Streptochlorin Suppresses Allergic Dermatitis and Mast Cell Activation via Regulation of Lyn/Fyn and Syk Signaling Pathways in Cellular and Mouse Models

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Lee, Seung Hwan ^a,e   Shin, Hee Jae ^b   Kim, Dong Young ^a   Shim, Do Wan ^a   Kim, Tack Joong ^c   Ye, Sang Kyu ^d   Won, Hyung Sik ^a   Koppula, Sushruta ^a   Kang, Tae Bong ^a   Lee, Kwang Ho ^a  

^a Konkuk University   (South Korea)

^b Korea Research Institute of Ships and Ocean Engineering   (South Korea)

^c Yonsei University Wonju   (South Korea)

^d Seoul National University   (South Korea)

^e University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; INTERLEUKIN 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE FYN; PROTEIN KINASE LYN; PROTEIN KINASE SYK; STREPTOCHLORIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY TEST; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE; GENE EXPRESSION; IL 4 GENE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; SKIN ALLERGY; T LYMPHOCYTE ACTIVATION; TNF ALPHA GENE;

ANIMALS; CELL DEGRANULATION; CELL LINE; DERMATITIS; FEMALE; HYPERSENSITIVITY; INDOLES; INFLAMMATION MEDIATORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; OXAZOLES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-FYN; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84884695634     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074194     Document Type: Article

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