Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS

International Journal of Hygiene and Environmental Health

Volumn 216, Issue 6, 2013, Pages 710-720

  Frederiksen, Hanne ^a   Aksglaede, Lise ^a   Sorensen, Kaspar ^a   Nielsen, Ole ^a   Main, Katharina M ^a   Skakkebaek, Niels E ^a   Juul, Anders ^a   Andersson, Anna Maria ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Benzophenone 3; Bisphenol A; Endocrine disruptor; Puberty; Triclosan; Urinary excretion

Indexed keywords

2,4 DICHLOROPHENOL; 2,4,5-TRICHLOROPHENOL; 2,4-DICHLOROPHENOL; 2,5 DICHLOROPHENOL; 2,5-DICHLOROPHENOL; 4,4' ISOPROPYLIDENEDIPHENOL; BENZHYDRYL DERIVATIVE; BENZOPHENONE DERIVATIVE; CHLOROPHENOL; ENDOCRINE DISRUPTOR; OXYBENZONE; PHENOL DERIVATIVE; TRICLOCARBAN; TRICLOSAN;

2,4,5-TCP; 2,4-DCP; 2,5-DCP; 2-PHENYLPHENOL; 2-PP; 4-PHENYLPHENOL; 4-PP; ADOLESCENT; AGE; ARTICLE; BP-3; BPA; CHILD; ENVIRONMENTAL EXPOSURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; METHODOLOGY; POLLUTANT; PUBERTY; TANDEM MASS SPECTROMETRY; TCCB; TCS; URINARY EXCRETION; URINE;

2,4,5-TCP; 2,4,5-TRICHLOROPHENOL; 2,4-DCP; 2,4-DICHLOROPHENOL; 2,5-DCP; 2,5-DICHLOROPHENOL; 2-PHENYLPHENOL; 2-PP; 4-PHENYLPHENOL; 4-PP; BENZOPHENONE-3; BISPHENOL A; BP-3; BPA; ENDOCRINE DISRUPTOR; PUBERTY; TCCB; TCS; TRICLOCARBAN; TRICLOSAN; URINARY EXCRETION;

ADOLESCENT; AGE FACTORS; BENZHYDRYL COMPOUNDS; BENZOPHENONES; CHILD; CHLOROPHENOLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; MALE; PHENOLS; TANDEM MASS SPECTROMETRY; TRICLOSAN;

EID: 84884592942     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2013.01.007     Document Type: Article

References (54)

1. ATSDR Public Health Statement Chlorophenols 1999, U.S. Department of Health and Human Service, Atlanta, GA. http://www.atsdr.cdc.gov/ToxProfiles/tp107-c1-b.pdf.
2. Ahn K.C., Zhao B., Chen J., Cherednichenko G., Sanmarti E., Denison M.S., Lasley B., Pessah I.N., Kultz D., Chang D.P., Gee S.J., Hammock B.D. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ. Health Perspect. 2008, 116:1203-1210.
3. Aksglaede L., Sorensen K., Petersen J.H., Skakkebaek N.E., Juul A. Recent decline in age at breast development: the Copenhagen Puberty Study. Pediatrics 2009, 123:e932-e939.
4. Amer S.M., Aly F.A. Genotoxic effect of 2,4-dichlorophenoxy acetic acid and its metabolite 2,4-dichlorophenol in mouse. Mutat. Res. 2001, 494:1-12.
5. Becker K., Goen T., Seiwert M., Conrad A., Pick-Fuss H., Muller J., Wittassek M., Schulz C., Kolossa-Gehring M. GerES IV: phthalate metabolites and bisphenol A in urine of German children. Int. J. Hyg. Environ. Health 2009, 212:685-692.
6. Blount B.C., Milgram K.E., Silva M.J., Malek N.A., Reidy J.A., Needham L.L., Brock J.W. Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS. Anal. Chem. 2000, 72:4127-4134.
7. Calafat A.M., Wong L.Y., Ye X., Reidy J.A., Needham L.L. Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003-2004. Environ. Health Perspect. 2008, 116:893-897.
8. Casas L., Fernandez M.F., Llop S., Guxens M., Ballester F., Olea N., Irurzun M.B., Rodriguez L.S., Riano I., Tardon A., Vrijheid M., Calafat A.M., Sunyer J. Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children. Environ. Int. 2011, 37:858-866.
9. CDC (Centers for Disease Control and Prevention, Atlanta, GA) Fourth National Report on Human Exposure to Environmental Chemicals 2009, pp. 1-529. http://www.cdc.gov/exposurereport/pdf/FourthReport.pdf.
10. CDC (Centers for Disease Control and Prevention, Atlanta, GA) Fourth National Report on Human Exposure and Environmental Chemicals, updated tables, February 2012 2012, pp. 1-241, http://www.cdc.gov/exposurereport/pdf/FourthReport_UpdatedTables_Feb2012.pdf.
11. Chen J., Ahn K.C., Gee N.A., Ahmed M.I., Duleba A.J., Zhao L., Gee S.J., Hammock B.D., Lasley B.L. Triclocarban enhances testosterone action: a new type of endocrine disruptor?. Endocrinology 2008, 149:1173-1179.
12. Clayton E.M., Todd M., Dowd J.B., Aiello A.E. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environ. Health Perspect. 2011, 119:390-396.
13. Dann A.B., Hontela A. Triclosan: environmental exposure, toxicity and mechanisms of action. J. Appl. Toxicol. 2011, 31:285-311.
14. Duleba A.J., Ahmed M.I., Sun M., Gao A.C., Villanueva J., Conley A.J., Turgeon J.L., Benirschke K., Gee N.A., Chen J., Green P.G., Lasley B.L. Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reprod. Sci. 2011, 18:119-127.
15. EFSA Scientific opinion on bisphenol A: evaluation of a study investigating its neurodevelopmental toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of bisphenol A. EFSA J. 2010, 243:1-116.
16. Frederiksen H., Aksglaede L., Sorensen K., Skakkebaek N.E., Juul A., Andersson A.M. Urinary excretion of phthalate metabolites in 129 healthy Danish children and adolescents: estimation of daily phthalate intake. Environ. Res. 2011, 111:656-663.
17. Frederiksen H., Jorgensen N., Andersson A.M. Correlations between phthalate metabolites in urine, serum, and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry. J. Anal. Toxicol. 2010, 34:400-410.
18. Genuis S.J., Beesoon S., Birkholz D., Lobo R.A. Human excretion of bisphenol A: blood, urine, and sweat (BUS) study. J. Environ. Public Health 2012, 2012:185731.
19. Henry N.D., Fair P.A. Comparison of in vitro cytotoxicity, estrogenicity and anti-estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid. J. Appl. Toxicol. 2013, 33:256-272.
20. Janjua N.R., Kongshoj B., Andersson A.M., Wulf H.C. Sunscreens in human plasma and urine after repeated whole-body topical application. J. Eur. Acad. Dermatol. Venereol. 2008, 22:456-461.
21. Jung E.M., An B.S., Choi K.C., Jeung E.B. Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells. Toxicol. Lett. 2012, 208:142-148.
22. Kasper-Sonnenberg M., Wittsiepe J., Koch H.M., Fromme H., Wilhelm M. Determination of bisphenol A in urine from mother-child pairs - results from the Duisburg birth cohort study, Germany. J. Toxicol. Environ. Health A 2012, 75:429-437.
23. Krause M., Klit A., Blomberg J.M., Soeborg T., Frederiksen H., Schlumpf M., Lichtensteiger W., Skakkebaek N.E., Drzewiecki K.T. Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters. Int. J. Androl. 2012, 35:424-436.
24. Li J., Ma M., Wang Z. In vitro profiling of endocrine disrupting effects of phenols. Toxicol. In Vitro 2010, 24:201-207.
25. Li X., Ying G.G., Zhao J.L., Chen Z.F., Lai H.J., Su H.C. 4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels. Environ. Int. 2013, 52:81-86.
26. Meeker J.D., Ehrlich S., Toth T.L., Wright D.L., Calafat A.M., Trisini A.T., Ye X., Hauser R. Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic. Reprod. Toxicol. 2010, 30:532-539.
27. Melzer D., Osborne N.J., Henley W.E., Cipelli R., Young A., Money C., McCormack P., Luben R., Khaw K.T., Wareham N.J., Galloway T.S. Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation 2012, 125:1482-1490.
28. Morgan M.K., Jones P.A., Calafat A.M., Ye X., Croghan C.W., Chuang J.C., Wilson N.K., Clifton M.S., Figueroa Z., Sheldon L.S. Assessing the quantitative relationships between preschool children's exposures to bisphenol A by route and urinary biomonitoring. Environ. Sci. Technol. 2011, 45:5309-5316.
29. Mosteller R.D. Simplified calculation of body-surface area. N. Engl. J. Med. 1987, 317:1098.
30. Nahar M.S., Soliman A.S., Colacino J.A., Calafat A.M., Battige K., Hablas A., Seifeldin I.A., Dolinoy D.C., Rozek L.S. Urinary bisphenol A concentrations in girls from rural and urban Egypt: a pilot study. Environ. Health 2012, http://www.ehjournal.net/content/11/1/20.
31. Palmer R.K., Hutchinson L.M., Burpee B.T., Tupper E.J., Pelletier J.H., Kormendy Z., Hopke A.R., Malay E.T., Evans B.L., Velez A., Gosse J.A. Antibacterial agent triclosan suppresses RBL-2H3 mast cell function. Toxicol. Appl. Pharmacol. 2012, 258:99-108.
32. Philippat C., Mortamais M., Chevrier C., Petit C., Calafat A.M., Ye X., Silva M.J., Brambilla C., Pin I., Charles M.A., Cordier S., Slama R. Exposure to phthalates and phenols during pregnancy and offspring size at birth. Environ. Health Perspect. 2012, 120:464-470.
33. Richter C.A., Birnbaum L.S., Farabollini F., Newbold R.R., Rubin B.S., Talsness C.E., Vandenbergh J.G., Walser-Kuntz D.R., vom Saal F.S. In vivo effects of bisphenol A in laboratory rodent studies. Reprod. Toxicol. 2007, 24:199-224.
34. Sandborgh-Englund G., dolfsson-Erici M., Odham G., Ekstrand J. Pharmacokinetics of triclosan following oral ingestion in humans. J. Toxicol. Environ. Health A 2006, 69:1861-1873.
35. Shankar A., Teppala S. Urinary bisphenol A and hypertension in a multiethnic sample of US adults. J. Environ. Public Health 2012, 481641. 10.1155/2012/481641.
36. Shankar A., Teppala S., Sabanayagam C. Bisphenol A and peripheral arterial disease: results from the NHANES. Environ. Health Perspect. 2012, 10.1289/ehp.1104114.
37. Silver M.K., O'Neill M.S., Sowers M.R., Park S.K. Urinary bisphenol A and type-2 diabetes in U.S. adults: data from NHANES 2003-2008. PLoS ONE 2011, 6:e26868.
38. Singer H., Muller S., Tixier C., Pillonel L. Triclosan: occurrence and fate of a widely used biocide in the aquatic environment: field measurements in wastewater treatment plants, surface waters, and lake sediments. Environ. Sci. Technol. 2002, 36:4998-5004.
39. Sorensen K., Aksglaede L., Petersen J.H., Juul A. Recent changes in pubertal timing in healthy Danish boys: associations with body mass index. J. Clin. Endocrinol. Metab. 2010, 95:263-270.
40. Teitelbaum S.L., Britton J.A., Calafat A.M., Ye X., Silva M.J., Reidy J.A., Galvez M.P., Brenner B.L., Wolff M.S. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ. Res. 2008, 106:257-269.
41. The Personal Care Products Council, 2011. http://www.personalcarecouncil.org/HBI/11.
42. U.S.EPA Reregistration Eligibility Decision for 2-Phenylphenol and Salts (Orthophenylphenol or OPP) 2006, pp. 1-156. http://www.epa.gov/oppsrrd1/REDs/phenylphenol_red.pdf.
43. Vandenberg L.N., Chahoud I., Heindel J.J., Padmanabhan V., Paumgartten F.J., Schoenfelder G. Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ. Health Perspect. 2010, 118:1055-1070.
44. Volkel W., Colnot T., Csanady G.A., Filser J.G., Dekant W. Metabolism and kinetics of bisphenol A in humans at low doses following oral administration. Chem. Res. Toxicol. 2002, 15:1281-1287.
45. vom Saal F.S., Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ. Health Perspect. 2005, 113:926-933.
46. vom Saal F.S., Nagel S.C., Coe B.L., Angle B.M., Taylor J.A. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol. Cell. Endocrinol. 2012, 354:74-84.
47. Wolff M.S., Engel S.M., Berkowitz G.S., Ye X., Silva M.J., Zhu C., Wetmur J., Calafat A.M. Prenatal phenol and phthalate exposures and birth outcomes. Environ. Health Perspect. 2008, 116:1092-1097.
48. Wolff M.S., Teitelbaum S.L., Pinney S.M., Windham G., Liao L., Biro F., Kushi L.H., Erdmann C., Hiatt R.A., Rybak M.E., Calafat A.M. Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls. Environ. Health Perspect. 2010, 118:1039-1046.
49. Wolff M.S., Teitelbaum S.L., Windham G., Pinney S.M., Britton J.A., Chelimo C., Godbold J., Biro F., Kushi L.H., Pfeiffer C.M., Calafat A.M. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ. Health Perspect. 2007, 115:116-121.
50. Ye X., Bishop A.M., Reidy J.A., Needham L.L., Calafat A.M. Temporal stability of the conjugated species of bisphenol A, parabens, and other environmental phenols in human urine. J. Expo. Sci. Environ. Epidemiol. 2007, 17:567-572.
51. Ye X., Tao L.J., Needham L.L., Calafat A.M. Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum. Talanta 2008, 76:865-871.
52. Ye X., Wong L.Y., Bishop A.M., Calafat A.M. Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections. Environ. Health Perspect. 2011, 119:983-988.
53. Ye X., Zhou X., Furr J., Ahn K.C., Hammock B.D., Gray E.L., Calafat A.M. Biomarkers of exposure to triclocarban in urine and serum. Toxicology 2011, 286:69-74.
54. Zhang X., Zha J., Li W., Yang L., Wang Z. Effects of 2,4-dichlorophenol on the expression of vitellogenin and estrogen receptor genes and physiology impairments in Chinese rare minnow (Gobiocypris rarus). Environ. Toxicol. 2008, 23:694-701.