Human Cytomegalovirus Gene UL76 Induces IL-8 Expression through Activation of the DNA Damage Response

PLoS Pathogens

Volumn 9, Issue 9, 2013, Pages

  Costa, Helena ^a   Nascimento, Rute ^a   Sinclair, John ^b   Parkhouse, Robert Michael Evans ^a  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; TRANSCRIPTION FACTOR AP 1; ATM PROTEIN, HUMAN; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; RECOMBINANT PROTEIN; RELA PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR RELA; UL76 PROTEIN, CYTOMEGALOVIRUS;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DELETION MUTANT; DNA DAMAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNOFLUORESCENCE TEST; PROTEIN EXPRESSION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; UL76 GENE; UPREGULATION; VIRUS GENE; VIRUS MUTANT; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL NUCLEUS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN TRANSPORT; REPORTER GENE; RNA INTERFERENCE; SECRETION (PROCESS); SIGNAL TRANSDUCTION; VIROLOGY; VIRUS REPLICATION;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL LINE; CELL NUCLEUS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA DAMAGE; GENES, REPORTER; HOST-PATHOGEN INTERACTIONS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-8; MUTATION; PROTEIN TRANSPORT; PROTEOLYSIS; RECOMBINANT PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR RELA; UP-REGULATION; VIRUS REPLICATION;

EID: 84884688989     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003609     Document Type: Article

References (29)

1. Mocarski ES, Shenk T, Pass RF (2007) Cytomegaloviruses. In: Knipe DM, Howley PM, editors. Fields Virology, 5th Edition: Lippincott Williams & Wilkins.
2. Murayama T, Kuno K, Jisaki F, Obuchi M, Sakamuro D, et al. (1994) Enhancement human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8. J Virol 68: 7582-7585.
3. Craigen JL, Yong KL, Jordan NJ, MacCormac LP, Westwick J, et al. (1997) Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration. Immunology 92: 138-145.
4. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M, (2002) Multiple control of interleukin-8 gene expression. J LeukocBiol 72: 847-855.
5. Kasahara T, Mukaida N, Yamashita K, Yagisawa H, Akahoshi T, et al. (1991) IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology 74: 60-67.
6. Aihara M, Tsuchimoto D, Takizawa H, Azuma A, Wakebe H, et al. (1997) Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 65: 3218-3224.
7. Medin CL, Rothman AL, (2006) Cell type-specific mechanisms of interleukin-8 induction by dengue virus and differential response to drug treatment. J Infect Dis 193: 1070-1077.
8. Khabar KS, Al-Zoghaibi F, Al-Ahdal MN, Murayama T, Dhalla M, et al. (1997) The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha. J Exp Med 186: 1077-1085.
9. Perkins ND, (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8: 49-62.
10. Miyamoto S, (2011) Nuclear initiated NF-κB signaling: NEMO and ATM take center stage. Cell Res 21: 116-130.
11. Abraham RT, (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196.
12. Wang SK, Duh CY, Wu CW, (2004) Human cytomegalovirus UL76 encodes a novel virion-associated protein that is able to inhibit viral replication. J Virol 78: 9750-9762.
13. Davison AJ, Dargan DJ, Stow ND, (2002) Fundamental and accessory systems in herpesviruses. Antiviral Res 56: 1-11.
14. Knizewski L, Kinch L, Grishin NV, Rychlewski L, Ginalski K, (2006) Human herpesvirus 1 UL24 gene encodes a potential PD-(D/E)XK endonuclease. J Virol 80: 2575-2577.
15. Murzin AG, Brenner SE, Hubbard T, Chothia C, (1995) SCOP: a structural classification of proteins database for the investigation of sequences and structures. J MolBiol 247: 536-540.
16. Yu D, Silva MC, Shenk T, (2003) Functional map of human cytomegalovirus AD169 defined by global mutational analysis. ProcNatlAcadSci U S A 100: 12396-12401.
17. Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, et al. (2010) The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene. PLoS One 5: e11901.
18. Nascimento R, Dias JD, Parkhouse RM, (2009) The conserved UL24 family of human alpha, beta and gamma herpesviruses induces cell cycle arrest and inactivation of the cyclinB/cdc2 complex. Arch Virol 154: 1143-1149.
19. Nascimento R, Parkhouse RM, (2007) Murine gammaherpesvirus 68 ORF20 induces cell-cycle arrest in G2 by inhibiting the Cdc2-cyclin B complex. J Gen Virol 88: 1446-1453.
20. Siew VK, Duh CY, Wang SK, (2009) Human cytomegalovirus UL76 induces chromosome aberrations. J Biomed Sci 16: 107.
21. Wu ZH, Shi Y, Tibbetts RS, Miyamoto S, (2006) Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311: 1141-1146.
22. Murayama T, Ohara Y, Obuchi M, Khabar KS, Higashi H, et al. (1997) Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene. J Virol 71: 5692-5695.
23. Gaspar M, Shenk T, (2006) Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins. ProcNatlAcadSci U S A 103: 2821-2826.
24. Luo MH, Rosenke K, Czornak K, Fortunato EA, (2007) Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. J Virol 81: 1934-1950.
25. Penfold ME, Dairaghi DJ, Duke GM, Saederup N, Mocarski ES, et al. (1999) Cytomegalovirus encodes a potent alpha chemokine. ProcNatlAcadSci U S A 96: 9839-9844.
26. Lüttichau HR, (2010) The cytomegalovirus UL146 gene product vCXCL1 targets both CXCR1 and CXCR2 as an agonist. J BiolChem 285: 9137-9146.
27. E X, Pickering MT, Debatis M, Castillo J, Lagadinos A, et al. (2011) An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoSPathog 7: e1001342.
28. Zandi E, Chen Y, Karin M, (1998) Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science 281: 1360-1363.
29. Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, et al. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol Cell Biol 15: 2809-2818.