메뉴 건너뛰기




Volumn 74, Issue 10, 2013, Pages 1327-1332

Pharmacokinetics and safety of silibinin in horses

Author keywords

[No Author keywords available]

Indexed keywords

NARINGENIN; SILIBININ;

EID: 84884805025     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.74.10.1327     Document Type: Article
Times cited : (15)

References (18)
  • 1
    • 84872407110 scopus 로고    scopus 로고
    • Milk thistle and its derivative compounds: A review of opportunities for treatment of liver disease
    • Hackett ES, Twedt DC, Gustafson DL. Milk thistle and its derivative compounds: a review of opportunities for treatment of liver disease. J Vet Intern Med 2013;27:10-16.
    • (2013) J Vet Intern Med , vol.27 , pp. 10-16
    • Hackett, E.S.1    Twedt, D.C.2    Gustafson, D.L.3
  • 2
    • 34249907027 scopus 로고    scopus 로고
    • Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.)
    • Tamayo C, Diamond S. Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.). Integr Cancer Ther 2007;6:146-157.
    • (2007) Integr Cancer Ther , vol.6 , pp. 146-157
    • Tamayo, C.1    Diamond, S.2
  • 3
    • 40549139768 scopus 로고    scopus 로고
    • An updated systematic review with meta-analysis for the clinical evidence of silymarin
    • Saller R, Brignoli R, Melzer J, et al. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed 2008;15:9-20.
    • (2008) Forsch Komplementmed , vol.15 , pp. 9-20
    • Saller, R.1    Brignoli, R.2    Melzer, J.3
  • 4
    • 34247536407 scopus 로고    scopus 로고
    • An updated systematic review of the pharmacology of silymarin
    • Saller R, Melzer J, Reichling J, et al. An updated systematic review of the pharmacology of silymarin. Forsch Komplementmed 2007;14:70-80.
    • (2007) Forsch Komplementmed , vol.14 , pp. 70-80
    • Saller, R.1    Melzer, J.2    Reichling, J.3
  • 5
    • 37549005182 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract
    • Wen Z, Dumas TE, Schrieber SJ, et al. Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. Drug Metab Dispos 2008;36:65-72.
    • (2008) Drug Metab Dispos , vol.36 , pp. 65-72
    • Wen, Z.1    Dumas, T.E.2    Schrieber, S.J.3
  • 6
    • 33845899681 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients
    • Flaig TW, Gustafson DL, Su LJ, et al. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Invest New Drugs 2007;25:139-146.
    • (2007) Invest New Drugs , vol.25 , pp. 139-146
    • Flaig, T.W.1    Gustafson, D.L.2    Su, L.J.3
  • 7
    • 33847687618 scopus 로고    scopus 로고
    • Bioavailability of a silybin-phosphatidylcholine complex in dogs
    • Filburn CR, Kettenacker R, Griffin DW. Bioavailability of a silybin-phosphatidylcholine complex in dogs. J Vet Pharmacol Ther 2007;30:132-138.
    • (2007) J Vet Pharmacol Ther , vol.30 , pp. 132-138
    • Filburn, C.R.1    Kettenacker, R.2    Griffin, D.W.3
  • 8
    • 84864397990 scopus 로고    scopus 로고
    • Bioavailability following oral administration of a silibinin-phosphatidylcholine complex in cats
    • Webb CB, Gustafson DL, Twedt DC. Bioavailability following oral administration of a silibinin-phosphatidylcholine complex in cats. Intern J Appl Res Vet Med 2012;10:107-112.
    • (2012) Intern J Appl Res Vet Med , vol.10 , pp. 107-112
    • Webb, C.B.1    Gustafson, D.L.2    Twedt, D.C.3
  • 9
    • 35548931533 scopus 로고    scopus 로고
    • Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application
    • Wu JW, Lin LC, Hung SC, et al. Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. J Pharm Biomed Anal 2007;45:635-641.
    • (2007) J Pharm Biomed Anal , vol.45 , pp. 635-641
    • Wu, J.W.1    Lin, L.C.2    Hung, S.C.3
  • 10
    • 0027466244 scopus 로고
    • Clinical pathology testing recommendations for nonclinical toxicity and safety studies. AACC-DACC/ASVCP Joint Task Force
    • Weingand K, Bloom J, Carakostas M, et al. Clinical pathology testing recommendations for nonclinical toxicity and safety studies. AACC-DACC/ASVCP Joint Task Force. Toxicol Pathol 1992;20:539-543.
    • (1992) Toxicol Pathol , vol.20 , pp. 539-543
    • Weingand, K.1    Bloom, J.2    Carakostas, M.3
  • 11
    • 12744281454 scopus 로고    scopus 로고
    • National Cancer Institute, Available at:, Accessed Aug 1, 2011
    • National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.03, 2010. Available at: www.evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_ QuickReference_8.5x11.pdf. Accessed Aug 1, 2011.
    • (2010) Common Terminology Criteria for Adverse Events (CTCAE). Version 4.03
  • 12
    • 70249084706 scopus 로고    scopus 로고
    • US FDA, Available at, US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research and Center for Biologics Evaluation and Research; 2009. Accessed Aug 1, 2011
    • US FDA. Guidance for industry drug-induced liver injury: premarketing clinical evaluation. Available at: www.fda.gov/ downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/UCM174090.pdf.US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research and Center for Biologics Evaluation and Research; 2009. Accessed Aug 1, 2011.
    • Guidance for industry drug-induced liver injury: Premarketing clinical evaluation
  • 13
    • 25644448238 scopus 로고    scopus 로고
    • A review of the bioavailability and clinical efficacy of milk thistle phytosome: A silybin-phosphatidylcholine complex (Siliphos)
    • Kidd P, Head K. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Altern Med Rev 2005;10:193-203.
    • (2005) Altern Med Rev , vol.10 , pp. 193-203
    • Kidd, P.1    Head, K.2
  • 14
    • 81855217432 scopus 로고    scopus 로고
    • Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C
    • Schrieber SJ, Hawke RL, Wen Z, et al. Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C. Drug Metab Dispos 2011;39:2182-2190.
    • (2011) Drug Metab Dispos , vol.39 , pp. 2182-2190
    • Schrieber, S.J.1    Hawke, R.L.2    Wen, Z.3
  • 15
    • 77957265017 scopus 로고    scopus 로고
    • Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C
    • Hawke RL, Schrieber SJ, Soule TA, et al. Silymarin ascending multiple oral dosing phase I study in noncirrhotic patients with chronic hepatitis C. J Clin Pharmacol 2010;50:434-449.
    • (2010) J Clin Pharmacol , vol.50 , pp. 434-449
    • Hawke, R.L.1    Schrieber, S.J.2    Soule, T.A.3
  • 17
    • 50049099550 scopus 로고    scopus 로고
    • The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity
    • Schrieber SJ, Wen Z, Vourvahis M, et al. The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. Drug Metab Dispos 2008;36:1909-1916.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1909-1916
    • Schrieber, S.J.1    Wen, Z.2    Vourvahis, M.3
  • 18
    • 80052947859 scopus 로고    scopus 로고
    • Disorders of the liver
    • In: Reed SM, Bayly WM, Sellon DC, eds, 3rd ed. St Louis: Saunders Elsevier
    • Barton MH. Disorders of the liver. In: Reed SM, Bayly WM, Sellon DC, eds. Equine internal medicine. 3rd ed. St Louis: Saunders Elsevier, 2010;939-975.
    • (2010) Equine internal medicine , pp. 939-975
    • Barton, M.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.