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Volumn 8, Issue 9, 2013, Pages 1947-1954

New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; FLUORESCENT DYE; VESICULAR MONOAMINE TRANSPORTER 2;

EID: 84884624929     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400259n     Document Type: Article
Times cited : (50)

References (47)
  • 2
    • 80054933792 scopus 로고    scopus 로고
    • Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine
    • Ellender, T. J., Huerta-Ocampo, I., Deisseroth, K., Capogna, M., and Bolam, J. P. (2011) Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine J. Neurosci. 31, 15340-15351
    • (2011) J. Neurosci. , vol.31 , pp. 15340-15351
    • Ellender, T.J.1    Huerta-Ocampo, I.2    Deisseroth, K.3    Capogna, M.4    Bolam, J.P.5
  • 3
    • 79956321249 scopus 로고    scopus 로고
    • Serotonin induces long-term depression at corticostriatal synapses
    • Mathur, B. N., Capik, N. A., Alvarez, V. A., and Lovinger, D. M. (2011) Serotonin induces long-term depression at corticostriatal synapses J. Neurosci. 31, 7402-7411
    • (2011) J. Neurosci. , vol.31 , pp. 7402-7411
    • Mathur, B.N.1    Capik, N.A.2    Alvarez, V.A.3    Lovinger, D.M.4
  • 4
    • 0033986964 scopus 로고    scopus 로고
    • Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders
    • Verhoeff, N. P. (1999) Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders Psychopharmacology (Berlin, Ger.) 147, 217-249
    • (1999) Psychopharmacology (Berlin, Ger.) , vol.147 , pp. 217-249
    • Verhoeff, N.P.1
  • 5
    • 79959573043 scopus 로고    scopus 로고
    • Vesicular monoamine transporters: Structure-function, pharmacology, and medicinal chemistry
    • Wimalasena, K. (2011) Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry Med. Res. Rev. 31, 483-519
    • (2011) Med. Res. Rev. , vol.31 , pp. 483-519
    • Wimalasena, K.1
  • 7
    • 0026756443 scopus 로고
    • Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium
    • Liu, Y., Roghani, A., and Edwards, R. H. (1992) Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium Proc. Natl. Acad. Sci. U.S.A. 89, 9074-9078
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 9074-9078
    • Liu, Y.1    Roghani, A.2    Edwards, R.H.3
  • 10
    • 0028263975 scopus 로고
    • The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors
    • Peter, D., Jimenez, J., Liu, Y., Kim, J., and Edwards, R. H. (1994) The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors J. Biol. Chem. 269, 7231-7237
    • (1994) J. Biol. Chem. , vol.269 , pp. 7231-7237
    • Peter, D.1    Jimenez, J.2    Liu, Y.3    Kim, J.4    Edwards, R.H.5
  • 11
    • 0029896966 scopus 로고    scopus 로고
    • Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter
    • Erickson, J. D., Schafer, M. K., Bonner, T. I., Eiden, L. E., and Weihe, E. (1996) Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter Proc. Natl. Acad. Sci. U.S.A. 93, 5166-5171
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 5166-5171
    • Erickson, J.D.1    Schafer, M.K.2    Bonner, T.I.3    Eiden, L.E.4    Weihe, E.5
  • 12
    • 0013891936 scopus 로고
    • Modification of sympathetic fuction
    • Carlsson, A. (1966) Modification of sympathetic fuction Pharmacol. Rev. 18, 541-549
    • (1966) Pharmacol. Rev. , vol.18 , pp. 541-549
    • Carlsson, A.1
  • 13
    • 33751242500 scopus 로고    scopus 로고
    • Vesicular monoamine transporter 2: Role as a novel target for drug development
    • Zheng, G., Dwoskin, L. P., and Crooks, P. A. (2006) Vesicular monoamine transporter 2: Role as a novel target for drug development AAPS J. 8, E682-E692
    • (2006) AAPS J. , vol.8
    • Zheng, G.1    Dwoskin, L.P.2    Crooks, P.A.3
  • 14
    • 33645798913 scopus 로고    scopus 로고
    • Tetrabenazine as antichorea therapy in Huntington disease: A randomized controlled trial
    • Group, H. S. (2006) Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial Neurology 66, 366-372
    • (2006) Neurology , vol.66 , pp. 366-372
    • Group, H.S.1
  • 15
    • 33645872123 scopus 로고    scopus 로고
    • Tetrabenazine in the treatment of hyperkinetic movement disorders
    • Kenney, C. and Jankovic, J. (2006) Tetrabenazine in the treatment of hyperkinetic movement disorders Expert Rev. Neurother. 6, 7-17
    • (2006) Expert Rev. Neurother. , vol.6 , pp. 7-17
    • Kenney, C.1    Jankovic, J.2
  • 17
    • 80053161730 scopus 로고    scopus 로고
    • Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release
    • Horton, D. B., Siripurapu, K. B., Zheng, G., Crooks, P. A., and Dwoskin, L. P. (2011) Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release J. Pharmacol. Exp. Ther. 339, 286-297
    • (2011) J. Pharmacol. Exp. Ther. , vol.339 , pp. 286-297
    • Horton, D.B.1    Siripurapu, K.B.2    Zheng, G.3    Crooks, P.A.4    Dwoskin, L.P.5
  • 18
    • 68349155545 scopus 로고    scopus 로고
    • Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2
    • Zhu, L., Liu, J., and Kung, H. F. (2009) Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2 Bioorg. Med. Chem. Lett. 19, 5026-5028
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5026-5028
    • Zhu, L.1    Liu, J.2    Kung, H.F.3
  • 19
    • 0035863172 scopus 로고    scopus 로고
    • Vesicular monoamine transporter concentrations in bipolar disorder type I, schizophrenia, and healthy subjects
    • Zubieta, J.-K., Taylor, S. F., Huguelet, P., Koeppe, R. A., Kilbourn, M. R., and Frey, K. A. (2001) Vesicular monoamine transporter concentrations in bipolar disorder type I, schizophrenia, and healthy subjects Biol. Psychiatry 49, 110-116
    • (2001) Biol. Psychiatry , vol.49 , pp. 110-116
    • Zubieta, J.-K.1    Taylor, S.F.2    Huguelet, P.3    Koeppe, R.A.4    Kilbourn, M.R.5    Frey, K.A.6
  • 20
    • 0030796597 scopus 로고    scopus 로고
    • In vivo radiotracers for vesicular neurotransmitter transporters
    • Kilbourn, M. R. (1997) In vivo radiotracers for vesicular neurotransmitter transporters Nucl. Med. Biol. 24, 615-619
    • (1997) Nucl. Med. Biol. , vol.24 , pp. 615-619
    • Kilbourn, M.R.1
  • 26
    • 0037984383 scopus 로고    scopus 로고
    • Binding and transport in norepinephrine transporters
    • Schwartz, J. W., Blakely, R. D., and DeFelice, L. J. (2003) Binding and transport in norepinephrine transporters J. Biol. Chem. 278, 9768-9777
    • (2003) J. Biol. Chem. , vol.278 , pp. 9768-9777
    • Schwartz, J.W.1    Blakely, R.D.2    Defelice, L.J.3
  • 28
    • 84858599858 scopus 로고    scopus 로고
    • 4-(4-(Dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter
    • Solis, E., Zdravkovic, I., Tomlinson, I. D., Noskov, S. Y., Rosenthal, S. J., and De Felice, L. J. (2012) 4-(4-(Dimethylamino)phenyl)-1-methylpyridinium (APP+) is a fluorescent substrate for the human serotonin transporter J. Biol. Chem. 287, 8852-8863
    • (2012) J. Biol. Chem. , vol.287 , pp. 8852-8863
    • Solis, E.1    Zdravkovic, I.2    Tomlinson, I.D.3    Noskov, S.Y.4    Rosenthal, S.J.5    De Felice, L.J.6
  • 29
    • 33751572179 scopus 로고    scopus 로고
    • A nonradioactive high-throughput/high-content assay for measurement of the human serotonin reuptake transporter function in vitro
    • Fowler, A., Seifert, N., Acker, V., Woehrle, T., Kilpert, C., and de Saizieu, A. (2006) A nonradioactive high-throughput/high-content assay for measurement of the human serotonin reuptake transporter function in vitro J. Biomol. Screen. 11, 1027-1034
    • (2006) J. Biomol. Screen. , vol.11 , pp. 1027-1034
    • Fowler, A.1    Seifert, N.2    Acker, V.3    Woehrle, T.4    Kilpert, C.5    De Saizieu, A.6
  • 30
    • 34047158667 scopus 로고    scopus 로고
    • High-throughput screening for norepinephrine transporter inhibitors using the FLIPRTetra
    • Wagstaff, R., Hedrick, M., Fan, J., Crowe, P. D., and DiSepio, D. (2007) High-throughput screening for norepinephrine transporter inhibitors using the FLIPRTetra J. Biomol. Screen. 12, 436-441
    • (2007) J. Biomol. Screen. , vol.12 , pp. 436-441
    • Wagstaff, R.1    Hedrick, M.2    Fan, J.3    Crowe, P.D.4    Disepio, D.5
  • 31
    • 39849100667 scopus 로고    scopus 로고
    • Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity
    • Jørgensen, S., Nielsen, E. Ø., Peters, D., and Dyhring, T. (2008) Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity J. Neurosci. Methods 169, 168-176
    • (2008) J. Neurosci. Methods , vol.169 , pp. 168-176
    • Jørgensen, S.1    Nielsen E.Ø2    Peters, D.3    Dyhring, T.4
  • 32
    • 84864073534 scopus 로고    scopus 로고
    • A fluorescent-based assay for live cell, spatially resolved assessment of vesicular monoamine transporter 2-mediated neurotransmitter transport
    • Bernstein, A. I., Stout, K. A., and Miller, G. W. (2012) A fluorescent-based assay for live cell, spatially resolved assessment of vesicular monoamine transporter 2-mediated neurotransmitter transport J. Neurosci. Methods 209, 357-366
    • (2012) J. Neurosci. Methods , vol.209 , pp. 357-366
    • Bernstein, A.I.1    Stout, K.A.2    Miller, G.W.3
  • 34
    • 77954281483 scopus 로고    scopus 로고
    • Development of pH-responsive fluorescent false neurotransmitters
    • Lee, M., Gubernator, N. G., Sulzer, D., and Sames, D. (2010) Development of pH-responsive fluorescent false neurotransmitters J. Am. Chem. Soc. 132, 8828-8830
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 8828-8830
    • Lee, M.1    Gubernator, N.G.2    Sulzer, D.3    Sames, D.4
  • 36
    • 0029583203 scopus 로고
    • The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters
    • Yelin, R. and Schuldiner, S. (1995) The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters FEBS Lett. 377, 201-207
    • (1995) FEBS Lett. , vol.377 , pp. 201-207
    • Yelin, R.1    Schuldiner, S.2
  • 37
  • 39
    • 0042152109 scopus 로고    scopus 로고
    • Pt(IV)-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation
    • Pastine, S. J., Youn, S. W., and Sames, D. (2003) Pt(IV)-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation Org. Lett. 5, 1055-1058
    • (2003) Org. Lett. , vol.5 , pp. 1055-1058
    • Pastine, S.J.1    Youn, S.W.2    Sames, D.3
  • 40
    • 0142248466 scopus 로고    scopus 로고
    • Pt(IV)-catalyzed cyclization of arene-alkyne substrates via C-H bond functionalization
    • Pastine, S. J., Youn, S. W., and Sames, D. (2003) Pt(IV)-catalyzed cyclization of arene-alkyne substrates via C-H bond functionalization Tetrahedron 59, 8859-8868
    • (2003) Tetrahedron , vol.59 , pp. 8859-8868
    • Pastine, S.J.1    Youn, S.W.2    Sames, D.3
  • 41
    • 84868097091 scopus 로고    scopus 로고
    • Catalytic coupling of arene C-H bonds and alkynes for the synthesis of coumarins: Substrate scope and application to the development of neuroimaging agents
    • Vadola, P. A. and Sames, D. (2012) Catalytic coupling of arene C-H bonds and alkynes for the synthesis of coumarins: substrate scope and application to the development of neuroimaging agents J. Org. Chem. 77, 7804-7814
    • (2012) J. Org. Chem. , vol.77 , pp. 7804-7814
    • Vadola, P.A.1    Sames, D.2
  • 42
    • 41949089632 scopus 로고    scopus 로고
    • Expression and function of the rat vesicular monoamine transporter 2
    • Adam, Y., Edwards, R. H., and Schuldiner, S. (2008) Expression and function of the rat vesicular monoamine transporter 2 Am. J. Physiol.: Cell Physiol. 294, C1004-C1011
    • (2008) Am. J. Physiol.: Cell Physiol. , vol.294
    • Adam, Y.1    Edwards, R.H.2    Schuldiner, S.3
  • 43
    • 0025084591 scopus 로고
    • Effect of compounds which disrupt proton gradients on secretion of neurosecretory proteins from pc12 pheochromocytoma cells
    • Sabban, E. L., Schwartz, J., and McMahon, A. (1990) Effect of compounds which disrupt proton gradients on secretion of neurosecretory proteins from pc12 pheochromocytoma cells Neuroscience 38, 561-570
    • (1990) Neuroscience , vol.38 , pp. 561-570
    • Sabban, E.L.1    Schwartz, J.2    McMahon, A.3
  • 44
    • 63249100822 scopus 로고    scopus 로고
    • Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2
    • Yasumoto, S., Tamura, K., Karasawa, J., Hasegawa, R., Ikeda, K., Yamamoto, T., and Yamamoto, H. (2009) Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2 Neurosci. Lett. 454, 229-232
    • (2009) Neurosci. Lett. , vol.454 , pp. 229-232
    • Yasumoto, S.1    Tamura, K.2    Karasawa, J.3    Hasegawa, R.4    Ikeda, K.5    Yamamoto, T.6    Yamamoto, H.7
  • 45
    • 0020004528 scopus 로고
    • [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites
    • Leysen, J. E., Niemegeers, C. J., Van Nueten, J. M., and Laduron, P. M. (1982) [3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites Mol. Pharmacol. 21, 301-314
    • (1982) Mol. Pharmacol. , vol.21 , pp. 301-314
    • Leysen, J.E.1    Niemegeers, C.J.2    Van Nueten, J.M.3    Laduron, P.M.4
  • 46
    • 0023952199 scopus 로고    scopus 로고
    • Ketanserin binds to the monoamine transporter of chromaffin granules and of synaptic vesicles
    • Darchen, F., Scherman, D., Laduron, P. M., and Henry, J.-P. (1998) Ketanserin binds to the monoamine transporter of chromaffin granules and of synaptic vesicles Mol. Pharmacol. 33, 672-677
    • (1998) Mol. Pharmacol. , vol.33 , pp. 672-677
    • Darchen, F.1    Scherman, D.2    Laduron, P.M.3    Henry, J.-P.4
  • 47
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang, J.-H., Chung, T. D. Y., and Oldenburg, K. R. (1999) A simple statistical parameter for use in evaluation and validation of high throughput screening assays J. Biomol. Screen. 4, 67-73
    • (1999) J. Biomol. Screen. , vol.4 , pp. 67-73
    • Zhang, J.-H.1    Chung, T.D.Y.2    Oldenburg, K.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.