Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells

Genetics and Molecular Research

Volumn 12, Issue 3, 2013, Pages 3588-3597

  Xing, T J ^a   Xu, H T ^a   Yu, W Q ^a   Jiang, D F ^a  

^a Tai Zhou People's Hospital   (China)

Author keywords

Apoptosis; Hepatocellular carcinoma; Methylation regulation; MicroRNA 122

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MICRORNA 122;

APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; RNA METHYLATION;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AZACITIDINE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; LIVER; LIVER NEOPLASMS; MICRORNAS; PROMOTER REGIONS, GENETIC;

EID: 84884557234     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2013.September.13.3     Document Type: Article

References (17)

1. Gramantieri L, Ferracin M, Fornari F, Veronese A, et al. (2007). Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res. 67: 6092-6099.
2. Jopling C (2012). Liver-specific microRNA-122: Biogenesis and function. RNA. Biol. 9: 137-142.
3. Jung CJ, Iyengar S, Blahnik KR, Ajuha TP, et al. (2011). Epigenetic modulation of miR-122 facilitates human embryonic stem cell self-renewal and hepatocellular carcinoma proliferation. Plos One 6: e27740.
4. Kutay H, Bai S, Datta J, Motiwala T, et al. (2006). Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J. Cell Biochem. 99: 671-678.
5. Laudadio I, Manfroid I, Achouri Y, Schmidt D, et al. (2012). A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation. Gastroenterology 142: 119-129.
6. Lee S, Lee HJ, Kim JH, Lee HS, et al. (2003). Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am. J. Pathol. 163: 1371-1378.
7. Lewis AP and Jopling CL (2010). Regulation and biological function of the liver-specific miR-122. Biochem. Soc. Trans. 38: 1553-1557.
8. Li ZY, Xi Y, Zhu WN, Zeng C, et al. (2011). Positive regulation of hepatic miR-122 expression by HNF4alpha. J. Hepatol. 55: 602-611.
9. Lin CJ, Gong HY, Tseng HC, Wang WL, et al. (2008). miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem. Biophys. Res. Commun. 375: 315-320.
10. Narbus CM, Israelow B, Sourisseau M, Michta ML, et al. (2011). HepG2 cells expressing microRNA miR-122 support the entire hepatitis C virus life cycle. J. Virol. 85: 12087-12092.
11. Nishida N and Goel A (2011). Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review. Curr. Genomics 12: 130-137.
12. Pitto L, Ripoli A, Cremisi F, Simili M, et al. (2008). microRNA(interference) networks are embedded in the gene regulatory networks. Cell Cycle 7: 2458-2461.
13. Varnholt H, Drebber U, Schulze F, Wedemeyer I, et al. (2008). MicroRNA gene expression profile of hepatitis C virus-associated hepatocellular carcinoma. Hepatology 47: 1223-1232.
14. Weber B, Stresemann C, Brueckner B and Lyko F (2007). Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle 6: 1001-1005.
15. Wu X, Wu S, Tong L, Luan T, et al. (2009). miR-122 affects the viability and apoptosis of hepatocellular carcinoma cells. Scand. J. Gastroenterol. 44: 1332-1339.
16. Xu J, Zhu X, Wu L, Yang R, et al. (2012). MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/beta-catenin pathway. Liver Int. 32: 752-760.
17. Young DD, Connelly CM, Grohmann C and Deiters A (2010). Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma. J. Am. Chem. Soc. 132: 7976-7981.