Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes

Angewandte Chemie - International Edition

Volumn 52, Issue 39, 2013, Pages 10286-10289

  Lee, Kyeong ^b   Ban, Hyun Seung ^a   Naik, Ravi ^b   Hong, Ye Seul ^a   Son, Seohyun ^b   Kim, Bo Kyung ^a   Xia, Yan ^b   Song, Kyung Bin ^c   Lee, Hong Sub ^d   Won, Misun ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Dongguk University   (South Korea)

^c Chungnam National University   (South Korea)

^d ILDONG Pharmaceutical Co   (South Korea)

Author keywords

click chemistry; fluorescent probes; HIF inhibitors; malate dehydrogenase 2; photoaffinity labeling

Indexed keywords

CHEMICAL PROBES; CLICK CHEMISTRY; FLUORESCENT PROBES; INHIBITORY ACTIVITY; MALATE DEHYDROGENASE; PHOTOACTIVATABLE; PHOTOAFFINITY LABELING; TARGET PROTEINS;

PROTEINS; TARGET TRACKING;

BIOSYNTHESIS;

HYPOXIA INDUCIBLE FACTOR 1; MALATE DEHYDROGENASE; MALATE DEHYDROGENASE 2;

ARTICLE; CLICK CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENT PROBES; HIF INHIBITORS; HUMAN; METABOLISM; MITOCHONDRION; PHOTOAFFINITY LABELING; PROTEIN BINDING; SYNTHESIS; TUMOR CELL LINE;

CLICK CHEMISTRY; FLUORESCENT PROBES; HIF INHIBITORS; MALATE DEHYDROGENASE 2; PHOTOAFFINITY LABELING;

CELL LINE, TUMOR; CLICK CHEMISTRY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MALATE DEHYDROGENASE; MITOCHONDRIA; PHOTOAFFINITY LABELS; PROTEIN BINDING;

EID: 84884824876     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201304987     Document Type: Article

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