Characterization of the anti-solvent batch, plug flow and MSMPR crystallization of benzoic acid

Chemical Engineering Science

Volumn 104, Issue , 2013, Pages 44-54

  Ferguson, Steven ^a,b   Morris, Gary ^a   Hao, Hongxun ^a,c   Barrett, Mark ^a   Glennon, Brian ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b Massachusetts Institute of Technology   (United States)

^c TIANJIN UNIVERSITY   (China)

Author keywords

Continuous crystallization; Crystallization; Multiphase flow; Pharmaceuticals; Pneumatic conveying; Process analytical technology

Indexed keywords

CRYSTALLIZATION; CRYSTALLIZERS; DRUG PRODUCTS; GRAIN SIZE AND SHAPE; MULTIPHASE FLOW; SIZE DISTRIBUTION;

ANTI-SOLVENT CRYSTALLIZATION; BATCH CRYSTALLIZATION; CONTINUOUS CRYSTALLIZATION; CONTINUOUS OPERATION; CRYSTAL SIZE DISTRIBUTIONS; PHARMACEUTICAL CRYSTALLIZATIONS; PNEUMATIC CONVEYING; PROCESS ANALYTICAL TECHNOLOGY;

BENZOIC ACID;

EID: 84884557060     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2013.09.006     Document Type: Article

References (24)

1. Alvarez A.J., Singh A., Myerson A.S. Crystallization of cyclosporine in a multi-stage MSMPR crystallizer. Crystal Growth and Design 2011, 11(10):4392-4400.
2. Barrett M., O'Grady D., Casey E., Glennon B. The role of meso-mxing in anti-solvent crystallization processes. Chemical Engineering Science 2011, 66(12):253-2534.
3. Barrett M., McNamara M., Hao H., Barrett P., Glennon B. Supersaturation tracking for the development, optimization and control of crystallization processes. Chemical Engineering Research and Design 2010, 88:1108-1119.
4. Braden, T.M.; Gonzalez, M.A.; Jines, A.R.; Johnson, M.D.; Sun, W.M., 2009. Reactors and Methods for Processing Reactants Therein. World Patent No. 023515 A2,Feb 19.
5. Bushrab F.N., Muller R.H. Nanocrystals of poorly soluble drugs for oral administration. Journal of New Drugs 2003, 5:20-22.
6. Chen J., Sarma B., Evans J.M.B., Myerson A.S. Pharmacuetical crystallization. Crystal Growth and Design 2011, 11(4):887-895.
7. Eder J.P.E, Radl S., Schmitt E., Innerhorfer S., Maier M., Gruber-Woelfler H., Khinast G. Continuously seeded, continuously operated tubular crystallizer for the production of active pharmaceutical ingredients. Crystal Growth and Design 2010, 10(5):2247-2257.
8. Ferguson S., Morris G., Hao H., Barrett M., Glennon B. In-situ monitoring and characterization of plug flow crystallizers. Chemical Engineering Science 2012, 77:105-111.
9. Hacherl J.M., Paul E.L., Buettner H.M. Investigation of impinging jet crystallization with a calcium oxalate model system. AIChE Journal 2003, 49:2352-2362.
10. Lawton S., Steele G., Shering P. Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer. Organic Process Research and Development 2009, 13:1357-1363.
11. Lipinski CA. Poor aqueous solubility - an industry wide problem in drug discovery. American Pharmaceutical Review 2003, 5:82-85.
12. Lindenberg C., Schöll J., Vicum L., Mazzotti M., Brozio J. Experimental characterization and multi-scale modeling of mixing in static mixers. Chemical Engineering Science 2008, 63:4135-4148.
13. Lindenberg C., Mazzotti M. Experimental characterization and multi-scale modeling of mixing in static mixers. Part 2. Effect of viscosity and scale-up. Chemical Engineering Science 2009, 64:4286-4294.
14. Lindenberg C., Mazzotti M. Continuous precipitation of l-glutamic acid monohydrate in a micromixer: estimation of nucleation and growth kinetics. AIChE Journal 2011, 57(4):942-950.
15. McKenzie P., Kiang S., Tom J., Rubin A.E., Futran M. Can pharmaceutical process development become high tech. AIChE Journal 2006, 52:3990-3994.
16. Méndez del Rio J.R., Rousseau R. Batch and tubular-batch crystallization of paracetmol: crystal size distribution and polymorph formation. Crystal Growth and Design 2006, 6(6):1407-1414.
17. Midler, M., Paul, E.L., Whittington, E.F., Futran, M., Liu, P.D., Hsu, J., Pan, S.H., 1991. Crystallization Method to Improve Crystal Structure and Size. U.S. Patent No. 5,314,506.
18. Nývlt J. The Kinetics of Industrial Crystallization 1985, Elsevier, Amsterdam.
19. O'Grady D., Barrett M., Casey E., Glennon B. The effect of mixing on the metastable zone width and nucleation kinetics in the anti-solvent crystallization of benzoic acid. Chemical Engineering Research and Design 2007, 85:945-952.
20. Plumb K. Continuous processing in the pharmaceutical industry: changing the mind set. Chemical Engineering Research and Design 2005, 2005(83):730-738.
21. Randolph A.D., Larson M.A. Theory of particulate processes: analysis and techniques of continuous crystallization 1988, Academic Press Inc., San Diego. 2nd ed.
22. Schaber S.D., Gerogiorgis D.I., Ramachandran R., Evans J.M.B, Barton P.I., Trout B.L. Economic analysis of integrated continuous and batch pharmaceutical manufacture: a case study. Industrial and Engineering Chemistry Research 2011, 50(17):10083-10092.
23. Ståhl M., Åslund B.L, Rasmuson Å.C. Reaction crystallization kinetics of benzoic acid. AIChE Journal 2001, 47:1544-1560.
24. Wong S.Y., Tatusko A.P, Trout B.L., Myerson A.S. Development of continuous crystallization processes using a single stage mixed-suspension, mixed-product removal crystallizer with recycle. Crystal Growth and Design 2012, 12(11):5701-5707.