Fusobacterium Spp. And Colorectal Cancer: Cause Or Consequence?

Trends in Microbiology

Volumn 21, Issue 10, 2013, Pages 506-508

  Keku, Temitope O ^a   McCoy, Amber N ^a   Azcarate Peril, Andrea M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; APC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PROTEIN FADA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN;

CANCER GROWTH; COLON CARCINOGENESIS; COLORECTAL ADENOMA; COLORECTAL CANCER; DISEASE ASSOCIATION; FUSOBACTERIUM NUCLEATUM; GENE MUTATION; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE DYSREGULATION; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LYMPHOCYTIC INFILTRATION; MICROBIOME; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR GENE;

BACTERIA (MICROORGANISMS); FUSOBACTERIUM;

ADHESINS, BACTERIAL; ANIMALS; BETA CATENIN; CADHERINS; CARCINOGENESIS; COLORECTAL NEOPLASMS; FUSOBACTERIUM NUCLEATUM; HUMANS; SIGNAL TRANSDUCTION; VIRULENCE FACTORS;

EID: 84884980162     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2013.08.004     Document Type: Short Survey

References (10)

1. Sanapareddy N., et al. Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME J. 2012, 6:1858-1868.
2. Shen X.J., et al. Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas. Gut Microbes 2010, 1:138-147.
3. Sobhani I., et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS ONE 2011, 6:e16393.
4. Castellarin M., et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012, 22:299-306.
5. Kostic A.D., et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012, 22:292-298.
6. McCoy A.N., et al. Fusobacterium is associated with colorectal adenomas. PLoS ONE 2013, 8:e53653.
7. Kostic A.D., et al. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013, 14:207-215.
8. Rubinstein M.R., et al. Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 2013, 14:195-206.
9. Dharmani P., et al. Fusobacterium nucleatum infection of colonic cells stimulates MUC2 mucin and tumor necrosis factor alpha. Infect. Immun. 2011, 79:2597-2607.
10. Grivennikov S.I., et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 2012, 491:254-258.