-
1
-
-
0021193451
-
Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans
-
Ames M.M., Kovach J.S., Rubin J. Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans. Cancer Res. 1984, 44:4151-4156.
-
(1984)
Cancer Res.
, vol.44
, pp. 4151-4156
-
-
Ames, M.M.1
Kovach, J.S.2
Rubin, J.3
-
2
-
-
84866099780
-
Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway
-
An J., Gao Y., Wang J., Zhu Q., Ma Y., Wu J., Sun J., Tang Y. Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. Biotechnol. Lett. 2012, 34:1781-1788.
-
(2012)
Biotechnol. Lett.
, vol.34
, pp. 1781-1788
-
-
An, J.1
Gao, Y.2
Wang, J.3
Zhu, Q.4
Ma, Y.5
Wu, J.6
Sun, J.7
Tang, Y.8
-
3
-
-
0019207501
-
Antitumoral effect in mice of a new triepoxyde derivative: 1,3,5-triglycidyl-s-triazinetrione (NSC 296934)
-
Atassi G., Spreafico F., Dumont P., Nayer P., Klastersky J. Antitumoral effect in mice of a new triepoxyde derivative: 1,3,5-triglycidyl-s-triazinetrione (NSC 296934). Eur. J. Cancer 1980, 16:1561-1567.
-
(1980)
Eur. J. Cancer
, vol.16
, pp. 1561-1567
-
-
Atassi, G.1
Spreafico, F.2
Dumont, P.3
Nayer, P.4
Klastersky, J.5
-
4
-
-
0021543114
-
Preclinical evaluation of the anti tumour activity of new epoxide derivatives
-
Atassi G., Dumont P., Fisher U., Zeidler M., Budnowski M. Preclinical evaluation of the anti tumour activity of new epoxide derivatives. Cancer Treat. Rev. 1984, 11(Suppl. A):99-110.
-
(1984)
Cancer Treat. Rev.
, vol.11
, Issue.SUPPL. A
, pp. 99-110
-
-
Atassi, G.1
Dumont, P.2
Fisher, U.3
Zeidler, M.4
Budnowski, M.5
-
5
-
-
45549104364
-
P53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK
-
Boehme K.A., Kulikov R., Blattner C. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:7785-7790.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 7785-7790
-
-
Boehme, K.A.1
Kulikov, R.2
Blattner, C.3
-
6
-
-
21244469091
-
Etoposide (VP-16) sensitizes p53-deficient human non-small cell lung cancer cells to caspase-7-mediated apoptosis
-
Chiu C.C., Lin C.H., Fang K. Etoposide (VP-16) sensitizes p53-deficient human non-small cell lung cancer cells to caspase-7-mediated apoptosis. Apoptosis 2005, 10:643-650.
-
(2005)
Apoptosis
, vol.10
, pp. 643-650
-
-
Chiu, C.C.1
Lin, C.H.2
Fang, K.3
-
7
-
-
22844445705
-
Temporal dissection of p53 function in vitro and in vivo
-
Christophorou M.A. Temporal dissection of p53 function in vitro and in vivo. Nat. Genet. 2005, 37:718-726.
-
(2005)
Nat. Genet.
, vol.37
, pp. 718-726
-
-
Christophorou, M.A.1
-
8
-
-
33748670457
-
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
-
Christophorou M.A., Ringshausen I., Finch A.J., Swigart L.B., Evan G.I. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006, 443:214-217.
-
(2006)
Nature
, vol.443
, pp. 214-217
-
-
Christophorou, M.A.1
Ringshausen, I.2
Finch, A.J.3
Swigart, L.B.4
Evan, G.I.5
-
9
-
-
79958081571
-
Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells
-
Crespo R., Villaverde M.L., Girotti J.R., Güerci A., Juárez M.P., de Bravo M.G. Cytotoxic and genotoxic effects of defence secretion of Ulomoides dermestoides on A549 cells. J. Ethnopharmacol. 2011, 136:204-209.
-
(2011)
J. Ethnopharmacol.
, vol.136
, pp. 204-209
-
-
Crespo, R.1
Villaverde, M.L.2
Girotti, J.R.3
Güerci, A.4
Juárez, M.P.5
de Bravo, M.G.6
-
10
-
-
16244389645
-
Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity
-
Dash B.C., El-Deiry W.S. Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity. Mol. Cell. Biol. 2005, 25:3364-3387.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 3364-3387
-
-
Dash, B.C.1
El-Deiry, W.S.2
-
11
-
-
0020591941
-
Phase-I study of alpha-1,3,5-triglycidyl-s-triazinetrione (NSC 296934)
-
Dombernowsky P., Lund B., Hansen H.H. Phase-I study of alpha-1,3,5-triglycidyl-s-triazinetrione (NSC 296934). Cancer Chemother. Pharmacol. 1983, 11:59-61.
-
(1983)
Cancer Chemother. Pharmacol.
, vol.11
, pp. 59-61
-
-
Dombernowsky, P.1
Lund, B.2
Hansen, H.H.3
-
12
-
-
0021358197
-
Investigation of the antitumor activity of new epoxide derivatives. Part I: s-triazinetrione derivatives
-
Fischer H., Zeidler U., Budnowski M., Atassi G., Dumont P., Venditti J., Yoder O.C. Investigation of the antitumor activity of new epoxide derivatives. Part I: s-triazinetrione derivatives. Arzneim. Forsch. 1984, 34:543-547.
-
(1984)
Arzneim. Forsch.
, vol.34
, pp. 543-547
-
-
Fischer, H.1
Zeidler, U.2
Budnowski, M.3
Atassi, G.4
Dumont, P.5
Venditti, J.6
Yoder, O.C.7
-
13
-
-
27644532408
-
Toxicity of tire debris extracts on human lung cell line A549
-
Gualtieri M., Rigamonti L., Galeotti V., Camatini M. Toxicity of tire debris extracts on human lung cell line A549. Toxicol. In Vitro 2005, 19:1001-1008.
-
(2005)
Toxicol. In Vitro
, vol.19
, pp. 1001-1008
-
-
Gualtieri, M.1
Rigamonti, L.2
Galeotti, V.3
Camatini, M.4
-
14
-
-
3042541878
-
The proliferative inhibition and apoptotic mechanism of saikosaponin D in human non-small cell lung cancer A549 cells
-
Hsu Y.L., Kuo P.L., Lin C.C. The proliferative inhibition and apoptotic mechanism of saikosaponin D in human non-small cell lung cancer A549 cells. Life Sci. 2004, 75:1231-1242.
-
(2004)
Life Sci.
, vol.75
, pp. 1231-1242
-
-
Hsu, Y.L.1
Kuo, P.L.2
Lin, C.C.3
-
15
-
-
84863686689
-
Pseudolaric acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells
-
Khan M., Zheng B., Yi F., Rasul A., Gu Z., Li T., Gao H., Qazi J.I., Yang H., Ma T. Pseudolaric acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells. Evidence-based Compl. Alt. Med.: eCAM 2012 2012, 957568.
-
(2012)
Evidence-based Compl. Alt. Med.: eCAM 2012
, pp. 957568
-
-
Khan, M.1
Zheng, B.2
Yi, F.3
Rasul, A.4
Gu, Z.5
Li, T.6
Gao, H.7
Qazi, J.I.8
Yang, H.9
Ma, T.10
-
16
-
-
81255208503
-
Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks
-
Lim S.W., Ting K.N., Bradshaw T.D., Zeenathul N.A., Wiart C., Khoo T.J., Lim K.H., Loh H.S. Acalypha wilkesiana extracts induce apoptosis by causing single strand and double strand DNA breaks. J. Ethnopharmacol. 2011, 138:616-623.
-
(2011)
J. Ethnopharmacol.
, vol.138
, pp. 616-623
-
-
Lim, S.W.1
Ting, K.N.2
Bradshaw, T.D.3
Zeenathul, N.A.4
Wiart, C.5
Khoo, T.J.6
Lim, K.H.7
Loh, H.S.8
-
17
-
-
79955394867
-
EDD inhibits ATM-mediated phosphorylation of p53
-
Ling S., Lin W.-C. EDD inhibits ATM-mediated phosphorylation of p53. J. Biol. Chem. 2011, 286:14972-14982.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 14972-14982
-
-
Ling, S.1
Lin, W.-C.2
-
18
-
-
70349438994
-
Tumour suppression by p53: a role for the DNA damage response?
-
Meek D.W. Tumour suppression by p53: a role for the DNA damage response?. Nat. Rev. Cancer 2009, 9:714-723.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 714-723
-
-
Meek, D.W.1
-
19
-
-
0021166040
-
Phase I trial of teroxirone
-
Neidhart J.A., Derocher D., Grever M.R., Kraut E.H., Malspeis L. Phase I trial of teroxirone. Cancer Treat. Rep. 1984, 68:1115-1119.
-
(1984)
Cancer Treat. Rep.
, vol.68
, pp. 1115-1119
-
-
Neidhart, J.A.1
Derocher, D.2
Grever, M.R.3
Kraut, E.H.4
Malspeis, L.5
-
20
-
-
0022574269
-
Phase I study of triglycidylurazol given on a 5-day i.v. schedule
-
Nicaise C., Rozencweig M., Crespeigne N., Dodion P., Gerard B., Lambert M., Decoster G., Kenis Y. Phase I study of triglycidylurazol given on a 5-day i.v. schedule. Cancer Treat. Rep. 1986, 70:599-603.
-
(1986)
Cancer Treat. Rep.
, vol.70
, pp. 599-603
-
-
Nicaise, C.1
Rozencweig, M.2
Crespeigne, N.3
Dodion, P.4
Gerard, B.5
Lambert, M.6
Decoster, G.7
Kenis, Y.8
-
21
-
-
0036317093
-
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
-
Offer H., Erez N., Zurer I., Tang X., Milyavsky M., Goldfinger N., Rotter V. The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis 2002, 23:1025-1032.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1025-1032
-
-
Offer, H.1
Erez, N.2
Zurer, I.3
Tang, X.4
Milyavsky, M.5
Goldfinger, N.6
Rotter, V.7
-
22
-
-
42249113878
-
Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11
-
Oliver P.G., LoBuglio A.F., Zinn K.R., Kim H., Nan L., Zhou T., Wang W., Buchsbaum D.J. Treatment of human colon cancer xenografts with TRA-8 anti-death receptor 5 antibody alone or in combination with CPT-11. Clin. Cancer Res. 2008, 14:2180-2189.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 2180-2189
-
-
Oliver, P.G.1
LoBuglio, A.F.2
Zinn, K.R.3
Kim, H.4
Nan, L.5
Zhou, T.6
Wang, W.7
Buchsbaum, D.J.8
-
23
-
-
79957894792
-
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
-
Petty T.J., Emamzadah S., Costantino L., Petkova I., Stavridi E.S., Saven J.G., Vauthey E., Halazonetis T.D. An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. EMBO J. 2011, 30:2067-2076.
-
(2011)
EMBO J.
, vol.30
, pp. 2067-2076
-
-
Petty, T.J.1
Emamzadah, S.2
Costantino, L.3
Petkova, I.4
Stavridi, E.S.5
Saven, J.G.6
Vauthey, E.7
Halazonetis, T.D.8
-
24
-
-
0019817489
-
Phase I clinical trial with alpha 1,3,5-triglycidyl-s-triazinetrione (NSC-296934)
-
Piccart M., Rozencweig M., Dodion P., Cumps E., Crespeigne N., Makaroff O., Atassi G., Kisner D., Kenis Y. Phase I clinical trial with alpha 1,3,5-triglycidyl-s-triazinetrione (NSC-296934). Eur. J. Cancer Clin. Oncol. 1981, 17:1263-1266.
-
(1981)
Eur. J. Cancer Clin. Oncol.
, vol.17
, pp. 1263-1266
-
-
Piccart, M.1
Rozencweig, M.2
Dodion, P.3
Cumps, E.4
Crespeigne, N.5
Makaroff, O.6
Atassi, G.7
Kisner, D.8
Kenis, Y.9
-
25
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
Riley T., Sontag E., Chen P., Levine A. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 2008, 9:402-412.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 402-412
-
-
Riley, T.1
Sontag, E.2
Chen, P.3
Levine, A.4
-
26
-
-
0023189593
-
Phase I study of two schedules of teroxirone
-
Rubin J., Kovach J.S., Ames M.M., Moertel C.G., Creagan E.T., O'Connell M.J. Phase I study of two schedules of teroxirone. Cancer Treat. Rep. 1987, 71:489-492.
-
(1987)
Cancer Treat. Rep.
, vol.71
, pp. 489-492
-
-
Rubin, J.1
Kovach, J.S.2
Ames, M.M.3
Moertel, C.G.4
Creagan, E.T.5
O'Connell, M.J.6
-
27
-
-
84862737578
-
CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy
-
Siddiqui-Jain A., Bliesath J., Macalino D., Omori M., Huser N., Streiner N., Ho C.B., Anderes K., Proffitt C., O'Brien S.E., Lim J.K.C., Von Hoff D.D., Ryckman D.M., Rice W.G., Drygin D. CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy. Mol. Cancer Ther. 2012, 11:994-1005.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 994-1005
-
-
Siddiqui-Jain, A.1
Bliesath, J.2
Macalino, D.3
Omori, M.4
Huser, N.5
Streiner, N.6
Ho, C.B.7
Anderes, K.8
Proffitt, C.9
O'Brien, S.E.10
Lim, J.K.C.11
Von Hoff, D.D.12
Ryckman, D.M.13
Rice, W.G.14
Drygin, D.15
-
28
-
-
0032890871
-
Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication
-
Simbulan-Rosenthal C.M., Rosenthal D.S., Iyer S., Boulares H., Smulson M.E. Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication. Mol. Cell. Biochem. 1999, 193:137-148.
-
(1999)
Mol. Cell. Biochem.
, vol.193
, pp. 137-148
-
-
Simbulan-Rosenthal, C.M.1
Rosenthal, D.S.2
Iyer, S.3
Boulares, H.4
Smulson, M.E.5
-
29
-
-
84880505516
-
A characterization of the activity of alpha-1,3,5-triglycidyl-s-triazinetrione, a novel antineoplastic compound
-
Spreafico F., Atassi G., Filippeschi S., Malfiore C., Noseda S., Boschetti D. A characterization of the activity of alpha-1,3,5-triglycidyl-s-triazinetrione, a novel antineoplastic compound. Cancer Chemother. Pharmacol. 1980, 5:103-108.
-
(1980)
Cancer Chemother. Pharmacol.
, vol.5
, pp. 103-108
-
-
Spreafico, F.1
Atassi, G.2
Filippeschi, S.3
Malfiore, C.4
Noseda, S.5
Boschetti, D.6
-
30
-
-
0034037611
-
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing
-
Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
-
(2000)
Environ. Mol. Mutagen.
, vol.35
, pp. 206-221
-
-
Tice, R.R.1
Agurell, E.2
Anderson, D.3
Burlinson, B.4
Hartmann, A.5
Kobayashi, H.6
Miyamae, Y.7
Rojas, E.8
Ryu, J.C.9
Sasaki, Y.F.10
-
31
-
-
33845270990
-
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
-
Toledo F., Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 2006, 6:909-923.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
32
-
-
0034080626
-
Paclitaxel-induced apoptosis in non-small cell lung cancer cell lines is associated with increased caspase-3 activity
-
Weigel T.L., Lotze M.T., Kim P.K., Amoscato A.A., Luketich J.D., Odoux C. Paclitaxel-induced apoptosis in non-small cell lung cancer cell lines is associated with increased caspase-3 activity. J. Thorac. Cardiovasc. Surg. 2000, 119:795-803.
-
(2000)
J. Thorac. Cardiovasc. Surg.
, vol.119
, pp. 795-803
-
-
Weigel, T.L.1
Lotze, M.T.2
Kim, P.K.3
Amoscato, A.A.4
Luketich, J.D.5
Odoux, C.6
-
33
-
-
77949878222
-
The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells
-
Yan K.H., Yao C.J., Chang H.Y., Lai G.M., Cheng A.L., Chuang S.E. The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. Mol. Carcinog. 2010, 49:235-246.
-
(2010)
Mol. Carcinog.
, vol.49
, pp. 235-246
-
-
Yan, K.H.1
Yao, C.J.2
Chang, H.Y.3
Lai, G.M.4
Cheng, A.L.5
Chuang, S.E.6
|