Comparison of functional and histological outcomes after intralesional, intracisternal, and intravenous transplantation of human bone marrow-derived mesenchymal stromal cells in a rat model of spinal cord injury

Acta Neurochirurgica

Volumn 155, Issue 10, 2013, Pages 1943-1950

  Shin, Dong Ah ^a   Kim, Jin Myung ^b   Kim, Hyoung Ihl ^b   Yi, Seong ^a   Ha, Yoon ^a   Yoon, Do Heum ^a   Kim, Keung Nyun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Recovery of function; Spinal cord injury; Stem cell; Transplantation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COUNT; CELL FUNCTION; CLINICAL EFFECTIVENESS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; FUNCTIONAL ASSESSMENT; HEMATOPOIETIC STEM CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; INTRACISTERNAL MESENCHYMAL STROMA CELL THERAPY; INTRALESIONAL MESENCHYMAL STROMA CELL THERAPY; INTRAVENOUS MESENCHYMAL STROMA CELL THERAPY; MALE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; THERAPY EFFECT;

ANIMALS; BONE MARROW; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 84884989748     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-013-1799-5     Document Type: Article

References (19)

1. Akiyama Y, Radtke C, Honmou O, Kocsis JD (2002) Remyelination of the spinal cord following intravenous delivery of bone marrow cells. J Ethnopharmacol 39(3):229-236
2. Bakshi A, Barshinger AL, Swanger SA, Madhavani V, Shumsky JS, Neuhuber B, Fischer I (2006) Lumbar puncture delivery of bone marrow stromal cells in spinal cord contusion: a novel method for minimally invasive cell transplantation. J Neurotrauma 23(1):55-65
3. Bambakidis NC, Butler J, Horn EM, Wang X, Preul MC, Theodore N, Spetzler RF, Sonntag VK (2008) Stem cell biology and its therapeutic applications in the setting of spinal cord injury. Neurosurg Focus 24(3-4):E20
4. Basso DM, Beattie MS, Bresnahan JC (1996) Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139(2):244-256
5. Björklund A, Lindvall O (2000) Cell replacement therapies for central nervous system disorders. Nat Neurosci 3(6):537-544
6. Carvalho KA, Vialle EN, Moreira GH, Cunha RC, Simeoni RB, Francisco JC, Guarita-Souza LC, Oliveira L, Zocche L, Olandoski M (2008) Functional outcome of bone marrow stem cells (CD45(+)/CD34(-)) after cell therapy in chronic spinal cord injury in Wistar rats. Transplant Proc 40(3):845-846
7. Chen Q, Long Y, Yuan X, Zou L, Sun J, Chen S, Perez-Polo JR, Yang K (2005) Protective effects of bone marrow stromal cell transplantation in injured rodent brain: synthesis of neurotrophic factors. J Neurosci Res 80(5):611-619
8. Cizkova D, Novotna I, Slovinska L, Vanicky I, Jergova S, Rosocha J, Radonak J (2011) Repetitive intrathecal catheter delivery of bone marrow mesenchymal stromal cells improves functional recovery in a rat model of contusive spinal cord injury. J Neurotrauma 28(6):1951-1962
9. Fujiwara Y, Tanaka N, Ishida O, Fujimoto Y, Murakami T, Kajihara H, Yasunaga Y, Ochi M (2004) Intravenously injected neural progenitor cells of transgenic rats can migrate to the injured spinal cord and differentiate into neurons, astrocytes and oligodendrocytes. Neurosci Lett 366(3):287-291
10. Goldsmith HS (2007) Can the standard treatment of acute spinal cord injury be improved? Perhaps the time has come. Neurol Res 29(1):16-20
11. Gruner JA (1992) A monitored contusion model of spinal cord injury in the rat. J Neurotrauma 9(2):123-126, discussion 126-8
12. Mahmood A, Lu D, Wang L, Chopp M (2002) Intracerebral transplantation of marrow stromal cells cultured with neurotrophic factors promotes functional recovery in adult rats subjected to traumatic brain injury. J Neurotrauma 19(12):1609-1617
13. Mansilla E, Marin GH, Sturla F, Drago HE, Gil MA, Salas E, Gardiner MC, Piccinelli G, Bossi S, Salas E, Petrelli L, Lorio G, Ramos CA, Soratti C (2005) Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries. Transplant Proc 37(1):292-294
14. Mothe AJ, Bozkurt G, Catapano J, Zabojova J, Wang X, Keating A, Tator CH (2011) Intrathecal transplantation of stem cells by lumbar puncture for thoracic spinal cord injury in the rat. 49(9):967-973
15. Rosenzweig ES, McDonald JW (2004) Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair. Curr Opin Neurol 17(2):121-131
16. Ruff CA, Wilcox JT, Fehlings MG (2012) Cell-based transplantation strategies to promote plasticity following spinal cord injury. Exp Neurol 235(1):78-90
17. Sasaki H, Tanaka N, Nakanishi K, Nishida K, Hamasaki T, Yamada K, Ochi M (2011) Therapeutic effects with magnetic targeting of bone marrow stromal cells in a rat spinal cord injury model. Spine 36(12):933-938
18. Takahashi Y, Tsuji O, Kumagai G, Hara CM, Okano HJ, Miyawaki A, Toyama Y, Okano H, Nakamura M (2010) Comparative study of methods for administering neural stem/progenitor cells to treat spinal cord injury in mice. Cell Transplant 20(2):727-739
19. Wu J, Feng D, Yang T (2007) Effect of transplanting marrow mesenchymal stem cells via subarachnoid space on spinal cord injury and T cell subpopulation in rats. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21(5):492-496