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Volumn 7, Issue , 2013, Pages 1015-1026

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Author keywords

6 mercaptopurine; Controlled release; Cytotoxicity; Drug delivery; Superparamagnetic nanoparticles

Indexed keywords

CHITOSAN; MERCAPTOPURINE; NANOCOMPOSITE; SOLVENT; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

EID: 84884557123     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S43035     Document Type: Article
Times cited : (55)

References (47)
  • 1
    • 56549123324 scopus 로고    scopus 로고
    • Chitosan-coated magnetic nano-particles as carriers of 5-fuorouracil: Preparation, characterization and cytotoxicity studies
    • Zhu L, Ma J, Jia N, Zhao Y, Shen H. Chitosan-coated magnetic nano-particles as carriers of 5-fuorouracil: preparation, characterization and cytotoxicity studies. Colloids Surf B Biointerfaces. 2009;68(1):1-6.
    • (2009) Colloids Surf B Biointerfaces , vol.68 , Issue.1 , pp. 1-6
    • Zhu, L.1    Ma, J.2    Jia, N.3    Zhao, Y.4    Shen, H.5
  • 2
    • 33749537287 scopus 로고    scopus 로고
    • Analytical detection and biological assay of antileukemic drug using gold nanoparticles
    • Selvaraj V, Alagar M, Hamerton I. Analytical detection and biological assay of antileukemic drug using gold nanoparticles. Electrochim Acta. 2006;52(3):1152-1160.
    • (2006) Electrochim Acta , vol.52 , Issue.3 , pp. 1152-1160
    • Selvaraj, V.1    Alagar, M.2    Hamerton, I.3
  • 3
    • 33750224090 scopus 로고    scopus 로고
    • Encapsulation of magnetic nanoparticles with polystyrene via emulsifer-free miniemulsion polymerization
    • Faridi-Majidi R, Sharif-Sanjani N, Agend F. Encapsulation of magnetic nanoparticles with polystyrene via emulsifer-free miniemulsion polymerization. Thin Solid Films. 2006;515(1):368-374.
    • (2006) Thin Solid Films , vol.515 , Issue.1 , pp. 368-374
    • Faridi-Majidi, R.1    Sharif-Sanjani, N.2    Agend, F.3
  • 4
    • 45949108839 scopus 로고    scopus 로고
    • Preparation and analysis of Fe3O4 magnetic nanoparticles used as targeted-drug carriers
    • Zhao Y, Qiu Z, Huang J. Preparation and analysis of Fe3O4 magnetic nanoparticles used as targeted-drug carriers. Chinese J Chem Eng. 2008;16(3):451-455.
    • (2008) Chinese J Chem Eng , vol.16 , Issue.3 , pp. 451-455
    • Zhao, Y.1    Qiu, Z.2    Huang, J.3
  • 6
    • 18144410153 scopus 로고    scopus 로고
    • Site-directed research of magnetic nanoparticles in magnetic drug targeting
    • Xu H, Song T, Bao X, Hu L. Site-directed research of magnetic nanoparticles in magnetic drug targeting. J Magn Magn Mater. 2005;293(1):514-519.
    • (2005) J Magn Magn Mater , vol.293 , Issue.1 , pp. 514-519
    • Xu, H.1    Song, T.2    Bao, X.3    Hu, L.4
  • 8
    • 0037472115 scopus 로고    scopus 로고
    • Chitosan-based gastrointestinal delivery systems
    • Hejazi R, Amiji M. Chitosan-based gastrointestinal delivery systems. J Control Release. 2003;89(2):151-165.
    • (2003) J Control Release , vol.89 , Issue.2 , pp. 151-165
    • Hejazi, R.1    Amiji, M.2
  • 9
    • 33344467489 scopus 로고    scopus 로고
    • Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system
    • Amidi M, Romeijn SG, Borchard G, Junginger HE, Hennink WE, Jiskoot W. Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J Control Release. 2006;111(1):107-116.
    • (2006) J Control Release , vol.111 , Issue.1 , pp. 107-116
    • Amidi, M.1    Romeijn, S.G.2    Borchard, G.3    Junginger, H.E.4    Hennink, W.E.5    Jiskoot, W.6
  • 10
    • 40649100957 scopus 로고    scopus 로고
    • Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice
    • Kim JH, Kim YS, Park K, et al. Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice. J Control Release. 2008;127(1):41-49.
    • (2008) J Control Release , vol.127 , Issue.1 , pp. 41-49
    • Kim, J.H.1    Kim, Y.S.2    Park, K.3
  • 11
    • 13844265668 scopus 로고    scopus 로고
    • Self-assembled nanoparticles containing hydrophobically modifed glycol chitosan for gene delivery
    • Sang Yo o H, Eun Lee J, Chung H, Chan Kwon I, Young Jeong S. Self-assembled nanoparticles containing hydrophobically modifed glycol chitosan for gene delivery. J Control Release. 2005;103(1):235-243.
    • (2005) J Control Release , vol.103 , Issue.1 , pp. 235-243
    • Sang, Y.1    Eun Lee, J.2    Chung, H.3    Chan Kwon, I.4    Young Jeong, S.5
  • 12
    • 4744362163 scopus 로고    scopus 로고
    • Surface modification using photocross-linkable chitosan for improving hemocompatibility
    • Mao C, Zhu JJ, Hu YF, et al. Surface modification using photocross-linkable chitosan for improving hemocompatibility. Colloids Surf B Biointerfaces. 2004;38(1):47-53.
    • (2004) Colloids Surf B Biointerfaces , vol.38 , Issue.1 , pp. 47-53
    • Mao, C.1    Zhu, J.J.2    Hu, Y.F.3
  • 13
    • 0016053706 scopus 로고
    • A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine
    • Tidd DM, Paterson ARP. A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine. Cancer Res. 1974;34(4):738-746.
    • (1974) Cancer Res , vol.34 , Issue.4 , pp. 738-746
    • Tidd, D.M.1    Paterson, A.R.P.2
  • 15
    • 84876739608 scopus 로고    scopus 로고
    • Simultaneous determination of 6-mercaptopurine and its oxidative metabolites in synthetic solutions and human plasma using spectrophotometric multivariate calibration methods
    • Sorouraddin MH, Khani M Y, Amini K, Naseri A, Asgari D, Rashidi MR. Simultaneous determination of 6-mercaptopurine and its oxidative metabolites in synthetic solutions and human plasma using spectrophotometric multivariate calibration methods. Bioimpacts. 2011;1(1):53-62.
    • (2011) Bioimpacts , vol.1 , Issue.1 , pp. 53-62
    • Sorouraddin, M.H.1    Khani, M.Y.2    Amini, K.3    Naseri, A.4    Asgari, D.5    Rashidi, M.R.6
  • 17
    • 0035819307 scopus 로고    scopus 로고
    • Synthesis Fourier transform infrared, nuclear magnetic resonance and thermal analysis of sodium and platinum complexes of 6-mercaptopurine
    • Bariyanga J, Luyt AS. Synthesis, Fourier transform infrared, nuclear magnetic resonance and thermal analysis of sodium and platinum complexes of 6-mercaptopurine. J Mol Struct. 2001;559(1): 49-54.
    • (2001) J Mol Struct , vol.559 , Issue.1 , pp. 49-54
    • Bariyanga, J.1    Luyt, A.S.2
  • 18
    • 27744503223 scopus 로고    scopus 로고
    • Synthesis of MRI contrast agent by coating superparamagnetic iron oxide with chitosan
    • Lee HS, Shao H, Huang Y, Kwak BK. Synthesis of MRI contrast agent by coating superparamagnetic iron oxide with chitosan. IEEE Trans Magn. 2005;41(10):4102-4104.
    • (2005) IEEE Trans Magn , vol.41 , Issue.10 , pp. 4102-4104
    • Lee, H.S.1    Shao, H.2    Huang, Y.3    Kwak, B.K.4
  • 19
    • 0031845277 scopus 로고    scopus 로고
    • Different molecular weight chitosan microspheres: Influence on drug loading and drug release
    • Genta I, Perugini P, Pavanetto F. Different molecular weight chitosan microspheres: influence on drug loading and drug release. Drug Dev Ind Pharm. 1998;24(8):779-784.
    • (1998) Drug Dev Ind Pharm , vol.24 , Issue.8 , pp. 779-784
    • Genta, I.1    Perugini, P.2    Pavanetto, F.3
  • 20
    • 1842452953 scopus 로고    scopus 로고
    • Chitosan microspheres as a potential carrier for drugs
    • Sinha VR, Singla AK, Wadhawan S, et al. Chitosan microspheres as a potential carrier for drugs. Int J Pharm. 2004;274(1):1-33.
    • (2004) Int J Pharm , vol.274 , Issue.1 , pp. 1-33
    • Sinha, V.R.1    Singla, A.K.2    Wadhawan, S.3
  • 21
    • 84859564400 scopus 로고    scopus 로고
    • Controlled release study of an anti-carcinogenic agent, gallate from the surface of magnetite nanoparticles
    • Ghotbi MY, bin Hussein MZ. Controlled release study of an anti-carcinogenic agent, gallate from the surface of magnetite nanoparticles. J Phys Chem Solids. 2012;73:936-942.
    • (2012) J Phys Chem Solids , vol.73 , pp. 936-942
    • Ghotbi, M.Y.1    Bin Hussein, M.Z.2
  • 22
    • 79952313772 scopus 로고    scopus 로고
    • Synthesis of iron oxide nanoparticles via sonochemical method and their characterization
    • Hassanjani-Roshan A, Vaezi MR, Shokuhfar A, Rajabali Z. Synthesis of iron oxide nanoparticles via sonochemical method and their characterization. Particuology. 2011;9(1):95-99.
    • (2011) Particuology , vol.9 , Issue.1 , pp. 95-99
    • Hassanjani-Roshan, A.1    Vaezi, M.R.2    Shokuhfar, A.3    Rajabali, Z.4
  • 23
    • 40749108037 scopus 로고    scopus 로고
    • Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo
    • Su C-C, Yang J-S, Lin S-Y, et al. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo. 2008;22(1):63-68.
    • (2008) In Vivo , vol.22 , Issue.1 , pp. 63-68
    • Su, C.-C.1    Yang, J.-S.2    Lin, S.-Y.3
  • 25
    • 55349123281 scopus 로고    scopus 로고
    • Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs
    • Xia SJ, Ni ZM, Xu Q, Hu BX, Hu J. Layered double hydroxides as supports for intercalation and sustained release of antihypertensive drugs. J Solid State Chem. 2008;181(10):2610-2619.
    • (2008) J Solid State Chem , vol.181 , Issue.10 , pp. 2610-2619
    • Xia, S.J.1    Ni, Z.M.2    Xu, Q.3    Hu, B.X.4    Hu, J.5
  • 26
    • 58249112847 scopus 로고    scopus 로고
    • Nanocomposites coated with xyloglucan for drug delivery: In vitro studies
    • Ribeiro C, Arizaga GGC, Wypych F, Sierakowski MR. Nanocomposites coated with xyloglucan for drug delivery: in vitro studies. Int J Pharm. 2009;367(1):204-210.
    • (2009) Int J Pharm , vol.367 , Issue.1 , pp. 204-210
    • Ribeiro, C.1    Arizaga, G.G.C.2    Wypych, F.3    Sierakowski, M.R.4
  • 27
    • 33646893652 scopus 로고    scopus 로고
    • Nanostructural drug-inorganic clay composites: Structure, thermal property and in vitro release of captopril-intercalated Mg-Al-layered double hydroxides
    • Zhang H, Zou K, Guo S, Duan X. Nanostructural drug-inorganic clay composites: structure, thermal property and in vitro release of captopril-intercalated Mg-Al-layered double hydroxides. J Solid State Chem. 2006;179(6):1792-1801.
    • (2006) J Solid State Chem , vol.179 , Issue.6 , pp. 1792-1801
    • Zhang, H.1    Zou, K.2    Guo, S.3    Duan, X.4
  • 28
    • 60449092023 scopus 로고    scopus 로고
    • Preparation and properties of chitosan-soybean trypsin inhibitor blend film with anti-Aspergillus favus activity
    • Zhang B, Wang D F, Li HY, Xu Y, Zhang L. Preparation and properties of chitosan-soybean trypsin inhibitor blend film with anti-Aspergillus favus activity. Ind Crop Prod. 2009;29(2):541-548.
    • (2009) Ind Crop Prod , vol.29 , Issue.2 , pp. 541-548
    • Zhang, B.1    Wang, D.F.2    Li, H.Y.3    Xu, Y.4    Zhang, L.5
  • 29
    • 62749193162 scopus 로고    scopus 로고
    • Preparation and characterization of chitosan/poly (vinyl alcohol) chemically crosslinked blends for biomedical applications
    • Costa-Júnior ES, Barbosa-Stancioli E F, Mansur AAP, Vasconcelos WL, Mansur HS. Preparation and characterization of chitosan/poly (vinyl alcohol) chemically crosslinked blends for biomedical applications. Carbohydr Polym. 2009;76(3):472-481.
    • (2009) Carbohydr Polym , vol.76 , Issue.3 , pp. 472-481
    • Costa-Júnior, E.S.1    Barbosa-Stancioli, E.F.2    Mansur, A.A.P.3    Vasconcelos, W.L.4    Mansur, H.S.5
  • 30
    • 67649825675 scopus 로고    scopus 로고
    • Preparation and structure of chitosan soluble in wide pH range
    • Fan M, Hu Q, Shen K. Preparation and structure of chitosan soluble in wide pH range. Carbohydr Polym. 2009;78(1):66-71.
    • (2009) Carbohydr Polym , vol.78 , Issue.1 , pp. 66-71
    • Fan, M.1    Hu, Q.2    Shen, K.3
  • 31
    • 40749087248 scopus 로고    scopus 로고
    • Synthesis of iron oxide nanoparticles of narrow size distribution on polysaccharide templates
    • Nidhin M, Indumathy R, Sreeram KJ, Nair BU. Synthesis of iron oxide nanoparticles of narrow size distribution on polysaccharide templates. Bull Mater Sci. 2008;31(1):93-96.
    • (2008) Bull Mater Sci , vol.31 , Issue.1 , pp. 93-96
    • Nidhin, M.1    Indumathy, R.2    Sreeram, K.J.3    Nair, B.U.4
  • 32
    • 33847111624 scopus 로고    scopus 로고
    • Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate
    • Ma H, Qi X, Maitani Y, Nagai T. Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate. Int J Pharm. 2007;333(1):177-186.
    • (2007) Int J Pharm , vol.333 , Issue.1 , pp. 177-186
    • Ma, H.1    Qi, X.2    Maitani, Y.3    Nagai, T.4
  • 33
    • 33847627943 scopus 로고    scopus 로고
    • Synthesis and characterization of lithium-doped tin dioxide nanocrystalline powders
    • Chaparadza A, Rananavare SB, Shutthanandan V. Synthesis and characterization of lithium-doped tin dioxide nanocrystalline powders. Mater Chem Phys. 2007;102(2):176-180.
    • (2007) Mater Chem Phys , vol.102 , Issue.2 , pp. 176-180
    • Chaparadza, A.1    Rananavare, S.B.2    Shutthanandan, V.3
  • 34
    • 80052309729 scopus 로고    scopus 로고
    • Synthesis and characterization of lawsone-intercalated ZnAl layered double hydroxides
    • Yasin Y, Ismail NM, Hussein MZ, Aminudin N. Synthesis and characterization of lawsone-intercalated ZnAl layered double hydroxides. J Biomed Nanotechnol. 2011;7(3):486-488.
    • (2011) J Biomed Nanotechnol , vol.7 , Issue.3 , pp. 486-488
    • Yasin, Y.1    Ismail, N.M.2    Hussein, M.Z.3    Aminudin, N.4
  • 35
    • 78049234703 scopus 로고    scopus 로고
    • Preparation and characterization of bio-functionalized iron oxide nanoparticles for biomedical application
    • Bajaj B, Malhotra BD, Choi S. Preparation and characterization of bio-functionalized iron oxide nanoparticles for biomedical application. Thin Solid Films. 2010;519(3):1219-1223.
    • (2010) Thin Solid Films , vol.519 , Issue.3 , pp. 1219-1223
    • Bajaj, B.1    Malhotra, B.D.2    Choi, S.3
  • 36
    • 68549111149 scopus 로고    scopus 로고
    • Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro
    • Ge Y, Zhang Y, Xia J, et al. Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro. Colloids Surf B Biointerfaces. 2009;73(2):294-301.
    • (2009) Colloids Surf B Biointerfaces , vol.73 , Issue.2 , pp. 294-301
    • Ge, Y.1    Zhang, Y.2    Xia, J.3
  • 37
    • 84866487988 scopus 로고    scopus 로고
    • PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: Preparation, characterization and cytotoxicity studies
    • Qu JB, Shao H, Jing GL, Huang F. PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity studies. Colloids Surf B Biointerfaces. 2013;102: 37-44.
    • (2013) Colloids Surf B Biointerfaces , vol.102 , pp. 37-44
    • Qu, J.B.1    Shao, H.2    Jing, G.L.3    Huang, F.4
  • 38
    • 23144463377 scopus 로고    scopus 로고
    • Intercalation compounds of hydrotalcite-like anionic clays with anti-infammatory agents, II: Uptake of diclofenac for a controlled release formulation
    • Ambrogi V, Fardella G, Grandolini G, Perioli L, Tiralti MC. Intercalation compounds of hydrotalcite-like anionic clays with anti-infammatory agents, II: uptake of diclofenac for a controlled release formulation. AAPS PharmSciTech. 2002;3(3):77-82.
    • (2002) AAPS PharmSciTech , vol.3 , Issue.3 , pp. 77-82
    • Ambrogi, V.1    Fardella, G.2    Grandolini, G.3    Perioli, L.4    Tiralti, M.C.5
  • 39
    • 84870359861 scopus 로고    scopus 로고
    • Comparative study of Mg/Al-and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme
    • Al Ali SHH, Al-Qubaisi M, Hussein MZ, Ismail M, Zainal Z, Hakim MN. Comparative study of Mg/Al-and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme. Int J Nanomedicine. 2002;7:4251-4262.
    • (2002) Int J Nanomedicine , vol.7 , pp. 4251-4262
    • Al Ali, S.H.H.1    Al-Qubaisi, M.2    Hussein, M.Z.3    Ismail, M.4    Zainal, Z.5    Hakim, M.N.6
  • 40
    • 27744539454 scopus 로고    scopus 로고
    • A magnetic organic-inorganic composite: Synthesis and characterization of magnetic 5-aminosalicylic acid intercalated layered double hydroxides
    • Zhang H, Zou K, Sun H, Duan X. A magnetic organic-inorganic composite: synthesis and characterization of magnetic 5-aminosalicylic acid intercalated layered double hydroxides. J Solid State Chem. 2005;178(11):3485-3493.
    • (2005) J Solid State Chem , vol.178 , Issue.11 , pp. 3485-3493
    • Zhang, H.1    Zou, K.2    Sun, H.3    Duan, X.4
  • 41
    • 0036846129 scopus 로고    scopus 로고
    • Intercalation chemistry of layered double hydroxides: Recent developments and applications
    • Khan AI, O'Hare D. Intercalation chemistry of layered double hydroxides: recent developments and applications. J Mater Chem. 2002;12(11): 3191-3198.
    • (2002) J Mater Chem , vol.12 , Issue.11 , pp. 3191-3198
    • Khan, A.I.1    O'Hare, D.2
  • 42
    • 84861553669 scopus 로고    scopus 로고
    • In vitro inhibition of histamine release behavior of cetirizine intercalated into zn/al-and mg/al-layered double hydroxides
    • Hussein-Al-Ali SH, Al-Qubaisi M, Hussein MZ, Ismail M, Zainal Z, Hakim MN. In vitro inhibition of histamine release behavior of cetirizine intercalated into zn/al-and mg/al-layered double hydroxides. Int J Mol Sci. 2002;13(5):5899-5916.
    • (2002) Int J Mol Sci , vol.13 , Issue.5 , pp. 5899-5916
    • Hussein-Al-Ali, S.H.1    Al-Qubaisi, M.2    Hussein, M.Z.3    Ismail, M.4    Zainal, Z.5    Hakim, M.N.6
  • 43
    • 77955466615 scopus 로고    scopus 로고
    • Synthesis and release behavior of composites of camptothecin and layered double hydroxide
    • Dong L, Yan L, Hou WG, Liu SJ. Synthesis and release behavior of composites of camptothecin and layered double hydroxide. J Solid State Chem. 2010;183(8):1811-1816.
    • (2010) J Solid State Chem , vol.183 , Issue.8 , pp. 1811-1816
    • Dong, L.1    Yan, L.2    Hou, W.G.3    Liu, S.J.4
  • 44
    • 33644545070 scopus 로고    scopus 로고
    • Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fber
    • Ho YS, Ofomaja AE. Pseudo-second-order model for lead ion sorption from aqueous solutions onto palm kernel fber. J Hazard Mater. 2006;129(1):137-142.
    • (2006) J Hazard Mater , vol.129 , Issue.1 , pp. 137-142
    • Ho, Y.S.1    Ofomaja, A.E.2
  • 45
    • 79960962419 scopus 로고    scopus 로고
    • 6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activities
    • Cuin A, Massabni AC, Pereira GA, et al. 6-Mercaptopurine complexes with silver and gold ions: anti-tuberculosis and anti-cancer activities. Biomed Pharmacother. 2011;65(5):334-338.
    • (2011) Biomed Pharmacother , vol.65 , Issue.5 , pp. 334-338
    • Cuin, A.1    Massabni, A.C.2    Pereira, G.A.3
  • 46
    • 4644268591 scopus 로고    scopus 로고
    • Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line
    • Serpe L, Catalano MG, Cavalli R, et al. Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line. Eur J Pharm Biopharm. 2004;58(3):673-680.
    • (2004) Eur J Pharm Biopharm , vol.58 , Issue.3 , pp. 673-680
    • Serpe, L.1    Catalano, M.G.2    Cavalli, R.3
  • 47
    • 77950476513 scopus 로고    scopus 로고
    • Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells
    • Ankamwar B, Lai TC, Huang JH, et al. Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells. Nanotechnology. 2010;21(7):075102.
    • (2010) Nanotechnology , vol.21 , Issue.7 , pp. 075102
    • Ankamwar, B.1    Lai, T.C.2    Huang, J.H.3


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