Morphologic characteristics and immunohistochemical profile of diffuse intrinsic pontine gliomas

American Journal of Surgical Pathology

Volumn 37, Issue 9, 2013, Pages 1357-1364

  Ballester, Leomar Y ^a   Wang, Zengfeng ^a   Shandilya, Shaefali ^b   Miettinen, Markku ^a   Burger, Peter C ^c   Eberhart, Charles G ^c   Rodriguez, Fausto J ^c   Raabe, Eric ^c   Nazarian, Javad ^d   Warren, Katherine ^b   Quezado, Martha M ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Brain tumor; Brainstem; DIPG; Gliomas; Pediatric glioma; Pontine

Indexed keywords

TUMOR MARKER;

ADOLESCENT; ARTICLE; BIOPSY; BRAIN STEM TUMOR; CANCER GRADING; CHEMISTRY; CHILD; FEMALE; GLIOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MITOSIS INDEX; MORTALITY; PATHOLOGY; PREDICTIVE VALUE; PRESCHOOL CHILD; PROGNOSIS; TISSUE MICROARRAY;

ADOLESCENT; BIOPSY; BRAIN STEM NEOPLASMS; CHILD; CHILD, PRESCHOOL; FEMALE; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MITOTIC INDEX; NEOPLASM GRADING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84884524085     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318294e817     Document Type: Article

References (27)

1. Pollack I, Finkelstein S, Woods J, et al. Expression of p53 and prognosis in children with malignant gliomas. N Engl J Med. 2002;346:420-427.
2. Fangusaro J. Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas. J Child Neurol. 2009;24:1409-1417.
3. Hargrave D, Bartels U, Bouffet E. Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol. 2006;7:241-248.
4. MacDonald T. Diffuse intrinsic pontine glioma (DIPG): time to biopsy again? Pediatr Blood Cancer. 2012;58:487-488.
5. Albright A, Packer R, Zimmerman R, et al. Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children's Cancer Group. Neurosurgery. 1993;33:1026.
6. Leach P, Estlin E, Coope D, et al. Diffuse brainstem gliomas in children: should we or shouldn't we biopsy? Br J Neurosurg. 2008; 22:619-624.
7. Wolff J, Rytting M, Vats T, et al. Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience. J Neurooncol. 2011;106:391-397.
8. Grill J, Puget S, Andreiuolo F, et al. Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer. 2012;58:489-491.
9. Khuong-Quang D.-A, Buczkowicz P, Rakopoulos P, et al. K27M mutation in histone H3. 3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 2012;124:439-447.
10. Guo Y, Liu S, Wang P, et al. Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology. 2011;59:763-775.
11. Monje M, Mitra SS, Freret ME, et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci USA. 2011;108:4453-4458.
12. Miettinen M. A simple method for generating multitissue blocks without special equipment. Appl Immunohistochem Mol Morphol. 2012;20:410-412.
13. Yoshimura J, Onda K, Tanaka R, et al. Clinicopathological study of diffuse type brainstem gliomas: analysis of 40 autopsy cases. Neurol Med Chir (Tokyo). 2003;43:375-382; discussion 382.
14. Wong AJ, Bigner SH, Bigner DD, et al. Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci USA. 1987;84:6899-6903.
15. Libermann TA, Nusbaum HR, Razon N, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature. 1985;313:144-147.
16. Otero J, Rowitch D, Vandenberg S. OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms. J Neurooncol. 2011;104:423-438.
17. Sturm D, Witt H, Hovestadt V, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell. 2012;22:425-437.
18. Ligon KL, Huillard E, Mehta S, et al. Olig2-regulated lineagerestricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007;53:503-517.
19. Arai H, Ikota H, Sugawara K.-I, et al. Nestin expression in brain tumors: its utility for pathological diagnosis and correlation with the prognosis of high-grade gliomas. Brain Tumor Pathol. 2012;29: 160-167.
20. Milde T, Hielscher T, Witt H, et al. Nestin Expression Identifies Ependymoma Patients with Poor Outcome. Brain Pathol. 2012; 22:848-860.
21. Park D, Xiang AP, Mao FF, et al. Nestin is required for the proper self-renewal of neural stem cells. Stem Cells. 2010;28:2162-2171.
22. Abdouh M, Facchino S, Chatoo W, et al. BMI1 sustains human glioblastoma multiforme stem cell renewal. J Neurosci. 2009;29: 8884-8896.
23. Louis D, RubioM, Correa K, et al. Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens. J Neuropathol Exp Neurol. 1993;52:507-515.
24. Oka H, Utsuki S, Tanizaki Y, et al. Clinicopathological features of human brainstem gliomas. Brain Tumor Pathol. 2013;30:1-7.
25. Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765-773.
26. Bredel M, Pollack I, Hamilton R, et al. Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood. Clin Cancer Res. 1999;5: 1786-1792.
27. Li G, Mitra S, Monje M, et al. Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas. J Neurooncol. 2012;108:395-402.