Impact of chronic liver disease in intensive care unit acquired pneumonia: A prospective study

Intensive Care Medicine

Volumn 39, Issue 10, 2013, Pages 1776-1784

  Di Pasquale, Marta ^a,b,c   Esperatti, Mariano ^a,b   Crisafulli, Ernesto ^d   Ferrer, Miquel ^a,b   Bassi, Gianluigi Li ^a,b   Rinaudo, Mariano ^a,b   Escorsell, Angels ^a   Fernandez, Javier ^a   Mas, Antoni ^a   Blasi, Francesco ^c   Torres, Antoni ^a,b,e  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^d Ospedale Villa Pineta   (Italy)

^e HOSPITAL CLÍNIC   (Spain)

Author keywords

Biomarkers; Intensive care unit; Liver cirrhosis; Lung; Nosocomial infection; Ventilator acquired pneumonia

Indexed keywords

ANTIBIOTIC AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CORTICOSTEROID; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALCOHOL ABUSE; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CHILD PUGH SCORE; CHRONIC LIVER DISEASE; CHRONIC LUNG DISEASE; CORTICOSTEROID THERAPY; CRITICALLY ILL PATIENT; ENDOTRACHEAL INTUBATION; FEMALE; HAEMOPHILUS; HEART DISEASE; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; INTENSIVE CARE UNIT ACQUIRED PNEUMONIA; LENGTH OF STAY; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MORAXELLA; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; SEPTIC SHOCK; STREPTOCOCCUS PNEUMONIAE; SURVIVAL TIME; TREATMENT FAILURE;

APACHE; CRITICAL ILLNESS; CROSS INFECTION; DRUG RESISTANCE, MULTIPLE; END STAGE LIVER DISEASE; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; MALE; MULTICENTER STUDIES AS TOPIC; OUTCOME ASSESSMENT (HEALTH CARE); PNEUMONIA; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SPAIN; SURVIVAL ANALYSIS;

EID: 84884586599     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-013-3025-6     Document Type: Article

References (39)

1. American Thoracic Society Infectious Diseases Society of America (2005) Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388-416
2. Chastre J, Fagon JY (2002) Ventilator-associated pneumonia. Am J Respir Crit Care Med 165:867-903
3. Esperatti M, Ferrer M, Theessen A, Liapikou A, Valencia M, Saucedo L, Zavala E, Welte T, Torres A (2013) Nosocomial pneumonia in the intensive care unit acquired during mechanical ventilation or not). Am J Respir Crit Care Med 182:1533-1539
4. Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gilbert C (1993) Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281-288
5. Kollef MH (2010) Review of recent clinical trials of hospital-acquired pneumonia and ventilator-associated pneumonia: a perspective from academia. Clin Infect Dis 51(Suppl 1):S29-S35
6. Nseir S, Di Pompeo C, Soubrier S, Cavestri B, Jozefowicz E, Saulnier F, Durocher A (2005) Impact of ventilator-associated pneumonia on outcome in patients with COPD. Chest 128:1650-1656
7. Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK (2010) Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology 139(4):1246-1256
8. Garcia-Tsao G (2004) Bacterial infections in cirrhosis. Can J Gastroenterol 18(6):405-406
9. Aggarwal A, Ong JP, Younossi ZM, Nelson DR, Hoffman-Hogg L, Arroliga AC (2001) Predictors of mortality and resource utilization in cirrhotic patients admitted to the medical ICU. Chest 119(5):1489-1497
10. Cheruvattah R, Balan V (2007) Infections in patients with end-stage liver disease. J Clin Gastroenterol 41(4):403-411
11. Fica A (2005) Diagnosis, management and prevention of infections in cirrhotic patients. Rev Chil Infect 22(1):63-74
12. Deschenes M, Villeneuve JP (1999) Risk factors for the development of bacterial infections in hospitalized patients with cirrhosis. Am J Gastroenterol 94:2193-2197
13. Mabee CL, Fromkes JJ, Pacht ER, Ayers LW, Kirkpatrick RB, Sundaram U (1998) Pulmonary infections in hospitalized patients with cirrhosis. J Clin Gastroenterol 26(1):44-49
14. Fernandez J, Acevedo J, Castro M, Garcia O, de Lope CR, Roca D, Pavesi M, Sola E, Moreira L, Silva A, Seva-Pereira T, Corradi F, Mensa J, Ginès P, Arroyo V (2012) Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: a prospective study. Hepatology 55(5):1551-1561
15. Hilbert G, Gruson D, Vargas F, Valentino R, Gbikpi-Benissan G, Dupon M, Reiffers J, Cardinaud JP (2001) Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 344:481-487
16. Fabregas N, Ewig S, Torres A, El Ebiary M, Ramirez J, de la Bellacasa JP, Bauer T, Cabello H (1999) Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies. Thorax 54:867-873
17. Luna CM, Blanzaco D, Niederman MS, Matarucco W, Baredes NC, Desmery P, Palizas F, Menga G, Rios F, Apezteguia C (2003) Resolution of ventilator-associated pneumonia: prospective evaluation of the clinical pulmonary infection score as an early clinical predictor of outcome. Crit Care Med 31:676-682
18. Sandiumenge A, Rello J (2012) Ventilator-associated pneumonia caused by ESKAPE organisms: cause, clinical features, and management. Curr Opin Pulm Med 18:187-193
19. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II a severity of disease classification system. Crit Care Med 13:818-829
20. Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270(24):2957-2963
21. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Int Care Med 22:707-710
22. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL (2008) Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36:296-327
23. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R (1994) The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149:818-824
24. Ramirez P, Ferrer M, Marti V, Reyes S, Martinez R, Menendez R, Ewig S, Torres A (2011) Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia. Crit Care Med 39:2211-2217
25. Ioanas M, Ferrer M, Cavalcanti M, Ferrer R, Ewig S, Filella X, de la Bellacasa JP, Torres A (2004) Causes and predictors of non-response to treatment of the ICU-acquired pneumonia. Crit Care Med 32:938-945
26. Caly WR, Strauss E (1993) A prospective study of bacterial infections in patients with cirrhosis. J Hepatol 18:353-358
27. Tandon P, Garcia-Tsao G (2008) Bacterial infections, sepsis, and multiorgan failure in cirrhosis. Semin Liver Dis 28:26-42
28. Wehler M, Kokoska J, Reulbach U, Hahn EG, Strauss R (2001) Short-term prognosis in critically ill patients with cirrhosis assessed by prognostic scoring systems. Hepatology 34(2):255-261
29. Fernandez J, Navasa M, Gomez J, Colmenero J, Vila J, Arroyo V, Rodés J (2002) Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology 35:140-148
30. Lynch J (2001) Hospital-acquired pneumonia: risk factors, microbiology and treatment. Chest 119:373S-384S
31. Jones RN (2010) Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis 51(S1):S81-S87
32. Kohlenberg A, Schwab F, Behnke M, Geffers C, Gastmeier P (2010) Pneumonia associated with invasive and noninvasive ventilation: an analysis of the German nosocomial infection surveillance system database. Intensive Care Med 36:971-978
33. Calabro P, Willerson JT, Yeh ET (2003) Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 108:1930-1932
34. Yasojima K, Schwab C, McGeer EG, McGeer PL (2000) Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Res 887:80-89
35. Huang D, Angus DC, Kellum JA, Pugh NA, Weissfeld LA, Struck J, Delude RL, Rosengart MR, Yealy DM (2009) Midregional proadrenomedullin as a prognostic tool in community-acquired pneumonia. Chest 136:823-831
36. Weinhold B, Ruther U (1997) Interleukin-6-dependent and independent regulation of the human C-reactive protein gene. Biochem J 327:425-429
37. Harden L (2013) Interleukin-10 modulates the synthesis of inflammatory mediators in the sensory circumventricular organs: implications for the regulation of fever and sickness behaviors. J Neuroinflammat 10:22
38. Bota DP, Van Nuffelen M, Zakariah AN, Vincent J (2005) Serum levels of C-reactive protein and procalcitonin in critically ill patients with cirrhosis of the liver. J Lab Clin Med 146(6):347-351
39. Rosa H, Silvério AO, Perini RF, Arruda CB (2000) Bacterial infections in cirrhotic patients and its relationship with alcohol. Am J Gastroenterol 95(5):1290-1293