Impact of targeting Kt instead of Kt/V

Nephrology Dialysis Transplantation

Volumn 28, Issue 10, 2013, Pages 2595-2603

  Maduell, Francisco ^a   Ramos, Rosa ^b   Palomares, Inés ^b   Martín Malo, Alejandro ^c   Molina, Manolo ^d   Bustamante, Jesús ^e   Pérez García, Rafael ^f   Grassmann, Aileen ^g   Merello, José Ignacio ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b NephroCare   (Spain)

^c HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^d HOSPITAL UNIVERSITARIO SANTA LUCÍA   (Spain)

^e HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^f HOSPITAL UNIVERSITARIO INFANTA LEONOR   (Spain)

^g Medical Board EMEALA   (United States)

Author keywords

adequacy; dialysis dose; ionic dialysance; Kt; online monitoring

Indexed keywords

AGE; AGED; ARTICLE; BLOOD FLOW VELOCITY; BODY WEIGHT; CENTRAL VENOUS CATHETER; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DOSE CALCULATION; FEMALE; GLOMERULONEPHRITIS; HEALTH CARE DELIVERY; HEMODIAFILTRATION; HEMODIALYSIS; HUMAN; INTERSTITIAL NEPHRITIS; KIDNEY ARTERIOVENOUS FISTULA; KIDNEY POLYCYSTIC DISEASE; KT SCORE; KT V SCORE; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PRIORITY JOURNAL; SEX DIFFERENCE; UROGENITAL SYSTEM PARAMETERS; VASCULAR ACCESS;

ADEQUACY; DIALYSIS DOSE; IONIC DIALYSANCE; KT; ONLINE MONITORING;

AGE FACTORS; AGED; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HEMODIAFILTRATION; HEMODIALYSIS SOLUTIONS; HUMANS; KIDNEY DISEASES; KINETICS; MALE; MODELS, STATISTICAL; MONITORING, PHYSIOLOGIC; ONLINE SYSTEMS; PROGNOSIS; RENAL DIALYSIS; TIME FACTORS; UREA;

EID: 84884921114     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft255     Document Type: Article

References (35)

1. Peticlerc T, Goux N, Reynier AL et al. A model for noninvasive estimation of in vivo dialyzer performances and patient's conductivity during hemodialysis. Int J Artif Organs 1993; 16: 585-591 (Pubitemid 23303702)
2. Steil H, Kaufman AM, Morris AT et al. In vivo verification of an automatic non invasive system for real time Kt evaluation. ASAIO 1993; 39: M348-M352 (Pubitemid 23311717)
3. Peticlerc T, Bene B, Jacobs C et al. Non-invasive monitoring of effective dialysis dose delivered to the haemodialysis patient. Nephrol Dial Transplant 1995; 10: 212-216
4. Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr 1980; 33: 27-39 (Pubitemid 10141676)
5. Ilstrup K, Hanson G, ShapiroWet al. Examining the foundations of urea kinetics. Trans Am Soc Artif Organs 1985; 31: 164-168
6. Lowrie EG, Chertow GM, Lew NL et al. The urea {clearance x dialysis time} product (Kt) as an outcome-based measure of hemodialysis dose. Kidney Int 1999; 56: 729-737 (Pubitemid 29353174)
7. Chertow GM, Owen WF, Lazarus JM et al. Exploring the reverse J-shaped curve between urea reduction ratio and mortality. Kidney Int 1999; 56: 1872-1878 (Pubitemid 29518188)
8. Lowrie EG, Li Z, Ofsthun NJ et al. The online measurement of hemodialysis dose (Kt): Clinical outcome as a function of body surface area. Kidney Int 2005; 68: 1344-1354 (Pubitemid 43246456)
9. Lowrie EG, Li Z, Ofsthun NJ et al. Evaluating a new method to judge dialysis treatment using online measurements of ionic clearance. Kidney Int 2006; 70: 211-217 (Pubitemid 44000141)
10. Aljama P. ORD Work and Initiative Group ('Optimising Results in Dialysis'). Nefrología 2012; 32: 701-703
11. Marcelli D, Moscardó V, Steil H et al. Data Management and Quality Assurance for Dialysis Network. Contrib Nephrol. 2002; 137: 293-299
12. Held PJ, Port FK, Wolfe RA et al. The dose of hemodialysis and patient mortality. Kidney Int 1996; 50: 550-556 (Pubitemid 26274384)
13. NKF-DOQI Hemodialysis Adequacy Work Group Membership. Guidelines for hemodialysis adequacy. Am J Kidney Dis 1997; 30: S22-S63
14. Maduell F, García M, Alcázar R. Dosificación y adecuación del tratamiento dialítico. Guías SEN: Guías de Centros de hemodiálisis. Nefrología 2006; 26: 15-21
15. European Best Practice Guidelines for Haemodialysis. Nephrol Dial Transplant 2002; 17: 17-21
16. The Canadian Society of Nephrology. Clinical practice guidelines the delivery of haemodialysis. J Am Soc Nephrol 1999; 10: S306-S310
17. The Renal Association. Recommended standards for haemodialysis. Royal College of Physicians of London. Treatment of adult patients with renal failure. Recommended standards and audit measure 1997; 17-29
18. Maduell F, Navarro V, García H et al. Results of monitoring the dose of hemodialysis in real time at every treatment session. Nefrología 1999; 19: 532-537
19. Teruel JL, Fernández Lucas M, Marcen R et al. Estimation of the Kt/V with a ionic dialysance monitor. Nefrología 2001; 21: 78-83
20. Maduell F, Puchades MJ, Navarro V et al. Monitoring hemodialysis dose with ionic dialysance in on-line hemodiafiltration. Nefrología 2005; 25: 521-526
21. Teruel JL, Álvarez Rancel LE, Fernández Lucas M et al. Control of the dialysis dose by ionic dialysance and bioimpedance. Nefrología 2007; 27: 68-73
22. Moret K, Beerenhout CH, van denWall Bake AWet al. Ionic dialysance and the assessment of Kt/V: the influence of different estimates of V on method agreement. Nephrol Dial Transplant 2007; 22: 2276-2282 (Pubitemid 47244706)
23. Lindley EJ, Chamney PW, Wuepper A et al. A comparison of methods for determining urea distribution volume for routine use in on-line monitoring of haemodialysis adequacy. Nephrol Dial Transplant 2009; 24: 211-216
24. Depner T, Daugirdas J, Greene T et al. Hemodialysis (HEMO) Study Group: Dialysis dose and the effect of gender and body sike on outcome in the HEMO Study. Kidney Int 2004; 65: 1386-1394 (Pubitemid 38406978)
25. Port FK, Wolfe RA, Hulbert-Shearon TE et al. High dialysis dose is associated with lower mortality among woman but not among men. Am J Kidney Dis 2004; 43: 1014-1023 (Pubitemid 38691496)
26. Spalding EM, Chandna SM, Davenport A et al. Kt/V underestimates the hemodialysis dose in women and small men. Kidney Int 2008; 74: 348-355 (Pubitemid 352001247)
27. Singer MA, Morton AR. Mouse to elephant: Biological scaling and Kt/V. Am J Kidney Dis 2000; 35: 306-309 (Pubitemid 30070854)
28. Singer MA. Of mice and men and elephant: Metabolic rate sets glomerular filtration rate. Am J Kidney Dis 2001; 37: 164-178 (Pubitemid 32055036)
29. Pisoni RL, Young EW, Dykstra DM et al. Vascular access use in Europe and the United States: results from the DOPPS. Kidney Int 2002; 61: 305-316 (Pubitemid 34075158)
30. Maduell F, Vera M, Arias M et al. How much should dialysis time be increased when catheters are used? Nefrología 2008; 28: 577-580.
31. Mohan S, Madhrira M, Mujtaba M et al. Effective Ionic dialysance/blood flow rate ratio: an indicator of access recirculation in arteriovenous fistulae. ASAIO J 2010; 56: 427-433
32. Tan J, Mohan S, Herbert L et al. Identifying hemodialysis catheter recirculation using effective ionic dialysance. ASAIO J 2012; 58: 522-525
33. Daugirdas JT, Depner TA, Kuhlmann MK et al. Surface-areanormalized Kt/V: A method of rescaling dialysis dose to body surface area- implications for different-size patients by gender. Semin Dial 2008; 21: 415-421
34. Ramirez SPB, Kapke A, Port FK et al. Dialysis dose scaled to body surface area and size-adjusted, sex-specific patient mortality. Clin J Am Soc Nephrol 2012; 7: 1977-1987
35. Basile C, Vernaglione L, Lomonte C et al. Comparison of alternative methods for scaling dialysis dose. Nephrol Dial Transplant 2010; 25: 1232-1239