메뉴 건너뛰기




Volumn 119, Issue 19, 2013, Pages 3504-3513

Prognostic impact of the activation status of the Akt/mTOR pathway in synovial sarcoma

Author keywords

Akt; mammalian target of rapamycin; mutation; prognosis; synovial sarcoma

Indexed keywords

CISPLATIN; DOXORUBICIN; IFOSFAMIDE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC SUBUNIT ALPHA; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 84884908724     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28255     Document Type: Article
Times cited : (37)

References (31)
  • 1
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: From protein synthesis to cell size
    • Ruvinsky I, Meyuhas O,. Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem Sci. 2006; 31: 342-348.
    • (2006) Trends Biochem Sci , vol.31 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 2
    • 0032514376 scopus 로고    scopus 로고
    • Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway
    • West MJ, Stoneley M, Willis AE,. Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway. Oncogene. 1998; 17: 769-780.
    • (1998) Oncogene , vol.17 , pp. 769-780
    • West, M.J.1    Stoneley, M.2    Willis, A.E.3
  • 3
    • 39749166236 scopus 로고    scopus 로고
    • Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth
    • Tornkvist M, Natalishvili N, Xie Y, et al. Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth. Biochem Biophys Res Commun. 2008; 368: 793-800.
    • (2008) Biochem Biophys Res Commun , vol.368 , pp. 793-800
    • Tornkvist, M.1    Natalishvili, N.2    Xie, Y.3
  • 4
    • 70349509457 scopus 로고    scopus 로고
    • Adaptor protein crk induces src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation
    • Watanabe T, Tsuda M, Tanaka S, et al. Adaptor protein crk induces src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. Mol Cancer Res. 2009; 7: 1582-1592.
    • (2009) Mol Cancer Res , vol.7 , pp. 1582-1592
    • Watanabe, T.1    Tsuda, M.2    Tanaka, S.3
  • 5
    • 79960911022 scopus 로고    scopus 로고
    • Phosphatidylinositol-3′-kinase/AKT signaling is essential in synovial sarcoma
    • Friedrichs N, Trautmann M, Endl E, et al. Phosphatidylinositol-3′- kinase/AKT signaling is essential in synovial sarcoma. Int J Cancer. 2011; 129: 1564-1575.
    • (2011) Int J Cancer , vol.129 , pp. 1564-1575
    • Friedrichs, N.1    Trautmann, M.2    Endl, E.3
  • 6
    • 84863836492 scopus 로고    scopus 로고
    • A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway
    • Hosaka S, Horiuchi K, Yoda M, et al. A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway. J Orthop Res. 2012; 30: 1493-1498.
    • (2012) J Orthop Res , vol.30 , pp. 1493-1498
    • Hosaka, S.1    Horiuchi, K.2    Yoda, M.3
  • 7
    • 84855556875 scopus 로고    scopus 로고
    • Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
    • Chawla SP, Staddon AP, Baker LH, et al. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J Clin Oncol. 2012; 30: 78-84.
    • (2012) J Clin Oncol , vol.30 , pp. 78-84
    • Chawla, S.P.1    Staddon, A.P.2    Baker, L.H.3
  • 8
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers [serial online]
    • Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers [serial online]. Science. 2004; 304: 554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 9
    • 34547172596 scopus 로고    scopus 로고
    • A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
    • Carpten JD, Faber AL, Horn C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature. 2007; 448: 439-444.
    • (2007) Nature , vol.448 , pp. 439-444
    • Carpten, J.D.1    Faber, A.L.2    Horn, C.3
  • 11
    • 64249099411 scopus 로고    scopus 로고
    • Edge S.B. Byrd D.R. Compton C.C. Fritz A.G. Greene F.L. Trotti A. eds. 7th ed. St. Louis, MO: Springer.
    • Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, eds. AJCC Cancer Staging Manual. 7th ed. St. Louis, MO: Springer; 2010.
    • (2010) AJCC Cancer Staging Manual
  • 12
    • 84857995538 scopus 로고    scopus 로고
    • The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas
    • Setsu N, Yamamoto H, Kohashi K, et al. The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas. Cancer. 2012; 118: 1637-1648.
    • (2012) Cancer , vol.118 , pp. 1637-1648
    • Setsu, N.1    Yamamoto, H.2    Kohashi, K.3
  • 13
    • 70349696530 scopus 로고    scopus 로고
    • EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors
    • Dobashi Y, Suzuki S, Sato E, Hamada Y, Yanagawa T, Ooi A,. EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors. Mod Pathol. 2009; 22: 1328-1340.
    • (2009) Mod Pathol , vol.22 , pp. 1328-1340
    • Dobashi, Y.1    Suzuki, S.2    Sato, E.3    Hamada, Y.4    Yanagawa, T.5    Ooi, A.6
  • 14
    • 67649698279 scopus 로고    scopus 로고
    • Molecular characterization of synovial sarcoma in children and adolescents: Evidence of Akt activation
    • Bozzi F, Ferrari A, Negri T, et al. Molecular characterization of synovial sarcoma in children and adolescents: evidence of Akt activation. Transl Oncol. 2008; 1: 95-101.
    • (2008) Transl Oncol , vol.1 , pp. 95-101
    • Bozzi, F.1    Ferrari, A.2    Negri, T.3
  • 15
    • 33744793989 scopus 로고    scopus 로고
    • Prognostic significance of activated AKT expression in soft-tissue sarcoma
    • Tomita Y, Morooka T, Hoshida Y, et al. Prognostic significance of activated AKT expression in soft-tissue sarcoma. Clin Cancer Res. 2006; 12: 3070-3077.
    • (2006) Clin Cancer Res , vol.12 , pp. 3070-3077
    • Tomita, Y.1    Morooka, T.2    Hoshida, Y.3
  • 16
    • 0033564810 scopus 로고    scopus 로고
    • Synovial sarcoma: Identification of low and high risk groups
    • Bergh P, Meis-Kindblom JM, Gherlinzoni F, et al. Synovial sarcoma: identification of low and high risk groups. Cancer. 1999; 85: 2596-2607.
    • (1999) Cancer , vol.85 , pp. 2596-2607
    • Bergh, P.1    Meis-Kindblom, J.M.2    Gherlinzoni, F.3
  • 17
    • 0035863551 scopus 로고    scopus 로고
    • Prognostic factors in localized primary synovial sarcoma: A multicenter study of 128 adult patients
    • Trassard M, Le Doussal V, Hacene K, et al. Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol. 2001; 19: 525-534.
    • (2001) J Clin Oncol , vol.19 , pp. 525-534
    • Trassard, M.1    Le Doussal, V.2    Hacene, K.3
  • 18
    • 1442353518 scopus 로고    scopus 로고
    • Synovial sarcoma: The importance of size and location for survival
    • Deshmukh R, Mankin HJ, Singer S,. Synovial sarcoma: the importance of size and location for survival. Clin Orthop Relat Res. 2004; 419: 155-161.
    • (2004) Clin Orthop Relat Res , vol.419 , pp. 155-161
    • Deshmukh, R.1    Mankin, H.J.2    Singer, S.3
  • 19
    • 67649887764 scopus 로고    scopus 로고
    • Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma
    • Sun Y, Sun B, Wang J, et al. Prognostic implication of SYT-SSX fusion type and clinicopathological parameters for tumor-related death, recurrence, and metastasis in synovial sarcoma. Cancer Sci. 2009; 100: 1018-1025.
    • (2009) Cancer Sci , vol.100 , pp. 1018-1025
    • Sun, Y.1    Sun, B.2    Wang, J.3
  • 20
    • 38749096959 scopus 로고    scopus 로고
    • Prognostic implication of SYT-SSX fusion type in synovial sarcoma: A multi-institutional retrospective analysis in Japan
    • Takenaka S, Ueda T, Naka N, et al. Prognostic implication of SYT-SSX fusion type in synovial sarcoma: a multi-institutional retrospective analysis in Japan. Oncol Rep. 2008; 19: 467-476.
    • (2008) Oncol Rep , vol.19 , pp. 467-476
    • Takenaka, S.1    Ueda, T.2    Naka, N.3
  • 21
    • 0035815669 scopus 로고    scopus 로고
    • Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver
    • Jiang YP, Ballou LM, Lin RZ,. Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver. J Biol Chem. 2001; 276: 10943-10951.
    • (2001) J Biol Chem , vol.276 , pp. 10943-10951
    • Jiang, Y.P.1    Ballou, L.M.2    Lin, R.Z.3
  • 22
    • 0034847757 scopus 로고    scopus 로고
    • Amino acid regulation of gene expression
    • discussion 2486S-2487S
    • Jefferson LS, Kimball SR,. Amino acid regulation of gene expression. J Nutr. 2001; 131: 2460S-2466S; discussion 2486S-2487S.
    • (2001) J Nutr , vol.131
    • Jefferson, L.S.1    Kimball, S.R.2
  • 23
    • 77955090106 scopus 로고    scopus 로고
    • Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
    • Barretina J, Taylor BS, Banerji S, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010; 42: 715-721.
    • (2010) Nat Genet , vol.42 , pp. 715-721
    • Barretina, J.1    Taylor, B.S.2    Banerji, S.3
  • 24
    • 79955695047 scopus 로고    scopus 로고
    • Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma
    • Teng HW, Wang HW, Chen WM, et al. Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma. J Surg Oncol. 2011; 103: 773-781.
    • (2011) J Surg Oncol , vol.103 , pp. 773-781
    • Teng, H.W.1    Wang, H.W.2    Chen, W.M.3
  • 25
    • 13444291031 scopus 로고    scopus 로고
    • Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma
    • Thomas DG, Giordano TJ, Sanders D, et al. Expression of receptor tyrosine kinases epidermal growth factor receptor and HER-2/neu in synovial sarcoma. Cancer. 2005; 103: 830-838.
    • (2005) Cancer , vol.103 , pp. 830-838
    • Thomas, D.G.1    Giordano, T.J.2    Sanders, D.3
  • 26
    • 20244389571 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas: A clinicopathologic study of 281 cases
    • Sato O, Wada T, Kawai A, et al. Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas: a clinicopathologic study of 281 cases. Cancer. 2005; 103: 1881-1890.
    • (2005) Cancer , vol.103 , pp. 1881-1890
    • Sato, O.1    Wada, T.2    Kawai, A.3
  • 27
    • 67650688576 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor 2 in mesenchymal neoplasms
    • Steigen SE, Schaeffer DF, West RB, Nielsen TO,. Expression of insulin-like growth factor 2 in mesenchymal neoplasms. Mod Pathol. 2009; 22: 914-921.
    • (2009) Mod Pathol , vol.22 , pp. 914-921
    • Steigen, S.E.1    Schaeffer, D.F.2    West, R.B.3    Nielsen, T.O.4
  • 28
    • 25844517872 scopus 로고    scopus 로고
    • Mutational analysis of the c-KIT and PDGFRalpha in a series of molecularly well characterized synovial sarcomas
    • Lopez-Guerrero JA, Navarro S, Noguera R, et al. Mutational analysis of the c-KIT AND PDGFRalpha in a series of molecularly well characterized synovial sarcomas. Diagn Mol Pathol. 2005; 14: 134-139.
    • (2005) Diagn Mol Pathol , vol.14 , pp. 134-139
    • Lopez-Guerrero, J.A.1    Navarro, S.2    Noguera, R.3
  • 29
    • 84865722534 scopus 로고    scopus 로고
    • PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: Implications for combination targeted therapy of synovial sarcoma
    • Ho AL, Vasudeva SD, Lae M, et al. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma. Cancer Res. 2012; 72: 4515-4525.
    • (2012) Cancer Res , vol.72 , pp. 4515-4525
    • Ho, A.L.1    Vasudeva, S.D.2    Lae, M.3
  • 30
    • 84861098484 scopus 로고    scopus 로고
    • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): A randomised, double-blind, placebo-controlled phase 3 trial
    • van der Graaf WT, Blay JY, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012; 379: 1879-1886.
    • (2012) Lancet , vol.379 , pp. 1879-1886
    • Van Der Graaf, W.T.1    Blay, J.Y.2    Chawla, S.P.3
  • 31
    • 84875803717 scopus 로고    scopus 로고
    • Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: A multicentre, open-label, phase 2 trial
    • Schwartz GK, Tap WD, Qin LX, et al. Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol. 2013; 14: 371-382.
    • (2013) Lancet Oncol , vol.14 , pp. 371-382
    • Schwartz, G.K.1    Tap, W.D.2    Qin, L.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.