Prognostic significance of partial tumor regression after preoperative chemoradiotherapy for rectal cancer: A meta-analysis

Diseases of the Colon and Rectum

Volumn 56, Issue 9, 2013, Pages 1093-1101

  Lee, Yen Chien ^a,b   Hsieh, Chung Cheng ^c   Chuang, Jen Pin ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b Tainan Hospital   (Taiwan)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Meta analysis; Partial tumor regression; Preoperative chemoradiotherapy; Rectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT;

ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CHEMORADIOTHERAPY; DATA BASE; DISEASE FREE SURVIVAL; HUMAN; META ANALYSIS; OUTCOME ASSESSMENT; PREOPERATIVE PERIOD; RECTUM CANCER; TREATMENT RESPONSE; TUMOR REGRESSION;

CHEMORADIOTHERAPY, ADJUVANT; DISEASE-FREE SURVIVAL; HUMANS; MODELS, STATISTICAL; NEOPLASM GRADING; PROGNOSIS; RECTAL NEOPLASMS; RECTUM; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 84884493712     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0b013e318298e36b     Document Type: Article

References (54)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
2. Guillem JG, Chessin DB, Cohen AM, et al. Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer. Ann Surg. 2005;241:829-836.
3. Osti MF, Valeriani M, Masoni L, Tombolini V, Enrici RM. Neoadjuvant chemoradiation for locally advanced carcinoma of the rectum. Tumori. 2004;90:303-309. (Pubitemid 38981277)
4. Wheeler JM, Warren BF, Mortensen NJ, et al. Quantification of histologic regression of rectal cancer after irradiation: a proposal for a modified staging system. Dis Colon Rectum. 2002;45:1051-1056.
5. Habr-Gama A, de Souza PM, Ribeiro U Jr, et al. Low rectal cancer: impact of radiation and chemotherapy on surgical treatment. Dis Colon Rectum. 1998;41:1087-1096. (Pubitemid 28432448)
6. Hiotis SP, Weber SM, Cohen AM, et al. Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients. J Am Coll Surg. 2002;194:131-135.
7. Zorcolo L, Rosman AS, Restivo A, et al. Complete pathologic response after combined modality treatment for rectal cancer and long-term survival: a meta-analysis. Ann Surg Oncol. 2012;19:2822-2832.
8. Martin ST, Heneghan HM, Winter DC. Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer. Br J Surg. 2012;99:918-928.
9. Maas M, Nelemans PJ, Valentini V, et al. Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data. Lancet Oncol. 2010;11:835-844.
10. Huebner M, Wolff BG, Smyrk TC, Aakre J, Larson DW. Partial pathologic response and nodal status as most significant prognostic factors for advanced rectal cancer treated with preoperative chemoradiotherapy. World J Surg. 2012;36:675-683.
11. Puppa G, Sonzogni A, Colombari R, Pelosi G. TNM staging system of colorectal carcinoma: a critical appraisal of challenging issues. Arch Pathol Lab Med. 2010;134:837-852.
12. Bujko K, Kolodziejczyk M, Nasierowska-Guttmejer A, et al.; Polish Colorectal Cancer Group. Tumour regression grading in patients with residual rectal cancer after preoperative chemoradiation. Radiother Oncol. 2010;95:298-302.
13. Dhadda AS, Dickinson P, Zaitoun AM, Gandhi N, Bessell EM. Prognostic importance of Mandard tumour regression grade following pre-operative chemo/radiotherapy for locally advanced rectal cancer. Eur J Cancer. 2011;47:1138-1145.
14. Mandard AM, Dalibard F, Mandard JC, et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma: clinicopathologic correlations. Cancer. 1994;73:2680-2686. (Pubitemid 24166250)
15. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis. 1997;12:19-23. (Pubitemid 27138353)
16. Rödel C, Martus P, Papadoupolos T, et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol. 2005;23:8688-8696. (Pubitemid 46211512)
17. Junker K. Therapy-induced morphological changes in lung cancer [in German]. Pathologe. 2004;25:475-480. (Pubitemid 40022471)
18. Glynne-Jones R, Anyamene N. Just how useful an endpoint is complete pathological response after neoadjuvant chemo radiation in rectal cancer? Int J Radiat Oncol Biol Phys. 2006;66:319-320. (Pubitemid 44332753)
19. Machiels JP, Aydin S, Bonny MA, Hammouch F, Sempoux C. What is the best way to predict disease-free survival after preoperative radiochemotherapy for rectal cancer patients: tumor regression grading, nodal status, or circumferential resection margin invasion? J Clin Oncol. 2006;24:1319-1321.
20. Morgan MJ, Koorey DJ, Painter D, et al. Histological tumour response to pre-operative combined modality therapy in locally advanced rectal cancer. Colorectal Dis. 2002;4:177-183. (Pubitemid 34567875)
21. Ryan R, Gibbons D, Hyland JM, et al. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology. 2005;47:141-146. (Pubitemid 41113116)
22. GA Wells, B Shea, D O?Connell, J Peterson, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis. http://www.ohri.ca/programs/clinical-epidemiology/oxford.htm. Accessed March 22, 2013.
23. García VM, Batlle JF, Casado E, et al. Immunohistochemical analysis of tumour regression grade for rectal cancer after neoadjuvant chemoradiotherapy. Colorectal Dis. 2011;13:989-998.
24. Beddy D, Hyland JM, Winter DC, et al. A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy. Ann Surg Oncol. 2008;15:3471-3477.
25. Losi L, Luppi G, Gavioli M, et al. Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy. Int J Colorectal Dis. 2006;21:645-651. (Pubitemid 44446064)
26. Suárez J, Vera R, Balén E, et al. Pathologic response assessed by Mandard grade is a better prognostic factor than down staging for disease-free survival after preoperative radiochemotherapy for advanced rectal cancer. Colorectal Dis. 2008; 10:563-568. (Pubitemid 351803062)
27. Wheeler JM, Dodds E, Warren BF, et al. Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: correlation with rectal cancer regression grade. Dis Colon Rectum. 2004;47:2025-2031. (Pubitemid 40179060)
28. Vecchio FM, Valentini V, Minsky BD, et al. The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys. 2005;62:752-760. (Pubitemid 40779765)
29. Lindebjerg J, Spindler KL, Ploen J, Jakobsen A. The prognostic value of lymph node metastases and tumour regression grade in rectal cancer patients treated with long-course preoperative chemoradiotherapy. Colorectal Dis. 2009;11:264-269.
30. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815-2834. (Pubitemid 28562978)
31. Shin JS, Jalaludin B, Solomon M, Hong A, Lee CS. Histopathological regression grading versus staging of rectal cancer following radiotherapy. Pathology. 2011;43:24-30.
32. Bouzourene H, Bosman FT, Seelentag W, Matter M, Coucke P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer. 2002;94:1121-1130. (Pubitemid 34150868)
33. Ruo L, Tickoo S, Klimstra DS, et al. Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg. 2002;236:75-81. (Pubitemid 34686453)
34. Keranen SR, Faus C, Garcia-Granero E, et al. iTumor regression grade after preoperative chemoradiotherapy in patients with locally advanced rectal cancer as a predictor of outcome. Ann Oncol. 2008;19:viii143.
35. Edden Y, Shawki S, Blount S, Stone E, Wexner S, Berho M. Capecitabine vs. 5-FU as neoadjuvant therapy for advanced rectal adenocarcinoma. Is there a difference in tumor regression grade and downstaging of the surgical specimen? Dis Colon Rectum. 2010;53:614.
36. Benzoni E, Terrosu G, Intersimone D, et al. Instrumental clinical restaging, pathological evaluation, and tumor regression grading: how to assess the response to neoadjuvant chemoradiotherapy for rectal cancer. Int J Colorectal Dis. 2007;22:7-13. (Pubitemid 44742333)
37. Vecchio FM, Barba MC, Gambacorta MA, et al. Pathologic tumor regression grade (TRG) and 10-year outcomes in 502 patients with rectal cancer treated with preoperative therapy. Lab Invest. 2010;90:171A.
38. Hongo K, Kazama S, Sunami E, et al. Immunohistochemical detection of CD133 is associated with tumor regression grade after chemoradiotherapy in rectal cancer. Med Oncol. 2012;29:2849-2857.
39. Rasulov AO , Shelygin Iu A, Boiko AV, Droshneva IV. Prognostic value of rectal cancer regression after preoperative chemoradiation therapy [in Russian]. Vestn Rentgenol Radiol. 2011:28-33.
40. Eich HT, Stepien A, Zimmermann C, et al. Neoadjuvant radiochemotherapy and surgery for advanced rectal cancer: prognostic significance of tumor regression. Strahlenther Onkol. 2011;187:225-230.
41. Park YJ, Oh BR, Lim SW, et al. Clinical significance of tumor regression grade in rectal cancer with preoperative chemoradiotherapy. J Korean Soc Coloproctol. 2010;26:279-286.
42. Roy P, Serra S, Kennedy E, Chetty R. The prognostic value of grade of regression and oncocytic change in rectal adenocarcinoma treated with neo-adjuvant chemoradiotherapy. J Surg Oncol. 2012;105:130-134.
43. Jakob C, Liersch T, Meyer W, et al. Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy. Am J Surg Pathol. 2006;30:1169-1174. (Pubitemid 44299350)
44. Arredondo J, Baixauli J, Beorlegui C, et al. Prognosis factors for recurrence in patients with locally advanced rectal cancer preoperatively treated with chemoradiotherapy and adjuvant chemotherapy. Dis Colon Rectum. 2013;56:416-421.
45. Marwick C. Can disease-free survival be a surrogate for overall survival for drug approvals? J Natl Cancer Inst. 2004;96:173. (Pubitemid 38263172)
46. Bernardshaw SV, Vrebø K, Eide GE, Skarstein A, Røkke O. Treatment of rectal cancer: reduction of local recurrence after the introduction of TME: experience from one university hospital. Dig Surg. 2006;23:51-59. (Pubitemid 44174841)
47. Chauvenet M, Lepage C, Jooste V, Cottet V, Faivre J, Bouvier AM. Prevalence of patients with colorectal cancer requiring follow-up or active treatment. Eur J Cancer. 2009;45:1460-1465.
48. Hughes R, Glynne-Jones R, Grainger J, et al. Can pathological complete response in the primary tumour following pre-operative pelvic chemoradiotherapy for T3-T4 rectal cancer predict for sterilisation of pelvic lymph nodes, a low risk of local recurrence and the appropriateness of local excision? Int J Colorectal Dis. 2006;21:11-17. (Pubitemid 41829760)
49. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al.; Polish Colorectal Study Group. Prediction of mesorectal nodal metastases after chemoradiation for rectal cancer: results of a randomised trial: implication for subsequent local excision. Radiother Oncol. 2005;76:234-240. (Pubitemid 41394272)
50. Benzoni E, Intersimone D, Terrosu G, et al. Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer. J Clin Pathol. 2006;59:505-512.
51. Kim TH, Chang HJ, Kim DY, et al. Pathologic nodal classification is the most discriminating prognostic factor for diseasefree survival in rectal cancer patients treated with preoperative chemoradiotherapy and curative resection. Int J Radiat Oncol Biol Phys. 2010;77:1158-1165.
52. Berho M, Oviedo M, Stone E, et al. The correlation between tumour regression grade and lymph node status after chemoradiation in rectal cancer. Colorectal Dis. 2009;11:254-258.
53. Vironen J, Juhola M, Kairaluoma M, Jantunen I, Kellokumpu I. Tumour regression grading in the evaluation of tumour response after different preoperative radiotherapy treatments for rectal carcinoma. Int J Colorectal Dis. 2005;20: 440-445. (Pubitemid 41086420)
54. Bhangu A, Ali SM, Darzi A, Brown G, Tekkis P. Meta-analysis of survival based on resection margin status following surgery for recurrent rectal cancer. Colorectal Dis. 2012;14:1457-1466.