Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Gu, Changmei ^a   Lu, Jiachun ^b   Cui, Tianpen ^c   Lu, Cheng ^d   Shi, Hao ^a   Xu, Wenmao ^c   Yuan, Xueli ^a   Yang, Xiaobo ^e   Huang, Yangxin ^f   Lu, Meixia ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c Wuhan Pulmonary Hospital   (China)

^d NANCHANG UNIVERSITY   (China)

^e GUANGXI MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ADULT; AGED; DATA ANALYSIS; DNA METHYLATION; EPIGENETICS; FEMALE; GENE ACTIVATION; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC DATABASE; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MALE; MGMT GENE; PROMOTER REGION; QUANTITATIVE STUDY; REVIEW; SYSTEMATIC REVIEW; TISSUE DISTRIBUTION;

CARCINOMA, NON-SMALL-CELL LUNG; CASE-CONTROL STUDIES; DNA METHYLATION; HUMANS; LUNG NEOPLASMS; PROMOTER REGIONS, GENETIC;

EID: 84884601345     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072633     Document Type: Review

References (36)

1. Siegel R, Naishadham D, Jemal A, (2013) Cancer statistics, 2013. CA Cancer J Clin 63: 11-30. doi:10.3322/caac.21166. PubMed: 23335087.
2. Esteller M, (2008) Epigenetics in cancer. N Engl J Med 358: 1148-1159. doi:10.1056/NEJMra072067. PubMed: 18337604.
3. Lu J, Liu R, Li B, Qiu X, Li Q, et al. (2003) MGMT expression and its relationship with efficacy of chemotherapy and prognosis in patients with non-small cell lung cancer. Chin J Lung Cancer 6: 63-66.
4. Ekim M, Caner V, Buyukpinarbasili N, Tepeli E, Elmas L, et al. (2010) Determination of O6-methylguanine DNA methyltransferase promoter methylation pattern in non-small cell lung cancer. Clin Genet 78: 65-67.
5. Belinsky SA, Klinge DM, Liechty KC, March TH, Kang T, et al. (2004) Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. Carcinogenesis 25: 1063-1067. doi:10.1093/carcin/bgh096. PubMed: 14742312.
6. Zou XP, Zhang B, Zhang XQ, Chen M, Cao J, et al. (2009) Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions. Hum Pathol 40: 1534-1542. doi:10.1016/j.humpath.2009.01.029. PubMed: 19695681.
7. Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, et al. (2012) Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma. Cancer Sci 103: 510-514. doi:10.1111/j.1349-7006.2011.02180.x. PubMed: 22146010.
8. Esteller M, Sanchez-Cespedes M, Rosell R, Sidransky D, Baylin SB, et al. (1999) Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59: 67-70. PubMed: 9892187.
9. Guo M, House MG, Hooker C, Han Y, Heath E, et al. (2004) Promoter hypermethylation of resected bronchial margins: a field defect of changes? Clin Cancer Res 10: 5131-5136. doi:10.1158/1078-0432.CCR-03-0763. PubMed: 15297416.
10. Citron M, Schoenhaus M, Graver M, Hoffman M, Lewis M, et al. (1993) O6-methylguanine-DNA methyltransferase in human normal and malignant lung tissues. Cancer Invest 11: 258-263. doi:10.3109/07357909309024850. PubMed: 8485648.
11. Higgins JP, (2008) Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol 37: 1158-1160. doi:10.1093/ije/dyn204. PubMed: 18832388.
12. Ali AH, Kondo K, Namura T, Senba Y, Takizawa H, et al. (2011) Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure. Mol Carcinog 50: 89-99. doi:10.1002/mc.20697. PubMed: 21229606.
13. Wu PF, Kuo KT, Kuo LT, Lin YT, Lee WC, et al. (2010) O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers. Lung Cancer 68: 484-490. doi:10.1016/j.lungcan.2009.08.010. PubMed: 19740564.
14. Moher D, Liberati A, Tetzlaff J, Altman DG, (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 151: 264-269.
15. Higgins JP, Thompson SG, Deeks JJ, Altman DG, (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560. doi:10.1136/bmj.327.7414.557. PubMed: 12958120.
16. Stuck AE, Rubenstein LZ, Wieland D, (1998) Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ 316: 469-471. doi:10.1136/bmj.316.7129.469.
17. Rücker G, Schwarzer G, Carpenter J, (2008) Arcsine test for publication bias in meta-analyses with binary outcomes. Stat Med 27: 746-763. doi:10.1002/sim.2971. PubMed: 17592831.
18. Rosenthal R, (1979) The file drawer problem and tolerance for null results. Psychol Bull 86: 638-641. doi:10.1037/0033-2909.86.3.638.
19. Zöchbauer-Müller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, et al. (2001) Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61: 249-255. PubMed: 11196170.
20. Brabender J, Usadel H, Metzger R, Schneider PM, Park J, et al. (2003) Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome. Clin Cancer Res 9: 223-227. PubMed: 12538473.
21. Topaloglu O, Hoque MO, Tokumaru Y, Lee J, Ratovitski E, et al. (2004) Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin Cancer Res 10: 2284-2288. doi:10.1158/1078-0432.CCR-1111-3. PubMed: 15073103.
22. Russo AL, Thiagalingam A, Pan H, Califano J, Cheng KH, et al. (2005) Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res 11: 2466-2470. doi:10.1158/1078-0432.CCR-04-1962. PubMed: 15814621.
23. Safar AM, Spencer HR, Su X, Coffey M, Cooney CA, et al. (2005) Methylation profiling of archived non-small cell lung cancer: a promising prognostic system. Clin Cancer Res 11: 4400-4405. doi:10.1158/1078-0432.CCR-04-2378. PubMed: 15958624.
24. Vallböhmer D, Brabender J, Yang D, Schneider PM, Metzger R, et al. (2006) DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value. Clin Lung Cancer 8: 39-44. doi:10.3816/CLC.2006.n.031. PubMed: 16870044.
25. Yanagawa N, Tamura G, Oizumi H, Kanauchi N, Endoh M, et al. (2007) Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer (Amst, Netherlands) 58: 131-138. doi:10.1016/j.lungcan.2007.05.011. PubMed: 17606310.
26. Belinsky SA, Grimes MJ, Casas E, Stidley CA, Franklin WA, et al. (2007) Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum. Br J Cancer 96: 1278-1283. doi:10.1038/sj.bjc.6603721. PubMed: 17406356.
27. Feng Q, Hawes SE, Stern JE, Wiens L, Lu H, et al. (2008) DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients. Cancer Epidemiol Biomarkers Prev 17: 645-654. doi:10.1158/1055-9965.EPI-07-2518. PubMed: 18349282.
28. Lin Q, Geng J, Ma K, Yu J, Sun J, et al. (2009) RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. J Cancer Res Clin Oncol 135: 1675-1684. doi:10.1007/s00432-009-0614-4. PubMed: 19506903.
29. De Jong WK, Verpooten GF, Kramer H, Louwagie J, Groen HJ, (2009) Promoter methylation primarily occurs in tumor cells of patients with non-small cell lung cancer. Anticancer Res 29: 363-369. PubMed: 19331174.
30. Liu Y, Wang J, Miao L, Wu Y, Wu Y, (2010) Promoter hyperthylation of MGMT gene and expression of K-ras in human NSCLC. J Medical FORUM 31: 1-4.
31. Jin Y, Xu H, Zhang C, Zhang H, Xue S, et al. (2010) Association of abnormal methylation of CpG islands in promoter domains of multiple tumor suppressor genes with non-small cell lung cancer. Chin J Clin Oncol 37: 1109-1114.
32. Zhang Y, Wang R, Song H, Huang G, Yi J, et al. (2011) Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett 303: 21-28. doi:10.1016/j.canlet.2010.12.011. PubMed: 21255913.
33. Hang C, Tao Z, Xiao H, Zhang X, Xue Y, (2011) Investigation on the relationgship between the promoter hypermethylationof MGMTand clinicopathologic feature inNSCLC. Chin J Laboratory Diagn 15: 81-82.
34. Kim YT, Lee SH, Sung SW, Kim JH, (2005) Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection? Ann Thorac Surg 79: 1180-1188. doi:10.1016/j.athoracsur.2004.09.060. PubMed: 15797047.
35. Kim DS, Cha SI, Lee JH, Lee YM, Choi JE, et al. (2007) Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population. Lung Cancer 58: 1-6. doi:10.1016/j.lungcan.2007.04.008. PubMed: 17532092.
36. Citron M, Decker R, Chen S, Schneider S, Graver M, et al. (1991) O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary. Cancer Res 51: 4131-4134. PubMed: 1868433.