메뉴 건너뛰기




Volumn 272, Issue 3, 2013, Pages 780-786

Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor

Author keywords

Antral follicles; Metabolites; Methoxychlor; Ovary; Pregnenolone; Steroidogenesis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROSTENEDIONE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); DIMETHYL SULFOXIDE; ESTRADIOL; ESTRONE; METHOXYCHLOR; MONOHYDROXY METHOXYCHLOR; PREGNENOLONE; PROGESTERONE; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84884718749     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.08.002     Document Type: Article
Times cited : (9)

References (40)
  • 1
    • 20444482544 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry U.S. Department of Health and Human Services Public Health Service, Atlanta, GA
    • Agency for Toxic Substances and Disease Registry Toxicological Profile for Methoxychlor 2002, U.S. Department of Health and Human Services Public Health Service, Atlanta, GA.
    • (2002) Toxicological Profile for Methoxychlor
  • 2
    • 37449008357 scopus 로고    scopus 로고
    • The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells
    • Akgul Y., Derk R., Meighan T., Rao K., Murono E. The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. Reprod. Toxicol. 2008, 25:67-75.
    • (2008) Reprod. Toxicol. , vol.25 , pp. 67-75
    • Akgul, Y.1    Derk, R.2    Meighan, T.3    Rao, K.4    Murono, E.5
  • 3
    • 0026701362 scopus 로고
    • Risk for developing osteoporosis in untreated premature menopause
    • Bagur A.C., Mautzlen C. Risk for developing osteoporosis in untreated premature menopause. Calcif. Tissue Int. 1992, 51:4-7.
    • (1992) Calcif. Tissue Int. , vol.51 , pp. 4-7
    • Bagur, A.C.1    Mautzlen, C.2
  • 4
    • 79956310493 scopus 로고    scopus 로고
    • Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro
    • Basavarajappa M., Craig Z., Hern ndez-Ochoa I., Paulose T., Leslie T., Flaws J. Methoxychlor reduces estradiol levels by altering steroidogenesis and metabolism in mouse antral follicles in vitro. Toxicol. Appl. Pharmacol. 2011, 253:161-169.
    • (2011) Toxicol. Appl. Pharmacol. , vol.253 , pp. 161-169
    • Basavarajappa, M.1    Craig, Z.2    Hern ndez-Ochoa, I.3    Paulose, T.4    Leslie, T.5    Flaws, J.6
  • 5
    • 0036667372 scopus 로고    scopus 로고
    • Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian surface epithelium in the mouse
    • Borgeest C., Symonds D., Mayer L., Hoyer P., Flaws J. Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian surface epithelium in the mouse. Toxicol. Sci. 2002, 68:473-478.
    • (2002) Toxicol. Sci. , vol.68 , pp. 473-478
    • Borgeest, C.1    Symonds, D.2    Mayer, L.3    Hoyer, P.4    Flaws, J.5
  • 6
    • 2642548115 scopus 로고    scopus 로고
    • Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol
    • Borgeest C., Miller K., Gupta R., Greenfeld C., Hruska K., Hoyer P., Flaws J. Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol. Biol. Reprod. 2004, 70:1828-1835.
    • (2004) Biol. Reprod. , vol.70 , pp. 1828-1835
    • Borgeest, C.1    Miller, K.2    Gupta, R.3    Greenfeld, C.4    Hruska, K.5    Hoyer, P.6    Flaws, J.7
  • 9
    • 0035665223 scopus 로고    scopus 로고
    • The diverse mechanism of action of dichlorodiphenyldichloroethylene (DDE) and methoxychlor in ovarian cells in vitro
    • Chedrese P., Feyles F. The diverse mechanism of action of dichlorodiphenyldichloroethylene (DDE) and methoxychlor in ovarian cells in vitro. Reprod. Toxicol. 2001, 15:693-698.
    • (2001) Reprod. Toxicol. , vol.15 , pp. 693-698
    • Chedrese, P.1    Feyles, F.2
  • 10
    • 0027999156 scopus 로고
    • Steroidogenesis in the preovulatory porcine follicle
    • Conley A., Howard H., Slanger W., Ford J. Steroidogenesis in the preovulatory porcine follicle. Biol. Reprod. 1994, 51:655-661.
    • (1994) Biol. Reprod. , vol.51 , pp. 655-661
    • Conley, A.1    Howard, H.2    Slanger, W.3    Ford, J.4
  • 11
    • 77958191682 scopus 로고    scopus 로고
    • Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles
    • Craig Z., Leslie T., Hatfield K., Gupta R., Flaws J. Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles. Toxicol. Appl. Pharmacol. 2010, 249:107-113.
    • (2010) Toxicol. Appl. Pharmacol. , vol.249 , pp. 107-113
    • Craig, Z.1    Leslie, T.2    Hatfield, K.3    Gupta, R.4    Flaws, J.5
  • 12
    • 84877080437 scopus 로고    scopus 로고
    • Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles
    • Craig Z., Hannon P., Wang W., Ziv-Gal A., Flaws J. Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles. Biol. Reprod. 2013, 88:23.
    • (2013) Biol. Reprod. , vol.88 , pp. 23
    • Craig, Z.1    Hannon, P.2    Wang, W.3    Ziv-Gal, A.4    Flaws, J.5
  • 13
    • 0035085904 scopus 로고    scopus 로고
    • Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line
    • Crellin N., Kang H., Swan C., Chedrese P. Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line. Reproduction 2001, 121:485-492.
    • (2001) Reproduction , vol.121 , pp. 485-492
    • Crellin, N.1    Kang, H.2    Swan, C.3    Chedrese, P.4
  • 14
    • 0024573314 scopus 로고
    • Antifertility effect of methoxychlor in female rats: dose- and time-dependent blockade of pregnancy
    • Cummings A., Gray L.J. Antifertility effect of methoxychlor in female rats: dose- and time-dependent blockade of pregnancy. Toxicol. Appl. Pharmacol. 1989, 97:454-462.
    • (1989) Toxicol. Appl. Pharmacol. , vol.97 , pp. 454-462
    • Cummings, A.1    Gray, L.J.2
  • 15
    • 0027351313 scopus 로고
    • Effect of methoxychlor on ovarian steroidogenesis: role in early pregnancy loss
    • Cummings A., Laskey J. Effect of methoxychlor on ovarian steroidogenesis: role in early pregnancy loss. Reprod. Toxicol. 1993, 7:17-23.
    • (1993) Reprod. Toxicol. , vol.7 , pp. 17-23
    • Cummings, A.1    Laskey, J.2
  • 17
    • 0033603028 scopus 로고    scopus 로고
    • The role of estrogen in folliculogenesis
    • Drummond A., Findlay J. The role of estrogen in folliculogenesis. Mol. Cell. Endocrinol. 1999, 151:57-64.
    • (1999) Mol. Cell. Endocrinol. , vol.151 , pp. 57-64
    • Drummond, A.1    Findlay, J.2
  • 18
    • 0029328334 scopus 로고
    • Neonatal exposures to technical methoxychlor alters ovaries in adult mice
    • Eroschenko V., Abuel-Atta A., Grober M. Neonatal exposures to technical methoxychlor alters ovaries in adult mice. Reprod. Toxicol. 1995, 9:379-387.
    • (1995) Reprod. Toxicol. , vol.9 , pp. 379-387
    • Eroschenko, V.1    Abuel-Atta, A.2    Grober, M.3
  • 19
    • 0020959872 scopus 로고
    • Progesterone inhibits the induction of aromatase activity in rat granulosa cells in vitro
    • Fortune J., Vincent S. Progesterone inhibits the induction of aromatase activity in rat granulosa cells in vitro. Biol. Reprod. 1983, 28:1078-1089.
    • (1983) Biol. Reprod. , vol.28 , pp. 1078-1089
    • Fortune, J.1    Vincent, S.2
  • 20
    • 33748755734 scopus 로고    scopus 로고
    • Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway
    • Gupta R.K., Miller K.P., Babus J.K., Flaws J.A. Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway. Toxicol. Sci. 2006, 93:382-389.
    • (2006) Toxicol. Sci. , vol.93 , pp. 382-389
    • Gupta, R.K.1    Miller, K.P.2    Babus, J.K.3    Flaws, J.A.4
  • 21
    • 67649230776 scopus 로고    scopus 로고
    • Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro
    • Harvey C., Esmail M., Wang Q., Brooks A., Zachow R., Uzumcu M. Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro. Toxicol. Sci. 2009, 110:95-106.
    • (2009) Toxicol. Sci. , vol.110 , pp. 95-106
    • Harvey, C.1    Esmail, M.2    Wang, Q.3    Brooks, A.4    Zachow, R.5    Uzumcu, M.6
  • 22
    • 29144445284 scopus 로고    scopus 로고
    • The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression
    • Havelock J., Rainey W., Bradshaw K., Carr B. The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression. Hum. Reprod. 2006, 21:317.
    • (2006) Hum. Reprod. , vol.21 , pp. 317
    • Havelock, J.1    Rainey, W.2    Bradshaw, K.3    Carr, B.4
  • 23
    • 0026356114 scopus 로고
    • Development of follicles in the mammalian ovary
    • Hirshfield A. Development of follicles in the mammalian ovary. Int. Rev. Cytol. 1991, 124:43-101.
    • (1991) Int. Rev. Cytol. , vol.124 , pp. 43-101
    • Hirshfield, A.1
  • 25
    • 0003633755 scopus 로고    scopus 로고
    • Institute of Laboratory, A.R. National Academies Press, Washington, DC
    • Institute of Laboratory, A.R. Guide for the Care and Use of Laboratory Animals 1996, National Academies Press, Washington, DC.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 26
    • 0014871527 scopus 로고
    • Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem
    • Kapoor I.P., Metcalf R.L., Nystrom R.F., Sangha G.K. Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem. J. Agric. Food Chem. 1970, 18:1145-1152.
    • (1970) J. Agric. Food Chem. , vol.18 , pp. 1145-1152
    • Kapoor, I.P.1    Metcalf, R.L.2    Nystrom, R.F.3    Sangha, G.K.4
  • 28
    • 77958162033 scopus 로고
    • Lippincott Williams & Wilkins, Philadelphia, PA, D.B. Seifer, P. Samuels, D.A. Kniss (Eds.)
    • Levi A.J., Widra E.A. Basic Infertility: Etiology and Therapy 1994, 245-263. Lippincott Williams & Wilkins, Philadelphia, PA. D.B. Seifer, P. Samuels, D.A. Kniss (Eds.).
    • (1994) Basic Infertility: Etiology and Therapy , pp. 245-263
    • Levi, A.J.1    Widra, E.A.2
  • 29
    • 27644502785 scopus 로고    scopus 로고
    • Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways
    • Miller K.P., Gupta R.K., Greenfeld C.R., Babus J.K., Flaws J.A. Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways. Toxicol. Sci. 2005, 88:213-221.
    • (2005) Toxicol. Sci. , vol.88 , pp. 213-221
    • Miller, K.P.1    Gupta, R.K.2    Greenfeld, C.R.3    Babus, J.K.4    Flaws, J.A.5
  • 30
    • 33747884778 scopus 로고    scopus 로고
    • Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways
    • Miller K.P., Gupta R.K., Flaws J.A. Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. Toxicol. Sci. 2006, 93:180-188.
    • (2006) Toxicol. Sci. , vol.93 , pp. 180-188
    • Miller, K.P.1    Gupta, R.K.2    Flaws, J.A.3
  • 31
    • 78650578160 scopus 로고    scopus 로고
    • Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway
    • Peretz J., Gupta R., Singh J., Hern ndez-Ochoa I., Flaws J. Bisphenol A impairs follicle growth, inhibits steroidogenesis, and downregulates rate-limiting enzymes in the estradiol biosynthesis pathway. Toxicol. Sci. 2011, 119:209-217.
    • (2011) Toxicol. Sci. , vol.119 , pp. 209-217
    • Peretz, J.1    Gupta, R.2    Singh, J.3    Hern ndez-Ochoa, I.4    Flaws, J.5
  • 32
    • 21844438554 scopus 로고    scopus 로고
    • Ovarian follicular growth and atresia: the relationship between cell proliferation and survival
    • Quirk S., Cowan R., Harman R., Hu C., Porter D. Ovarian follicular growth and atresia: the relationship between cell proliferation and survival. J. Anim. Sci. 2004, 82:E40-E52.
    • (2004) J. Anim. Sci. , vol.82
    • Quirk, S.1    Cowan, R.2    Harman, R.3    Hu, C.4    Porter, D.5
  • 35
    • 0027015074 scopus 로고
    • Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnancies
    • Swartz W., Corkern M. Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnancies. Reprod. Toxicol. 1992, 6:431-437.
    • (1992) Reprod. Toxicol. , vol.6 , pp. 431-437
    • Swartz, W.1    Corkern, M.2
  • 36
    • 0027216910 scopus 로고
    • Steroidogenesis in sheep ovarian antral follicles in culture: time course study and supplementation with a precursor
    • Tambe S., Nandedkar T. Steroidogenesis in sheep ovarian antral follicles in culture: time course study and supplementation with a precursor. Steroids 1993, 58:379-383.
    • (1993) Steroids , vol.58 , pp. 379-383
    • Tambe, S.1    Nandedkar, T.2
  • 37
    • 33846813346 scopus 로고    scopus 로고
    • Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression
    • Taniguchi F., Couse J., Rodriguez K., Emmen J., Poirier D., Korach K. Estrogen receptor-alpha mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cyp17a1 (cytochrome P450, steroid 17alpha-hydroxylase/17,20 lyase) expression. FASEB J. 2007, 21:586-595.
    • (2007) FASEB J. , vol.21 , pp. 586-595
    • Taniguchi, F.1    Couse, J.2    Rodriguez, K.3    Emmen, J.4    Poirier, D.5    Korach, K.6
  • 38
    • 0030585785 scopus 로고    scopus 로고
    • Influence of organochlorine pesticides on physiological potency of cultured granulosa cells from bovine preovulatory follicles
    • Tiemann U., P'hland R., Schneider F. Influence of organochlorine pesticides on physiological potency of cultured granulosa cells from bovine preovulatory follicles. Theriogenology 1996, 46:253-265.
    • (1996) Theriogenology , vol.46 , pp. 253-265
    • Tiemann, U.1    P'hland, R.2    Schneider, F.3
  • 39
    • 35548974394 scopus 로고    scopus 로고
    • In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones
    • Tiemann U., Schneider F., Vanselow J., Tomek W. In vitro exposure of porcine granulosa cells to the phytoestrogens genistein and daidzein: effects on the biosynthesis of reproductive steroid hormones. Reprod. Toxicol. 2007, 24:317-325.
    • (2007) Reprod. Toxicol. , vol.24 , pp. 317-325
    • Tiemann, U.1    Schneider, F.2    Vanselow, J.3    Tomek, W.4
  • 40
    • 33749637179 scopus 로고    scopus 로고
    • The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro
    • Zachow R., Uzumcu M. The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro. Reprod. Toxicol. 2006, 22:659-665.
    • (2006) Reprod. Toxicol. , vol.22 , pp. 659-665
    • Zachow, R.1    Uzumcu, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.