Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane

Journal of Biological Chemistry

Volumn 288, Issue 39, 2013, Pages 28331-28345

  De Oliveira, Guilherme A P ^a   Pereira, Elen G ^a   Ferretti, Giulia D S ^a   Valente, Ana Paula ^a   Cordeiro, Yraima ^a   Silva, Jerson L ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR MEMBRANES; CHIMERIC PROTEINS; INTRAMOLECULAR DYNAMICS; MEMBRANE ANCHORING; PROTEIN ACTIVATION; REGULATORY REGIONS; REGULATORY UNITS; TYROSINE KINASE;

AMINO ACIDS; CELL MEMBRANES;

DISEASES;

ABELSON KINASE;

ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; MEMBRANE BINDING; MOLECULAR DYNAMICS; MYRISTYLATION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

C-ABL PROTEIN; CHRONIC MYELOID LEUKEMIA; MYRISTOYLATION; NMR; PROTEIN DYNAMICS; PROTEIN STRUCTURE; SAXS; TYROSINE PROTEIN KINASE (TYROSINE KINASE); X-RAY SCATTERING;

ANIMALS; APOPTOSIS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ABL; SCATTERING, RADIATION; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; SRC HOMOLOGY DOMAINS; VERO CELLS; X-RAYS;

EID: 84884760040     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.500926     Document Type: Article

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