A randomized, double-blind, active-controlled trial of fluoroscopic lumbar interlaminar epidural injections in chronic axial or discogenic low back pain: Results of 2-year follow-up

Pain Physician

Volumn 16, Issue 5, 2013, Pages

  Manchikanti, Laxmaiah ^a,b   Cash, Kimberly A ^a   Mcmanus, Carla D ^a   Pampati, Vidyasagar ^a   Benyamin, Ramsin M ^c,d  

^a PAIN MANAGEMENT CENTER OF PADUCAH   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c MILLENNIUM PAIN CENTER   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Axial or discogenic pain; Controlled comparative local anesthetic blocks; Local anesthetic; Lumbar disc herniation; Lumbar interlaminar epidural injections; Steroids

Indexed keywords

BETAMETHASONE; LIDOCAINE; NARCOTIC ANALGESIC AGENT; STEROID;

ADULT; ANALGESIA; ARTHRALGIA; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DISCOGENIC PAIN; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FLUOROSCOPY; FOLLOW UP; FUNCTIONAL ASSESSMENT; FUNCTIONAL STATUS; HUMAN; INTERVERTEBRAL DISK HERNIA; KINESIOTHERAPY; LOW BACK PAIN; MAJOR CLINICAL STUDY; MALE; NERVE ROOT INJURY; NUMERIC RATING SCALE; OSWESTRY DISABILITY INDEX; OUTCOME ASSESSMENT; RADICULITIS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SIDE EFFECT; TREATMENT DURATION; UNITED STATES; WEIGHT GAIN;

ADULT; AGED; ANESTHETICS, LOCAL; CHRONIC PAIN; DOUBLE-BLIND METHOD; FEMALE; FLUOROSCOPY; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, EPIDURAL; LOW BACK PAIN; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; PAIN MANAGEMENT; STEROIDS; TREATMENT OUTCOME;

EID: 84884679392     PISSN: 15333159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (104)

1. US Burden of Disease Collaborators. The state of US health, 1999-2010: Burden of diseases, injuries, and risk factors. JAMA 2013; 310:591-608.
2. Gaskin DJ, Richard P. The economic costs of pain in the United States. J Pain 2012; 13:715-724.
3. Freburger JK, Holmes GM, Agans RP, Jackman AM, Darter JD, Wallace AS, Castel LD, Kalsbeek WD, Carey TS. The rising prevalence of chronic low back pain. Arch Intern Med 2009; 169:251-258.
4. Institute of Medicine (IOM). Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. The National Academies Press, Washington, DC, June 29, 2011. www.iom.edu//media/Files/Report%20Files/2011/Relieving-Pain-in-America-A-Blueprint-for-Transforming-Prevention-Care-Education-Research/Pain%20Research%202011%20Report%20Brief.pdf
5. Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, Sullivan SD. Expenditures and health status among adults with back and neck problems. JAMA 2008; 299:656-664
6. Martin BI, Turner JA, Mirza SK, Lee MJ, Comstock BA, Deyo RA. Trends in health care expenditures, utilization, and health status among US adults with spine problems, 1997-2006. Spine (Phila Pa 1976) 2009; 34:2077-2084.
7. Hong J, Reed C, Novick D, Happich M. Costs associated with treatment of chronic low back pain: an analysis of the UK General Practice Research Database. Spine (Phila Pa 1976) 2013; 38:75-82.
8. Manchikanti L, Abdi S, Atluri S, Benyamin RM, Boswell MV, Buenaventura RM, Bryce DA, Burks PA, Caraway DL, Calodney AK, Cash KA, Christo PJ, Cohen SP, Colson J, Conn A, Cordner HJ, Coubarous S, Datta S, Deer TR, Diwan SA, Falco FJE, Fellows B, Geffert SC, Grider JS, Gupta S, Hameed H, Hameed M, Hansen H, Helm II S, Janata JW, Justiz R, Kaye AD, Lee M, Manchikanti KN, McManus CD, Onyewu O, Parr AT, Patel VB, Racz GB, Sehgal N, Sharma M, Simopoulos TT, Singh V, Smith HS, Snook LT, Swicegood J, Vallejo R, Ward SP, Wargo BW, Zhu J, Hirsch JA. An update of comprehensive evidence-based guidelines for interventional techniques of chronic spinal pain: Part II: Guidance and recommendations. Pain Physician 2013; 16:S49-S283.
9. Schwarzer AC, Aprill CN, Derby R, Fortin J, Kine G, Bogduk N. The prevalence and clinical features of internal disc disruption in patients with chronic low back pain. Spine (Phila Pa 1976) 1995; 20:1878-1883.
10. Mooney V. Presidential address. International Society for the Study of the Lumbar Spine. Dallas, 1986. Where is the pain coming from? Spine (Phila Pa 1976) 1987; 12:754-759.
11. Manchikanti L, Singh V, Pampati V, Damron KS, Barnhill RC, Beyer CD, Cash KA. Evaluation of the relative contributions of various structures in chronic low back pain. Pain Physician 2001; 4:308-316.
12. DePalma MJ, Ketchum JM, Saullo T. What is the source of chronic low back pain and does age play a role? Pain Med 2011; 12:224-233.
13. Bogduk N, Aprill C, Derby R. Lumbar discogenic pain: State-of-the-art review. Pain Med 2013; 14:813-836.
14. Peng B, Fu X, Pang X, Li D, Liu W, Gao C, Yang H. Prospective clinical study on natural history of discogenic low back pain at 4 years of follow-up. Pain Physician 2012; 15:525-532.
15. Manchikanti L, Cash KA, McManus CD, Pampati V. Fluoroscopic caudal epidural injections in managing chronic axial low back pain without disc herniation, radiculitis or facet joint pain. J Pain Res 2012; 5:381-390.
16. Manchikanti L, Cash KA, McManus CD, Pampati V, Benyamin R. Fluoroscopic lumbar interlaminar epidural injections in managing chronic lumbar axial or discogenic pain. J Pain Res 2012; 5:301-311.
17. Peng B, Wu W, Hou S, Li P, Zhang C, Yang Y. The pathogenesis of discogenic low back pain. J Bone Joint Surg Br 2005; 87:62-67.
18. Crock HV. A reappraisal of intervertebral disc lesions. Med J Aust 1970; 1:983-989.
19. Singh K, Ledet E, Carl A. Intradiscal therapy. A review of current treatment modalities. Spine (Phila Pa 1976) 2005; 30:S20-26.
20. Alimasi W, Sawaji Y, Endo K, Yorifuji M, Suzuki H, Kosaka T, Shishido T, Yamamoto K. Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-1. Spine (Phila Pa 1976) 2013; 38:1466-1472.
21. Liu Q, Jin L, Mahon BH, Chordia MD, Shen FH, Li X. Novel treatment of neuroinflammation against low back pain by soluble fullerol nanoparticles. Spine (Phila Pa 1976) 2013; 38:1443-1451.
22. Moon HJ, Kim JH, Lee HS, Chotai S, Kang JD, Suh JK, Park YK. Annulus fibrosus cells interact with neuron-like cells to modulate production of growth factors and cytokines in symptomatic disc degeneration. Spine (Phila Pa 1976) 2012; 37:2-9.
23. Inoue G, Ohtori S, Aoki Y, Ozawa T, Doya H, Saito T, Ito T, Akazawa T, Moriya H, Takahashi K. Exposure of the nucleus pulposus to the outside of the anulus fibrosus induces nerve injury and regeneration of the afferent fibers innervating the lumbar intervertebral discs in rats. Spine (Phila Pa 1976) 2006; 31:1433-1438.
24. Levi-Montalcini R. The nerve growth factor 35 years later. Science 1987; 237:1154-1162.
25. Hadjipavlou AG, Simmons JW, Yang JP, Bi LX, Simmons DJ, Necessary JT. Torsional injury resulting in disc degeneration in the rabbit: II. Associative changes in dorsal root ganglion and spinal cord neurotransmitter production. J Spinal Disord 1998; 11:318-321.
26. Lewin GR, Ritter AM, Mendell LM. Nerve growth factor induced hyperalgesia in the neonatal and adult rat. J Neurosci 1993; 13:2136-2148.
27. Woolf CJ, Ma QP, Allchorne A, Poole S. Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation. J Neurosci 1996; 16:2716-2723.
28. Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O'Brien J, Jayson MI. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997; 350:178-181.
29. Takahashi K, Aoki Y, Ohtori S. Resolving discogenic pain. Eur Spine J 2008; 17:428-431.
30. Coppes MH, Marani E, Thomeer RT, Groen GJ. Innervation of "painful" lumbar discs. Spine (Phila Pa 1976) 1997; 22: 2342-2349; discussion 2349-2350.
31. Abe Y, Akeda K, An HS, Aoki Y, Pichika R, Muehleman C, Kimura T, Masuda K. Proinflammatory cytokines stimulate the expression of nerve growth factor by human intervertebral disc cells. Spine (Phila Pa 1976) 2007; 32:635-642.
32. Malik KM, Cohen SP, Walega DR, Benzon HT. Diagnostic criteria and treatment of discogenic pain: A systematic review of recent clinical literature. Spine J 2013; [Epub ahead of print].
33. Mirza SK, Deyo RA, Heagerty PJ, Turner JA, Martin BI, Comstock BA. One-year outcomes of surgical versus nonsurgical treatments for discogenic back pain: A community-based prospective cohort study. Spine J 2013 Jul 23 [Epub ahead of print].
34. Brox JI, Reikerås O, Nygaard Ø, Sørensen R, Indahl A, Holm I, Keller A, Ingebrigtsen T, Grundnes O, Lange JE, Friis A. Lumbar instrumented fusion compared with cognitive intervention and exercises in patients with chronic back pain after previous surgery for disc herniation: A prospective randomized controlled study. Pain 2006; 122:145-155.
35. Brox JI, Sørensen R, Friis A, Nygaard Ø, Indahl A, Keller A, Ingebrigtsen T, Eriksen HR, Holm I, Koller AK, Riise R, Reikerås O. Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration. Spine (Phila Pa 1976) 2003; 28:1913-1921.
36. Fairbank J, Frost H, Wilson-MacDonald J, Yu LM, Barker K, Collins R; Spine Stabilisation Trial Group. Randomised controlled trial to compare surgical stabilisation of the lumbar spine with an intensive rehabilitation programme for patients with chronic low back pain: The MRC spine stabilisation trial. BMJ 2005; 330:1233.
37. Fritzell P, Hagg O, Wessberg P, Nordwall A. 2001 Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: A multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group. Spine (Phila Pa 1976) 2001; 26:2521-2532; discussion 2532-2534.
38. Mirza SK, Deyo RA. Systematic review of randomized trials comparing lumbar fusion surgery to nonoperative care for treatment of chronic back pain. Spine (Phila Pa 1976) 2007; 32:816-823.
39. Blumenthal S, McAfee PC, Guyer RD, Hochschuler SH, Geisler FH, Holt RT, Garcia R Jr, Regan JJ, Ohnmeiss DD. A prospective, randomized, multicenter Food and Drug Administration investigational device exemptions study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: Part I: Evaluation of clinical outcomes. Spine (Phila Pa 1976) 2005; 30: 1565-1575; discussion E387-E391.
40. McAfee PC, Cunningham B, Holsapple G, Adams K, Blumenthal S, Guyer RD, Dmietriev A, Maxwell JH, Regan JJ, Isaza J. A prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of lumbar total disc replacement with the CHARITE artificial disc versus lumbar fusion: Part II: Evaluation of radiographic outcomes and correlation of surgical technique accuracy with clinical outcomes. Spine (Phila Pa 1976) 2005; 30:1576-1583; discussion E388-E390.
41. Zigler J, Delamarter R, Spivak JM, Linovitz RJ, Danielson GO 3rd, Haider TT, Cammisa F, Zuchermann J, Balderston R, Kitchel S, Foley K, Watkins R, Bradford D, Yue J, Yuan H, Herkowitz H, Geiger D, Bendo J, Peppers T, Sachs B, Girardi F, Kropf M, Goldstein J. Results of the prospective, randomized, multicenter Food and Drug Administration investigational device exemption study of the ProDisc-L total disc replacement versus circumferential fusion for the treatment of 1-level degenerative disc disease. Spine (Phila Pa 1976) 2007; 32:1155-1162; discussion 1163.
42. Jacobs WC, van der Gaag NA, Kruyt MC, Tuschel A, de Kleuver M, Peul WC, Verbout AJ, Oner FC. Total disc replacement for chronic discogenic low back pain: A Cochrane review. Spine (Phila Pa 1976) 2013; 38:24-36.
43. Health Technology Assessment, Washington State Health Care Authority. Spinal fusion for treatment of degenerative disc disease affecting the lumbar spine. Washington Health Technology Assessment. Agency for Healthcare Research and Quality, Rockville, MD, 2006. www.cms.gov/Medicare/Coverage/DeterminationProcess/downloads/id41ta.pdf
44. Health Technology Assessment, Washington State Health Care Authority. Spinal fusion and discography for chronic low back pain and uncomplicated lumbar degenerative disc disease. Washington Health Technology Assessment. October 19, 2007. www.hta.hca.wa.gov/documents/spinal_fusion_discography_final_101907.pdf
45. Wuertz K, Quero L, Sekiguchi M, Klawitter M, Nerlich A, Konno S, Kikuchi S, Boos N. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. Spine (Phila Pa 1976) 2011; 36:E1373-E1384.
46. Peng BG. Pathophysiology, diagnosis, and treatment of discogenic low back pain. World J Orthop 2013; 4:42-52.
47. Kapural L, Vrooman B, Sarwar S, Krizanac-Bengez L, Rauck R, Gilmore C, North J, Girgis G, Mekhail N. A randomized, placebo-controlled trial of transdiscal radiofrequency, biacuplasty for treatment of discogenic lower back pain. Pain Med 2013; 14:362-373.
48. Kim SH, Ahn SH, Cho YW, Lee DG. Effect of Intradiscal methylene blue injection for the chronic discogenic low back pain: One year prospective follow-up study. Ann Rehabil Med 2012; 36:657-664.
49. Fukui S, Nitta K, Iwashita N, Tomie H, Nosaka S, Rohof O. Intradiscal pulsed radiofrequency for chronic lumbar discogenic low back pain: A one year prospective outcome study using discoblock for diagnosis. Pain Physician 2013; 16:E435-E442.
50. Helm II S, Deer TR, Manchikanti L, Datta S, Chopra P, Singh V, Hirsch JA. Effectiveness of thermal annular procedures in treating discogenic low back pain. Pain Physician 2012; 15:E279-E304.
51. Manchikanti L, Singh V, Cash KA, Pampati V, Damron KS, Boswell MV. A randomized, controlled, double-blind trial of fluoroscopic caudal epidural injections in the treatment of lumbar disc herniation and radiculitis. Spine (Phila Pa 1976) 2011; 36:1897-1905.
52. Manchikanti L, Singh V, Cash KA, Pampati V, Falco FJE. The role of fluoroscopic interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: A randomized, double-blind trial. Pain Pract 2013; 13:547-558.
53. Manchikanti L, Cash KA, McManus CD, Pampati V, Fellows B. Fluoroscopic caudal epidural injections with or without steroids in managing pain of lumbar spinal stenosis: One year results of randomized, double-blind, active-controlled trial. J Spinal Disord Tech 2012; 25:226-234.
54. Manchikanti L, Singh V, Cash KA, Pampati V, Datta S. Fluoroscopic caudal epidural injections in managing post lumbar surgery syndrome: Two-year results of a randomized, double-blind, activecontrol trial. Int J Med Sci 2012; 9:582-591.
55. Manchikanti L, Singh V, Rivera JJ, Pampati V, Beyer CD, Damron KS, Barnhill RC. Effectiveness of caudal epidural injections in discogram positive and negative chronic low back pain. Pain Physician 2002; 5:18-29.
56. Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gøtzsche PC, Lang T; CONSORT GROUP (Consolidated Standards of Reporting Trials). The revised CONSORT statement for reporting randomized trials: Explanation and elaboration. Ann Intern Med 2001; 134:663-694.
57. Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials. BMJ 2010; 340:c869.
58. Manchikanti L, Boswell MV, Singh V, Pampati V, Damron KS, Beyer CD. Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord 2004; 5:15.
59. Manchukonda R, Manchikanti KN, Cash KA, Pampati V, Manchikanti L. Facet joint pain in chronic spinal pain: An evaluation of prevalence and false-positive rate of diagnostic blocks. J Spinal Disord Tech 2007; 20:539-545.
60. National Institutes of Health. Warren Grant Magnuson Clinical Center. Pain Intensity Instruments, Numeric Rating Scale, July 2003. www.mvltca.net/Presentations/mvltca. pdf
61. Mousavi SJ, Parnianpour M, Mehdian H, Montazeri A, Mobini B. The Oswestry Disability Index, the Roland-Morris Disability Questionnaire, and the Quebec Back Pain Disability Scale: Translation and validation studies of the Iranian versions. Spine (Phila Pa 1976) 2006; 31:E454-E459.
62. Fairbank JC, Pynsent PB. The Oswestry Disability Index. Spine (Phila Pa 1976) 2000; 25:2940-2952.
63. Carragee EJ. The rise and fall of the "minimum clinically important difference." Spine J 2010; 10:283-284.
64. Carragee EJ, Chen I. Minimum acceptable outcomes after lumbar spinal fusion. Spine J 2010; 10:313-320.
65. Gatchel RJ, Mayer TG, Choi Y, Chou R. Validation of a consensus-based minimal clinically important difference (MCID) threshold using an objective functional external anchor. Spine J 2013; 13:889-893.
66. Copay AG, Subach BR, Glassman SD, Polly DW Jr, Schuler TC. Understanding the minimum clinically important difference: A review of concepts and methods. Spine J 2007; 7:541-546.
67. Pereira J, Lawlor P, Vigano A, Dorgan M, Bruera E. Equianalgesic dose ratios for opioids. A critical review and proposals for long-term dosing. J Pain Symptom Manage 2001; 22: 672-687. Narcotic analgesic converter, GlobalRPh Inc. www.globalrph.com/narcotic.cgi
68. Browner WS, Newman TB, Cummings SR, Hulley SB. Estimating sample size and power. In: Hulley SB, Cummings SR, Browner WS, Grady D, Hearst N, Newman TB (eds). Designing Clinical Research: An Epidemiologic Approach. 2nd ed. Lippincott, Williams & Wilkins, Philadelphia, 2001, pp 65-84.
69. Manchikanti L, Cash KA, Pampati V, Malla Y. Fluoroscopic cervical epidural injections in chronic axial or disc-related neck pain without disc herniation, facet joint pain, or radiculitis. J Pain Res 2012; 5:227-236.
70. Pinto RZ, Maher CG, Ferreira ML, Hancock M, Oliveira VC, McLachlan AJ, Koes B, Ferreira PH. Epidural corticosteroid injections in the management of sciatica: A systematic review and meta-analysis. Ann Intern Med 2012; 157:865-877.
71. Staal JB, de Bie RA, de Vet HC, Hildebrandt J, Nelemans P. Injection therapy for subacute and chronic low back pain: An updated Cochrane review. Spine (Phila Pa 1976) 2009; 34:49-59.
72. Chou R, Huffman L. Guideline for the Evaluation and Management of Low Back Pain: Evidence Review. American Pain Society, Glenview, IL, 2009. www.americanpainsociety.org/uploads/ pdfs/LBPEvidRev.pdf
73. Manchikanti L, Falco FJE, Hirsch JA. Epidural corticosteroid injections in the management of sciatica. Ann Intern Med 2012; 157:865-877; online comment post
74. Manchikanti L, Datta S, Gupta S, Munglani R, Bryce DA, Ward SP, Benyamin RM, Sharma ML, Helm II S, Fellows B, Hirsch JA. A critical review of the American Pain Society clinical practice guidelines for interventional techniques: Part 2. Therapeutic interventions. Pain Physician 2010; 13:E215-E264.
75. Chou R, Atlas SJ, Loeser JD, Rosenquist RW, Stanos SP. Guideline warfare over interventional therapies for low back pain: Can we raise the level of discourse? J Pain 2011; 12:833-839.
76. Manchikanti L, Benyamin RM, Falco FJE, Caraway DL, Datta S, Hirsch JA. Guidelines warfare over interventional techniques: Is there a lack of discourse or straw man? Pain Physician 2012; 15:E1-E26.
77. Iversen T, Solberg TK, Romner B, Wilsgaard T, Twisk J, Anke A, Nygaard O, Hasvold T, Ingebrigtsen T. Effect of caudal epidural steroid or saline injection in chronic lumbar radiculopathy: Multicentre, blinded, randomised controlled trial. BMJ 2011; 343:d5278.
78. Carette S, Leclaire R, Marcoux S, Morin F, Blaise GA, St-Pierre A, Truchon R, Parent F, Levesque J, Bergeron V, Montminy P, Blanchette C. Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. N Engl J Med 1997; 336:1634-1640.
79. Karppinen J, Malmivaara A, Kurunlahti M, Kyllönen E, Pienimäki T, Nieminen P, Ohinmaa A, Tervonen O, Vanharanta H. Periradicular infiltration for sciatica: A randomized controlled trial. Spine (Phila Pa 1976) 2001; 26:1059-1067.
80. Ghahreman A, Ferch R, Bogduk N. The efficacy of transforaminal injection of steroids for the treatment of lumbar radicular pain. Pain Med 2010; 11:1149-1168.
81. Gerdesmeyer L, Wagenpfeil S, Birkenmaier C, Veihelmann A, Hauschild M, Wagner K, Al Muderis M, Gollwitzer H, Diehl P, Toepfer A. Percutaneous epidural lysis of adhesions in chronic lumbar radicular pain: A randomized double-blind placebo controlled trial. Pain Physician 2013; 16:185-196.
82. Howick J, Bishop FL, Heneghan, Wolstenholme J, Stevens S, Hobbs FDR, Lewith G. Placebo use in the United Kingdom: Results from a national survey of primary care practitioners. PLOS One 2013; 8:e58247.
83. Howick J, Friedemann C, Tsakok M, Watson R, Tsakok T, Thomas J, Perera R, Fleming S, Heneghan C. Are treatments more effective than placebos? A systematic review and meta-analysis. PLoS One 2013; 8:e62599.
84. Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, Kowalczykowski M, Miller FG, Kirsch I, Lembo AJ. Placebos without deception: A randomized controlled trial in irritable bowel syndrome. PLoS One 2010; 5:e15591.
85. Byrod G, Otani K, Brisby H, Rydevik B, Olmarker K. Methylprednisolone reduces the early vascular permeability increase in spinal nerve roots induced by epidural nucleus pulposus application. J Orthop Res 2000; 18:983-987.
86. Hayashi N, Weinstein JN, Meller ST, Lee HM, Spratt KF, Gebhart GF. The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine (Phila Pa 1976) 1998; 23:877-885.
87. Lee HM, Weinstein JN, Meller ST, Hayashi N, Spratt KF, Gebhart GF. The role of steroids and their effects on phospholipase A2: An animal model of radiculopathy. Spine (Phila Pa 1976) 1998; 23:1191-1196.
88. Minamide A, Tamaki T, Hashizume H, Yoshida M, Kawakami M, Hayashi N. Effects of steroids and lipopolysaccharide on spontaneous resorption of herniated intervertebral discs: An experimental study in the rabbit. Spine (Phila Pa 1976) 1998; 23:870-876.
89. Pasqualucci A, Varrassi G, Braschi A, Peduto VA, Brunelli A, Marinangeli F, Gori F, Colò F, Paladini A, Mojoli F. Epidural local anesthetic plus corticosteroid for the treatment of cervical brachial radicular pain: single injection verus continuous infusion. Clin J Pain 2007; 23:551-557.
90. Mao J, Chen LL. Systemic lidocaine for neuropathic pain relief. Pain 2000; 87:7-17.
91. Pasqualucci A. Experimental and clinical studies about the preemptive analgesia with local anesthetics. Possible reasons of the failure. Minerva Anestesiol 1998; 64:445-457.
92. Tachihara H, Sekiguchi M, Kikuchi S, Konno S. Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation. Spine (Phila Pa 1976) 2008; 33:743-747.
93. Sato C, Sakai A, Ikeda Y, Suzuki H, Sakamoto A. The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain. Anesth Analg. 2008; 106:313-320.
94. Manchikanti L, Singh V, Falco FJE, Cash KA, Pampati V. Evaluation of lumbar facet joint nerve blocks in managing chronic low back pain: A randomized, doubleblind, controlled trial with a 2-year follow-up. Int J Med Sci 2010; 7:124-135.
95. Manchikanti L, Singh V, Falco FJ, Cash KA, Fellows B. Cervical medial branch blocks for chronic cervical facet joint pain: A randomized double-blind, controlled trial with one-year follow-up. Spine (Phila Pa 1976) 2008; 33:1813-1820.
96. Manchikanti L, Singh V, Falco FJE, Cash KA, Pampati V, Fellows B. The role of thoracic medial branch blocks in managing chronic mid and upper back pain: A randomized, double-blind, active-control trial with a 2-year follow-up. Anesthesiol Res Pract 2012; 2012:585806.
97. Manchikanti L, Falco FJE, Pampati V, Cash KA, Benyamin RM, Hirsch JA. Cost utility analysis of caudal epidural injections in the treatment of lumbar disc herniation, central spinal stenosis, post lumbar surgery syndrome, and axial or discogenic low back pain. Pain Physician 2013; 16:E129-E143.
98. Rajaee SS, Bae HW, Kanim LE, Delamarter RB. Spinal fusion in the United States: Analysis of trends from 1998 to 2008. Spine (Phila Pa 1976) 2012; 37:67-76.
99. Bae HW, Rajaee SS, Kanim LE. Nationwide trends in the surgical management of lumbar spinal stenosis. Spine (Phila Pa 1976) 2013; 38:916-926.
100. Kim CH, Chung CK, Park CS, Choi B, Kim MJ, Park BJ. Reoperation rate after surgery for lumbar herniated intervertebral disc disease: Nationwide cohort study. Spine (Phila Pa 1976) 2013; 38:581-590.
101. Manchikanti L, Pampati V, Falco FJE, Hirsch JA. Growth of spinal interventional pain management techniques: Analysis of utilization trends and Medicare expenditures 2000 to 2008. Spine (Phila Pa 1976) 2013; 38:157-168.
102. Abbott ZI, Nair KV, Allen RR, Akuthota VR. Utilization characteristics of spinal interventions. Spine J 2012; 1:35-43.
103. Manchikanti L, Pampati V, Falco FJE, Hirsch JA. Assessment of the growth of epidural injections in the Medicare population from 2000 to 2011. Pain Physician 2013; 16:E349-E364.
104. Manchikanti L, Falco FJE, Singh V, Pampati V, Parr AT, Benyamin RM, Fellows B, Hirsch JA. Utilization of interventional techniques in managing chronic pain in the Medicare population: Analysis of growth patterns from 2000 to 2011. Pain Physician 2012; 15:E969-E982.