Evaluation of ocular and general safety following repeated dosing of dexamethasone phosphate delivered by transscleral iontophoresis in rabbits

Journal of Ocular Pharmacology and Therapeutics

Volumn 29, Issue 8, 2013, Pages 760-769

  Patane, Michael A ^a   Schubert, William ^a   Sanford, Thomas ^a   Gee, Raymond ^a   Burgos, Melissa ^a   Isom, William P ^a   Ruiz Perez, Begona ^a  

^a Jade Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; DEXAMETHASONE SODIUM PHOSPHATE;

ANEMIA; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMOSIS; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; CORNEA OPACITY; DRUG BLOOD LEVEL; DRUG DELIVERY DEVICE; DRUG SAFETY; ERYTHROCYTE; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; HEMOGLOBIN DETERMINATION; HEPATOMEGALY; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; IONTOPHORESIS; LEUKOCYTE; LIVER FUNCTION; LYMPHOCYTE COUNT; MAXIMUM PLASMA CONCENTRATION; MEAN CORPUSCULAR HEMOGLOBIN; NONHUMAN; ORGAN WEIGHT; RABBIT; REPEATED DRUG DOSE; SPLEEN WEIGHT; TIME TO MAXIMUM PLASMA CONCENTRATION; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG DELIVERY SYSTEMS; EYE; FEMALE; GLUCOCORTICOIDS; IONTOPHORESIS; OPHTHALMIC SOLUTIONS; ORGAN SIZE; ORGAN SPECIFICITY; RABBITS;

EID: 84885004267     PISSN: 10807683     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.2012.0175     Document Type: Article

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