Encecalol angelate, an unstable chromene from Ageratum conyzoides L.: Total synthesis and investigation of its antiprotozoal activity

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 620-625

  Harel, Dipak ^a   Khalid, Sami A ^b   Kaiser, Marcel ^c,d   Brun, Reto ^c,d   Wünsch, Bernhard ^a   Schmidt, Thomas J ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b University of Science and Technology   (Sudan)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Ageratum conyzoides L.; Antiprotozoal activity; Asteraceae; Chromenes; Encecalol angelate; Total synthesis

Indexed keywords

2 METHYLBUT 3 EN 2 OL; CHROMENE DERIVATIVE; ENCECALOL ANGELATE; METHYL GROUP; RESORCINOL; UNCLASSIFIED DRUG;

AGERATUM CONYZOIDES; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DEGRADATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; LEISHMANIA DONOVANI; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM FALCIPARUM; SPECTROSCOPY; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AGERATUM; ANIMALS; ANTIPROTOZOAL AGENTS; BENZOPYRANS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HALF-LIFE; LEISHMANIA DONOVANI; MAGNETIC RESONANCE SPECTROSCOPY; METHACRYLATES; MOLECULAR STRUCTURE; MYOBLASTS, SKELETAL; PARASITIC SENSITIVITY TESTS; PLANT PREPARATIONS; PLASMODIUM FALCIPARUM; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

AGERATUM CONYZOIDES; ASTERACEAE; LEISHMANIA DONOVANI; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 80052027353     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.06.015     Document Type: Article

References (17)

1. B. Aguilar-Guadarrama, V. Navarro, I. Leon-Rivera, and M.Y. Rios Active compounds against tinea pedis dermatophytes from Ageratina pichinchensis var. bustamenta Natural Products Research 23 2009 1559 1565
2. B.H. Alizadeh, S.N. Ostad, A. Foroumadi, M. Amini, R. Dowlatabadi, L. Navidpour, and A. Shafiee Synthesis and cytotoxic activity of novel chromenes ARKIVOC 8 2008 45 56
3. B.H. Alizadeh, A. Fouroumadi, S.K. Ardestani, F. Poorrajab, and A. Shafiee Leishmanicidal evaluation of novel synthetic chromenes Archives of Pharmaceutical and Chemical Life Sciences 341 2008 787 793
4. J.M. Batista Jr., A.A. Lopes, D.L. Ambrosio, L.O. Regasini, M.J. Kato, V.d.S. Bolzani, R.M.B. Cicarelli, and M. Furlan Natural chromenes and chromene derivatives as potential anti-trypanosomal agents Biological and Pharmaceutical Bulletin 31 2008 538 540 (Pubitemid 351442156)
5. F. Bohlmann, and M. Grenz Constituents of the genus Flourensia Chemische Berichte 110 1 1977 295 300
6. F. Bohlmann, E. Tsankova, J. Jakupovic, R.M. King, and H. Robinson Dimeric chromenes and mixed dimers of a chromene from Encelia canescens Phytochemistry 22 1983 557 560
7. S. Ganapaty, P. Steve Thomas, G. Karagianis, P.G. Waterman, and R. Brun Antiprotozoal and cytotoxic naphthalene derivatives from Diospyros assimilis Phytochemistry 67 2006 1950 1956 (Pubitemid 44382675)
8. A.G. Gonzalez, Z.E. Aguiar, T.A. Grillo, J.G. Luis, A. Rivera, and J. Calle Chromenes from Ageratum conyzoides Phytochemistry 30 1991 1137 1139
9. T. Johnson CRC Ethnobotany Desk Reference 1999 CRC Press LLC Boca Raton
10. A. Kamboj, and A.K. Saluja Ageratum conyzoides L.: a review on its phytochemical and pharmacological profile International Journal of Green Pharmacy 2008 59 68
11. A.M.M. Nour, S.A. Khalid, M. Kaiser, R. Brun, W.E. Abdalla, and T.J. Schmidt The antiprotozoal activity of sixteen Asteraceae species native to Sudan and bioactivity-guided isolation of Xanthanolides from Xanthium brasilicum Planta Medica 75 2009 1363 1368
12. A.M.M. Nour, S.A. Khalid, M. Kaiser, R. Brun, W.E. Abdalla, and T.J. Schmidt The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of Ethnopharmacology 129 2010 127 130
13. C. Steelink, and P. Marshall Structures, syntheses, and chemotaxonomic significance of some new acetophenone derivatives from Encelia farinosa Gray Journal of Organic Chemistry 44 1978 1429 1433
14. R. Verpoorte, Y.-H. Choi, and H.K. Kim Ethnopharmacology and systems biology: a perfect holistic match Journal of Ethnopharmacology 100 2005 53 56 (Pubitemid 41073521)
15. Q. Wang, X. She, X. Ren, X. Ma, and X. Pan The first asymmetric total synthesis of several 3,4-dihydroxy-2,2-dimethyl-chroman derivatives Tetrahedron: Asymmetry 15 2004 29 34 (Pubitemid 38032730)
16. M. Weber Biavatti Synergy: an old wisdom, a new paradigm for pharmacotherapy Brazilian Journal of Pharmaceutical Sciences 45 2009 371 378
17. E.M. Williamson Synergy and other interactions in phytomedicines Phytomedicine 8 2001 401 408