Insights into insulin-mediated regulation of CYP2E1: miR-132/-212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase, Akt (protein kinase B), mammalian target of rapamycin signaling in regulating miR-132/-212 and miR-122/-181a expression in primary cultured rat hepatocytes

Drug Metabolism and Disposition

Volumn 41, Issue 10, 2013, Pages 1769-1777

  Shukla, Upasana ^a   Tumma, Nithin ^a   Gratsch, Theresa ^a   Dombkowski, Alan ^a   Novak, Raymond F ^a,b  

^a CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^b SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; [1 (1H INDOL 3 YL) 3 [5 (3 METHYL 1H INDAZOL 5 YL)PYRIDIN 3 YL]OXY]PROPAN 2 AMINE; A 443654; CYTOCHROME P450 2E1; INSULIN; LUCIFERASE; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 122; MICRORNA 132; MICRORNA 181A; MICRORNA 212; MICRORNA LET 7A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL CULTURE; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; GENE TARGETING; GENETIC REGULATION; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER DISEASE; LIVER METABOLISM; MALE; MONOTHERAPY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FOLDING; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION;

3' UNTRANSLATED REGIONS; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOCHROME P-450 CYP2E1; HEPATOCYTES; INSULIN; MICRORNAS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84884686952     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.052860     Document Type: Article

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