Nrf2 implicated as a novel therapeutic target for renal regeneration after acute kidney injury

Nephrology Dialysis Transplantation

Volumn 28, Issue 8, 2013, Pages 1969-1971

  Fledderus, Joost O ^a   Goldschmeding, Roel ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN MDM2; PROTEIN P53; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

ACUTE KIDNEY FAILURE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; DISEASE ASSOCIATION; HUMAN; KIDNEY FUNCTION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENAL PROTECTION; SIGNAL TRANSDUCTION; TISSUE REGENERATION; UPREGULATION;

ACUTE KIDNEY INJURY; ANIMALS; EPITHELIAL CELLS; KIDNEY TUBULES; NF-E2-RELATED FACTOR 2; PROTO-ONCOGENE PROTEINS C-MDM2; REGENERATION;

EID: 84884558614     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft202     Document Type: Article

References (22)

1. Nath KA, Norby SM. Reactive oxygen species and acute renal failure. Am J Med 2000; 109: 665-678
2. Pannu N, Nadim MK. An overview of drug-induced acute kidney injury. Crit Care Med 2008; 36: S216-S223
3. Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011; 121: 4210-4221
4. Humphreys BD, Bonventre JV. The contribution of adult stem cells to renal repair. Nephrol Ther 2007; 3: 3-10
5. Romagnani P. Family portrait: renal progenitor of Bowman's capsule and its tubular brothers. Am J Pathol 2011; 178: 490-493
6. Yang L, Humphreys BD, Bonventre JV. Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. Contrib Nephrol 2011; 174: 149-155
7. Rosenberger C, Rosen S, Shina A et al. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant 2008; 23: 3472-3478
8. Kim TH, Hur EG, Kang SJ et al. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α. Cancer Res 2011; 71: 2260-2275
9. Loboda A, Stachurska A, Florczyk U et al. HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells. Antioxid Redox Signal 2009; 11: 1501-1517
10. Malec V, Gottschald OR, Li S et al. HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells. Free Radic Biol Med 2010; 48: 1626-1635
11. Hagemann JH, Thomasova D, Mulay SR et al. Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2. Nephrol Dial Transplant 2013; 28: 2028-2037
12. Mulay SR, Thomasova D, Ryu M et al. MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice. Kidney Int 2012; 81: 1199-1211
13. Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007; 47: 89-116
14. Pedruzzi LM, Stockler-Pinto MB, Leite M, Jr et al. Nrf2-keap1 system versus NF-κB: the good and the evil in chronic kidney disease?. Biochimie 2012; 94: 2461-2466
15. You A, Nam CW, Wakabayashi N et al. Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Arch Biochem Biophys 2011; 507: 356-364
16. Chapple SJ, Siow RC, Mann GE. Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. Int J Biochem Cell Biol 2012; 44: 1315-1320
17. Evans PC. The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease. EPMA J 2011; 2: 9-14
18. Kensler TW, Egner PA, Agyeman AS et al. Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem 2013; 329: 163-177
19. Park LK, Friso S, Choi SW. Nutritional influences on epigenetics and age-related disease. Proc Nutr Soc 2012; 71: 75-83
20. Guerrero-Beltrán CE, Calderón-Oliver M, Tapia E et al. Sulforaphane protects against cisplatin-induced nephrotoxicity. Toxicol Lett 2010; 192: 278-285
21. Yoon HY, Kang NI, Lee HK et al. Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem Pharmacol 2008; 75: 2214-2223
22. Zheng H, Whitman SA, Wu W et al. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes 2011; 60: 3055-3066