Similarities and differences between sexes in regional loss of cortical and trabecular bone in the mid-femoral neck: The AGES-Reykjavik longitudinal study

Journal of Bone and Mineral Research

Volumn 28, Issue 10, 2013, Pages 2165-2176

  Johannesdottir, Fjola ^a   Aspelund, Thor ^a,b   Reeve, Jonathan ^c   Poole, Kenneth E ^d   Sigurdsson, Sigurdur ^b   Harris, Tamara B ^e   Gudnason, Vilmundur G ^a,b   Sigurdsson, Gunnar ^a,b,f  

^a UNIVERSITY OF ICELAND   (Iceland)

^b ICELANDIC HEART ASSOCIATION   (Iceland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e NATIONAL INSTITUTE ON AGING   (United States)

^f LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

aging; cortical thickness; longitudinal; proximal end of femur; QCT

Indexed keywords

AGED; ARTICLE; BONE DENSITY; BONE MASS; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; CORTICAL THICKNESS (BONE); DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; OSTEOLYSIS; SEX DIFFERENCE; TRABECULAR BONE;

AGING; CORTICAL THICKNESS; LONGITUDINAL; PROXIMAL END OF FEMUR; QCT;

AGED; AGING; BONE RESORPTION; FEMALE; FEMUR NECK; FOLLOW-UP STUDIES; GENE-ENVIRONMENT INTERACTION; HUMANS; ICELAND; IMAGING, THREE-DIMENSIONAL; LONGITUDINAL STUDIES; MALE; MOTOR ACTIVITY; SEX CHARACTERISTICS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84884508823     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1960     Document Type: Article

References (59)

1. Kanis J., The incidence of hip fracture in Europe. Osteoporos Int. 1993; 3: 10-5.
2. Moyad M., Osteoporosis: a rapid review of risk factors and screening methods. Urol Oncol. 2003; 21: 375-9.
3. Lang TF, Augat P, Lane NE, Genant HK., Trochanteric hip fracture: strong association with spinal trabecular bone mineral density measured with quantitative CT. Radiology. 1998; 209: 525-30.
4. Mautalen CA, Vega EM, Einhorn TA., Are the etiologies of cervical and trochanteric hip fractures different?. Bone. 1996; 18: 133S-7S.
5. Johannesdottir F, Poole KE, Reeve J, Siggeirsdottir K, Aspelund T, Mogensen B, Jonsson BY, Sigurdsson S, Harris TB, Gudnason VG, Sigurdsson G., Distribution of cortical bone in the femoral neck and hip fracture: a prospective case-control analysis of 143 incident hip fractures; the AGES-REYKJAVIK Study. Bone. 2011; 48: 1268-76.
6. Burger H, Van Daele PL, Algra D, van den Ouweland FA, Grobbee DE, Hofman A, van Kuijk C, Schutte HE, Birkenhager JC, Pols HA., The association between age and bone mineral density in men and women aged 55 years and over: the Rotterdam study. Bone Miner. 1994; 25: 1-13.
7. Cawthon PM, Ewing SK, McCulloch CE, Ensrud KE, Cauley JA, Cummings SR, Orwoll ES., Loss of hip BMD in older men: the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 2009; 24: 1728-35.
8. Melton LJ 3rd, Khosla S, Atkinson EJ, Oconnor MK, Ofallon WM, Riggs BL., Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporos Int. 2000; 11: 592-9.
9. Riggs BL, Melton LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, McDaniel L, Amin S, Rouleau PA, Khosla S., A population based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008; 23: 205-14.
10. Sigurdsson G, Aspelund T, Chang M, Jonsdottir B, Sigurdsson S, Eiriksdottir G, Gudmundsson A, Harris TB, Gudnason V, Lang T., Increasing sex difference in bone strength in old age: the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-REYKJAVIK). Bone. 2006; 39: 644-51.
11. Steiger P, Cummings SR, Black DM, Spencer NE, Genant HK., Age-related decrements in bone mineral density in women over 65. J Bone Miner Res. 1992; 7: 625-32.
12. Greenspan SL, Maitland LA, Myers ER, Krasnow MB, Kido TH., Femoral bone loss progresses with age: a longitudinal study in women over age 65. J Bone Miner Res. 1994; 9: 1959-65.
13. Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA., Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ. 1994; 309: 691-5.
14. Boyce TM, Bloebaum RD., Cortical aging differences and fracture implications for the human femoral neck. Bone. 1993; 14: 769-78.
15. Mayhew PM, Thomas CD, Clement JG, Loveridge N, Beck TJ, Bonfield W, Burgoyne CJ, Reeve J., Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet. 2005; 366: 129-35.
16. Poole KE, Mayhew PM, Rose CM, Brown JK, Bearcroft PJ, Loveridge N, Reeve J., Changing structure of the femoral neck across the adult female lifespan. J Bone Miner Res. 2010; 25: 482-91.
17. Thomas CD, Mayhew PM, Power J, Poole KE, Loveridge N, Clement JG, Burgoyne CJ, Reeve J., Femoral neck trabecular bone: loss with aging and role in preventing fracture. J Bone Miner Res. 2009; 24: 1808-18.
18. Milovanovic P, Djonic D, Marshall R, Hahn M, Nikolic S, Zivkovic V, Amling M, Djuric M., Micro-structural basis for particular vulnerability of the superolateral neck trabecular bone in the postmenopausal women with hip fractures. Bone. 2012; 50: 63-8.
19. Lotz JC, Cheal EJ, Hayes WC., Stress distributions within the proximal femur during gait and falls: Implications for osteoporotic fracture. Osteoporosis Int. 1995; 5: 252-61.
20. Verhulp E, van Rietbergen B, Huiskes R., Load distribution in the healthy and osteoporotic human proximal femur during a fall to the side. Bone. 2008; 42: 30-5.
21. Khoo BCC, Brown K, Cann C, Zhu K, Henzell S, Low V, Gustafsson S, Price RI, Prince RL., Comparison of QCT-derived and DXA-derived areal bone mineral density and T scores. Osteoporos Int. 2009; 20: 1539-45.
22. Harris TB, Launer LJ, Eiriksdottir G, Kjartansson O, Jonsson PV, Sigurdsson G, Thorgeirsson G, Aspelund T, Garcia ME, Cotch MF, Hoffman HJ, Gudnason V., Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol. 2007; 165: 1076-87.
23. Crabtree N, Loveridge N, Parker M, Rushton N, Power J, Bell KL, Beck TJ, Reeve J., Intracapsular hip fracture and the region-specific loss of cortical bone: analysis by peripheral quantitative computed tomography. J Bone Miner Res. 2001; 16: 1318-28.
24. Kuiper J, Van Kuijk C, Grashuis J., Distribution of trabecular and cortical bone related to geometry. a quantitative computed tomography study of the femoral neck. Invest Radiol. 1997; 32: 83-9.
25. Stephenson P, Seedhom BB., Modelling femoral curvature in the sagittal plane: a cadaveric study. Proc Inst Mech Eng. 2001; 215: 221-8.
26. Poole KES, Rose CM, Mayhew PM, Brown JK, Clement JG, Thomas CD, Reeve J, Loveridge N., editors. Thresholds for the measurement of cortical thickness in-vivo using computed tomography (The 100 women study). Bone Research Society/British Orthopaedic Research Society (BRS/BORS) Second Joint Meeting; 2008 June 23-25; Manchester, UK.
27. Bell KL, Loveridge N, Jordan GR, Power J, Constant CR, Reeve J., A novel mechanism for induction of increased cortical porosity in cases of intracapsular hip fracture. Bone. 2000; 27: 297-304.
28. Lovejoy CO., Evolution of human walking. Sci Am. 1988; 259: 118-25.
29. Power J, Loveridge N, Lyon A, Rushton N, Parker M, Reeve J., Osteoclastic cortical erosion as a determinant of subperiosteal osteoblastic bone formation in the femoral neck's response to BMU imbalance: effects of stance-related loading and hip fracture. Osteoporos Int. 2005; 16: 1049-56.
30. Nikander R, Kannus P, Dastidar P, Hannula M, Harrison L, Cervinka T, Narra NG, Aktour R, Arola T, Eskola H, Soimakallio S, Heinonen A, Hyttinen J, Sievänen H., Targeted exercises against hip fragility. Osteoporos Int. 2008; 20: 1321-8.
31. Gudmundsdottir SL, Oskarsdottir D, Indridason OS, Franzson L, Sigurdsson G., Risk factors for bone loss in the hip of 75-year-old women: a 4-year follow-up study. Maturitas. 2010; 67: 256-61.
32. Knoke JD, Barrett-Connor E., Weight loss: a determinant of hip bone loss in older men and women. The Rancho Bernardo Study. Am J Epidemiol. 2003; 158: 1132-8.
33. Uusi-Rasi K, Sievanen H, Pasanen M, Oja P, Vuori I., Maintenance of body weight, physical activity and calcium intake helps preserve bone mass in elderly women. Osteoporos Int. 2001; 12: 373-9.
34. Reid IR., Fat and bone. Arch Biochem Biophys. 2010; 503: 20-7.
35. Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B., Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1998; 339: 733-8.
36. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang T, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES., Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res. 2008; 23: 1326-33.
37. Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM., Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993; 341: 72-5.
38. Bonnet N, Ferrari S., Exercise and the skeleton: how it works and what it really does. IBMS BoneKEy. 2010; 7: 235-48.
39. Cousins J, Petit M, Paudel M, Taylor B, Hughes J, Cauley J, Zmuda J, Cawthon P, Ensrud K., Muscle power and physical activity are associated with bone strength in older men: the osteoporotic fractures in men study. Bone. 2010; 47: 205-11.
40. Sherrington C, Whitney J, Lord S, Herbert R, Cumming R, Close J., Effective exercise for the prevention of falls: a systematic review and meta-analysis. J Am Geriatr Soc. 2008; 56: 2234-43.
41. Rianon N, Lang T, Sigurdsson G, Eiriksdottir G, Sigurdsson S, Garcia M, Pajala S, Koster A, Yu B, Selwyn B, Taylor W, Kapadia A, Gudnason V, Launer L, Harris T., Lifelong physical activity in maintaining bone strength in older men and women of the Age, Gene/Environment Susceptibility-Reykjavik Study. Osteoporos Int. 2012; 23: 2303-12.
42. Ito M, Nakata T, Nishida A, Uetani M., Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women. Bone. 2011; 48: 627-30.
43. Riggs BL, Melton LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S., Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004; 19: 1945-54.
44. Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD., Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res. 2006; 21: 1856-63.
45. Power J, Loveridge N, Rushton N, Parker M, Reeve J., Intracapsular bone formation on the external "periosteal" surface of the femoral neck: an investigation in cases of hip fracture and controls. Osteoporos Int. 2003; 14: 146-51.
46. Kaptoge S, Dalzell N, Loveridge N, Beck TJ, Khaw KT, Reeve J., Effects of gender, anthropometric variables, and aging on the evolution of hip strength in men and women aged over 65. Bone. 2003; 32: 561-70.
47. Marshall L, Lang T, Lambert L, Zmuda J, Ensrud K, Orwoll E., Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res. 2006; 21: 1197-206.
48. Schapira D, Schapira C., Osteoporosis: the evolution of a scientific term. Osteoporos Int. 1992; 2: 164-7.
49. Zebaze RM, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E., Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. 2010; 375: 1729-36.
50. de Bakker PM, Manske SL, Ebacher V, Oxland TR, Cripton PA, Guy P., During sideways falls proximal femur fractures initiate in the superolateral cortex: evidence from high-speed video of simulated fractures. J Biomech. 2009; 42: 1917-25.
51. Poole KES, Treece GM, Mayhew PM, Vaculík J, Dungl P, Horák M, Stepán JJ, Gee AH., Cortical thickness mapping to identify focal osteoporosis in patients with hip fracture. PLoS One. 2012; 7: e38466.
52. Treece GM, Gee AH, Mayhew PM, Poole KE., High resolution cortical bone thickness measurement from clinical CT data. Med Image Anal. 2010; 14: 276-90.
53. Davis KA, Burghardt AJ, Link TM., The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography. Calcif Tissue Int. 2007; 81: 364-71.
54. Prevrhal S, Fox JC, Shepherd JA, Genant HK., Accuracy of CT-based thickness measurement of thin structures: modeling of limited spatial resolution in all three dimensions. Med Phys. 2003; 30: 1-8.
55. Loveridge N, Power J, Reeve J, Boyde A., Bone mineralization density and femoral neck fragility. Bone. 2004; 35: 929-41.
56. Khoo BC, Beck TJ, Qiao QH, Parakh P, Semanick L, Prince RL, Singer KP, Price RI., In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials. Bone. 2005; 37: 112-21.
57. Walker M, McMahon D, Udesky J, Liu G, Bilezikian J., Application of high resolution skeletal imaging to measurements of volumetric bone density and skeletal microarchitecture in Chinese American and white women: explanation of a paradox. J Bone Miner Res. 2009; 24: 1953-9.
58. Wang X, Wang Q, Ghasem-Zadesh A, Evans A, McLeod C, Iuiano-Burns S, Seeman E., Differences in macro and micro-architecture of the appendicular skeleton in young Chinese and white women. J Bone Miner Res. 2009; 24: 1946-52.
59. Lorentzon M, Landin K, Mellström D, Ohlsson C., Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men. J Bone Miner Res. 2006; 21: 1871-8.