Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine

Arthritis and Rheumatism

Volumn 63, Issue 12, 2011, Pages 3998-4001

  Graf, Jonathan ^a,b   Lynch, Kara ^a   Yeh, Chia Lin ^a   Tarter, Laura ^a   Richman, Nicole ^a   Nguyen, Thuy ^a   Kral, Alex ^a   Dominy, Steven ^a   Imboden, John ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLIPIN ANTIBODY; CATHEPSIN G; COCAINE; ELASTASE; IMMUNOGLOBULIN M; LACTOFERRIN; LEVAMISOLE; LUPUS ANTICOAGULANT; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEINASE;

ADULT; ARTICLE; DRUG ABUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; NEUTROPENIA; NEUTROPHIL GRANULE; PRIORITY JOURNAL; PURPURA; SKIN BIOPSY; SKIN BLOOD VESSEL DISORDER; SKIN NECROSIS; SMALL VESSEL THROMBOTIC VASCULOPATHY; TANDEM MASS SPECTROMETRY; URINALYSIS; VASCULITIS;

ADULT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BIOPSY; COCAINE; COCAINE-RELATED DISORDERS; DRUG CONTAMINATION; FEMALE; HUMANS; LEVAMISOLE; MIDDLE AGED; NECROSIS; PURPURA; RETROSPECTIVE STUDIES; SKIN; SYNDROME;

EID: 82455198843     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30590     Document Type: Article

References (17)

1. Hobday T, Erlichman C,. Adjuvant therapy of colon cancer: a review. Clin Colorectal Cancer 2002; 1: 230-6. (Pubitemid 34269383)
2. Davin JC, Merkus MP,. Levamisole in steroid-sensitive nephrotic syndrome of childhood: the lost paradise? Pediatr Nephrol 2005; 20: 10-4. (Pubitemid 40057846)
3. Substance Abuse and Mental Health Services Administration. Nationwide public health alert issued concerning life-threatening risk posed by cocaine laced with veterinary anti-parasite drug. URL:.
4. Centers for Disease Control and Prevention. Agranulocytosis associated with cocaine use: four States, March 2008-November 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 1381-5.
5. Zhu NY, Legatt DF, Turner AR,. Agranulocytosis after consumption of cocaine adulterated with levamisole. Ann Intern Med 2009; 150: 287-9.
6. Walsh NM, Green PJ, Burlingame RW, Pasternak S, Hanly JG,. Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole. J Cutan Pathol 2010; 37: 1212-9.
7. Wiik A, Stummann L, Kjeldsen L, Borregaard N, Ullman S, Jacobsen S, et al. The diversity of perinuclear antineutrophil cytoplasmic antibodies (pANCA) antigens. Clin Exp Immunol 1995; 101 Suppl 1: 15-7.
8. Laux-End R, Inaebnit D, Gerber HA, Bianchetti MG,. Vasculitis associated with levamisole and circulating autoantibodies. Arch Dis Child 1996; 75: 355-6. (Pubitemid 26354616)
9. Barbano G, Ginevri F, Ghiggeri GM, Gusmano R,. Disseminated autoimmune disease during levamisole treatment of nephrotic syndrome. Pediatr Nephrol 1999; 13: 602-3. (Pubitemid 29403481)
10. Scheinberg MA, Bezerra JB, Almeida FA, Silveira LA,. Cutaneous necrotising vasculitis induced by levamisole. Br Med J 1978; 1: 408. (Pubitemid 8318799)
11. Macfarlane DG, Bacon PA,. Levamisole-induced vasculitis due to circulating immune complexes. Br Med J 1978; 1: 407-8. (Pubitemid 8318798)
12. Powell J, Grech H, Holder J,. A boy with cutaneous necrosis occurring during treatment with levamisole. Clin Exp Dermatol 2002; 27: 32-3. (Pubitemid 34309935)
13. Rongioletti F, Ghio L, Ginevri F, Bleidl D, Rinaldi S, Edefonti A, et al. Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long-term treatment with levamisole in children. Br J Dermatol 1999; 140: 948-51. (Pubitemid 29238474)
14. Menni S, Pistritto G, Gianotti R, Ghio L, Edefonti A,. Ear lobe bilateral necrosis by levamisole-induced occlusive vasculitis in a pediatric patient. Pediatr Dermatol 1997; 14: 477-9. (Pubitemid 28012032)
15. Casale J, Corbeil E, Hays P,. Identification of levamisole impurities in illicit cocaine exhibits. DEA Resources, Microgram Journal 2008; 6. URL:.
16. Bradford M, Rosenberg B, Moreno J, Dumyati G,. Bilateral necrosis of earlobes and cheeks: another complication of cocaine contaminated with levamisole. Ann Intern Med 2010; 152: 758-9.
17. Substance Abuse and Mental Health Services Administration, Office of Applied Studies. Results from the 2008 NSDUH: national findings. URL:.