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Volumn 19, Issue 18, 2013, Pages 5227-5239

Predicting response to bevacizumab in ovarian cancer: A panel of potential biomarkers informing treatment selection

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CA 125 ANTIGEN; MESOTHELIN; OROSOMUCOID; VASCULOTROPIN RECEPTOR 3;

EID: 84884562902     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0489     Document Type: Article
Times cited : (65)

References (50)
  • 2
    • 80051913984 scopus 로고    scopus 로고
    • 2010 Gynecologic Cancer InterGroup (GCIG) consensus statement on clinical trials in ovarian cancer: Report from the Fourth Ovarian Cancer Consensus Conference
    • Stuart GC, Kitchener H, Bacon M, du Bois A, Friedlander M, Ledermann J, et al. 2010 Gynecologic Cancer InterGroup (GCIG) consensus statement on clinical trials in ovarian cancer: report from the Fourth Ovarian Cancer Consensus Conference. Int J Gynecol Cancer 2011;21:750-5.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 750-755
    • Stuart, G.C.1    Kitchener, H.2    Bacon, M.3    Du Bois, A.4    Friedlander, M.5    Ledermann, J.6
  • 3
    • 0034046917 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma
    • Shen GH, Ghazizadeh M, Kawanami O, Shimizu H, Jin E, Araki T, et al. Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma. Br J Cancer 2000;83:196-203.
    • (2000) Br J Cancer , vol.83 , pp. 196-203
    • Shen, G.H.1    Ghazizadeh, M.2    Kawanami, O.3    Shimizu, H.4    Jin, E.5    Araki, T.6
  • 4
    • 78149359739 scopus 로고    scopus 로고
    • Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer
    • Han ES, Burger RA, Darcy KM, Sill MW, Randall LM, Chase D, et al. Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer. Gynecol Oncol 2010;119:484-90.
    • (2010) Gynecol Oncol , vol.119 , pp. 484-490
    • Han, E.S.1    Burger, R.A.2    Darcy, K.M.3    Sill, M.W.4    Randall, L.M.5    Chase, D.6
  • 7
    • 79956260679 scopus 로고    scopus 로고
    • A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses
    • Smith MP, Wood SL, Zougman A, Ho JT, Peng J, Jackson D, et al. A systematic analysis of the effects of increasing degrees of serum immunodepletion in terms of depth of coverage and other key aspects in top-down and bottom-up proteomic analyses. Proteomics 2011;11:2222-35.
    • (2011) Proteomics , vol.11 , pp. 2222-2235
    • Smith, M.P.1    Wood, S.L.2    Zougman, A.3    Ho, J.T.4    Peng, J.5    Jackson, D.6
  • 8
    • 67349266694 scopus 로고    scopus 로고
    • Universal sample preparation method for proteome analysis
    • Wisniewski JR, Zougman A, Nagaraj N, Mann M. Universal sample preparation method for proteome analysis. Nat Methods 2009;6:359-62.
    • (2009) Nat Methods , vol.6 , pp. 359-362
    • Wisniewski, J.R.1    Zougman, A.2    Nagaraj, N.3    Mann, M.4
  • 9
    • 84876299279 scopus 로고    scopus 로고
    • Proteomic analysis of formalin-fixed paraffin-embedded (FFPE) renal tissue samples by label-free mass spectrometry: Assessment of overall technical variability and the impact of block age
    • Craven RA, Cairns DA, Zougman A, Harnden P, Selby PJ, Banks RE. Proteomic analysis of formalin-fixed paraffin-embedded (FFPE) renal tissue samples by label-free mass spectrometry: assessment of overall technical variability and the impact of block age. Proteomics Clin Appl 2013;7:273-82.
    • (2013) Proteomics Clin Appl , vol.7 , pp. 273-282
    • Craven, R.A.1    Cairns, D.A.2    Zougman, A.3    Harnden, P.4    Selby, P.J.5    Banks, R.E.6
  • 10
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized P. P. B.-range mass accuracies and proteome-wide protein quantification
    • Cox J, Mann M. MaxQuant enables high peptide identification rates, individualized p. p. b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 2008;26:1367-72.
    • (2008) Nat Biotechnol , vol.26 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 14
    • 70449647008 scopus 로고
    • Proportional hazards tests and diagnostics based on weighted residuals
    • Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994;81:515-26.
    • (1994) Biometrika , vol.81 , pp. 515-526
    • Grambsch, P.M.1    Therneau, T.M.2
  • 15
    • 79961135005 scopus 로고    scopus 로고
    • R Development Core Team, Vienna, Austria: R Foundation for Statistical Computing
    • R Development Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2011.
    • (2011) R: A Language and Environment for Statistical Computing
  • 16
    • 0030069896 scopus 로고    scopus 로고
    • Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors
    • Harrell FE Jr, Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996;15:361-87.
    • (1996) Stat Med , vol.15 , pp. 361-387
    • Harrell Jr., F.E.1    Lee, K.L.2    Mark, D.B.3
  • 17
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patientswith previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, Fehrenbacher L, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patientswith previously treated metastatic breast cancer. J Clin Oncol 2005;23:792-9.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3    Cobleigh, M.A.4    Marcom, P.K.5    Fehrenbacher, L.6
  • 19
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. NEngl J Med 2004;350:2335-42.
    • (2004) NEngl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 20
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, Stadler WM, Vaena DA, Ou SS, et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008;20:5422-8.
    • (2008) J Clin Oncol , vol.20 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Ou, S.S.6
  • 21
    • 0027136747 scopus 로고
    • Sample size requirements and length of study for testing interaction in a 2 x k factorial design when time-to-failure is the outcome
    • Peterson B, George SL. Sample size requirements and length of study for testing interaction in a 2 x k factorial design when time-to-failure is the outcome. Control Clin Trials 1993;14:511-22.
    • (1993) Control Clin Trials , vol.14 , pp. 511-522
    • Peterson, B.1    George, S.L.2
  • 22
    • 84874820023 scopus 로고    scopus 로고
    • The role of mesothelin in tumor progression and targeted therapy
    • Tang Z, Qian M, Ho M. The role of mesothelin in tumor progression and targeted therapy. Anticancer Agents Med Chem 2013;13:276-80.
    • (2013) Anticancer Agents Med Chem , vol.13 , pp. 276-280
    • Tang, Z.1    Qian, M.2    Ho, M.3
  • 23
    • 84863116491 scopus 로고    scopus 로고
    • Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways
    • Chang MC, Chen CA, Chen PJ, Chiang YC, Chen YL, Mao TL, et al. Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. Biochem J 2012;442:293-302.
    • (2012) Biochem J , vol.442 , pp. 293-302
    • Chang, M.C.1    Chen, C.A.2    Chen, P.J.3    Chiang, Y.C.4    Chen, Y.L.5    Mao, T.L.6
  • 24
    • 63949085839 scopus 로고    scopus 로고
    • High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
    • Cheng WF, Huang CY, Chang MC, Hu YH, Chiang YC, Chen YL, et al. High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. Br J Cancer 2009;100:1144-53.
    • (2009) Br J Cancer , vol.100 , pp. 1144-1153
    • Cheng, W.F.1    Huang, C.Y.2    Chang, M.C.3    Hu, Y.H.4    Chiang, Y.C.5    Chen, Y.L.6
  • 27
    • 84858187904 scopus 로고    scopus 로고
    • Soluble mesothelin-related peptides levels in patients with malignant mesothelioma
    • Franko A, Dolzan V, Kovac V, Arneric N, Dodic-Fikfak M. Soluble mesothelin-related peptides levels in patients with malignant mesothelioma. Dis Markers 2012;32:123-31.
    • (2012) Dis Markers , vol.32 , pp. 123-131
    • Franko, A.1    Dolzan, V.2    Kovac, V.3    Arneric, N.4    Dodic-Fikfak, M.5
  • 29
    • 0032933883 scopus 로고    scopus 로고
    • VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
    • Valtola R, Salven P, Heikkila P, Taipale J, Joensuu H, Rehn M, et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am J Pathol 1999;154:1381-90.
    • (1999) Am J Pathol , vol.154 , pp. 1381-1390
    • Valtola, R.1    Salven, P.2    Heikkila, P.3    Taipale, J.4    Joensuu, H.5    Rehn, M.6
  • 30
    • 84855173597 scopus 로고    scopus 로고
    • A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma
    • Zurita AJ, Jonasch E, Wang X, Khajavi M, Yan S, Du DZ, et al. A cytokine and angiogenic factor (CAF) analysis in plasma for selection of sorafenib therapy in patients with metastatic renal cell carcinoma. Ann Oncol 2012;23:46-52.
    • (2012) Ann Oncol , vol.23 , pp. 46-52
    • Zurita, A.J.1    Jonasch, E.2    Wang, X.3    Khajavi, M.4    Yan, S.5    Du, D.Z.6
  • 31
    • 79960562089 scopus 로고    scopus 로고
    • Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone
    • El-Najjar N, Ketola RA, Nissila T, Mauriala T, Antopolsky M, Janis J, et al. Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone. J Chem Biol 2011;4:97-107.
    • (2011) J Chem Biol , vol.4 , pp. 97-107
    • El-Najjar, N.1    Ketola, R.A.2    Nissila, T.3    Mauriala, T.4    Antopolsky, M.5    Janis, J.6
  • 32
    • 78650740396 scopus 로고    scopus 로고
    • Statistical evaluation of CZE-UV and CZE-ESI-MS data of intact alpha-1-acid glycoprotein isoforms for their use as potential biomarkers in bladder cancer
    • Ongay S, Martin-Alvarez PJ, Neususs C, de FM. Statistical evaluation of CZE-UV and CZE-ESI-MS data of intact alpha-1-acid glycoprotein isoforms for their use as potential biomarkers in bladder cancer. Electrophoresis 2010;31:3314-25.
    • (2010) Electrophoresis , vol.31 , pp. 3314-3325
    • Ongay, S.1    Martin-Alvarez, P.J.2    Neususs, C.3    De, F.M.4
  • 34
    • 77951759264 scopus 로고    scopus 로고
    • Banking of clinical samples for proteomic biomarker studies: A consideration of logistical issues with a focus on pre-analytical variation
    • Jackson DH, Banks RE. Banking of clinical samples for proteomic biomarker studies: a consideration of logistical issues with a focus on pre-analytical variation. Proteomics Clin Appl 2010;4:250-70.
    • (2010) Proteomics Clin Appl , vol.4 , pp. 250-270
    • Jackson, D.H.1    Banks, R.E.2
  • 35
    • 74249092481 scopus 로고    scopus 로고
    • Biomarkers of angiogenesis and their role in the development of VEGF inhibitors
    • Murukesh N, Dive C, Jayson GC. Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Br J Cancer 2010;102:8-18.
    • (2010) Br J Cancer , vol.102 , pp. 8-18
    • Murukesh, N.1    Dive, C.2    Jayson, G.C.3
  • 36
    • 84860366086 scopus 로고    scopus 로고
    • Antiangiogenic therapy-evolving view based on clinical trial results
    • Jayson GC, Hicklin DJ, Ellis LM. Antiangiogenic therapy-evolving view based on clinical trial results. Nat Rev Clin Oncol 2012;9:297-303.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 297-303
    • Jayson, G.C.1    Hicklin, D.J.2    Ellis, L.M.3
  • 37
    • 84863897798 scopus 로고    scopus 로고
    • Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: A biomarker evaluation from the AVAGAST randomized phase III trial
    • van Cutsem E, de HS, Kang YK, Ohtsu A, Tebbutt NC, Ming XJ, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial. J Clin Oncol 2012;30:2119-27.
    • (2012) J Clin Oncol , vol.30 , pp. 2119-2127
    • Van Cutsem, E.1    De, H.S.2    Kang, Y.K.3    Ohtsu, A.4    Tebbutt, N.C.5    Ming, X.J.6
  • 38
    • 84863092492 scopus 로고    scopus 로고
    • VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: An analysis of data from the AViTA and AVOREN randomised trials
    • Lambrechts D, Claes B, Delmar P, Reumers J, Mazzone M, Yesilyurt BT, et al. VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials. Lancet Oncol 2012;13:724-33.
    • (2012) Lancet Oncol , vol.13 , pp. 724-733
    • Lambrechts, D.1    Claes, B.2    Delmar, P.3    Reumers, J.4    Mazzone, M.5    Yesilyurt, B.T.6
  • 39
    • 27644517412 scopus 로고    scopus 로고
    • Benefit from bevacizumab (BV) is independent of pretreatment plasma vascular endothelial growth factor-A (pl-VEGF) in patients (pts) with metastatic colorectal cancer (mCRC)
    • suppl; abstr 3555
    • Holden SN, Ryan E, Kearns A, Holmgren E, Hurwitz. Benefit from bevacizumab (BV) is independent of pretreatment plasma vascular endothelial growth factor-A (pl-VEGF) in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol 23:16S, 2005(suppl; abstr 3555).
    • (2005) J Clin Oncol , vol.23
    • Holden, S.N.1    Ryan, E.2    Kearns, A.3    Holmgren, E.4    Hurwitz5
  • 40
    • 79251473728 scopus 로고    scopus 로고
    • Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer
    • Jubb AM, Miller KD, Rugo HS, Harris AL, Chen D, Reimann JD, et al. Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer. Clin Cancer Res 2011;17:372-81.
    • (2011) Clin Cancer Res , vol.17 , pp. 372-381
    • Jubb, A.M.1    Miller, K.D.2    Rugo, H.S.3    Harris, A.L.4    Chen, D.5    Reimann, J.D.6
  • 41
    • 53749093040 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    • Schneider BP, Wang M, Radovich M, Sledge GW, Badve S, Thor A, et al. Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 2008;26:4672-8.
    • (2008) J Clin Oncol , vol.26 , pp. 4672-4678
    • Schneider, B.P.1    Wang, M.2    Radovich, M.3    Sledge, G.W.4    Badve, S.5    Thor, A.6
  • 42
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study
    • Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study. Clin Cancer Res 2008;14:1407-12.
    • (2008) Clin Cancer Res , vol.14 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 43
    • 80051950288 scopus 로고    scopus 로고
    • Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for bevacizumab
    • Matsusaka S, Mishima Y, Suenaga M, Terui Y, Kuniyoshi R, Mizunuma N, et al. Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for bevacizumab. Cancer 2011;117:4026-32.
    • (2011) Cancer , vol.117 , pp. 4026-4032
    • Matsusaka, S.1    Mishima, Y.2    Suenaga, M.3    Terui, Y.4    Kuniyoshi, R.5    Mizunuma, N.6
  • 44
    • 82455166762 scopus 로고    scopus 로고
    • Bevacizumabrelated arterial hypertension as a predictive marker in metastatic colorectal cancer patients
    • de Stefano A, Carlomagno C, Pepe S, Bianco R, De PS. Bevacizumabrelated arterial hypertension as a predictive marker in metastatic colorectal cancer patients. Cancer Chemother Pharmacol 2011;68:1207-13.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1207-1213
    • De Stefano, A.1    Carlomagno, C.2    Pepe, S.3    Bianco, R.4    De, P.S.5
  • 45
    • 79951673901 scopus 로고    scopus 로고
    • Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy
    • Osterlund P, Soveri LM, Isoniemi H, Poussa T, Alanko T, Bono P. Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy. Br J Cancer 2011;104:599-604.
    • (2011) Br J Cancer , vol.104 , pp. 599-604
    • Osterlund, P.1    Soveri, L.M.2    Isoniemi, H.3    Poussa, T.4    Alanko, T.5    Bono, P.6
  • 46
    • 84861460201 scopus 로고    scopus 로고
    • Correlation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin (CAPOX) plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection
    • Dewdney A, Cunningham D, Barbachano Y, Chau I. Correlation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin (CAPOX) plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection. Br J Cancer 2012;106:1718-21.
    • (2012) Br J Cancer , vol.106 , pp. 1718-1721
    • Dewdney, A.1    Cunningham, D.2    Barbachano, Y.3    Chau, I.4
  • 47
    • 84861661737 scopus 로고    scopus 로고
    • Biomarkers in the development of anti-angiogenic therapies for ovarian cancer
    • Raja FA, Hook JM, Ledermann JA. Biomarkers in the development of anti-angiogenic therapies for ovarian cancer. Cancer Treat Rev 2012;38:662-72.
    • (2012) Cancer Treat Rev , vol.38 , pp. 662-672
    • Raja, F.A.1    Hook, J.M.2    Ledermann, J.A.3
  • 48
    • 78049477139 scopus 로고    scopus 로고
    • Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer
    • Chambers SK, Clouser MC, Baker AF, Roe DJ, Cui H, Brewer MA, et al. Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer. Clin Cancer Res 2010;16:5320-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 5320-5328
    • Chambers, S.K.1    Clouser, M.C.2    Baker, A.F.3    Roe, D.J.4    Cui, H.5    Brewer, M.A.6
  • 49
    • 80052514816 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarker exploration in a phase II study of bevacizumab, oxaliplatin, and gemcitabine in recurrent mullerian carcinoma
    • Horowitz NS, Penson RT, Duda DG, di TE, Boucher Y, Ancukiewicz M, et al. Safety, efficacy, and biomarker exploration in a phase II study of bevacizumab, oxaliplatin, and gemcitabine in recurrent mullerian carcinoma. Clin Ovarian Cancer Other Gynecol Malig 2011;4:26-33.
    • (2011) Clin Ovarian Cancer Other Gynecol Malig , vol.4 , pp. 26-33
    • Horowitz, N.S.1    Penson, R.T.2    Duda, D.G.3    Di, T.E.4    Boucher, Y.5    Ancukiewicz, M.6
  • 50
    • 84866275588 scopus 로고    scopus 로고
    • Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab
    • Madsen CV, Steffensen KD, Olsen DA, Waldstrom M, Adimi P, Smerdel M, et al. Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab. J Ovarian Res 2012;5:23.
    • (2012) J Ovarian Res , vol.5 , pp. 23
    • Madsen, C.V.1    Steffensen, K.D.2    Olsen, D.A.3    Waldstrom, M.4    Adimi, P.5    Smerdel, M.6


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