A door opener for future research: Agonist-induced β3- adrenoceptor desensitization in HEK cells but not CHO cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 386, Issue 10, 2013, Pages 841-842

  Seifert, Roland ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; MESSENGER RNA; SMALL INTERFERING RNA;

ANIMAL CELL; EDITORIAL; HUMAN; HUMAN CELL; NONHUMAN; RECEPTOR DOWN REGULATION; STRUCTURE ACTIVITY RELATION;

ADRENERGIC BETA-3 RECEPTOR AGONISTS; ANIMALS; COLFORSIN; CYCLIC AMP; HUMANS; RECEPTORS, ADRENERGIC, BETA-3;

EID: 84884673692     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0884-x     Document Type: Editorial

References (15)

1. 3- adrenergic receptors. Biochem Pharmacol 41:853-859
2. Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27:107-144
3. Göttle M, Geduhn J, König B, Gille A, Höcherl K, Seifert R (2009) Characterization of mouse heart adenylyl cyclase. J Pharmacol Exp Ther 329:1156-1165
4. 3- adrenoceptor agonists in clinical development of the treatment of overactive bladder syndrome. Naunyn-Schmiedeberg's Arch Pharmacol 386:177-183
5. Kinast L, von der Ohe J, Burhenne H, Seifert R (2012) Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool. Naunyn-Schmiedeberg's Arch Pharmacol 385:671-683
6. Laurenza A, Sutkowski EM, Seamon KB (1989) Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? Trends Pharmacol Sci 10:442-447
7. 3-adrenoceptors expressed in human embryonic kidney cells. Naunyn-Schmiedebergs Arch Pharmacol (this issue)
8. 2-agonists in COPD patients. Lung 190:411-417
9. 3-adrenergic receptor is resistant to short term agonist-promoted desensitization. Mol Pharmacol 43:548-555
10. Ostrom RS, Bogard AS, Gros R, Feldman RD (2012) Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps. Naunyn-Schmiedeberg's Arch Pharmacol 385:5-12
11. Reiter E, Ahn S, Shukla AK, Lefkowitz RJ (2012) Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol 52:179-197
12. Sacco E, Bientinesi R (2012) Mirabegron: a review of recent data and its prospects in the management of overactive bladder. Ther Adv Urol 4:315-324
13. Scott JD, Dessauer CW, Tasken K (2013) Creating order from chaos: cellular regulation by kinase anchoring. Annu Rev Pharmacol Toxicol 53:187-210
14. Seifert R, Lushington GH, Mou TC, Gille A, Sprang SR (2012) Inhibitors of membranous adenylyl cyclases. Trends Pharmacol Sci 33:64-78
15. 3-adrenergic receptor-induced production of interleukin-6 in adipocytes. Mol Immunol 46:2256-2266