Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions

General and Comparative Endocrinology

Volumn 194, Issue , 2013, Pages 102-109

  Almeida, Daniela Volcan ^a   Bianchini, Adalto ^a   Marins, Luis Fernando ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE   (Brazil)

Author keywords

Aerobic metabolism; Anaerobic metabolism; Hypoxia; Transgenesis

Indexed keywords

CITRATE SYNTHASE; COMPLEMENTARY DNA; CREATINE KINASE MM; GROWTH HORMONE; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; LACTIC ACID; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; RNA;

ANAEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; EXPOSURE; FEMALE; GENE EXPRESSION; HYPOXIA; JUVENILE ANIMAL; MALE; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN CONSUMPTION; PHD GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SURVIVAL; TRANSGENIC ANIMAL; TRANSGENICS; ZEBRA FISH;

AEROBIC METABOLISM; ANAEROBIC METABOLISM; HYPOXIA; TRANSGENESIS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANOXIA; FEMALE; GROWTH HORMONE; MALE; ZEBRAFISH;

EID: 84884965806     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2013.08.017     Document Type: Article

References (41)

1. Aberg N.D., Brywe K.G., Isgaard Jörgen. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci. World J. 2006, 6:53-80.
2. Acker T., Acker H. Cellular oxygen sensing need in CNS function: physiological and pathological implications. J. Exp. Biol. 2004, 207:3171-3188.
3. Aleström P., Holter J.L., Nourizadeh-Lillabadi R. Zebrafish in functional genomics and aquatic biomedicine. Trends Biotechnol. 2006, 24:15-21.
4. Almeida D.V., Martins C.M.G., Figueiredo Márcio Azevedo, Lanes Carlos Frederico Ceccon, Bianchini A., Marins Luis Fernando Growth hormone transgenesis affects osmoregulation and energy metabolism in zebrafish (Danio rerio). Transgenic Res. 2013, 22:75-88.
5. Almeida-Val V.M.F., Oliveira A.R., Silva Maria de Nazaré Paula, Ferreira-Nozawa M.S., Araújo R.M., Val A.L., Nozawa S.R. Anoxia- and hypoxia-induced expression of LDH-A* in the Amazon Oscar, Astronotus crassipinis. Genet. Mol. Biol. 2011, 34:315-322.
6. Canosa L.F., Chang J.P., Peter R.E. Neuroendocrine control of growth hormone in fish. Gen. Comp. Endocrinol. 2007, 151:1-26.
7. Deitch E.J., Fletcher G.L., Petersen L.H., Costa I.A., Shears M.A., Driedzic W.R., Gamperl A.K. Cardiorespiratory modifications, and limitations, in post-smolt growth hormone transgenic Atlantic salmon Salmo salar. J. Exp. Biol. 2006, 209:1310-1325.
8. Devlin Robert.H., Yesaki T.Y., Donaldson E.M., Hew C. Transmission and phenotypic effects of an antifreeze/GH gene construct in coho salmon (Oncorhynchus kisutch). Gene 1995, 137:161-169.
9. de Figueiredo M.A., Lanes Carlos Frederico Ceccon, Almeida D.V., Proietti M.C., Marins Luis Fernando The effect of GH overexpression on GHR and IGF-I gene regulation in different genotypes of GH-transgenic zebrafish. Comp. Biochem. Physiol. D 2007, 12:228-233.
10. Figueiredo M.D.A., Lanes Carlos Frederico Ceccon, Almeida D.V., Marins Luis Fernando Improving the production of transgenic fish germlines: in vivo evaluation of mosaicism in zebrafish (Danio rerio) using a green fluorescent protein (GFP) and growth hormone cDNA transgene co-injection strategy. Genet. Mol. Biol. 2007, 30:31-36.
11. Figueiredo M.A., Fernandes R.V., Studzinski A.L., Rosa C.E., Corcini C.D., Junior A.S.V., Marins L.F. GH overexpression decreases spermatic parameters and reproductive success in two-years-old transgenic zebrafish males. Anim. Reprod. Sci. 2013, 139:162-167.
12. Firth J.D., Ebert B.L., Pugh C.W., Ratcliffe P.J. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. Proc. Nat. Acad. Sci. USA 1994, 91:6496-6500.
13. Fisher J.W. Erythropoietin: physiology and pharmacology update. Exp. Biol. Med. 2003, 228:1-14.
14. Freeman R.S., Barone M.C. Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Current drug targets. CNS Neurol. Disord. 2005, 4:85-92.
15. Guan B., Hu W., Zhang T., Wang Y., Zhu Z. Metabolism traits of "all-fish" growth hormone transgenic common carp (Cyprinus carpio L.). Aquaculture 2008, 284:217-223.
16. Guan B., Ma H., Wang Y., Hu Y., Lin Z., Zhu Z., Hu W. Vitreoscilla hemoglobin (VHb) overexpression increases hypoxia tolerance in zebrafish (Danio rerio). Mar. Biotechnol. (New York, N.Y.) 2011, 13:336-344.
17. Gustafson K., Hagberg H., Bengtsson B.A., Brantsing C., Isgaard J. Possible protective role of growth hormone in hypoxia-ischemia in neonatal rats. Pediatr. Res. 1999, 45:318-323.
18. Jhingan E., Devlin R.H., Iwama G.K. Disease resistance, stress response and effects of triploidy in growth hormone transgenic coho salmon. J. Fish Biol. 2003, 63:806-823.
19. Lee C.G., Devlin R.H., Farrell A.P. Swimming performance, oxygen consumption and excess post-exercise oxygen consumption in adult transgenic and ocean-ranched coho salmon. J. Fish Biol. 2003, 62:753-766.
20. Leggatt R.A., Raven P.A., Mommsen T.P., Sakhrani D., Higgs D., Devlin R.H. Growth hormone transgenesis influences carbohydrate, lipid and protein metabolism capacity for energy production in coho salmon (Oncorhynchus kisutch). Comp. Biochem. Physiol. B 2009, 154:121-133.
21. Levesque H.M., Shears M.A., Fletcher G.L., Moon T.W. Myogenesis and muscle metabolism in juvenile Atlantic salmon (Salmo salar) made transgenic for growth hormone. J. Exp. Biol. 2008, 128-137.
22. Li R.C., Guo S.Z., Raccurt M., Moudilou E., Morel G., Brittian K.R., Gozal D. Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience 2011, 196:237-250.
23. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif.) 2001, 25:402-408.
24. Marques I.J., Leito J.T.D., Spaink H.P., Testerink J., Jaspers R.T., Witte F., Van den Berg S., Bagowski C.P. Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts. J. Comp. Physiol. B. 2008, 178:77-92.
25. Mauras N., Haymond M.W. Are the metabolic effects of GH and IGF-I separable?. Growth Horm. IGF Res. 2005, 15:19-27.
26. Maxwell P.H. Hypoxia-inducible factor as a physiological regulator. Exp. Physiol. 2005, 90:791-797.
27. McKenzie D.J., Martinez R., Morales A., Acosta J., Morales R., Taylor E.W., Steffensen J.F., Estrada M.P. Effects of growth hormone transgenesis on metabolic rate, exercise performance and hypoxia tolerance in tilapia hybrids. J. Fish Biol. 2003, 63:398-409.
28. Mori T., Hiraka I., Kurata Y., Kawachi H., Mano N., Devlin Robert.H., Nagoya H., Araki K. Changes in hepatic gene expression related to innate immunity, growth and iron metabolism in GH-transgenic amago salmon (Oncorhynchus masou) by cDNA subtraction and microarray analysis, and serum lysozyme activity. Gen. Comp. Endocrinol. 2007, 151:42-54.
29. Rosa C.E., Figueiredo M.A., Lanes C.F.C., Almeida D.V., Monserrat J.M., Marins L.F. Metabolic rate and reactive oxygen species production in different genotypes of GH-transgenic zebrafish. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2008, 149:209-214.
30. Rosa C.E., Kuradomi R.Y., Almeida D.V., Lannes C.F.C., Figueiredo M.A., Dytz A.G., Fonseca D.B., Marins Luis.Fernando. GH overexpression modifies muscle expression of anti-oxidant enzymes and increases spinal curvature of old zebrafish. Exp. Gerontol. 2010, 45:449-456.
31. Rosa C.E., Figueiredo M.A., Lanes C.F.C., Almeida D.V., Marins L.F. Genotype-dependent gene expression profile of the antioxidant defense system (ADS) in the liver of a GH-transgenic zebrafish model. Transgenic Res. 2011, 20:85-89.
32. Scheepens A., Sirimanne E., Beilharz E., Breier B.H., Waters M.J., Gluckman P.D., Williams C.E.B.H. Alterations in the neural growth hormone axis following hypoxic-ischemic brain injury. Brain Res. Mol. Brain Res. 1999, 68:88-100.
33. Shin D.H., Lee E., Kim J.-W., Kwon B., Jung M.K., Jee Y.H., Kim J., Bae S., Chang Y.P. Protective effect of growth hormone on neuronal apoptosis after hypoxia-ischemia in the neonatal rat brain. Neurosci. Lett. 2004, 354:64-68.
34. Stecyk J.A., Stensløkken K.-O., Farrell Anthony P., Nilsson G.E. Maintained cardiac pumping in anoxic crucian carp. Science 2004, 306:77.
35. Stevens E.D., Sutterlin A., Cook T. Respiratory metabolism and swimming performance in growth hormone transgenic Atlantic salmon. Can. J. Fish. Aquat. Sci. 1998, 55:2028-2035.
36. Studzinski A.L.M., Almeida D.V., Lanes C.F.C., Figueiredo M.A., Marins L.F. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Gen. Comp. Endocrinol. 2009, 161:67-72.
37. Sundström L.Fredrik., Lõhmus M., Johnsson J.I., Devlin Robert.H. Growth hormone transgenic salmon pay for growth potential with increased predation mortality. Proc. Biol. Sci. 2004, 271(Suppl.):S350-S352.
38. Sundt-Hansen L., Sundström L.F., Einum S., Hindar K., Fleming I.A., Devlin R.H. Genetically enhanced growth causes increased mortality in hypoxic environments. Biol. Lett. 2007, 3:165-168.
39. Ton C., Stamatiou D., Liew C.-C. Gene expression profile of zebrafish exposed to hypoxia during development. Physiol. Genomics 2003, 13:97-106.
40. Wenger R.H. Review mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 2000, 203:1253-1263.
41. Zhan H., Spitsbergen J.M., Qing W., Wu Y.L., Paul T.A., Casey J.W., Her G.M., Gong Z. Transgenic expression of walleye dermal sarcoma virus rv-cyclin gene in zebrafish and its suppressive effect on liver tumor development after carcinogen treatment. Mar. Biotechnol. (New York, N.Y.) 2010, 12:640-649.