Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 12, 2013, Pages 1702-1713

  Horn, Thomas ^a   Ivanov, Igor ^b   Di Venere, Almerinda ^c   Kakularam, Kumar Reddy ^d   Reddanna, Pallu ^d   Conrad, Melanie L ^a   Richter, Constanze ^e   Scheerer, Patrick ^a   Kuhn, Hartmut ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY OF HYDERABAD   (India)

^e TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

ALOX15; ALOX15 gene variation; Lipid peroxidation; Lipoxygenase; Misfolding

Indexed keywords

ALOX15; ARACHIDONATE LIPOXYGENASE; ENZYME VARIANT; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; COMPUTER MODEL; ENZYME PURIFICATION; GENE EXPRESSION; GENE MUTATION; IMMUNOBLOTTING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING;

(5Z,8Z,10E,14Z)-12-HYDROPEROXYEICOSA-5,8,10,14-TETRAENOIC ACID; (5Z,8Z,11Z,13E)-15-HYDROPEROXYEICOSA-5,8,11,13-TETRAENOIC ACID; (5Z,9E,11Z,14Z)-8-HYDROPEROXYICOSA-5,9,11,14-TETRAENOIC ACID; (9Z,11E,13S)-13-HYDROPEROXYOCTADECA-9,11-DIENOIC ACID; 12-H(P)ETE; 13-H(P)ODE; 15-H(P)ETE; 8-H(P)ETE; ALOX; ALOX15; ALOX15 GENE VARIATION; ARACHIDONATE LIPOXYGENASE; HETE; HPETE; HYDROPEROXYEICOSATETRAENOIC ACID; HYDROXYEICOSATETRAENOIC ACID; IPTG; ISOPROPYL-Β-D-THIOGALACTOPYRANOSIDE; LIPID PEROXIDATION; LIPOXYGENASE; LIPOXYGENASES; LOXS; MISFOLDING; UNTRANSLATED REGION; UTR;

AMINO ACID SEQUENCE; ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; ENZYME STABILITY; ESCHERICHIA COLI; GLUTAMINE; GLYCINE; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN FOLDING; RABBITS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS;

MAMMALIA;

EID: 84884950397     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.08.004     Document Type: Article

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