What's in a Name?-Lipolysosome: Ultrastructural features of a lipid-containing organelle

Ultrastructural Pathology

Volumn 37, Issue 5, 2013, Pages 293-303

  Iancu, Theodore C ^a,b   Manov, Irena ^b,c   Shaoul, Ron ^a,d   Haimi, Motti ^e   Lerner, Aaron ^a,f  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Milman David Biomedical Research Unit   (Israel)

^c UNIVERSITY OF HAIFA   (Israel)

^d MEYER CHILDREN S HOSPITAL   (Israel)

^e CLALIT HEALTH SERVICES   (Israel)

^f CARMEL MEDICAL CENTER   (Israel)

Author keywords

Autophagy; Cirrhosis; Electron microscopy; Fatty liver; Lysosomes; NAFLD, NASH; Steatosis

Indexed keywords

BIOLOGICAL MARKER; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; LIPID; LIPOFUSCIN;

ADOLESCENT; BIOPSY; CELL ORGANELLE; CHEMISTRY; CHILD; CHILDHOOD OBESITY; CLASSIFICATION; CONFERENCE PAPER; FATTY LIVER; FEMALE; HUMAN; LIVER; LYSOSOME; MALE; METABOLISM; NOMENCLATURE; NONALCOHOLIC FATTY LIVER; PATHOLOGY; SEVERITY OF ILLNESS INDEX; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ADOLESCENT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BIOLOGICAL MARKERS; BIOPSY; CHILD; FATTY LIVER; FEMALE; HUMANS; LIPIDS; LIPOFUSCIN; LIVER; LYSOSOMES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; ORGANELLES; PEDIATRIC OBESITY; SEVERITY OF ILLNESS INDEX; TERMINOLOGY AS TOPIC;

EID: 84884621184     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.3109/01913123.2013.799625     Document Type: Conference Paper

References (35)

1. Nehemiah JL, Novikoff AB. Unusual lysosomes in hamster hepatocytes. Exp Mol Pathol 1974;21: 398-423.
2. Hayashi H, Sternlieb I. Lipolysosomes in human hepatocytes: ultrastructural and cytochemical studies of patients with Wilson's disease. Lab Invest 1975;33: 1-7.
3. Kanai M, Soji T, Herbert DC. Biogenesis and function of lipolysosomes in developing chick hepatocytes. Microsc Res Tech 1997;39: 444-52.
4. Hayashi H, Winship DH, Sternlieb I. Lipolysosomes in human liver: distribution in livers with fatty infiltration. Gastroenterology 1977;73: 651-4.
5. Haimi M, Iancu TC, Shaffer LG, Lerner A. Severe lysosomal storage disease of liver in del(1)(p36): a new presentation. Eur J Med Genet 2011;54: 209-13.
6. Brunt E. Pathology of fatty liver disease. Mod Pathol 2007; 20: S40-8.
7. Brunt E. Non-alcoholic fatty liver disease. Gut 2011;60: 1152-8.
8. Brunt EM. Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2010;7: 195-203.
9. Brunt E, Kleiner DE, Wilsom LA, et al. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings. Hepatology 2011;53: 810-20.
10. Iancu T, Manov I. Electron microscopy of liver biopsies. In: Takahashi H, ed. Liver Biopsy. Rijeka: InTech, 2011:109-36.
11. Tanikawa K, Eguchi T, Ikejiri N. Ultrastructural Aspects of the Liver and Its Disorders. Tokyo: Igaku-Shoin, 1979.
12. Phillips M, Poucell S, Patterson J, Valencia P. The Liver: An Atlas and Text of Ultrastructural Pathology. New York: Raven Press, 1987:214.
13. Kanai M. Ultrastructural and biochemical studies of lipolysis by lipolysosomes in chick hepatocytes. Cell Tissue Res 1989;255: 559-65.
14. Barshop NJ, Francis CS, Schwimmer JB, Lavine JE. Nonalcoholic fatty liver disease as a comorbidity of childhood obesity. Pediatr Health 2009;3: 271-81.
15. Das K, Das K, Mukherjee PS, et al. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology 2010;51: 1593-602.
16. Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37: 917-23.
17. Tannapfel A, Denk H, Dienes HP, et al. Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease. Virchows Arch 2011;458: 511-23.
18. Schwimmer JB, Behling C, Newbury R, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology 2005;42: 641-9.
19. Takahashi Y, Fukusato T. Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology. World J Gastroenterol 2010;16: 5280-5.
20. Brunt EM. Histological assessment of nonalcoholic fatty liver diseas in adults and children. Clin Liver Dis 2012;1: 108-11.
21. Angulo P. Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance? Hepatology 2010;51: 373-5.
22. Younossi ZM, Stepanova M, Rafiq N, et al. Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology 2011;53: 1874-82.
23. Hayashi H, Sameshima Y, Lee M, Hotta Y, Kosaka T. Lipolysosomes in human hepatocytes: their increase in number associated with serum level of cholesterol in chronic liver diseases. Hepatology 1983;3: 221-5.
24. Sternlieb I. Evolution of the hepatic lesion in Wilson's disease (hepatolenticular degeneration). Prog Liver Dis 1972;4: 511-25.
25. LeoMA, Sato M. Effect of hepatic vitaminAdepletion on the liver in humans and rats. Gastroenterology 1983;84: 562-72.
26. Kanai M, Watari N, Soji T, Sugawara E. Formation and accumulation of lipolysosomes in developing chick hepatocytes. Cell Tissue Res 1994;275: 125-32.
27. Essner E, Novikoff AB. Human hepatocellular pigments and lysosomes. J Ultrastruct Res 1960;3: 374-91.
28. Kuriwaki K, Yoshida H. Morphological characteristics of lipid accumulation in liver-constituting cells of acid lipase deficiency rats (Wolman's disease model rats). Pathol Int 1999;49: 291-7.
29. Ong KT, Mashek MT. Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology 2011;53: 116-26.
30. Wu JW, Wang SP, Alvarez F, et al. Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis. Hepatology 2011;54: 122-32.
31. Czaja MJ. Autophagy in health and disease, 2: regulation of lipid metabolism and storage by autophagy-pathophysiological implications. Am J Physiol Cell Physiol 2010;298: C973-8.
32. Liu K, Czaja MJ. Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ 2012;20: 1-9.
33. Singh R. Autophagy and regulation of lipid metabolism. Results Probl Cell Differ 2010;52: 35-46.
34. Angulo P. Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance? Hepatology. 2010;51: 373-5.
35. Angulo P. Diagnosing steatohepatitis and predicting liverrelated mortality in patients with NAFLD: two distinct concepts. Hepatology 2011;53: 1792-4.