Enhancement of CIITA transcriptional function by ubiquitin

Nature Immunology

Volumn 4, Issue 11, 2003, Pages 1074-1082

  Greer, Susanna F ^a,b   Zika, Eleni ^a   Conti, Brian ^b   Zhu, Xin Sheng ^a,c   Ting, Jenny P Y ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; MESSENGER RNA; TRANSCRIPTION FACTOR; UBIQUITIN;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; GENE EXPRESSION; GENETIC CODE; HELA CELL; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; TRANSACTIVATION;

ANIMALS; CHROMATIN; HISTOCOMPATIBILITY ANTIGENS CLASS II; HISTONE DEACETYLASES; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; UBIQUITIN;

EID: 0242708771     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni985     Document Type: Article

References (44)

1. Hershko, A. & Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem. 67, 425-479 (1998).
2. Chau, V. et al. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243, 1576-1583 (1989).
3. Thrower, J.S., Hoffman, L., Rechsteiner, M. & Pickart, C.M. Recognition of the polyubiquitin proteolytic signal. EMBO J. 19, 94-102 (2000).
4. Pickart, C.M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533 (2001).
5. Pickart, C.M. Ubiquitin enters the new millennium. Mol. Cell 8, 499-504 (2001).
6. Hansen, J.C., Tse, C. & Wolffe, A.P. Structure and function of the core histone N-termini: more than meets the eye. Biochemistry 37, 17637-17641 (1998).
7. Johnson, E.S. Ubiquitin branches out. Nat. Cell Biol. 4, E295-E298 (2002).
8. Sun, Z.W. & Allis, C.D. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418, 104-108 (2002).
9. Conaway, R.C., Brower, C.S. & Conaway, J.W. Emerging roles of ubiquitin in transcription regulation. Science 296, 1254-1258 (2002).
10. Ghosh, S., May, M.J. & Kopp, E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260 (1998).
11. Salghetti, S.E., Caudy, A.A., Chenoweth, J.G. & Tansey, W.P. Regulation of transcriptional activation domain function by ubiquitin. Science 293, 1651-1653 (2001).
12. Harton, J.A. & Ting, J.P. Class II transactivator: mastering the art of major histocompatibility complex expression. Mol. Cell Biol. 20, 6185-6194 (2000).
13. Ting, J.P. & Trowsdale, J. Genetic control of MHC class II expression. Cell 109 (suppl.), S21-S33 (2002).
14. Steimle, V., Otten, L.A., Zufferey, M. & Mach, B. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75, 135-146 (1993).
15. Mach, B., Steimle, V., Martinez-Soria, E. & Reith, W. Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14, 301-331 (1996).
16. Masternak, K. et al. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 14, 1156-1166 (2000).
17. Zhu, X.S. et al. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol. Cell. Biol. 20, 6051-6061 (2000).
18. Fontes, J.D., Jiang, B. & Peterlin, B.M. The class II trans-activator CIITA interacts with the TBP-associated factorTAFII32. Nucleic Acids Res. 25, 2522-2528 (1997).
19. Jabrane-Ferrat, N., Nekrep, N., Tosi, G., Esserman, L. & Peterlin, B.M. MHC class II enhanceosome: how is the class II transactivator recruited to DNA-bound activators? Int. Immunol. 15, 467-475 (2003).
20. Terrell, J., Shih, S., Dunn, R. & Hicke, L. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol. Cell 1, 193-202 (1998).
21. Robzyk, K., Recht, J. & Osley, M.A. Rad6-dependent ubiquitination of histone H2B in yeast. Science 287, 501-504 (2000).
22. Pham, A.D. & Sauer, F. Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila. Science 289, 2357-2360 (2000).
23. Zika, E., Greer, S. F., Zhu, X.S. & Ting, J.P. Histone deacetylase 1/mSin3A disrupts γ-interferon-induced CIITA function and major histocompatibility complex class II enhanceosome formation. Mol. Cell. Biol. 23, 3091-3102 (2003).
24. Pattenden, S.G., Klose, R., Karaskov, E. & Bremner, R. Interferon-γ-induced chromatin remodeling at the CIITA locus is BRG1 dependent. EMBO J. 21, 1978-1986 (2002).
25. Fontes, J.D., Kanazawa, S., Nekrep, N. & Peterlin, B.M. The class II transactivator CIITA is a transcriptional integrator. Microbes Infect. 1, 863-869 (1999).
26. Mahanta, S.K., Scholl, T., Yang, F.C. & Strominger, J.L. Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. Proc. Natl. Acad. Sci. USA 94, 6324-6329 (1997).
27. Masternak, K. & Reith, W. Promoter-specific functions of CIITA and the MHC class II enhanceosome in transcriptional activation. EMBO J. 21, 1379-1388 (2002).
28. Sisk, T.J., Gourley, T., Roys, S. & Chang, C.H. MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300. J. Immunol. 165, 2511-2517 (2000).
29. Spilianakis, C., Papamatheakis, J. & Kretsovali, A. Acetylation by PCAF enhances CIITA nuclear accumulation and transactivation of major histocompatibility complex class II genes. Mol. Cell. Biol. 20, 8489-8498 (2000).
30. 2l and other promoters. Mol. Cell Biol. 21, 7078-7088 (2001).
31. Magner, W.J. et al. Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors. J. Immunol. 165, 7017-7024 (2000).
32. Jiang, H. et al. PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. Mol. Cell. Biol. 19, 8136-8145 (1999).
33. Beresford, G.W. & Boss, J.M. CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter. Nat. Immunol. 2, 652-657 (2001).
34. Fontes, J.D., Kanazawa, S., Jean, D. & Peterlin, B.M. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell. Biol. 19, 941-947 (1999).
35. Kretsovali, A. et al. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18, 6777-6783 (1998).
36. Grossman, S.R. et al. Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science 300, 342-344 (2003).
37. Cressman, D.E., O'Connor, W.J., Greer, S.F., Zhu, X.S. & Ting, J.P. Mechanisms of nuclear import and export that control the subcellular localization of class II transactivator. J. Immunol. 167, 3626-3634 (2001).
38. Cressman, D.E., Chin, K.C., Taxman, D.J. & Ting, J.P. A defect in the nuclear translocation of CIITA causes a form of type II bare lymphocyte syndrome. Immunity 10, 163-171 (1999).
39. Ashburner, B.P., Westerheide, S.D. & Baldwin, A.S. Jr. The p65 (RelA) subunit of NF-κB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21, 7065-7077 (2001).
40. Riley, J.L., Westerheide, S.D., Price, J.A., Brown, J.A. & Boss, J.M. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 2, 533-543 (1995).
41. Lafarga, M. et al. Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. Mol. Biol. Cell. 13, 2771-2782 (2002).
42. Piskurich, J.F., Linhoff, M.W., Wang, Y. & Ting, J.P. Two distinct γ-interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor β. Mol. Cell. Biol. 19, 431-440 (1999).
43. Wong, A.W. et al. Regulation and specificity of MHC2TA promoter usage in human primary T lymphocytes and cell line. J. Immunol. 169, 3112-3119 (2002).
44. Osborne, A., Zhang, H., Yang, W.M., Seto, E. & Blanck, G. Histone deacetylase activity represses γ-interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation. Mol. Cell. Biol. 21, 6495-6506