Novel promising linezolid analogues: Rational design, synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 779-785

  De Rosa, Margherita ^a   Zanfardino, Anna ^b   Notomista, Eugenio ^b   Wichelhaus, Thomas A ^c   Saturnino, Carmela ^a   Varcamonti, Mario ^b   Soriente, Annunziata ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Antibacterial; Linezolid; Oxazolidinone; Structure activity relationship; Thiourea

Indexed keywords

1 ((3 (3 FLUORO 4 MORPHOLINOPHENYL) 2 OXOOXAZOLIDIN 5 YL)METHYL) 3 (4 METHOXYPHENYL)THIOUREA; 1 ((3 (3 FLUORO 4 MORPHOLINOPHENYL) 2 OXOOXAZOLIDIN 5 YL)METHYL) 3 (4 METHOXYPHENYL)UREA; 1 ((3 (3 FLUORO 4 MORPHOLINOPHENYL) 2 OXOOXAZOLIDIN 5 YL)METHYL) 3 (4 NITRO PHENYL)THIOUREA; 1 ((3 (3 FLUORO 4 MORPHOLINOPHENYL) 2 OXOOXAZOLIDIN 5 YL)METHYL) 3 (4 NITRO PHENYL)UREA; 1 ((3 (3 FLUORO 4 MORPHOLINOPHENYL) 2 OXOOXAZOLIDIN 5 YL)METHYL) 3 PHENYL THIOUREA; 1 ((3 (3 FLUORO 4 MORPHOLINOPHENYL) 2 OXOOXAZOLIDIN 5 YL)METHYL) 3 PHENYLUREA; ANTIBIOTIC AGENT; OXAZOLIDINONE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DESIGN; DRUG SYNTHESIS; HALOARCULA MARISMORTUI; HYDROGENATION; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RIBOSOME; STAPHYLOCOCCUS AUREUS;

ANTIBACTERIAL; LINEZOLID; OXAZOLIDINONE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

ACETAMIDES; ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLIDINONES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884913239     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.035     Document Type: Article

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