Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles

Toxicology and Applied Pharmacology

Volumn 249, Issue 2, 2010, Pages 107-113

  Craig, Zelieann R ^a   Leslie, Traci C ^a   Hatfield, Kimberly P ^b   Gupta, Rupesh K ^a   Flaws, Jodi A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Antral follicles; Estradiol; Metabolites; Methoxychlor; Ovary; Steroidogenesis

Indexed keywords

ANDROSTENEDIONE; DIMETHYL SULFOXIDE; ESTRADIOL; MESSENGER RNA; METHOXYCHLOR; MONOHYDROXYMETHOXYCHLOR; PROGESTERONE; SEX HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYP11A1 GENE; CYP17A1 GENE; CYP19A1 GENE; CYP1B1 GENE; EXPOSURE; FEMALE; GENE; GENE EXPRESSION; HSD17B1 GENE; HSD3B1 GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY FOLLICLE; PROTEIN EXPRESSION; STAR GENE; STEROIDOGENESIS;

ANDROSTENES; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; HYDROXYSTEROID DEHYDROGENASES; INSECTICIDES; METHOXYCHLOR; MICE; OVARIAN FOLLICLE; PHOSPHOPROTEINS; PROGESTERONE; RNA, MESSENGER;

MUS; RODENTIA;

EID: 77958191682     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.001     Document Type: Article

References (43)

1. Agency for Toxic Substances and Disease Registry Toxicological Profile for Methoxychlor 2002, Department of Health and Human Services Public Health Service, Atlanta, GA, USA.
2. Akgul Y., Derk R., Meighan T., Rao K., Murono E. The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells. Reprod. Toxicol. 2008, 25:67-75.
3. Altschul S.F., Gish W., Miller W., Myers E., Lipman D. Basic local alignment search tool. J. Mol. Biol. 1990, 215:403-410.
4. Altschul S.F., Madden T., Schäffer A., Zhang J., Zhang J., Zhang Z., Miller W., Lipman D. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25:3389-3402.
5. Bagur A.C., Mautzlen C.A. Risk for developing osteoporosis in untreated premature menopause. Calcif. Tissue Int. 1992, 51:4-7.
6. Borgeest C., Symonds D., Mayer L.P., Hoyer P.B., Flaws J.A. Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse. Toxicol. Sci. 2002, 68:473-478.
7. Borgeest C., Miller K., Gupta R., Greenfeld C., Hruska K., Hoyer P., Flaws J. Methoxychlor-induced atresia in the mouse involves Bcl-2 family members, but not gonadotropins or estradiol. Biol. Reprod. 2004, 70:1828-1835.
8. Britt K., Saunders P.K., McPherson S.J., Misso M.L., Simpson E.R., Findlay J.K. Estrogen actions on follicle formation and early follicle development. Biol. Reprod. 2004, 71:1712-1723.
9. Chedrese P., Feyles F. The diverse mechanism of action of dichlorodiphenyldichloroethylene (DDE) and methoxychlor in ovarian cells in vitro. Reprod. Toxicol. 2001, 15:693-698.
10. Conley A., Howard H., Slanger W., Ford J. Steroidogenesis in the preovulatory porcine follicle. Biol. Reprod. 1994, 51:655-661.
11. Cortvrindt R.G., Smitz J. Follicle culture in reproductive toxicology: a tool for in-vitro testing of ovarian function?. Hum. Reprod. Update 2002, 8:243-254.
12. Crellin N.K., Kang H.G., Swan C.L., Chedrese P.J. Inhibition of basal and stimulated progesterone synthesis by dichlorodiphenyldichloroethylene and methoxychlor in a stable pig granulosa cell line. Reproduction 2001, 121:485-492.
13. Cummings A. Methoxychlor as a model for environmental estrogens. Crit. Rev. Toxicol. 1997, 27:367-379.
14. Cummings A., Gray L.J. Antifertility effect of methoxychlor in female rats: dose- and time-dependent blockade of pregnancy. Toxicol. Appl. Pharmacol. 1989, 97:454-462.
15. Cummings A., Laskey J. Effect of methoxychlor on ovarian steroidogenesis: role in early pregnancy loss. Reprod. Toxicol. 1993, 7:17-23.
16. Dennerstein L., Lehert P., Burger H., Dudley E. Mood and the menopausal transition. J. Nerv. Ment. Dis. 1999, 187(11):685-691.
17. Eroschenko V.P., Abuel-Atta A.A., Grober M.S. Neonatal exposures to technical methoxychlor alters ovaries in adult mice. Reprod. Toxicol. 1995, 9:379-387.
18. Gupta R.K., Miller K.P., Babus J.K., Flaws J.A. Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway. Toxicol. Sci. 2006, 93:382-389.
19. Gupta R.K., Meachum S., Hernández-Ochoa I., Peretz J., Yao H.H., Flaws J.A. Methoxychlor inhibits growth of antral follicles by altering cell cycle regulators. Toxicol. Appl. Pharmacol. 2009, 240:1-7.
20. Harvey C., Esmail M., Wang Q., Brooks A.I., Zachow R., Uzumcu M. Effect of the methoxychlor metabolite HPTE on the rat ovarian granulosa cell transcriptome in vitro. Toxicol. Sci. 2009, kfp089.
21. Havelock J., Rainey W., Bradshaw K., Carr B. The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression. Hum. Reprod. 2006, 21:317.
22. Hayes C., Spink D., Spink B., Cao J., Walker N. 17β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. 1996, 93:9776-9781.
23. Hirshfield A. Development of follicles in the mammalian ovary. Int. Rev. Cytol. 1991, 124:43-101.
24. Hu F.B., Grodstein F., Hennekens C.H., Colditz G.A., Johnson M., Manson J.E., et al. Age at natural menopause and risk of cardiovascular disease. Arch. Intern. Med. 1999, 159(10):1061-1066.
25. Imai I., Coulston F. Ultrastructural studies of absorption of methoxychlor in the jejunal mucosa of the rat. Exp. Mol. Pathol. 1968, 8:135-158.
26. Institute of Laboratory Animal Resources Guide for the care and use of laboratory animals 1996, National Academies Press, Washington, DC.
27. Jones E., DeCherney A. The female reproductive system. Medical physiology: a cellular and molecular approach 2005, Elsevier Saunders, Philadelphia, PA. W. Boron, E. Boulpaep (Eds.).
28. Kapoor I.P., Metcalf R.L., Nystrom R.F., Sangha G.K. Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem. J. Agric. Food Chem. 1970, 18:1145-1152.
29. Levi A.J., Widra E.A. Basic infertility: Etiology and Therapy. The physiologic basis of gynecology and obstetrics 1994, 245-263. Lippincott Williams & Wilkins, Philadelphia, PA. D.B. Seifer, P. Samuels, D.A. Kniss (Eds.).
30. Magoffin D., Erickson G. Primary culture of differentiating ovarian androgen-producing cells in defined medium. J. Biol. Chem. 1982, 25:4507-4513.
31. Martinez E.M., Swartz W.J. Effects of methoxychlor on the reproductive system of the adult female mouse. 1. Gross and histologic observations. Reprod. Toxicol. 1991, 5:139-147.
32. Miller W. Regulation of mRNAs for human steroidogenic enzymes. Endocr. Res. 1989, 15:1-16.
33. Miller K.P., Gupta R.K., Greenfeld C.R., Babus J.K., Flaws J.A. Methoxychlor directly affects ovarian antral follicle growth and atresia through Bcl-2- and Bax-mediated pathways. Toxicol. Sci. 2005, 88:213-221.
34. Miller K.P., Gupta R.K., Flaws J.A. Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. Toxicol. Sci. 2006, 93:180-188.
35. Ohyama K., Maki S., Sato K., Kato Y. Comparative in vitro metabolism of methoxychlor in male and female rats: metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slices. Xenobiotica 2005, 35:683-695.
36. Ohyama K., Maki S., Sato K., Kato Y. Comparative in vitro metabolism of the suspected pro-estrogenic compound, methoxychlor in precision-cut liver slices from male and female rats. Xenobiotica 2005, 35:331-342.
37. Pfaffl M. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:e45.
38. Swartz W., Corkern M. Effects of methoxychlor treatment of pregnant mice on female offspring of the treated and subsequent pregnancies. Reprod. Toxicol. 1992, 6:431-437.
39. Swartz W.J., Eroschenko V.P. Neonatal exposure to technical methoxychlor alters pregnancy outcome in female mice. Reprod. Toxicol. 1998, 12:565-573.
40. Tiemann U., Pöhland R., Schneider F. Influence of organochlorine pesticides on physiological potency of cultured granulosa cells from bovine preovulatory follicles. Theriogenology 1996, 46:253-265.
41. Wallner W.E., Leeling N.C., Zabik M.J. The fate of methoxychlor applied by helicopter for smaller European elm bark beetle control. J. Econ. Entomol. 1969, 62:1039-1042.
42. Wang C., Hsueh A., Erickson G. The role of cyclic AMP in the induction of estrogen and progestin synthesis in cultured granulosa cells. Mol. Cell. Endocrinol. 1982, 25:73-83.
43. Zachow R., Uzumcu M. The methoxychlor metabolite, 2, 2-bis-(p-hydroxyphenyl)-1, 1, 1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro. Reprod. Toxicol. 2006, 22:659-665.