Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity

Toxicology

Volumn 314, Issue 1, 2013, Pages 1-10

  Noya, Yoichi ^a   Seki, Koh ichi ^a   Asano, Hiroshi ^b   Mai, Yosuke ^b   Horinouchi, Takahiro ^b   Higashi, Tsunehito ^b   Terada, Koji ^b   Hatate, Chizuru ^b   Hoshi, Akimasa ^b   Nepal, Prabha ^b   Horiguchi, Mika ^b   Kuge, Yuji ^a   Miwa, Soichi ^b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

2 Cyclopenten 1 one; Acrolein; Cell apoptosis; Cigarette smoke extract; Methyl vinyl ketone; Plasma membrane damage

Indexed keywords

2 CYCLOPENTEN 1 ONE; ACETONE; ACROLEIN; CIGARETTE SMOKE; CIGARETTE SMOKE EXTRACT; CYTOTOXIC FACTOR; DICHLOROMETHANE; GLASS FIBER; METHYLVINYL KETONE; NICOTINE; O (2,3,4,5,6 PENTAFLUOROBENZYL) HYDROXYLAMINE HYDROCHLORIDE; PROPIDIUM IODIDE; PROPIONALDEHYDE; TAR; UNCLASSIFIED DRUG; 3-BUTEN-2-ONE; ALKANONE; CYCLOPENTANE DERIVATIVE; CYCLOPENTENONE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLOROX REAGENT; HYDROXYLAMINE; PASSIVE SMOKING; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL CULTURE; CELL DEATH; CELL MEMBRANE; CELL VIABILITY; CHEMICAL STRUCTURE; CYTOTOXICITY; DERIVATIZATION; DISSOLUTION; DNA FRAGMENTATION; EXTRACT; FILTER; FLUORESCENCE MICROSCOPY; FRACTIONATION; GAS; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; INCUBATION TIME; ION MONITORING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE DAMAGE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCANNING ELECTRON MICROSCOPY; SMOKING; ANTAGONISTS AND INHIBITORS; CELL FREE SYSTEM; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; PASSIVE SMOKING; STATISTICAL ANALYSIS; TOXICITY; TUMOR CELL LINE;

BUTANONES; CELL LINE, TUMOR; CELL SURVIVAL; CELL-FREE SYSTEM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOPENTANES; DATA INTERPRETATION, STATISTICAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYLAMINES; INDICATORS AND REAGENTS; MASS SPECTROMETRY; NADPH OXIDASE; NICOTINE; PROTEIN KINASE C; TARS; TOBACCO SMOKE POLLUTION;

EID: 84884719456     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.08.015     Document Type: Article

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