Natural product derived antiprotozoal agents: Synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives

Journal of Medicinal Chemistry

Volumn 56, Issue 18, 2013, Pages 7442-7448

  Harel, Dipak ^a   Schepmann, Dirk ^a   Prinz, Helge ^a   Brun, Reto ^b   Schmidt, Thomas J ^c   Wünsch, Bernhard ^a  

^a INST OF REPRO MED OF THE UNIV   (Germany)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIMETHYL 6 [1 [(3 PHENYLPROPYL)AMINO]ETHYL] 2H CHROMEN 7 OL; 6 [1 (BENZYLAMINO)ETHYL] 2,2 DIMETHYL 2H CHROMEN 7 OL; 6 [1 (BENZYLOXY)ETHYL] 7 METHOXY 2,2 DIMETHYL 2H CHROMENE; ANTIPROTOZOAL AGENT; BENZNIDAZOLE; CHLOROQUINE; CHROMAN DERIVATIVE; CHROMENE DERIVATIVE; MELARSOPROL; MILTEFOSINE; N [1 (7 METHOXY 2,2 DIMETHYL 2H CHROMEN 6 YL)ETHYL] BENZAMIDE; N [1 (7 METHOXY 2,2 DIMETHYLCHROMAN 6 YL)ETHYL] 4 PHENYLBUTAN 1 AMINE; N BENZYL 1 (7 METHOXY 2,2 DIMETHYL 2H CHROMEN 6 YL) ETHANAMINE; PENTAMIDINE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG;

AMINATION; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; DEHYDROGENATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; IC 50; LEISHMANIA DONOVANI; MICROWAVE IRRADIATION; NONHUMAN; PLASMODIUM FALCIPARUM; PROMASTIGOTE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

ANTIPROTOZOAL AGENTS; BIOLOGICAL PRODUCTS; CHEMISTRY TECHNIQUES, SYNTHETIC; CHROMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884992932     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401007p     Document Type: Article

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