Faster Metabolite 1H Transverse Relaxation in the Elder Human Brain

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Marjańska, Małgorzata ^a   Emir, Uzay E ^a,b   Deelchand, Dinesh K ^a   Terpstra, Melissa ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; ASCORBIC ACID; ASPARTIC ACID; CHOLINE; CREATINE PHOSPHATE; CREATININE; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLYCEROPHOSPHORYLCHOLINE; GLYCINE; HYDROGEN; INOSITOL; LACTIC ACID; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; PHOSPHOETHANOLAMINE; PHOSPHORYLCHOLINE; TAURINE; THREONINE;

ADULT; AGED; AGING; ARTICLE; BRAIN; BRAIN ATROPHY; BRAIN DEGENERATION; CEREBROSPINAL FLUID LEVEL; FEMALE; GERIATRIC DEPRESSION SCALE; HUMAN; IN VIVO STUDY; INFORMED CONSENT; MALE; METABOLITE; MILD COGNITIVE IMPAIRMENT; MONTE CARLO METHOD; MONTREAL COGNITIVE ASSESSMENT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL CORTEX; PSYCHOLOGIC TEST; RELAXATION TIME; SIGNAL NOISE RATIO; TISSUE WATER; WATER CONTENT;

ADOLESCENT; AGED; AGED, 80 AND OVER; AGING; ASPARTIC ACID; CELLULAR MICROENVIRONMENT; CHOLINE; CREATINE; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OCCIPITAL LOBE;

EID: 84884867494     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077572     Document Type: Article

References (40)

1. de Graaf RA, (2007) In Vivo NMR Spectroscopy. Principles and Techniques. John Wiley & Sons, Ltd.
2. Nicolay K, Braun KP, Graaf RA, Dijkhuizen RM, Kruiskamp MJ, (2001) Diffusion NMR spectroscopy. NMR Biomed 14: 94-111. doi:10.1002/nbm.686. PubMed: 11320536.
3. Ross B, Bluml S, (2001) Magnetic resonance spectroscopy of the human brain. Anat Rec 265: 54-84. doi:10.1002/ar.1058. PubMed: 11323770.
4. Birken DL, Oldendorf WH, (1989) N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1 H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 13: 23-31. doi:10.1016/S0149-7634(89)80048-X. PubMed: 2671831.
5. Valette J, Guillermier M, Besret L, Hantraye P, Bloch G, et al. (2007) Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by 1 H nuclear magnetic resonance spectroscopy of the monkey brain. J Cereb Blood Flow Metab 27: 588-596. doi:10.1038/sj.jcbfm.9600353. PubMed: 16788716.
6. Ongür D, Prescot AP, Jensen JE, Rouse ED, Cohen BM, et al. (2010) T2 relaxation time abnormalities in bipolar disorder and schizophrenia. Magn Reson Med 63: 1-8. PubMed: 19918902.
7. Lei H, Zhang Y, Zhu XH, Chen W, (2003) Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T. Magn Reson Med 49: 979-984.
8. Larvaron P, Bielicki G, Boespflug-Tanguy O, Renou JP, (2006) Proton MRS of early post-natal mouse brain modifications in vivo. NMR Biomed 19: 180-187. doi:10.1002/nbm.997. PubMed: 16470692.
9. Tunc-Skarka N, Weber-Fahr W, Hoerst M, Meyer-Lindenberg A, Zink M, et al. (2009) MR spectroscopic evaluation of N-acetylaspartate's T2 relaxation time and concentration corroborates white matter abnormalities in schizophrenia. NeuroImage 48: 525-531. doi:10.1016/j.neuroimage.2009.06.061. PubMed: 19573608.
10. Christiansen P, Toft P, Larsson HB, Stubgaard M, Henriksen O, (1993) The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn Reson Imaging 11: 799-806. doi:10.1016/0730-725X(93)90197-L. PubMed: 8371635.
11. Kirov I, Fleysher L, Fleysher R, Patil V, Liu S, et al. (2008) Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T. Magn Reson Med 60: 790-795.
12. Kreis R, Slotboom J, Hofmann L, Boesch C, (2005) Integrated data acquisition and processing to determine metabolite contents, relaxation times, and macromolecule baseline in single examinations of individual subjects. Magn Reson Med 54: 761-768. doi:10.1002/mrm.20673. PubMed: 16161114.
13. Brooks JC, Roberts N, Kemp GJ, Gosney MA, Lye M, et al. (2001) A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations. Cereb Cortex 11: 598-605. doi:10.1093/cercor/11.7.598. PubMed: 11415962.
14. Double KL, Reyes S, Werry EL, Halliday GM, (2010) Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions? Prog Neurobiol 92: 316-329. doi:10.1016/j.pneurobio.2010.06.001. PubMed: 20541584.
15. Wang X, Michaelis ML, Michaelis EK, (2010) Functional genomics of brain aging and Alzheimer's disease: focus on selective neuronal vulnerability. Curr Genomics 11: 618-633. doi:10.2174/138920210793360943. PubMed: 21629439.
16. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, et al. (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53: 695-699. doi:10.1111/j.1532-5415.2005.53221.x. PubMed: 15817019.
17. Onishi J, Suzuki Y, Umegaki H, Endo H, Kawamura T, et al. (2006) A comparison of depressive mood of older adults in a community, nursing homes, and a geriatric hospital: factor analysis of Geriatric Depression Scale. J Geriatr Psychiatry Neurol 19: 26-31. doi:10.1177/0891988705284725. PubMed: 16449757.
18. Adriany G, Gruetter R, (1997) A half-volume coil for efficient proton decoupling in humans at 4 tesla. J Magn Reson 125: 178-184. doi:10.1006/jmre.1997.1113. PubMed: 9245377.
19. Hennig J, Nauerth A, Friedburg H, (1986) RARE imaging: a fast imaging method for clinical MR. Magn Reson Med 3: 823-833. doi:10.1002/mrm.1910030602. PubMed: 3821461.
20. Gruetter R, (1993) Automatic, localized in vivo adjustment of all first- and second-order shim coils. Magn Reson Med 29: 804-811. doi:10.1002/mrm.1910290613. PubMed: 8350724.
21. Gruetter R, Tkác I, (2000) Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 43: 319-323. doi:10.1002/(SICI)1522-2594(200002)43:2. PubMed: 10680699.
22. Tkáč I, Gruetter R, (2005) Methodology of 1 H NMR Spectroscopy of the Human Brain at Very High Magnetic Fields. Appl Magn Reson 29: 139-157. doi:10.1007/BF03166960. PubMed: 20179773.
23. Tkác I, Oz G, Adriany G, Uǧurbil K, Gruetter R, (2009) In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T. Magn Reson Med 62: 868-879. doi:10.1002/mrm.22086. PubMed: 19591201.
24. Tkác I, Starcuk Z, Choi IY, Gruetter R, (1999) In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 41: 649-656. doi:10.1002/(SICI)1522-2594(199904)41:4. PubMed: 10332839.
25. Pfeuffer J, Tkác I, Provencher SW, Gruetter R, (1999) Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time 1H NMR spectra of the rat brain. J Magn Reson 141: 104-120. doi:10.1006/jmre.1999.1895. PubMed: 10527748.
26. Provencher SW, (1993) Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30: 672-679. doi:10.1002/mrm.1910300604. PubMed: 8139448.
27. Provencher SW, (2001) Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed 14: 260-264. doi:10.1002/nbm.698. PubMed: 11410943.
28. Henry PG, Marjanska M, Walls JD, Valette J, Gruetter R, et al. (2006) Proton-observed carbon-edited NMR spectroscopy in strongly coupled second-order spin systems. Magn Reson Med 55: 250-257. doi:10.1002/mrm.20764. PubMed: 16402370.
29. Govindaraju V, Young K, Maudsley AA, (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13: 129-153. doi:10.1002/1099-1492(200005)13:3. PubMed: 10861994.
30. Kaiser LG, Marjańska M, Matson GB, Iltis I, Bush SD, et al. (2010) H MRS detection of glycine residue of reduced glutathione in vivo pp. 1. J Magn Reson 202: 259-266 doi:10.1016/j.jmr.2009.11.013. PubMed: 20005139.
31. Ernst T, Kreis R, Ross BD, (1993) Absolute Quantitation of Water and Metabolites in the Human Brain. 1. Compartments and Water. J Magn Reson B 102: 1-8. doi:10.1006/jmrb.1993.1055.
32. Kruse T, Reiber H, Neuhoff V, (1985) Amino acid transport across the human blood-CSF barrier. An evaluation graph for amino acid concentrations in cerebrospinal fluid. J Neurol Sci 70: 129-138. doi:10.1016/0022-510X(85)90082-6. PubMed: 4056818.
33. Hetherington HP, Mason GF, Pan JW, Ponder SL, Vaughan JT, et al. (1994) Evaluation of cerebral gray and white matter metabolite differences by spectroscopic imaging at 4.1T. Magn Reson Med 32: 565-571. doi:10.1002/mrm.1910320504. PubMed: 7808257.
34. Posse S, Cuenod CA, Risinger R, Le Bihan D, Balaban RS, (1995) Anomalous transverse relaxation in 1 H spectroscopy in human brain at 4 Tesla. Magn Reson Med 33: 246-252. doi:10.1002/mrm.1910330215. PubMed: 7707916.
35. Michaeli S, Garwood M, Zhu XH, DelaBarre L, Andersen P, et al. (2002) Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T. Magn Reson Med 47: 629-633.
36. Dickstein DL, Kabaso D, Rocher AB, Luebke JI, Wearne SL, et al. (2007) Changes in the structural complexity of the aged brain. Aging Cell 6: 275-284. doi:10.1111/j.1474-9726.2007.00289.x. PubMed: 17465981.
37. Bishop NA, Lu T, Yankner BA, (2010) Neural mechanisms of ageing and cognitive decline. Nature 464: 529-535. doi:10.1038/nature08983. PubMed: 20336135.
38. Peters A, (2002) The effects of normal aging on myelin and nerve fibers: a review. J Neurocytol 31: 581-593. doi:10.1023/A:1025731309829. PubMed: 14501200.
39. Mitsumori F, Watanabe H, Takaya N, (2009) Estimation of brain iron concentration in vivo using a linear relationship between regional iron and apparent transverse relaxation rate of the tissue water at 4.7T. Magn Reson Med 62: 1326-1330. doi:10.1002/mrm.22097. PubMed: 19780172.
40. Schenker C, Meier D, Wichmann W, Boesiger P, Valavanis A, (1993) Age distribution and iron dependency of the T2 relaxation time in the globus pallidus and putamen. Neuroradiology 35: 119-124. doi:10.1007/BF00593967. PubMed: 8433786.