Increased prevalence of luminal narrowing and stricturing identified by enterography in pediatric crohn's disease patients with elevated granulocyte-macrophage colony stimulating factor autoantibodies

Inflammatory Bowel Diseases

Volumn 19, Issue 10, 2013, Pages 2146-2154

  Dykes, Dana M H ^a,d   Towbin, Alexander J ^b   Bonkowski, Erin ^a   Chalk, Claudia ^c   Bezold, Ramona ^a   Lake, Kathleen ^a   Kim, Mi Ok ^a,b   Heubi, James E ^a   Trapnell, Bruce C ^c   Podberesky, Daniel J ^b   Denson, Lee A ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c Division of Pulmonary Biology   (United States)

^d College of Medicine ^*  (United States)

Author keywords

CT enterography; Cytokine autoantibody; Enterography; Granulocyte macrophage colony stimulating factor; Luminal narrowing; MR enterography; Pediatric Crohn's disease; Stricture

Indexed keywords

AUTOANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR ANTIBODY;

ABDOMINAL ABSCESS; ADOLESCENT; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CROHN DISEASE; DISEASE ACTIVITY; DISEASE SEVERITY; ENTEROPATHY; FEMALE; HUMAN; INTESTINE FISTULA; LUMINAL NARROWING; LUMINAL STRICTURE; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PREVALENCE; PRIORITY JOURNAL; SCORING SYSTEM;

ADOLESCENT; AUTOANTIBODIES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CONSTRICTION, PATHOLOGIC; CROHN DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTESTINAL DISEASES; MAGNETIC RESONANCE IMAGING; MALE; PROGNOSIS; PROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84884547644     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e31829706e0     Document Type: Article

References (36)

1. Malaty HM, Fan X, Opekun AR, et al. Rising incidence of inflammatory bowel disease among children: a 12-year study. J Pediatr Gastroenterol Nutr. 2010;50:27-31.
2. Polito JM II, Childs B, Mellits ED, et al. Crohn's disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology. 1996; 111:580-586.
3. Schaefer ME, Machan JT, Kawatu D, et al. Factors that determine risk for surgery in pediatric patients with Crohn's disease. Clin Gastroenterol Hepatol. 2010;8:789-794.
4. Van Limbergen J, Russell RK, Drummond HE, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology. 2008;135:1114-1122.
5. Levine A, Griffiths A, Markowitz J, et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis. 2011;17:1314-1321.
6. Heyman MB, Kirschner BS, Gold BD, et al. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr. 2005;146:35-40.
7. Vernier-Massouille G, Balde M, Salleron J, et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology. 2008;135:1106-1113.
8. Han X, Uchida K, Jurickova I, et al. Granulocyte-macrophage colonystimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009;136:1261-1271, e1-e3.
9. Uchida K, Beck DC, Yamamoto T, et al. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med. 2007;356:567-579.
10. Nylund CM, D'Mello S, Kim MO, et al. Granulocyte macrophagecolony- stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. J Pediatr Gastroenterol Nutr. 2011;52:542-548.
11. Solem CA, Loftus EV Jr, Fletcher JG, et al. Small-bowel imaging in Crohn's disease: a prospective, blinded, 4-way comparison trial. Gastrointest Endosc. 2008;68:255-266.
12. Lee SS, Kim AY, Yang SK, et al. Crohn disease of the small bowel: comparison of CT enterography, MR enterography, and small-bowel followthrough as diagnostic techniques. Radiology. 2009;251:751-761.
13. Siddiki HA, Fidler JL, Fletcher JG, et al. Prospective comparison of stateof-the-art MR enterography and CT enterography in small-bowel Crohn's disease. AJR Am J Roentgenol. 2009;193:113-121.
14. Bruining DH, Siddiki HA, Fletcher JG, et al. Prevalence of penetrating disease and extraintestinal manifestations of Crohn's disease detected with CT enterography. Inflamm Bowel Dis. 2008;14:1701-1706.
15. Messaris E, Chandolias N, Grand D, et al. Role of magnetic resonance enterography in the management of Crohn disease. Arch Surg. 2010;145: 471-475.
16. Wallihan DB, Towbin AJ, Denson LA, et al. Inflammatory bowel disease in children and adolescents: assessing the diagnostic performance and interreader agreement of magnetic resonance enterography compared to histopathology. Acad Radiol. 2012;19:819-826.
17. Vogel J, da Luz Moreira A, Baker M, et al. CT enterography for Crohn's disease: accurate preoperative diagnostic imaging. Dis Colon Rectum. 2007;50:1761-1769.
18. Bruining DH, Siddiki HA, Fletcher JG, et al. Benefit of computed tomography enterography in Crohn's disease: effects on patient management and physician level of confidence. Inflamm Bowel Dis. 2012; 18:219-225.
19. Horsthuis K, de Ridder L, Smets AM, et al. Magnetic resonance enterography for suspected inflammatory bowel disease in a pediatric population. J Pediatr Gastroenterol Nutr. 2010;51:603-609.
20. Fornasa F, Benassuti C, Benazzato L. Role of magnetic resonance enterography in differentiating between fibrotic and active inflammatory small bowel stenosis in patients with Crohn's disease. J Clin Imaging Sci. 2011;1:35.
21. Adler J, Punglia DR, Dillman JR, et al. Computed tomography enterography findings correlate with tissue inflammation, not fibrosis in resected small bowel Crohn's disease. Inflamm Bowel Dis. 2012;18:849-856.
22. Horsthuis K, Bipat S, Stokkers PC, et al. Magnetic resonance imaging for evaluation of disease activity in Crohn's disease: a systematic review. Eur Radiol. 2009;19:1450-1460.
23. Rimola J, Rodriguez S, Garcia-Bosch O, et al. Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease. Gut. 2009;58:1113-1120.
24. Rimola J, Ordas I, Rodriguez S, et al. Magnetic resonance imaging for evaluation of Crohn's disease: validation of parameters of severity and quantitative index of activity. Inflamm Bowel Dis. 2011;17:1759-1768.
25. Lawrance IC, Welman CJ, Shipman P, et al. Correlation of MRI-determined small bowel Crohn's disease categories with medical response and surgical pathology. World J Gastroenterol. 2009;15:3367-3375.
26. Kappelman MD, Crandall WV, Colletti RB, et al. Short pediatric Crohn's disease activity index for quality improvement and observational research. Inflamm Bowel Dis. 2011;17:112-117.
27. Turner D, Otley AR, Mack D, et al. Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology. 2007;133:423-432.
28. Siegel CA, Siegel LS, Hyams JS, et al. Real-time tool to display the predicted disease course and treatment response for children with Crohn's disease. Inflamm Bowel Dis. 2011;17:30-38.
29. Lichtenstein GR, Targan SR, Dubinsky MC, et al. Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior. Inflamm Bowel Dis. 2011;17:2488-2496.
30. Amre DK, Lu SE, Costea F, et al. Utility of serological markers in predicting the early occurrence of complications and surgery in pediatric Crohn's disease patients. Am J Gastroenterol. 2006;101:645-652.
31. Markowitz J, Kugathasan S, Dubinsky M, et al. Age of diagnosis influences serologic responses in children with Crohn's disease: a possible clue to etiology? Inflamm Bowel Dis. 2009;15:714-719.
32. Ilangovan R, Burling D, George A, et al. CT enterography: review of technique and practical tips. Br J Radiol. 2012;85:876-886.
33. Higgins PD, Caoili E, Zimmermann M, et al. Computed tomographic enterography adds information to clinical management in small bowel Crohn's disease. Inflamm Bowel Dis. 2007;13:262-268.
34. Jensen MD, Ormstrup T, Vagn-Hansen C, et al. Interobserver and intermodality agreement for detection of small bowel Crohn's disease with MR enterography and CT enterography. Inflamm Bowel Dis. 2011;17:1081-1088.
35. Uchida K, Nakata K, Suzuki T, et al. Granulocyte/macrophage- colonystimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood. 2009;113:2547-2556.
36. Svenson M, Hansen MB, Ross C, et al. Antibody to granulocyte-macrophage colony-stimulating factor is a dominant anti-cytokine activity in human IgG preparations. Blood. 1998;91:2054-2061.