The carbon monoxide re-breathing method can underestimate Hbmass due to incomplete blood mixing

European Journal of Applied Physiology

Volumn 113, Issue 9, 2013, Pages 2425-2430

  Keiser, Stefanie ^a,b   Siebenmann, Christoph ^a   Bonne, Thomas Christian ^a   Sørensen, Henrik ^a   Robach, Paul ^c   Lundby, Carsten ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c Ecole Nationale des Sports de Montagne   (France)

Author keywords

Blood volume; CO; nHb; RCV; Red cell mass

Indexed keywords

CARBON MONOXIDE; CARBOXYHEMOGLOBIN; HEMOGLOBIN;

ADULT; ARTICLE; BLOOD; BREATHING; EXERCISE; HUMAN; MALE; METABOLISM; PHYSIOLOGY; VEIN;

ADULT; CARBON MONOXIDE; CARBOXYHEMOGLOBIN; EXERCISE; HEMOGLOBINS; HUMANS; MALE; RESPIRATION; VEINS;

EID: 84884812492     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-013-2681-0     Document Type: Article

References (26)

1. Ashenden MJ, Gore CJ, Burge CM, Clough ML, Bourdon PC, Dobson GP, Hahn AG (1999) Skin-prick blood samples are reliable for estimating Hb mass with the CO-dilution technique. Eur J Appl Physiol 79:535-537
2. Blackmore DJ (1970) Distribution of HbCO in human erythrocytes following inhalation of CO. Nature 227:386
3. Bruce MC, Bruce EN (2006) Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multi compartment model. J Appl Physiol 100:1171-1180
4. Burge CM, Skinner SL (1995) Determination of hemoglobin mass and blood volume with CO: evaluation and application of a method. J Appl Physiol 79:623-631
5. Flamm SD, Taki J, Moore R, Lewis SF, Keech F, Maltais F, Ahmad M, Callahan R, Dragotakes S, Alpert N (1990) Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects. Circulation 81:1550-1559
6. Froelich JW, Strauss HW, Moore RH, McKusick KA (1988) Redistribution of visceral blood volume in upright exercise in healthy volunteers. J Nucl Med 29:1714-1718
7. Garvican LA, Burge CM, Cox AJ, Clark SA, Martin DT, Gore CJ (2010) Carbon monoxide uptake kinetics of arterial, venous and capillary blood during CO rebreathing. Exp Physiol 95:1156-1166
8. Gore CJ, Hopkins WG, Burge CM (2005) Errors of measurement for blood volume parameters: a meta-analysis. J Appl Physiol 99:1745-1758
9. Gough CE, Eastwood A, Saunders PU, Anson JM, Gore CJ (2012) Spurious Hb mass increases following exercise. Int J Sports Med 33:691-695
10. Hopkins WG (2000) Measures of reliability in sports medicine and science. Sports Med 30:1-15
11. Hutler M, Beneke R, Boning D (2000) Determination of circulating hemoglobin mass and related quantities by using capillary blood. Med Sci Sports Exerc 32:1024-1027
12. International Committee for Standardization in Haematology (1980) Recommended methods for measurement of red-cell and plasma volume. J Nucl Med 21:793-800
13. Laub M, Hvid-Jacobsen K, Hovind P, Kanstrup IL, Christensen NJ, Nielsen SL (1993) Spleen emptying and venous hematocrit in humans during exercise. J Appl Physiol 74:1024-1026
14. Lundby C, Thomsen JJ, Boushel R, Koskolou M, Warberg J, Calbet JA, Robach P (2007) Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. J Physiol 578:309-314
15. Morkeberg J, Sharpe K, Belhage B, Damsgaard R, Schmidt W, Prommer N, Gore CJ, Ashenden MJ (2011) Detecting autologous blood transfusions: a comparison of three passport approaches and four blood markers. Scand J Med Sci Sports 21:235-243
16. Prommer N, Schmidt W (2007) Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method. Eur J Appl Physiol 100:383-391
17. Prommer N, Sottas PE, Schoch C, Schumacher YO, Schmidt W (2008) Total hemoglobin mass: a new parameter to detect blood doping? Med Sci Sports Exerc 40:2112-2118
18. Robach P, Schmitt L, Brugniaux JV, Nicolet G, Duvallet A, Fouillot JP, Moutereau S, Lasne F, Pialoux V, Olsen NV, Richalet JP (2006) Living high-training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers. Eur J Appl Physiol 97:695-705
19. Robach P, Boisson RC, Vincent L, Lundby C, Moutereau S, Gergelé L, Michel N, Duthil E, Féasson L, Millet GY (2012) Hemolysis induced by an extreme mountain ultra-marathon is not associated with a decrease in total red blood cell volume. Scand J Med Sci Sports: n/a-n/a
20. Sandler MP, Kronenberg MW, Forman MB, Wolfe OH, Clanton JA, Partain CL (1984) Dynamic fluctuations in blood and spleen radioactivity: splenic contraction and relation to clinical radionuclide volume calculations. J Am Coll Cardiol 3:1205-1211
21. Schmidt W, Prommer N (2005) The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely. Eur J Appl Physiol 95:486-495
22. Steiner T, Wehrlin JP (2011) Does hemoglobin mass increase from age 16 to 21 and 28 in elite endurance athletes? Med Sci Sports Exerc 43:1735-1743
23. Stewart IB, McKenzie DC (2002) The human spleen during physiological stress. Sports Med 32:361-369
24. Thomsen JK, Fogh-Andersen N, Bulow K, Devantier A (1991) Blood and plasma volumes determined by carbon monoxide gas, 99mTc-labelled erythrocytes, 125I-albumin and the T 1824 technique. Scand J Clin Lab Invest 51:185-190
25. Ulrich G, Bartsch P, Friedmann-Bette B (2011) Total haemoglobin mass and red blood cell profile in endurance-trained and non-endurance-trained adolescent athletes. Eur J Appl Physiol 111:2855-2864
26. Wennesland R, Brown E, Hopper J Jr, Scott KG, Hodges JL Jr, Bradley B (1962) Experiences with the radiochromium method for determination of red cell volume. Scand J Clin Lab Invest 14:355-367