Synthesis and structure-activity relationship of (E)-phenoxyacrylic amide derivatives as Hypoxia-Inducible Factor (HIF) 1α inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 23, 2012, Pages 10564-10571

  Naik, Ravi ^a   Won, Misun ^b   Kim, Bo Kyung ^b   Xia, Yan ^a   Choi, Hyun Kyung ^a   Jin, Guanghai ^a   Jung, Youngjin ^c   Kim, Hwan Mook ^d   Lee, Kyeong ^a  

^a Dongguk University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

^d Gachon University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 (4 ADAMANTAN 1 YLPHENOXY)ACRYLAMIDO]BENZOIC ACID METHYL ESTER; 3 [3 (4 ADAMANTAN 1 YLPHENOXY)ACRYLAMIDO]BENZOIC ACID MORPHOLINOETHYL ESTER; ACRYLIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SUNITINIB; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL HYPOXIA; CELL MIGRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; CELL LINE, TUMOR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871002070     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301419d     Document Type: Article

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