Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin

Oncotarget

Volumn 4, Issue 9, 2013, Pages 1427-1437

  Chen, Bailing ^a   Yu, Miaomiao ^a   Chang, Qingshan ^a   Lu, Yongju ^a   Thakur, Chitra ^a   Ma, Danjun ^a   Yi, Zhenping ^a   Chen, Fei ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Demethylation; H19; mdig; Prognosis

Indexed keywords

HISTONE H3; LONG UNTRANSLATED RNA; RNA H19;

ARTICLE; CANCER CELL; CANCER PROGNOSIS; CANCER SURVIVAL; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEMETHYLATION; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; HETEROCHROMATIN; HISTONE METHYLATION; HUMAN; HUMAN CELL; MDIG GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; PROMOTER REGION; RNA H19 GENE;

ADENOCARCINOMA; CELL LINE, TUMOR; DOWN-REGULATION; HETEROCHROMATIN; HISTONES; HUMANS; LUNG NEOPLASMS; METHYLATION; NUCLEAR PROTEINS; RNA, LONG NONCODING; RNA, SMALL INTERFERING; SURVIVAL ANALYSIS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84884692423     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1155     Document Type: Article

References (42)

1. Zhang Y, et al. (2005) The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene 24(31):4873-4882.
2. Lu Y, et al. (2009) Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. Cell Cycle 8(13):2101-2109.
3. Tsuneoka M, Koda Y, Soejima M, Teye K, & Kimura H (2002) A novel myc target gene, mina53, that is involved in cell proliferation. J Biol Chem 277(38):35450-35459.
4. Eilbracht J, Kneissel S, Hofmann A, & Schmidt-Zachmann MS (2005) Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66. Eur J Cell Biol 84(2-3):279-294.
5. Teye K, et al. (2004) Increased expression of a Myc target gene Mina53 in human colon cancer. Am J Pathol 164(1):205-216.
6. Tsuneoka M, et al. (2004) Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. Clin Cancer Res 10(21):7347-7356.
7. Kuratomi K, et al. (2006) Immunohistochemical expression of Mina53 and Ki67 proteins in human primary gingival squamous cell carcinoma. Kurume Med J 53(3-4):71-78.
8. Teye K, et al. (2007) Expression of Myc target gene mina53 in subtypes of human lymphoma. Oncol Rep 18(4):841-848.
9. Ishizaki H, et al. (2007) Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma. Pathol Int 57(10):672-680.
10. Fukahori S, et al. (2007) Immunohistochemical expressions of Cap43 and Mina53 proteins in neuroblastoma. J Pediatr Surg 42(11):1831-1840.
11. Zhang Q, et al. (2008) Expression of Mina53 and its significance in gastric carcinoma. Int J Biol Markers 23(2):83-88.
12. Ogasawara S, et al. (2010) Accelerated expression of a Myc target gene Mina53 in aggressive hepatocellular carcinoma. Hepatol Res 40(4):330-336.
13. Tan XP, Zhang Q, Dong WG, Lei XW, & Yang ZR (2012) Upregulated expression of Mina53 in cholangiocarcinoma and its clinical significance. Oncol Lett 3(5):1037-1041.
14. Klose RJ, Kallin EM, & Zhang Y (2006) JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 7(9):715-727.
15. Okamoto M, et al. (2009) Mina, an Il4 repressor, controls T helper type 2 bias. Nat Immunol 10(8):872-879.
16. Ge W, et al. (2012) Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat Chem Biol 8(12):960-962.
17. Bartolomei MS, Webber AL, Brunkow ME, & Tilghman SM (1993) Epigenetic mechanisms underlying the imprinting of the mouse H19 gene. Genes Dev 7(9):1663-1673.
18. Srivastava M, et al. (2000) H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19. Genes Dev 14(10):1186-1195.
19. Singh P, Lee DH, & Szabo PE (2012) More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain. Front Genet 3:214.
20. Nativio R, et al. (2011) Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Hum Mol Genet 20(7):1363-1374.
21. Bartolomei MS, Zemel S, & Tilghman SM (1991) Parental imprinting of the mouse H19 gene. Nature 351(6322):153-155.
22. Looijenga LH, Verkerk AJ, De Groot N, Hochberg AA, & Oosterhuis JW (1997) H19 in normal development and neoplasia. Mol Reprod Dev 46(3):419-439.
23. Matouk I, et al. (2013) The increasing complexity of the oncofetal h19 gene locus: functional dissection and therapeutic intervention. Int J Mol Sci 14(2):4298-4316.
24. Hao Y, Crenshaw T, Moulton T, Newcomb E, & Tycko B (1993) Tumour-suppressor activity of H19 RNA. Nature 365(6448):764-767.
25. Keniry A, et al. (2012) The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol 14(7):659-665.
26. Lottin S, et al. (2002) Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells. Carcinogenesis 23(11):1885-1895.
27. Barsyte-Lovejoy D, et al. (2006) The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis. Cancer Res 66(10):5330-5337.
28. Chang Q, et al. (2009) JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma. Mol Cancer 8:64.
29. Chang Q, et al. (2009) Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol 50(2):323-333.
30. Guetg C & Santoro R (2012) Formation of nuclear heterochromatin: the nucleolar point of view. Epigenetics 7(8):811-814.
31. Guetg C, et al. (2010) The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats. EMBO J 29(13):2135-2146.
32. Yamane K, et al. (2006) JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 125(3):483-495.
33. Beisel C & Paro R (2011) Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet 12(2):123-135.
34. Horakova AH, Moseley SC, McLaughlin CR, Tremblay DC, & Chadwick BP (2012) The macrosatellite DXZ4 mediates CTCF-dependent long-range intrachromosomal interactions on the human inactive X chromosome. Hum Mol Genet 21(20):4367-4377.
35. Klose RJ, et al. (2006) The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442(7100):312-316.
36. Kurukuti S, et al. (2006) CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A 103(28):10684-10689.
37. Gyorffy B, Lanczky A, & Szallasi Z (2012) Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients. Endocr Relat Cancer 19(2):197-208.
38. Chi P, Allis CD, & Wang GG (2010) Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer 10(7):457-469.
39. Peters AH, et al. (2001) Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107(3):323-337.
40. Kappes F, et al. (2011) The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Genes Dev 25(7):673-678.
41. Hemberger M, Dean W, & Reik W (2009) Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol 10(8):526-537.
42. Tsang WP, et al. (2010) Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis 31(3):350-358.