reddy A. Non-linear heart rate variability and risk stratification in cardiovascular disease. Indian Pacing Electrophysiol J 2005;5:210-20. (Pubitemid 41581745)
19. La Rovere MT, Pinna GD, Hohnloser SH, et al. Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: Implications for clinical trials. Circulation 2001;103:2072-7.
20. Balanescu S, Corlan AD, Dorobantu M, Gherasim L. Prognostic value of heart rate variability after acute myocardial infarction. Med Sci Monit 2004;10:CR307-15. (Pubitemid 38988175)
21. La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) investigators. Lancet 1998;351:478-84.
22. Sosnowski M, MacFarlane PW, Czyz Z, Skrzypek-Wanha J, Boczkowska-Gaik E, Tendera M. Age-adjustment of HRV measures and its prognostic value for risk assessment in patients late after myocardial infarction. Int J Cardiol 2002;86:249-58. (Pubitemid 35284815)
23. Steeds R, Fletcher J, Smith M, West J, Channer K, Townend J. Prognostic significance of early short-term measurements of heart rate variability following acute myocardial infarction. Am J Cardiol 2004;94:1275-8. (Pubitemid 39469947)
24. Hohnloser SH, Kuck KH, Dorian P, et al. Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med 2004;351:2481-8. (Pubitemid 39603155)
25. Bigger JT Jr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE, Rottman JN. Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction. Am J Cardiol 1992;69:891-8.
26. Kiviniemi AM, Tulppo MP, Wichterle D, et al. Novel spectral indexes of heart rate variability as predictors of sudden and non-sudden cardiac death after an acute myocardial infarction. Ann Med 2007;39:54-62. (Pubitemid 46272634)
27. Stein PK, Domitrovich PP, Kleiger RE, CAST Investigators. Including patients with diabetes mellitus or coronary artery bypass grafting decreases the association between heart rate variability and mortality after myocardial infarction. Am Heart J 2004;147:309-16.
28. Wichterle D, Simek J, La Rovere MT, Schwartz PJ, Camm AJ, Malik M. Prevalent low-frequency oscillation of heart rate: Novel predictor of mortality after myocardial infarction. Circulation 2004;110:1183-90. (Pubitemid 39202330)
29. Galinier M, Pathak A, Fourcade J, et al. Depressed low frequency power of heart rate variability as an independent predictor of sudden death in chronic heart failure. Eur Heart J 2000;21:475-82. (Pubitemid 30122135)
30. Aronson D, Mittleman MA, Burger AJ. Measures of heart period variability as predictors of mortality in hospitalized patients with decompensated congestive heart failure. Am J Cardiol 2004;93:59-63. (Pubitemid 38022034)
31. Bilchick KC, Fetics B, Djoukeng R, et al. Prognostic value of heart rate variability in chronic congestive heart failure (veterans affairs' survival trial of antiarrhythmic therapy in congestive heart failure). Am J Cardiol 2002;90:24-8. (Pubitemid 34671197)
32. Makikallio TH, Huikuri HV, Hintze U, et al. Fractal analysis and time- and frequency-domain measures of heart rate variability as predictors of mortality in patients with heart failure. Am J Cardiol 2001;87:178-82. (Pubitemid 32057228)
33. Nolan J, Batin PD, Andrews R, et al. Prospective study of heart rate variability and mortality in chronic heart failure: Results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation 1998;98:1510-6.
34. Ponikowski P, Anker SD, Chua TP, et al. Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 1997;79:1645-50.
35. La Rovere MT, Pinna GD, Maestri R, et al. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 2003;107:565-70.
36. Lucreziotti S, Gavazzi A, Scelsi L, et al. Five-minute recording of heart rate variability in severe chronic heart failure: Correlates with right ventricular function and prognostic implications. Am Heart J 2000;139:1088-95.
37. Lanza GA, Cianflone D, Rebuzzi AG, et al. Prognostic value of ventricular arrhythmias and heart rate variability in patients with unstable angina. Heart 2006;92:1055-63. (Pubitemid 44125216)
38. Lanza GA, Pedrotti P, Rebuzzi AG, Pasceri V, Quaranta G, Maseri A. Usefulness of the addition of heart rate variability to Holter monitoring in predicting in-hospital cardiac events in patients with unstable angina pectoris. Am J Cardiol 1997;80:263-7. (Pubitemid 27330139)
39. Milicevic G, Fort L, Majsec M, Bakula V. Heart rate variability decreased by coronary artery surgery has no prognostic value. Eur J Cardiovasc Prev Rehabil 2004;11:228-32.
40. Stein PK, Domitrovich PP, Kleiger RE, Schechtman KB, Rottman JN. Clinical and demographic determinants of heart rate variability in patients post myocardial infarction: Insights from the Cardiac Arrhythmia Suppression Trial (CAST). Clin Cardiol 2000;23:187-94.
41. Javorka M, Javorkova J, Tonhajzerova I, Javorka K. Parasympathetic versus sympathetic control of the cardiovascular system in young patients with type 1 diabetes mellitus. Clin Physiol Funct Imaging 2005;25:270-4. (Pubitemid 41223529)
42. Perciaccante A, Fiorentini A, Paris A, Serra P, Tubani L. Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia, impaired fasting glycemia, impaired glucose tolerance, type 2 diabetes mellitus. BMC Cardiovasc Disord 2006;6:19. (Pubitemid 44164728)
43. Chessa M, Butera G, Lanza GA, et al. Role of heart rate variability in the early diagnosis of diabetic autonomic neuropathy in children. Herz 2002;27:785-90. (Pubitemid 36105567)
44. Boysen A, Lewin MA, Hecker W, Leichter HE, Uhlemann F. Autonomic function testing in children and adolescents with diabetes mellitus. Pediatr Diabetes 2007;8:261-4. (Pubitemid 47422898)
45. Astrup AS, Nielsen FS, Rossing P, et al. Predictors of mortality in patients with type 2 diabetes with or without diabetic nephropathy: A follow-up study. J Hypertens 2007;25:2479-85. (Pubitemid 350060387)
46. Kataoka M, Ito C, Sasaki H, Yamane K, Kohno N. Low heart rate variability is a risk factor for sudden cardiac death in type 2 diabetes. Diabetes Res Clin Pract 2004;64:51-8. (Pubitemid 38249457)
47. Wheeler SG, Ahroni JH, Boyko EJ. Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes. Diabetes Res Clin Pract 2002;58:131-8.
48. Burger AJ, D'Elia JA, Weinrauch LA, Lerman I, Gaur A. Marked abnormalities in heart rate variability are associated with progressive deterioration of renal function in type I diabetic patients with overt nephropathy. Int J Cardiol 2002;86:281-7. (Pubitemid 35284819)
49. Gottsater A, Ahlgren AR, Taimour S, Sundkvist G. Decreased heart rate variability may predict the progression of carotid atherosclerosis in type 2 diabetes. Clin Auton Res 2006;16:228-34. (Pubitemid 43885550)
50. Dixon EM, Kamath MV, McCartney N, Fallen EL. Neural regulation of heart rate variability in endurance athletes and sedentary controls. Cardiovasc Res 1992;26:713-9.
51. Furlan R, Piazza S, Dell'Orto S, et al. Early and late effects of exercise and athletic training on neural mechanisms controlling heart rate. Cardiovasc Res 1993;27:482-8. (Pubitemid 23116151)
52. Pichot V, Roche F, Denis C, et al. Interval training in elderly men increases both heart rate variability and baroreflex activity. Clin Auton Res 2005;15:107-15. (Pubitemid 40591300)
53. Malfatto G, Facchini M, Sala L, Branzi G, Bragato R, Leonetti G. Effects of cardiac rehabilitation and beta-blocker therapy on heart rate variability after first acute myocardial infarction. Am J Cardiol 1998;81:834-40. (Pubitemid 28204636)
54. Oya M, Itoh H, Kato K, Tanabe K, Murayama M. Effects of exercise training on the recovery of the autonomic nervous system and exercise capacity after acute myocardial infarction. Jpn Circ J 1999;63:843-8. (Pubitemid 29535713)
55. La Rovere MT, Mortara A, Sandrone G, Lombardi F. Autonomic nervous system adaptations to short-term exercise training. Chest 1992;101:299S-303S.
56. Kaufmann H. Investigation of autonomic cardiovascular dysfunction. In: Korczyn AD, ed. Handbook of Autonomic Nervous System Dysfunction. New York: Marcel Dekkler Inc, 1995:427-68.
57. Sandercock GR, Grocott-Mason R, Brodie DA. Changes in short-term measures of heart rate variability after eight weeks of cardiac rehabilitation. Clin Auton Res 2007;17:39-45. (Pubitemid 46255149)
58. Malfatto G, Facchini M, Bragato R, Branzi G, Sala L, Leonetti G. Short and long term effects of exercise training on the tonic autonomic modulation of heart rate variability after myocardial infarction. Eur Heart J 1996;17:532-8. (Pubitemid 26136873)
59. Leitch JW, Newling RP, Basta M, Inder K, Dear K, Fletcher PJ. Randomized trial of a hospital-based exercise training program after acute myocardial infarction: Cardiac autonomic effects. J Am Coll Cardiol 1997;29:1263-8. (Pubitemid 27201944)
60. Bryniarski L, Kawecka-Jaszcz K, Bacior B, Grodecki J, Rajzer M. Effect of exercise rehabilitation on heart rate variability in hypertensives after myocardial infarction. J Hypertens 1997;15:1739-43. (Pubitemid 28029674)
61. Mazzuero G, Lanfranchi P, Colombo R, Giannuzzi P, Giordano A. Long-term adaptation of 24-h heart rate variability after myocardial infarction. The EAMI study group. Exercise training in anterior myocardial infarction. Chest 1992;101:304S-8S.
62. Drexler H, Coats AJ. Explaining fatigue in congestive heart failure. Annu Rev Med 1996;47:241-56. (Pubitemid 26138889)
63. Casolo G, Balli E, Taddei T, Amuhasi J, Gori C. Decreased spontaneous heart rate variability in congestive heart failure. Am J Cardiol 1989;64:1162-7. (Pubitemid 19279995)
64. Kiilavuori K, Toivonen L, Naveri H, Leinonen H. Reversal of autonomic derangements by physical training in chronic heart failure assessed by heart rate variability. Eur Heart J 1995;16:490-5.
65. Malfatto G, Branzi G, Riva B, Sala L, Leonetti G, Facchini M. Recovery of cardiac autonomic responsiveness with low-intensity physical training in patients with chronic heart failure. Eur J Heart Fail 2002;4:159-66. (Pubitemid 34233502)
66. Pietila M, Malminiemi K, Vesalainen R, et al. Exercise training in chronic heart failure: Beneficial effects on cardiac (11) C-hydroxyephedrine PET, autonomic nervous control, and ventricular repolarization. J Nucl Med 2002;43:773-9.
67. Selig SE, Carey MF, Menzies DG, et al. Moderate-intensity resistance exercise training in patients with chronic heart failure improves strength, endurance, heart rate variability, and forearm blood flow. J Card Fail 2004;10:21-30.
68. Iellamo F, Legramante JM, Massaro M, Raimondi G, Galante A. Effects of a residential exercise training on baroreflex sensitivity and heart rate variability in patients with coronary artery disease: A randomized, controlled study. Circulation 2000;102:2588-92.
69. Lucini D, Milani RV, Costantino G, Lavie CJ, Porta A, Pagani M. Effects of cardiac rehabilitation and exercise training on autonomic regulation in patients with coronary artery disease. Am Heart J 2002;143:977-83. (Pubitemid 34666887)
70. Takeyama J, Itoh H, Kato M, et al. Effects of physical training on the recovery of the autonomic nervous activity during exercise after coronary artery bypass grafting: Effects of physical training after CABG. Jpn Circ J 2000;64:809-13.
71. Tsai MW, Chie WC, Kuo TB, et al. Effects of exercise training on heart rate variability after coronary angioplasty. Phys Ther 2006;86:626-35.
72. Figueroa A, Baynard T, Fernhall B, Carhart R, Kanaley JA. Endurance training improves post-exercise cardiac autonomic modulation in obese women with and without type 2 diabetes. Eur J Appl Physiol 2007;100:437-44. (Pubitemid 46773993)
73. Zoppini G, Cacciatori V, Gemma ML, et al. Effect of moderate aerobic exercise on sympatho-vagal balance in type 2 diabetic patients. Diabet Med 2007;24:370-6. (Pubitemid 46452395)
74. Loimaala A, Huikuri HV, Koobi T, Rinne M, Nenonen A, Vuori I. Exercise training improves baroreflex sensitivity in type 2 diabetes. Diabetes 2003;52:1837-42. (Pubitemid 36792476)
75. Peterson JA. Get moving! Physical activity counselling in primary care. J Am Acad Nurse Pract 2007;19:349-57.
76. Buch AN, Coote JH, Townend JN. Mortality, cardiac vagal control and physical training - What's the link? Exp Physiol 2002;87:423-35.
77. Watanabe AM, McConnaughey MM, Strawbridge RA, Fleming JW, Jones LR, Besch HR Jr. Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines. J Biol Chem 1978;253:4833-6.
78. Casado MA, Sevilla MA, Alonso MJ, Marin J, Salaices M. Muscarinic receptors involved in modulation of norepinephrine release and vasodilatation in guinea pig carotid arteries. J Pharmacol Exp Ther 1994;271:1638-46. (Pubitemid 24382681)
79. Townend JN, al-Ani M, West JN, Littler WA, Coote JH. Modulation of cardiac autonomic control in humans by angiotensin II. Hypertension 1995;25:1270-5.
80. Fagard R, Grauwels R, Groeseneken D, et al. Plasma levels of renin, angiotensin II, and 6-ketoprostaglandin F1 alpha in endurance athletes. J Appl Physiol 1985;59:947-52. (Pubitemid 16223426)
81. Lijnen P, Hespel P, Van Oppens S, et al. Erythrocyte 2,3- diphosphoglycerate and serum enzyme concentrations in trained and sedentary men. Med Sci Sports Exerc 1986;18:174-9. (Pubitemid 16115132)
82. Chowdhary S, Townend JN. Role of nitric oxide in the regulation of cardiovascular autonomic control. Clin Sci 1999;97:5-17. (Pubitemid 29353890)
83. Hambrecht R, Wolf A, Gielen S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000;342:454-60. (Pubitemid 30100232)
84. Kingwell BA. Nitric oxide as a metabolic regulator during exercise: Effects of training in health and disease. Clin Exp Pharmacol Physiol 2000;27:239-50.
85. Carter JB, Banister EW, Blaber AP. The effect of age and gender on heart rate variability after endurance training. Med Sci Sports Exerc 2003;35:1333-40.
86. Carpeggiani C, L'Abbate A, Landi P, et al. Early assessment of heart rate variability is predictive of in-hospital death and major complications after acute myocardial infarction. Int J Cardiol 2004;96:361-8. (Pubitemid 39099497)
87. Lanza GA, Guido V, Galeazzi MM, et al. Prognostic role of heart rate variability in patients with a recent acute myocardial infarction. Am J Cardiol 1998;82:1323-8. (Pubitemid 28565316)
88. Bigger JT Jr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE, Rottman JN. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 1992;85:164-71.
89. Anastasiou-Nana MI, Terrovitis JV, Athanasoulis T, et al. Prognostic value of iodine-123-metaiodobenzylguanidine myocardial uptake and heart rate variability in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2005;96:427-31. (Pubitemid 41058876)