Cav3-type α1T calcium channels mediate transient calcium currents that regulate repetitive firing in Drosophila antennal lobe PNs

Journal of Neurophysiology

Volumn 110, Issue 7, 2013, Pages 1490-1496

  Iniguez, Jorge ^a   Schutte, Soleil S ^a   O'Dowd, Diane K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cav3; Drosophila brain; Excitability; Transient calcium current

Indexed keywords

AMILORIDE; RNA; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL 3 TYPE ALPHA1T; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; DROSOPHILA PROTEIN;

ANTENNA (ORGAN); ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EVOKED RESPONSE; GENETIC CODE; KNOCKOUT GENE; NERVE CELL; NERVE CELL EXCITABILITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROJECTION NEURON; REDUCTION; RNA INTERFERENCE; ACTION POTENTIAL; ANIMAL; BRAIN; CAV3; CYTOLOGY; DROSOPHILA; DROSOPHILA BRAIN; EXCITABILITY; INNERVATION; METABOLISM; PHYSIOLOGY; TRANSIENT CALCIUM CURRENT;

CAV3; DROSOPHILA BRAIN; EXCITABILITY; TRANSIENT CALCIUM CURRENT;

ACTION POTENTIALS; AMILORIDE; ANIMALS; ARTHROPOD ANTENNAE; BRAIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; DROSOPHILA; DROSOPHILA PROTEINS; NEURONS;

EID: 84884964988     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00368.2013     Document Type: Article

References (35)

1. Adams CM, Anderson MG, Motto DG, Price MP, Johnson WA, Welsh MJ. Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. J Cell Biol 140: 143-152, 1998.
2. Baines RA, Bate M. Electrophysiological development of central neurons in the Drosophila embryo. J Neurosci 18: 4673-4683, 1998.
3. Bell TJ, Thaler C, Castiglioni AJ, Helton TD, Lipscombe D. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 41: 127-138, 2004.
4. Byerly L, Leung HT. Ionic currents of Drosophila neurons in embryonic cultures. J Neurosci 8: 4379-4393, 1988.
5. Catterall WA. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol 3: a003947, 2011.
6. Gielow ML, Gu GG, Singh S. Resolution and pharmacological analysis of the voltage-dependent calcium channels of Drosophila larval muscles. J Neurosci 15: 6085-6093, 1995.
7. Gouwens NW, Wilson RI. Signal propagation in Drosophila central neurons. J Neurosci 29: 6239-6249, 2009.
8. Gu H, Jiang SA, Campusano JM, Iniguez J, Su H, Hoang AA, Lavian M, Sun X, O'Dowd DK. Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J Neurophysiol 101: 42-53, 2009.
9. Gu H, O'Dowd DK. Cholinergic synaptic transmission in adult Drosophila Kenyon cells in situ. J Neurosci 26: 265-272, 2006.
10. Gu H, O'Dowd DK. Whole cell recordings from brain of adult Drosophila. J Vis Exp 6: 248, 2007.
11. Hildebrand JG, Shepherd GM. Mechanisms of olfactory discrimination: converging evidence for common principles across phyla. Annu Rev Neurosci 20: 595-631, 1997.
12. 2+ currents in canine cardiac Purkinje cells. Am J Physiol Heart Circ Physiol 256: H1478-H1492, 1989.
13. Ito K, Suzuki K, Estes P, Ramaswami M, Yamamoto D, Strausfeld NJ. The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen. Learn Mem 5: 52-77, 1998.
14. King GF. Modulation of insect Ca(v) channels by peptidic spider toxins. Toxicon 49: 513-530, 2007.
15. Lipscombe D, Andrade A, Allen SE. Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim Biophys Acta 1828: 1522-1529, 2013.
16. Littleton JT, Ganetzky B. Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26: 35-43, 2000.
17. Liu L, Johnson WA, Welsh MJ. Drosophila DEG/ENaC pickpocket genes are expressed in the tracheal system, where they may be involved in liquid clearance. Proc Natl Acad Sci USA 100: 2128-2133, 2003.
18. Mangoni ME, Traboulsie A, Leoni AL, Couette B, Marger L, Le Quang K, Kupfer E, Cohen-Solal A, Vilar J, Shin HS, Escande D, Charpentier F, Nargeot J, Lory P. Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ Res 98: 1422-1430, 2006.
19. Nowycky MC, Fox AP, Tsien RW. Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316: 440-443, 1985.
20. Olsen SR, Wilson RI. Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452: 956-960, 2008.
21. Olsen SR, Bhandawat V, Wilson RI. Excitatory interactions between olfactory processing channels in the Drosophila antennal lobe. Neuron 54: 89-103, 2007.
22. 2+ currents and a trigger for K+ channel homeostatic regulation. J Neurosci 27: 1072-1081, 2007.
23. Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 83: 117-161, 2003.
24. Rieckhof GE, Yoshihara M, Guan Z, Littleton JT. Presynaptic N-type calcium channels regulate synaptic growth. J Biol Chem 278: 41099-41108, 2003.
25. Root CM, Masuyama K, Green DS, Enell LE, Nassel DR, Lee CH, Wang JW. A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59: 311-321, 2008.
26. Ryglewski S, Lance K, Levine RB, Duch C. Cav2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. J Physiol 590: 809-825, 2012.
27. Smith LA, Wang X, Peixoto AA, Neumann EK, Hall LM, Hall JC. A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci 16: 7868-7879, 1996.
28. Stocker RF. The organization of the chemosensory system in Drosophila melanogaster: a review. Cell Tissue Res 275: 3-26, 1994.
29. Tang CM, Presser F, Morad M. Amiloride selectively blocks the low threshold (T) calcium channel. Science 240: 213-215, 1988.
30. Vosshall LB, Stocker RF. Molecular architecture of smell and taste in Drosophila. Annu Rev Neurosci 30: 505-533, 2007.
31. Wilson RI, Turner GC, Laurent G. Transformation of olfactory representations in the Drosophila antennal lobe. Science 303: 366-370, 2004.
32. Wilson RI, Mainen ZF. Early events in olfactory processing. Annu Rev Neurosci 29: 163-201, 2006.
33. 2+ currents in identified Drosophila motoneurons in situ. J Neurophysiol 100: 868-878, 2008.
34. Zelle KM, Lu B, Pyfrom SC, Ben-Shahar Y. The genetic architecture of degenerin/epithelial sodium channels in Drosophila. G3 (Bethesda) 3: 441-450, 2013.
35. Zheng W, Feng G, Ren D, Eberl DF, Hannan F, Dubald M, Hall LM. Cloning and characterization of a calcium channel alpha 1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform. J Neurosci 15: 1132-1143, 1995.