LC/ESI-MS/MS analysis of urinary 3β-sulfooxy-7β-N- acetylglucosaminyl- 5-cholen-24-oic acid and its amides: New biomarkers for the detection of Niemann-Pick type C disease

Steroids

Volumn 78, Issue 10, 2013, Pages 967-972

  Maekawa, Masamitsu ^a   Misawa, Yasushi ^b   Sotoura, Ayako ^b   Yamaguchi, Hiroaki ^a,g   Togawa, Masami ^c   Ohno, Kousaku ^c   Nittono, Hiroshi ^d   Kakiyama, Genta ^e,h   Iida, Takashi ^e   Hofmann, Alan F ^f   Goto, Junichi ^a   Shimada, Miki ^a,b   Mano, Nariyasu ^a,b  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

^d Junshin Clinic Bile Acid Institute   (Japan)

^e NIHON UNIVERSITY   (Japan)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g HOKKAIDO UNIVERSITY   (Japan)

^h VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarker; LC ESI MS MS; Multiple conjugate; Niemann Pick type C disease

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3BETA SULFOOXY 7BETA N ACETYLGLUCOSAMINYL 5 CHOLEN 24 OIC ACID; AMIDE; BILE ACID; BIOLOGICAL MARKER; GLYCINE; TAURINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; KIDNEY CONCENTRATING CAPACITY; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY ELECTROSPRAY TANDEM MASS SPECTROMETRY; NIEMANN PICK DISEASE; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE;

3Β-HSD; 3Β-HYDROXY-Δ(5)-C(27)-STEROID DEHYDROGENASE/ISOMERASE; BIOMARKER; C.V.; CE; COEFFICIENT OF VARIATION; COLLISION VOLTAGE; ELECTROSPRAY IONIZATION; ESI; GLCNAC; GLYCINE-AMIDATED 3Β-SULFOOXY-7Β-N-ACETYLGLUCOSAMINYL-5-CHOLEN-24-OIC ACID; INTERNAL STANDARD; IS; LC/ESI-MS/MS; LC/MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MULTIPLE CONJUGATE; N-ACETYLGLUCOSAMINE; NIEMANN-PICK DISEASE TYPE C; NIEMANN-PICK TYPE C DISEASE; NONAMIDATED 3Β-SULFOOXY-7Β-N-ACETYLGLUCOSAMINYL-5-CHOLEN-24-OIC ACID; NPC; R.E.; RELATIVE ERROR; S/N; SELECTED REACTION MONITORING; SIGNAL-TO-NOISE RATIO; SNAG-Δ(5)-CA; SNAG-Δ(5)-CG; SNAG-Δ(5)-CT; SRM; TAURINE-AMIDATED 3Β-SULFOOXY-7Β-N-ACETYLGLUCOSAMINYL-5-CHOLEN-24-OIC ACID;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFANT; MALE; NIEMANN-PICK DISEASE, TYPE C; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84885000878     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2013.05.017     Document Type: Article

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