Histopathological regression grading versus staging of rectal cancer following radiotherapy

Pathology

Volumn 43, Issue 1, 2011, Pages 24-30

  Shin, Joo Shik ^a,b   Jalaludin, Bin ^a,d   Solomon, Michael ^c,e   Hong, Angela ^c,e   Lee, C Soon ^a,b  

^a LIVERPOOL HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN SYDNEY   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Radiotherapy response; Rectal cancer; Staging; Tumour regression grading

Indexed keywords

EID: 80052249715     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0b013e328340bb5b     Document Type: Article

References (26)

1. Colorectal Cancer Collaborative Group. Adjuvant radiotherapy for rectal cancer: a systematic overview of 8, 507 patients from 22 randomised trials. Lancet 2001; 358: 1291-304.
2. Glimelius B, Gronberg H, Jarhult J, Wallgren A, Cavallin-stahl E. A systematic overview of radiation therapy effects in rectal cancer. Acta Oncol 2003; 42: 476-92. (Pubitemid 37193839)
3. Ortholan C, Francois E, Thomas O, et al. Role of radiotherapy with surgery for T3 and resectable T4 rectal cancer: evidence from randomized trials. Dis Colon Rectum 2006; 49: 302-10.
4. Losi L, Luppi G, Gavioli M, et al. Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy. Int J Colorectal Dis 2006; 21: 645-51. (Pubitemid 44446064)
5. Rodel C, Martus P, Papadoupolos T, et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005; 23: 8688-96. (Pubitemid 46211512)
6. Vecchio FM, Valentini V, Minsky BD, et al. The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys 2005; 62: 752-60. (Pubitemid 40779765)
7. Rosenberg R, Nekarda H, Zimmermann F, et al. Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival. J Surg Oncol 2008; 97: 8-13.
8. Mandard A-M, Dalibard F, Mandard J-C, et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer 1994; 73: 2680-6. (Pubitemid 24166250)
9. Ryan R, Gibbons D, Hyland JMP, et al. Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology 2005; 47: 141-6. (Pubitemid 41113116)
10. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 1997; 12: 19-23. (Pubitemid 27138353)
11. Wheeler JMD, Warren BF, Mortensen NJM, et al. Quantification of histologic regression of rectal cancer after irradiation: a proposal for a modified staging system. Dis Colon Rectum 2002; 45: 1051-6.
12. Berger C, de Muret A, Garaud P, et al. Preoperative radiotherapy (RT) for rectal cancer: predictive factors of tumor downstaging and residual tumor cell density (RTCD): prognostic implications. Int J Radiat Oncol Biol Phys 1997; 37: 619-27. (Pubitemid 27175318)
13. Spitz FR, Giacco GG, Hess K, et al. p53 immunohistochemical staining predicts residual disease after chemoradiation in patients with high-risk rectal cancer. Clin Cancer Res 1997; 3: 1685-90. (Pubitemid 27444705)
14. Bozzetti F, Andreola S, Rossetti C, et al. Preoperative radiotherapy for resectable cancer of the middle-distal rectum: its effect on the primary lesion as determined by endorectal ultrasound using flexible echo colonoscope. Int J Colorectal Dis 1996; 11: 283-6. (Pubitemid 27007842)
15. Marsh RdW, Chu N-M, Vauthey J-N, et al. Preoperative treatment of patients with locally advanced unresectable rectal adenocarcinoma utilizing continuous chronobiologically shaped 5-fluorouracil infusion and radiation therapy. Cancer 1996; 78: 217-25. (Pubitemid 26234562)
16. Hamilton SR, Aaltonen LA, editors. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press, 2000.
17. Davis NC, Newland RC. Terminology and classification of colorectal adenocarcinoma: the Australian clinico-pathological staging system. Aust NZ J Surg 1983; 53: 211-21. (Pubitemid 14226709)
18. Greene F, Page D, Fleming I, editors. AJCC Cancer Staging Manual. Berlin: Springer-Verlag, 2002.
19. Chua YJ, Sargent D, Cunningham D. Definition of disease-free survival: this is my truth-show me yours. Ann Oncol 2005; 16: 1719-21. (Pubitemid 41631233)
20. Bouzourene H, Bosman FT, SeelentagW, Matter M, Coucke P. Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 2002; 94: 1121-30. (Pubitemid 34150868)
21. Glimelius B, Isacsson U. Preoperative radiotherapy for rectal cancer-is 5 x 5 Gy a good or a bad schedule? Acta Oncol 2001; 40: 958-67. (Pubitemid 34098483)
22. Francois Y, Nemoz CJ, Baulieux J, et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial. J Clin Oncol 1999; 17: 2396-402. (Pubitemid 29368238)
23. Lim S-BM, Choi HSM, Jeong S-YM, et al. Optimal surgery time after preoperative chemoradiotherapy for locally advanced rectal cancers. Ann Surg 2008; 248: 243-51.
24. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, et al. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 2006; 93: 1215-23. (Pubitemid 44547018)
25. Ruo L, Tickoo S, Klimstra DS, et al. Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg 2002; 236: 75-81. (Pubitemid 34686453)
26. Morgan MJ, Koorey DJ, Painter D, et al. Histological tumour response to pre-operative combined modality therapy in locally advanced rectal cancer. Colorectal Dis 2002; 4: 177-83. (Pubitemid 34567875)