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Volumn 6, Issue 1, 2013, Pages

Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers

Author keywords

Epigenetics; Histone acetylation; Histone methylation; mRNA microarray

Indexed keywords

CHEMOKINE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 2; GROWTH FACTOR; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 4; PHOSPHATIDYLINOSITOL; SIRTUIN 1; TRANSCRIPTION FACTOR EZH2; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

EID: 84884769274     PISSN: None     EISSN: 17558794     Source Type: Journal    
DOI: 10.1186/1755-8794-6-35     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: From mechanism to therapy
    • 10.1016/j.cell.2012.06.013 22770212
    • Cancer epigenetics: from mechanism to therapy. Dawson MA, Kouzarides T, Cell 2012 150 1 12 27 10.1016/j.cell.2012.06.013 22770212
    • (2012) Cell , vol.150 , Issue.1 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 2
    • 33847084602 scopus 로고    scopus 로고
    • Genome Regulation by Polycomb and Trithorax Proteins
    • DOI 10.1016/j.cell.2007.02.009, PII S0092867407001900
    • Genome regulation by polycomb and trithorax proteins. Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G, Cell 2007 128 4 735 745 10.1016/j.cell.2007.02.009 17320510 (Pubitemid 46273581)
    • (2007) Cell , vol.128 , Issue.4 , pp. 735-745
    • Schuettengruber, B.1    Chourrout, D.2    Vervoort, M.3    Leblanc, B.4    Cavalli, G.5
  • 3
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • 21386836
    • Cancer epigenetics reaches mainstream oncology. Rodriguez-Paredes M, Esteller M, Nat Med 2011 17 3 330 339 21386836
    • (2011) Nat Med , vol.17 , Issue.3 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 5
    • 0347090327 scopus 로고    scopus 로고
    • Adjustment of systematic microarray data biases
    • DOI 10.1093/bioinformatics/btg385
    • Adjustment of systematic microarray data biases. Benito M, Parker J, Du Q, Wu J, Xiang D, Perou CM, Marron JS, Bioinformatics 2004 20 1 105 114 10.1093/bioinformatics/btg385 14693816 (Pubitemid 38094234)
    • (2004) Bioinformatics , vol.20 , Issue.1 , pp. 105-114
    • Benito, M.1    Parker, J.2    Du, Q.3    Wu, J.4    Xiang, D.5    Perou, C.M.6    Marron, J.S.7
  • 11
    • 33751384465 scopus 로고    scopus 로고
    • GATHER: A systems approach to interpreting genomic signatures
    • DOI 10.1093/bioinformatics/btl483
    • GATHER: a systems approach to interpreting genomic signatures. Chang JT, Nevins JR, Bioinformatics 2006 22 23 2926 2933 10.1093/bioinformatics/btl483 17000751 (Pubitemid 44811565)
    • (2006) Bioinformatics , vol.22 , Issue.23 , pp. 2926-2933
    • Chang, J.T.1    Nevins, J.R.2
  • 13
    • 84855392434 scopus 로고    scopus 로고
    • EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR
    • 10.1158/0008-5472.CAN-11-0961 22068036
    • EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, et al. Cancer Res 2012 72 1 315 324 10.1158/0008-5472.CAN-11-0961 22068036
    • (2012) Cancer Res , vol.72 , Issue.1 , pp. 315-324
    • Wang, C.1    Liu, Z.2    Woo, C.W.3    Li, Z.4    Wang, L.5    Wei, J.S.6    Marquez, V.E.7    Bates, S.E.8    Jin, Q.9    Khan, J.10
  • 14
    • 79953680754 scopus 로고    scopus 로고
    • Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells
    • 10.1093/nar/gkq864 20952403
    • Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells. Angrisano T, Sacchetti S, Natale F, Cerrato A, Pero R, Keller S, Peluso S, Perillo B, Avvedimento VE, Fusco A, et al. Nucleic Acids Res 2011 39 6 1993 2006 10.1093/nar/gkq864 20952403
    • (2011) Nucleic Acids Res , vol.39 , Issue.6 , pp. 1993-2006
    • Angrisano, T.1    Sacchetti, S.2    Natale, F.3    Cerrato, A.4    Pero, R.5    Keller, S.6    Peluso, S.7    Perillo, B.8    Avvedimento, V.E.9    Fusco, A.10
  • 16
    • 84866324536 scopus 로고    scopus 로고
    • Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1
    • 10.1158/2159-8290.CD-12-0112 22961666
    • Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Byers LA, Wang J, Nilsson MB, Fujimoto J, Saintigny P, Yordy J, Giri U, Peyton M, Fan YH, Diao L, et al. Cancer Discov 2012 2 9 798 811 10.1158/2159-8290.CD-12-0112 22961666
    • (2012) Cancer Discov , vol.2 , Issue.9 , pp. 798-811
    • Byers, L.A.1    Wang, J.2    Nilsson, M.B.3    Fujimoto, J.4    Saintigny, P.5    Yordy, J.6    Giri, U.7    Peyton, M.8    Fan, Y.H.9    Diao, L.10
  • 17
    • 84867569866 scopus 로고    scopus 로고
    • Different expression of EZH2, BMI1 and Ki67 in low and high grade neuroendocrine tumors of the lung
    • 23011159
    • Different expression of EZH2, BMI1 and Ki67 in low and high grade neuroendocrine tumors of the lung. Bondgaard AL, Poulsen TT, Poulsen HS, Skov BG, Cancer Biomark 2012 11 2-3 123 128 23011159
    • (2012) Cancer Biomark , vol.11 , Issue.2-3 , pp. 123-128
    • Bondgaard, A.L.1    Poulsen, T.T.2    Poulsen, H.S.3    Skov, B.G.4
  • 18
    • 79959267832 scopus 로고    scopus 로고
    • Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
    • 10.1111/j.1349-7006.2011.01958.x 21539681
    • Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Takawa M, Masuda K, Kunizaki M, Daigo Y, Takagi K, Iwai Y, Cho HS, Toyokawa G, Yamane Y, Maejima K, et al. Cancer Sci 2011 102 7 1298 1305 10.1111/j.1349-7006.2011.01958.x 21539681
    • (2011) Cancer Sci , vol.102 , Issue.7 , pp. 1298-1305
    • Takawa, M.1    Masuda, K.2    Kunizaki, M.3    Daigo, Y.4    Takagi, K.5    Iwai, Y.6    Cho, H.S.7    Toyokawa, G.8    Yamane, Y.9    Maejima, K.10
  • 19
    • 80055077899 scopus 로고    scopus 로고
    • HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia
    • 10.1074/jbc.M111.257055 21917920
    • HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia. Geng H, Harvey CT, Pittsenbarger J, Liu Q, Beer TM, Xue C, Qian DZ, J Biol Chem 2011 286 44 38095 38102 10.1074/jbc.M111.257055 21917920
    • (2011) J Biol Chem , vol.286 , Issue.44 , pp. 38095-38102
    • Geng, H.1    Harvey, C.T.2    Pittsenbarger, J.3    Liu, Q.4    Beer, T.M.5    Xue, C.6    Qian, D.Z.7
  • 20
    • 33749006252 scopus 로고    scopus 로고
    • Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α
    • DOI 10.1158/0008-5472.CAN-05-4598
    • Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Qian DZ, Kachhap SK, Collis SJ, Verheul HM, Carducci MA, Atadja P, Pili R, Cancer Res 2006 66 17 8814 8821 10.1158/0008-5472.CAN-05-4598 16951198 (Pubitemid 44449199)
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8814-8821
    • Qian, D.Z.1    Kachhap, S.K.2    Collis, S.J.3    Verheul, H.M.W.4    Carducci, M.A.5    Atadja, P.6    Pili, R.7
  • 22
    • 48249100925 scopus 로고    scopus 로고
    • A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers
    • 10.1371/journal.pgen.1000129 18636107
    • A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, et al. PLoS Genetics 2008 4 7 1000129 10.1371/journal.pgen.1000129 18636107
    • (2008) PLoS Genetics , vol.4 , Issue.7 , pp. 51000129
    • Yu, K.1    Ganesan, K.2    Tan, L.K.3    Laban, M.4    Wu, J.5    Zhao, X.D.6    Li, H.7    Leung, C.H.8    Zhu, Y.9    Wei, C.L.10
  • 23
    • 77955094541 scopus 로고    scopus 로고
    • Histone deacetylase 1 is required for transforming growth factor-beta1-induced epithelial-mesenchymal transition
    • 10.1016/j.biocel.2010.05.006 20580679
    • Histone deacetylase 1 is required for transforming growth factor-beta1-induced epithelial-mesenchymal transition. Lei W, Zhang K, Pan X, Hu Y, Wang D, Yuan X, Shu G, Song J, Int J Biochem Cell Biol 2010 42 9 1489 1497 10.1016/j.biocel.2010.05.006 20580679
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.9 , pp. 1489-1497
    • Lei, W.1    Zhang, K.2    Pan, X.3    Hu, Y.4    Wang, D.5    Yuan, X.6    Shu, G.7    Song, J.8
  • 24
    • 37049001617 scopus 로고    scopus 로고
    • Clinical significance of histone deacetylase 1 expression in patients with hepatocellular carcinoma
    • DOI 10.1159/000111106
    • Clinical significance of histone deacetylase 1 expression in patients with hepatocellular carcinoma. Rikimaru T, Taketomi A, Yamashita Y, Shirabe K, Hamatsu T, Shimada M, Maehara Y, Oncology 2007 72 1-2 69 74 18004079 (Pubitemid 350249132)
    • (2007) Oncology , vol.72 , Issue.1-2 , pp. 69-74
    • Rikimaru, T.1    Taketomi, A.2    Yamashita, Y.-I.3    Shirabe, K.4    Hamatsu, T.5    Shimada, M.6    Maehara, Y.7
  • 25
    • 84867790360 scopus 로고    scopus 로고
    • Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response
    • 10.1021/jm3011838 23061376
    • Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response. Wong JC, Tang G, Wu X, Liang C, Zhang Z, Guo L, Peng Z, Zhang W, Lin X, Wang Z, et al. J Med Chem 2012 55 20 8903 8925 10.1021/jm3011838 23061376
    • (2012) J Med Chem , vol.55 , Issue.20 , pp. 8903-8925
    • Wong, J.C.1    Tang, G.2    Wu, X.3    Liang, C.4    Zhang, Z.5    Guo, L.6    Peng, Z.7    Zhang, W.8    Lin, X.9    Wang, Z.10
  • 26
    • 78651506355 scopus 로고    scopus 로고
    • High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients
    • 20844838
    • High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, Lin MC, Guan XY, Kung HF, Zeng YX, et al. Mol Med 2011 17 1-2 12 20 20844838
    • (2011) Mol Med , vol.17 , Issue.1-2 , pp. 12-20
    • Cai, M.Y.1    Hou, J.H.2    Rao, H.L.3    Luo, R.Z.4    Li, M.5    Pei, X.Q.6    Lin, M.C.7    Guan, X.Y.8    Kung, H.F.9    Zeng, Y.X.10
  • 27
    • 79957912993 scopus 로고    scopus 로고
    • EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis
    • 10.1158/0008-5472.CAN-10-3342 21512140
    • EZH2-mediated concordant repression of Wnt antagonists promotes beta-catenin-dependent hepatocarcinogenesis. Cheng AS, Lau SS, Chen Y, Kondo Y, Li MS, Feng H, Ching AK, Cheung KF, Wong HK, Tong JH, et al. Cancer Res 2011 71 11 4028 4039 10.1158/0008-5472.CAN-10-3342 21512140
    • (2011) Cancer Res , vol.71 , Issue.11 , pp. 4028-4039
    • Cheng, A.S.1    Lau, S.S.2    Chen, Y.3    Kondo, Y.4    Li, M.S.5    Feng, H.6    Ching, A.K.7    Cheung, K.F.8    Wong, H.K.9    Tong, J.H.10
  • 28
    • 84859157028 scopus 로고    scopus 로고
    • 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells
    • 10.1002/ijc.26264 21717453
    • 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells. Chiba T, Suzuki E, Negishi M, Saraya A, Miyagi S, Konuma T, Tanaka S, Tada M, Kanai F, Imazeki F, et al. Int J Cancer 2012 130 11 2557 2567 10.1002/ijc.26264 21717453
    • (2012) Int J Cancer , vol.130 , Issue.11 , pp. 2557-2567
    • Chiba, T.1    Suzuki, E.2    Negishi, M.3    Saraya, A.4    Miyagi, S.5    Konuma, T.6    Tanaka, S.7    Tada, M.8    Kanai, F.9    Imazeki, F.10
  • 29
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • DOI 10.1053/jhep.2001.22507
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S, Hepatology 2001 33 3 561 568 10.1053/jhep.2001.22507 11230735 (Pubitemid 32185217)
    • (2001) Hepatology , vol.33 , Issue.3 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 30
    • 74249098871 scopus 로고    scopus 로고
    • Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma
    • 10.1186/1471-2407-9-461 20028503
    • Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, Zeng YX, Xie D, BMC Cancer 2009 9 461 10.1186/1471-2407-9-461 20028503
    • (2009) BMC Cancer , vol.9 , pp. 461
    • He, L.R.1    Liu, M.Z.2    Li, B.K.3    Rao, H.L.4    Liao, Y.J.5    Guan, X.Y.6    Zeng, Y.X.7    Xie, D.8
  • 31
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • 10.1126/science.1227604 23239736
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, et al. Science 2012 338 6113 1465 1469 10.1126/science. 1227604 23239736
    • (2012) Science , vol.338 , Issue.6113 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3    He, H.H.4    Cai, C.5    Lis, R.T.6    Wu, X.7    Stack, E.C.8    Loda, M.9    Liu, T.10
  • 34
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • 10.1016/j.ccr.2009.12.020 20129251
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, et al. Cancer Cell 2010 17 1 98 110 10.1016/j.ccr.2009.12. 020 20129251
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6    Miller, C.R.7    Ding, L.8    Golub, T.9    Mesirov, J.P.10
  • 38
    • 84856518779 scopus 로고    scopus 로고
    • Distinct patterns of promoter CpG island methylation of breast cancer subtypes are associated with stem cell phenotypes
    • 22037257
    • Distinct patterns of promoter CpG island methylation of breast cancer subtypes are associated with stem cell phenotypes. Park SY, Kwon HJ, Choi Y, Lee HE, Kim SW, Kim JH, Kim IA, Jung N, Cho NY, Kang GH, Mod Pathol 2012 25 2 185 196 22037257
    • (2012) Mod Pathol , vol.25 , Issue.2 , pp. 185-196
    • Park, S.Y.1    Kwon, H.J.2    Choi, Y.3    Lee, H.E.4    Kim, S.W.5    Kim, J.H.6    Kim, I.A.7    Jung, N.8    Cho, N.Y.9    Kang, G.H.10
  • 39
    • 78951487862 scopus 로고    scopus 로고
    • DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables
    • 10.1016/j.molonc.2010.11.002
    • DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Kamalakaran S, Varadan V, Giercksky Russnes HE, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, et al. Molecular Oncol 2011 5 1 77 92 10.1016/j.molonc.2010.11.002
    • (2011) Molecular Oncol , vol.5 , Issue.1 , pp. 77-92
    • Kamalakaran, S.1    Varadan, V.2    Giercksky Russnes, H.E.3    Levy, D.4    Kendall, J.5    Janevski, A.6    Riggs, M.7    Banerjee, N.8    Synnestvedt, M.9    Schlichting, E.10
  • 41
    • 80052222327 scopus 로고    scopus 로고
    • Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers
    • 10.1016/j.molcel.2011.08.011 21884980
    • Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers. Lee ST, Li Z, Wu Z, Aau M, Guan P, Karuturi RK, Liou YC, Yu Q, Mol Cell 2011 43 5 798 810 10.1016/j.molcel.2011.08.011 21884980
    • (2011) Mol Cell , vol.43 , Issue.5 , pp. 798-810
    • Lee, S.T.1    Li, Z.2    Wu, Z.3    Aau, M.4    Guan, P.5    Karuturi, R.K.6    Liou, Y.C.7    Yu, Q.8
  • 43
    • 84864828790 scopus 로고    scopus 로고
    • The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
    • 10.1186/1471-2407-12-306 22824040
    • The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. Medrek C, Ponten F, Jirstrom K, Leandersson K, BMC Cancer 2012 12 306 10.1186/1471-2407-12-306 22824040
    • (2012) BMC Cancer , vol.12 , pp. 306
    • Medrek, C.1    Ponten, F.2    Jirstrom, K.3    Leandersson, K.4
  • 46
    • 84870989699 scopus 로고    scopus 로고
    • Molecular subtype is determinant on inflammatory status and immunological profile from invasive breast cancer patients
    • 10.1007/s00262-012-1283-8 22618884
    • Molecular subtype is determinant on inflammatory status and immunological profile from invasive breast cancer patients. Herrera AC, Panis C, Victorino VJ, Campos FC, Colado-Simao AN, Cecchini AL, Cecchini R, Cancer Immunol Immunother 2012 61 11 2193 2201 10.1007/s00262-012-1283-8 22618884
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.11 , pp. 2193-2201
    • Herrera, A.C.1    Panis, C.2    Victorino, V.J.3    Campos, F.C.4    Colado-Simao, A.N.5    Cecchini, A.L.6    Cecchini, R.7


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