Russian VX

Handbook of Toxicology of Chemical Warfare Agents

Volumn , Issue , 2009, Pages 69-91

  Radilov, Andrey ^a   Rembovskiy, Vladimir ^a   Rybalchenko, Igor ^b   Savelieva, Elena ^a   Podolskaya, Ekaterina ^b   Babakov, Vladimir ^a   Ermolaeva, Elena ^a   Dulov, Sergey ^a   Kuznetsov, Sergey ^c   Mindukshev, Igor ^c   Shpak, Alexey ^d   Krasnov, Ilia ^b   Khlebnikova, Natalia ^a   Jenkins, Richard ^e   Goncharov, Nikolay ^a  

^a Research Institute of Hygiene Occupational Pathology and Human Ecology   (Russian Federation)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

^c SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

^d MOSCOW STATE UNIVERSITY   (Russian Federation)

^e DE MONTFORT UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884801891     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374484-5.00007-9     Document Type: Chapter

References (125)

1. Anderson R.J., Dunham C.B. Electrophysiologic changes in peripheral nerve following repeated exposure to organophosphorus agents. Arch. Toxicol. 1985, 58:97-101.
2. Anon A Book of Instructions and Technical Documentation on the Problem of Chemical Weapon Destruction. Pt II. Organophosphorus Agents 2001, Vol. 1. pp. Federal Agency "Medbioextrem', Moscow, 208.
3. Bacani C., Frishman W.H. Chymase: a new pharmacologic target in cardiovascular disease. Cardiol. Rev. 2006, 14:187-193.
4. Bauvois B., Dauzonne D. Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biologic evaluations, and therapeutic prospects. Med. Res. Rev. 2006, 26:88-130.
5. Beck, J.M., Hadad, C.M. (2008). Hydrolysis of nerve agents by model nucleophiles: a computational study. Chem. Biol. Interact. May 2. (Epub ahead of print).
6. Bhagwat S.V., Lahdenranta J., Giordano R., Arap W., Pasqualini R., Shapiro L.H. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation. Blood 2001, 97:652-659.
7. Bisaro L.L., Ramos A.M., Sanchez M.C., Montenegro R., Chiabrando G.A. Structural evaluation of plasma a2-macroglobulin in acute pancreatitis. Clin. Chem. Lab. Med. 2005, 43:1183-1189.
8. Blomback B. Fibrinogen to fibrin transformation. Blood Clotting Enzymology 1967, 143-215. Academic Press, New York. W.H. Seegers (Ed.).
9. Bursian A.V. Early Ontogenesis of Motor Apparatus of Endotherms. Russian 1983, pp. Nauka, Leningrad, 164.
10. Carvalho F.A., Graça L.M., Martins-Silva J., Saldanha C. Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. FEBS J. 2005, 272:5584-5594.
11. Chang F.C.T., Hoffman B.E., DeBus S. Pharmacological antagonism of lethal effects induced by O-isobutyl S-2-(diethylamino)ethyl]-methylphosphonothioate. Drug Chem. Toxicol. 2002, 25:321-337.
12. Chemnitius J.M., Zech R. Inhibition of brain carboxylesterases by neurotoxic and nonneurotoxic organophosphorus compounds. Mol. Pharmacol. 1983, 23:717-723.
13. Costa L.G., Cole T.B., Furlong C.E. Paraoxonase (PON1): from toxicology to cardiovascular medicine. Acta Biomed. 76. Suppl. 2005, 2):50-57.
14. Crenshaw M.D., Hayes T.L., Miller T.L., Shahnuon C.M. Comparison of the hydrolytic stability of S-(N, N-diethylaminoethyl) isobutyl methylphosphonothiolate with VX in dilute solution. J. Appl. Toxicol. 2001, 21:S53-S56.
15. Crook, J.W., Hott, P., Owens, E.J., Cummings, E.G., Farrand, R.L., Cooper, A.E. (1983). The effects of subacute exposures of the mouse, rat, guinea pig, and rabbit to low-level VX concentrations. ARCSL-TR-82038, AD B086567L. Aberdeen Proving Ground, MD: US Army Armament Research and Development Command.
16. Curtin B.F., Seetharam K.I., Dhoieam P., Gordon R.K., Doctor B.P., Nambiar M.P. Resveratrol induces catalytic bioscavenger paraoxonase 1 expression and protects against chemical warfare nerve agent toxicity in human cell lines. J. Cell Biochem. 2008, 103:1524-1535.
17. DeFrank J.J., Beaudry W.T., Cheng T.C., Harvey S.P., Stroup A.N., Szafraniec L.L. Screening of halophilic bacteria and Alteromonas species for organophosphorus hydrolyzing enzyme activity. Chem. Biol. Interact 1993, 87:141-148.
18. Desi I., Nagimajtenyi L. Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. Toxicol. Lett. 1999, 107:55-64.
19. Doggrell S.A., Wanstall J.C. Vascular chymase: pathophysiological role and therapeutic potential of inhibition. Cardiovasc. Res. 2004, 61:653-662.
20. Ehrich M., Jortner B.S. Organophosphorus-induced delayed neuropathy. Handbook of Pesticide Toxicology 2001, 987-1012. Academic Press, San Diego. 2nd edition. R. Krieger (Ed.).
21. Ellman G.L., Courtney K.D., Andres V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol 1961, 7:88-95.
22. Erdos E.G., Boggs L.E. Hydrolysis of paraoxon in mammalian blood. Nature 1961, 190:716-717.
23. Favaloro E.J., Browning T., Facey D. CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. Exp. Hematol 1993, 21:1695-1701.
24. Fedorchenko, A.N., Prokhorenko, O.A., Yanno, L.V. (2003). Analysis of tumor and pretumor illnesses in persons previously engaged in VX production. Khimicheskaya I Biologicheskaya Bezopasnost [Chemical and Biological Safety] 9-10: 188-9. Proceedings of the International Symposium "Medical and Biological Aspects of Chemical Weapons Stockpile Demilitarization", August 26-28, 2003, Volgograd. (In Russian).
25. Filippov, V.L., Krinitsyn, N.V., Filippova, Yu. V., Kiselev, D.B. (2005). Principal parameters of public health and dynamics of disability of the personnel engaged in VX production up to 1987. Khimicheskaya I Biologicheskaya Bezopasnost [Chemical and Biological Safety] 1-2: 143-4. Proceedings of the 2nd Research and Practical Conference "Scientific and Technical Aspects of Safety during Destruction, Storage, and Transport of Chemical Weapons", Moscow, October 6-8, 2004. (In Russian).
26. Geiger J., Nolte C., Walter U. Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors. Amer. J. Physiol. 1994, 267:C236-C244.
27. Germanchuk, V.G., Zabrodskii, P.F. (2005). Effects of antidotal therapy on development of immunodeficient conditions after acute intoxications with warfare agents and their destruction products. Vestnik Rossiiskoi Medicinskoi Akademii [Bulletin of Russian Medical Academy] 1(4): 234. (In Russian).
28. Goldman M., Klein A.K., Kawakami T.G., Rosenblatt L.S. Toxicity studies on agents GB and GD 1987, University of California, Davis, CA, final report.
29. Goldman, M., Rosenblatt, L.S., Wilson, B.W., Kawakami, T.G., Culbertson, M.R., Schreider, J.P., Remsen, J.F., Shifrine, M. (1988). Toxicity studies on agent VX. Final report. AD A201397. Ft Detrick, Frederick, MD, US Army Medical Research and Development Command, Fort Detrick, Frederick, MD.
30. Goncharov, N.V., Mindukshev, I.V., Radilov, A.S., Kuznetsov, A.V., Dobrylko, I.A. (2001). Effects of VX low doses on rat platelets in chronic experiment. In Medical Aspects of Radiation and Chemical Safety. Proceedings of the Russian Scientific Conference, Saint Petersburg, pp. 281-4. (In Russian).
31. Goncharov, N.V., Radilov, A.S., Kuznetsov, A.V., Mindukshev, I.V., Dobrylko, I.A. (2002). Assessment of functional state of blood platelets after chronic exposure to organophosphate warfare agents (of Vx type). In Proceedings of the Scientific and Practical Conference Devoted to the 40th Anniversary of RIHOPHE. Saint Petersburg, pp. 209-15. (In Russian).
32. Goncharov N.V., Radilov A.S., Mindukshev I.V. Effects of RVX low dose chronic exposure on rat platelet aggregation and physiology of nerve fibers. In Economy, Logistic, and Ecology in Armed Forces III. International Scientific Conference in Brno. Yermolayeva, Ye. Ye., Kuznetsov, S.V., Glashkina, L.M., Dobrylko, I.A., Kuznetsov, A.V 2003, 63-70.
33. Gorbunova, I.F., Maximova, E. Yu. (2003). On the question of bioindication in the soil of highly toxic organophosphorus agents. Khimicheskaya I Biologicheskaya Bezopasnost [Chemical and Biological Safety] 9-10: 232-3. Proceedings of the International Symposium "Medical and Biological Aspects of Chemical Weapons Stockpile Demilitarization", August 26-28, 2003, Volgograd. (In Russian).
34. Gordon J.J., Inns R.H., Johnson M.K., Leadbeater L., Maidment M.P., Upshall D.G., Cooper G.H., Rickard R.L. The delayed neuropathic effects of nerve agents and some other organophosphorus compounds. Arch. Toxicol. 1983, 52:71-82.
35. Grigoryan, H., Schopfer, L.M., Thompson, C.M., Terry, A.V., Masson, P., Lockridge, O. (2008). Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents. Chem. Biol. Interact. April 22. (Epub ahead of print).
36. Groenewold G., Williams J., Appelhans A., Gresham G., Olson J., Jeffery M., Rowland B. Hydrolysis of VX on concrete: rate of degradation by direct surface interrogation using an ion trap secondary ion mass spectrometer. Environ. Sci. Technol. 2002, 36:4790-4794.
37. Gu J., Wang C.Q., Fang H.H., Ding H.Y., Xie X.L., Xu Y.M., Wang B.Y., Huang D.J. Effects of resveratrol on endothelial progenitor cells and their contributions to reendothelialization in intima-injured rats. J. Cardiovasc. Pharmacol 2006, 47:711-721.
38. Guittin P. In vivo and in vitro embryotoxicity of VX, a powerful organophosphate. Teratology 1988, 38:19A.
39. Guittin P., Trouiller G., Derrien J. Postnatal behavioral toxicity in rats following prenatal exposure to an organophosphate. Teratology 1987, 36:25A.
40. Gur'eva, L.M., Dubovskaia, L.V., Musichuk, Iu. I., Semenovskaia, N.A., Tatarinova, O.M., Tikhomirova, O.V., Filippov, V.L., Filicheva, A.P., Shul'man, V. Sh., Ianno, L.V. (1997). Chronic poisoning by organophosphoric VX. Med. Tr. Prom. Ekol.6: 7-11. (In Russian).
41. Hsu S.H., Tsou T.C., Chiu S.J., Chao J.I. Inhibition of alpha7-nicotinic acetylcholine receptor expression by arsenite in the vascular endothelial cells. Toxicol. Lett. 2005, 159:47-59.
42. Jewell W.T., Miller M.J. Identification of a carboxylesterase as the major protein bound by molinate. Toxicol. Appl. Pharmacol. 1998, 149:226-234.
43. Johnson M.K. The delayed neurotoxic effect of some organophosphorus compounds. Identification of the phosphorylation site as an esterase. Biochem. J. 1969, 114:711-717.
44. Karalliedde L., Baker D., Marrs T.C. Organophosphate-induced intermediate syndrome: aetiology and relationships with myopathy. Toxicol. Rev. 2006, 25:1-14.
45. Kassa J., Jun D., Kuca K. The reactivating and therapeutic efficacy of oximes to counteract Russian VX poisonings. Int. J. Toxicol. 2006, 25:397-401.
46. Kirkpatrick C.J., Bittinger F., Unger R.E., Kriegsmann J., Kilbinger H., Wessler I. The non-neuronal cholinergic system in the endothelium: evidence and possible pathobiological significance. Jpn. J. Pharmacol. 2001, 85:24-28.
47. Kirkpatrick C.J., Bittinger F., Nozadze K., Wessler I. Expression and function of the non-neuronal cholinergic system in endothelial cells. Life Sci. 2003, 72:2111-2116.
48. Kiryukhin V.G., Osadchaya L.I., Tochilkina L.P., Khodykina N.V., et al. Activity of cholinesterase in tissues under exposure to organophosphorus agents. Voprosy khimicheskoi bezopasnosti v Rossiiskoi Federatsii [Problems of Chemical Safety in the Russian Federation] 2007, Proceedings of the Scientific and Practical Conference Devoted to the 45th Anniversary of RIHOPHE, Saint Petersburg, pp. 250-1In Russian.
49. Krishnasamy S., Gross N.J., Teng A.L., Schultz R.M., Dhand R. Lung "surfactant convertase' is a member of the carboxylesterase family. Biochem. Biophys. Res. Commun 1997, 235:180-184.
50. Kuca K., Jun D., Cabal J., Hrabinova M., Bartosova L., Opletalova V. Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent. Basic Clin. Pharmacol. Toxicol. 2006, 98:389-394.
51. Lalu K., Lampelo S., Vanha-Perttula T. Characterization of three aminopeptidases purified from maternal serum. Biochim. Biophys. Acta 1986, 873:190-197.
52. Lenz D.E., Maxwell D.M., Austin L.W. Development of a rat model for subacute exposure to the toxic organophosphate VX. Int. J. Toxicol. 1996, 15:S69-S77.
53. Li W.F., Costa L.G., Furlong C.E. Serum paraoxonase status: a major factor in determining resistance to organophosphates. J. Toxicol. Environ. Health 1993, 40:337-346.
54. Li B., Schopfer L.M., Hinrichs S.H., Masson P., Lockridge O. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411. Anal. Biochem. 2007, 361:263-272.
55. Lonberg-Holm K., Reed D.L., Roberts R.C., Damato-McCabe D. Three high molecular weight protease inhibitors of rat plasma. Reactions with trypsin. J. Biol. Chem. 1987, 262:438-445.
56. Lotti M. The pathogenesis of organophosphate polyneuropathy. Crit. Rev. Toxicol. 1991, 21:465-487.
57. Lotti M., Moretto A. Organophosphate-induced delayed polyneuropathy. Toxicol. Rev. 2005, 24:37-49.
58. Love A.H., Vance A.L., Reynolds J.G., Davisson M.L. Investigating the affinities and persistence of VX nerve agent in environmental matrices. Chemosphere 2004, 57:1257-1264.
59. Low P.A. Endoneurial fluid pressure and microenvironment of nerve. Peripheral Neuropathy 1984, 599-617. Saunders, Philadelphia, WB. P.J. Dyck (Ed.).
60. Maslennikov, A.A., Kiryukhin, V.G. (2003). Comparative analysis of the general toxic and gonadotoxic effects of Vx at chronic percutaneous exposure. Khimicheskaya I Biologicheskaya Bezopasnost [Chemical and Biological Safety] 9-10: 233-4. Proceedings of the International Symposium "Medical and Biological Aspects of Chemical Weapons Stockpile Demilitarization", August 26-28, 2003, Volgograd. (In Russian).
61. Maslennikov, A.A., Ermilova, E.S. (2005). Experimental assessment of toxic properties of Vx at its intragastric administration. Vestnik Rossiiskoi Medicinskoi Akademii [Bulletin of Russian Medical Academy] 1(4): 244. (In Russian).
62. Maslennikov A.A., Ermilova E.S. Experimental substantiation of Vx safety standards in water reservoirs. Medicina Extremalnykh Situaciy [Medicine of Extreme Situations] 2006, 1(15):66-72. Russian.
63. McNamara, B.P., Vocci, F.J., Leitnaker, F.C. (1973). Proposed limits for human exposure to VX vapor in nonmilitary operations. EASP 1100-1 (R-1). US Department of the Army Headquarters, Aberdeen Proving Ground, MD.
64. Means G.E., Wu H.L. The reactive tyrosine residue of human serum albumin: characterization of its reaction with diisopropylfluorophosphate. Arch. Biochem. Biophys. 1979, 194:526-530.
65. Mindukshev, I.V., Jahatspanian, I.E., Goncharov, N.V., Jenkins, R.O., Krivchenko, A.I. (2005a). A new method for studying platelets, based upon the low-angle light scattering technique. 1. Theoretical and experimental foundations of the method. Spectroscopy Int. J.19: 235-46.
66. Mindukshev, I.V., Ermolaeva, E.E., Vivulanets, E.V., Shabanova, E. Yu., Petrishchev, N.N., Goncharov, N.V., Jenkins, R.O., Krivchenko, A.I. (2005b). A new method for studying platelets, based upon the low-angle light scattering technique. 2. Application of the method in experimental toxicology and clinical pathology. Spectroscopy Int. J.19: 247-57.
67. Munro N., Ambrose K.R., Watson A.P. Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: implications for public protection. Environ. Health Perspect. 1994, 102:18-38.
68. Munro N.B., Talmage S.S., Griffin G.D., Waters L.C., Watson A.P., King J.F., Hauschild V. The sources, fate and toxicity of chemical warfare agent degradation products. Environ. Health Perspect. 1999, 107:933-974.
69. Murachi T. A general reaction of diisopropylphosphorofluoridate with proteins without direct effect on enzymic activities. Biochim. Biophy. Acta 1963, 71:239-241.
70. Nomura D.K., Leung D., Chiang K.P., Quistad G.B., Cravatt B.F., Casida J.E. A brain detoxifying enzyme for organophosphorus nerve poisons. Proc. Natl Acad. Sci. USA 2005, 102:6195-6200.
71. Novikova O.N., Tochilkina L.P., Khodykina N.V. Study of dynamics and structure of the higher nervous activity of small laboratory animals after acute intoxication with Vx. Voprosy khimicheskoi bezopasnosti v Rossiiskoi Federatsii [Problems of Chemical Safety in the Russian Federation] 2007, Proceedings of the Scientific and Practical Conference Devoted to the 45th Anniversary of RIHOPHE, Saint Petersburg, pp. 262-3In Russian.
72. Odman S., Levitan H., Robinson P.J., Michel M.E., Ask P., Rapoport S.I. Peripheral nerve as an osmometer: role of endoneurial capillaries in frog sciatic nerve. Am. J. Physiol. 1987, 252:C335-C341.
73. Olsson Y. Vascular permeability in the peripheral nervous system. Peripheral Neuropathy 1984, 579-597. WB Saunders, Philadelphia. P.J. Dyck (Ed.).
74. O'Neill J.J. Non-cholinesterase effects of anticholinesterases. Fundam. Appl. Toxicol. 1981, 1:154-160.
75. Pasqualini R., Koivunen E., Kain R., Lahdenranta J., Sakamoto M., Stryhn A., Ashmun R.A., Shapiro L.H., Arap W., Ruoslahti E. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 2000, 60:722-727.
76. Poulson E., Aldridge W.N. Studies on esterases in the chicken central nervous system. Biochem. J. 1964, 90:182-189.
77. Prozorovskii, V.B., Chepur, S.V. (2001). New data on non-synaptic (distant) effects of organophosphorus inhibitors of cholinesterase. Toksikologicheskii vestnik [Toxicological Bulletin] 4: 2-7. (In Russian).
78. Quistad G.B., Sparks S.E., Casida J.E. Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides. Toxicol. Appl. Pharmacol. 2001, 173:48-55.
79. Quistad G.B., Klintenberg R., Caboni P., Liang S.N., Casida J.E. Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice. Toxicol. Appl. Pharmacol. 2006, 211:78-83.
80. Radilov A.S., Nagornyy S.V., Rembovskiy V.R., Ermolaeva E.E., Savelieva E.I., Goncharov N.V., Koryagina N.L., Tsybulskaya E.A., Khlebnikova N.S., Tsymbal F.A. Toxicological and sanitary assessment of waste products of the former chemical weapon production facilities. Rossiyskii Khimicheskii Zhurnal 2007, 77-82. [Russian Chemical Journal]LI(2)Russian.
81. Rautio, M. (ed.) (1994). Recommended Operating Procedures for Sampling and Analyses in the Verification of Chemical Disarmament. The Ministry for Foreign Affairs of Finland, Helsinki.
82. Ray, D.E., Richards, P.G. (2001). The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol. Lett. 120: 343-51.
83. Ray D.E., Richards P.G. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol. Lett. 2001, 120:343-351.
84. Richards P.G., Johnson M.K., Ray D.E. Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Mol. Pharmacol. 2000, 58:577-583.
85. Richter R., Schulz-Knappe P., Schrader M., Ständker L., Jürgens M., Tammen H., Forssmann W.G. Composition of the peptide fraction in human blood plasma: database of circulating human peptides. J. Chromatogr. B Biomed. Sci. Appl. 1999, 726:25-35.
86. Rodin, I.A., Shpak, A.V., Shpigun, O.A., Rybalchenko, I.V., Goncharov, V.M., Vasilevsky, S.V., Savelieva, E.I. (2006). Determination of methylphosphonic and alkyl methylphosphosnic acids -degradation products of chemical warfare nerve agents by HPLC-MS and GC-MS in plasma and urine. Abstracts of the International Congress on Analytical Sciences: ICAS-2006, 477 pp., Moscow, Russia, June 25-30.
87. Rodin I.A., Shpak A.V., Shpigun O.A., Rybalchenko I.V., Savelieva E.I. Highly sensitive determination of alkyl methylphosphonic acids -degradation products of chemical warfare nerve agents by HPLC-MS in rats' plasma. European Conference on Analytical Chemistry "Euroanalysis XIV', Antwerpen, Belgium. September 2007, 9-14. 684pp.
88. Rybalko, V.M., Oksas, A.E., Morozov V.A. (2005). Sodium and potassium metabolism under intoxication with organophosphorus agents. Vestnik Rossiiskoi Medicinskoi Akademii [Bulletin of Russian Medical Academy] 1(4): 252. (In Russian).
89. Sanger F. Amino-acid sequences in the active centers of certain enzymes. Proc. Chem. Soc. 1963, 5:76-83.
90. Santos, S.C., Vala, I., Miguel, C., Barata, J.T., Garção, P., Agostinho, P., Mendes, M., Coelho, A.V., Calado, A., Oliveira, C.R., e Silva, J.M., Saldanha, C. (2007). Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. J. Biol. Chem.282: 25597-603.
91. Savateev N.V., Musiychuk Yu. I., Kozyakov V.P. Errors in diagnostics and treatment of intoxications caused by neuroparalytic warfare agents. Medical Aspects of Radiation and Chemical Safety 2001, Proceedings of the Russian Scientific Conference, Saint Petersburg, pp. 341-2In Russian.
92. Savelieva, E.I., Khlebnikova, N.S., Radilov, A.S. (2003). Principal approaches to analysis of the markers of chemical warfare agents in biological media. Khimicheskaya I Biologicheskaya Bezopasnost [Chemical and Biological Safety] 9-10: 273-4. Proceedings of the International Symposium "Medical and Biological Aspects of Chemical Weapons Stockpile Demilitarization", August 26-28, 2003, Volgograd. (In Russian).
93. Schoenberger O.L., Sprows J.L., Schechter N.M., Cooperman B.S., Rubin H. Limited proteolysis of C1-inhibitor by chymotrypsin-like proteinases. FEBS Lett. 1989, 259:165-167.
94. Schopfer L.M., Champion M.M., Tamblyn N., Thompson C.M., Lockridge O. Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410). Anal. Biochem. 2005, 345:122-132.
95. Seifert J., Casida J.E. Relation of yolk sac membrane kynurenine formamidase inhibition to certain teratogenic effects of organophosphorus insecticides and of carbaryl and eserine in chicken embryos. Biochem. Pharmacol. 1978, 27:2611-2615.
96. Shabasheva L.V., Popov V.B., Protasova G.A., Shkaeva I.E. Express assessment of gametogenesis in male rats under chronic exposure to VX. Voprosy khimicheskoi bezopasnosti v Rossiiskoi Federatsii [Problems of Chemical Safety in the Russian Federation] 2007, Proceedings of the Scientific and Practical Conference Devoted to the 45th Anniversary of RIHOPHE, Saint Petersburg, pp. 183-6In Russian.
97. Shattil S.J., Kashiwagi H., Pampori M. Integrin signaling: the platelet paradigm. Blood 1998, 91:2645-2657.
98. Shestova, G.V., Sizova, K.V. (2005). On the mechanisms of development of hypoxic syndrome under acute intoxications with OPs and possible ways of its correction. Vestnik Rossiiskoi Medicinskoi Akademii [Bulletin of Russian Medical Academy] 1(4): 271. (In Russian).
99. Sidell F.R., GroffW.A. The reactivatibility of cholinesterase inhibited by VX and sarin in man. Toxicol. Appl. Pharmacol. 1974, 27:241-252.
100. Snawder J.E., Chambers J.E. Osteolathyrogenic effects of malathion in Xenopus embryos. Toxicol. Appl. Pharmacol 1993, 212:210-216.
101. Sogorb M.A., Díaz-Alejo N., Escudero M.A., Vilanova E. Phosphotriesterase activity identified in purified serum albumins. Arch. Toxicol. 1998, 72:219-226.
102. Sottrup-Jensen L. Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. J. Biol. Chem. 1989, 264:11539-11542.
103. Staton C.A., Brown N.J., Rodgers G.R., Corke K.P., Tazzyman S., Underwood J.C., Lewis C.E. Alphastatin, a 24-amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo. Blood 2004, 103:601-606.
104. Stephens R., Spurgeon A., Calvert I.A., Beach J., Levy L.S., Berry H., Harrington J.M. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet 1995, 345:1135-1139.
105. Stuart M.J., Murphy S., Oski F.A. simple nonradioisotope technique for the determination of platelet life-span. N. Engl. J. Med. 1975, 292:1310-1313. A.
106. Sugio S., Kashima A., Mochizuki S., Noda M., Kobayashi K. Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng 1999, 12:439-446.
107. Terry A.V., Gearhart D.A., Beck W.D., Truan J.N., Middlemore M.L., Williamson L.N., Bartlett M.G., Prendergast M.A., Sickles D.W., Buccafusco J.J. Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. J. Pharmacol. Exp. Ther. 2007, 322:1117-1128.
108. Tochilkina L.P., Kiryukhin V.G. Experimental study of embryotoxicity of Vx. Medicina Extremalnykh Situaciy [Medicine of Extreme Situations] 2007, 2(20):97-106. Russian.
109. Tsuji A., Akamatsu T., Nagamune H., Matsuda Y. Identification of targeting proteinase for rat alpha 1-macroglobulin in vivo. Mast-cell tryptase is a major component of the alpha 1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. Biochem. J. 1994, 298:79-85.
110. Uiba V.V., Filatov B.N., Klauchek V.V., Britanov N.G. On the main directions of providing the sanitary safety during the chemical weapon destruction. Rossiyskii Khimicheskii Zhurnal 2007, 86-91. [Russian Chemical Journal]LI(2)Russian.
111. Van Hinsbergh V.W., Engelse M.A., Quax P.H. Pericellular proteases in angiogenesis and vasculogenesis. Arterioscler. Thromb. Vasc. Biol. 2006, 26:716-728.
112. Van Kampen K.R., Shupe J.L., Johnson A.E., James L.F., Smart R.A., Rasmussen J.E. Effects of nerve gas poisoning in sheep in Skull Valley, Utah. J. Am. Vet. Med. Assoc. 1970, 156:1032-1035.
113. Villanueva J., Shaffer D.R., Philip J., Chaparro C.A., Erdjument-Bromage H., Olshen A.B., Fleisher M., Lilja H., Brogi E., Boyd J., Sanchez-Carbayo M., Holland E.C., Cordon-Cardo C., Scher H.I., Tempst P. Differential exoprotease activities confer tumor-specific serum peptidome patterns. J. Clin. Invest. 2006, 116:271-284.
114. Vranken M.A., De Bisschop H.C., Willems J.L. In vitro inhibition of neurotoxic esterase by organophosphorus nerve agents. Arch. Int. Pharmacodyn. Ther. 1982, 260:316-318.
115. Williams N.H., Harrison J.M., Read R.W., Black R.M. Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents. Arch. Toxicol. 2007, 81:627-639.
116. Wilson, B.W., Henderson, J.D., Chow, E., Schreider, J., Goldman, M., Culbertson, R., Dacre, J. (1988a). Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken. J. Toxicol. Environ. Health23: 103-13.
117. Wilson, B.W., Henderson, J.D., Kellner, T.P., Goldman, M., Higgins, R.J., Dacre, J.C. (1988b). Toxicity of repeated doses of organophosphorus esters in the chicken. J. Toxicol. Environ. Health23: 115-26.
118. Worek F., Koller M., Thiermann H., Szinicz L. Diagnostic aspects of organophosphate poisoning. Toxicology 2005, 214:182-189.
119. Xia, L., Wang, X.X., Hu, X.S., Guo, X.G., Shang, Y.P., Chen, H.J., Zeng, C.L., Zhang, F.R., Chen, J.Z. (2008). Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms. Br. J. Pharmacol. June 30. (Epub ahead of print).
120. Yang Y. Chemical detoxification of nerve agent VX. Accounts of Chemical Research 1999, 32:109-115.
121. Yang Y., Szafraniec L.L., Beaudry W.T., Rohrbaugh D.K., Procell L.R., Samuel J.B. Autocatalytic hydrolysis of V-type nerve agents. J. Org. Chem. 1996, 61:8407-8413.
122. Yanno, L.V., Fedorchenko, A.N., Pimenova, M.N., Bakina, V.I. (2000). Clinical picture of chronic intoxication of the personnel that was engaged in organophosphorus warfare agents production and particular qualities of its development. In Meditsinskiye posledstviya extremalnykh vozdeystvii na organism [Medical Consequences of Extreme Impacts on Organism]. Proceedings of the Military Scientific Conference, March 28-29, 2000, Saint Petersburg, p. 319. (In Russian).
123. Zabrodskii P.F., Germanchuk V.G., Kirichuk V.F., Nodel' M.L., Aredakov A.N. Anticholinesterase mechanism as a factor of immunotoxicity of various chemical compounds. Bull. Exp. Biol. Med 2003, 136:176-178.
124. Zabrodskii P.F., Germanchuk V.G., Kovalev A. Yu., Kadushkin A.M. Functional disturbance of T-lymphocyte subpopulations under subacute exposure to toxic chemical agents. Rossiyskii Khimicheskii Zhurnal 2007, 98-100. [Russian Chemical Journal]LI(2)Russian.
125. Zhukov V.E., Kuznetsova E.A., Frolova I.G., Skalich I.P. Estimation of maximal permissible level of contamination of protective suits by organophosphorus agents. Voprosy khimicheskoi bezopasnosti v Rossiiskoi Federatsii [Problems of Chemical Safety in the Russian Federation] 2007, Proceedings of the Scientific and Practical Conference Devoted to the 45th Anniversary of RIHOPHE, Saint Petersburg, pp. 108-110In Russian.