Neoadjuvant radiochemotherapy and surgery for advanced rectal cancer: Prognostic significance of tumor regression

Strahlentherapie und Onkologie

Volumn 187, Issue 4, 2011, Pages 225-230

  Eich, Hans Theodor ^a   Stepien, Anna ^a   Zimmermann, Christian ^a   Hellmich, Martin ^a   Metzger, Ralf ^a   Hölscher, Arnulf ^a   Müller, Rolf Peter ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Neoadjuvant radiochemotherapy; Prognostic factors; Radiotherapy; Rectal carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER RELAPSE; CANCER STAGING; CHEMORADIOTHERAPY; CONFERENCE PAPER; CONTINUOUS INFUSION; DISEASE FREE SURVIVAL; DRUG DOSE REDUCTION; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTASIS; PATIENT SAFETY; PREOPERATIVE PERIOD; PROGNOSIS; RADIATION DOSE; RECTUM CANCER; RETROSPECTIVE STUDY; TREATMENT RESPONSE; TUMOR REGRESSION; UNSPECIFIED SIDE EFFECT;

ADENOCARCINOMA; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA; CARCINOMA, SIGNET RING CELL; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PROGNOSIS; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; RECTUM; RETROSPECTIVE STUDIES;

EID: 79955735534     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-011-2113-1     Document Type: Conference Paper

References (32)

1. J.F. Bosset G. Calais L. Mineur 2005 Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preleminary results - EORTC 22921 J Clin Oncol 23 5620 7 16009958 10.1200/JCO.2005.02.113 1:CAS:528:DC%2BD2MXhtVersr%2FF
2. J.F. Bosset L. Collette G. Calais 2006 Chemotherapy with preoperative radiotherapy in rectal cancer N Engl J Med 355 1114 23 16971718 10.1056/NEJMoa060829 1:CAS:528:DC%2BD28XpsFKkur8%3D (Pubitemid 44394918)
3. C. Capirci V. Valentini L. Cionini 2008 Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients Int J Radiat Oncol Biol Phys 72 99 107 18407433 10.1016/j.ijrobp.2007.12.019
4. Colorectal cancer colaborative Group 2001 Adjuvant radiochemotherapy for rectal cancer. A systemic overview of 8507 patients from 22 randomised trials Lancet 358 1291 1304 10.1016/S0140-6736(01)06409-1 (Pubitemid 33016492)
5. W. Dörr T. Herrmann 2008 Second tumors after oncologic treatment Strahlenther Onkol 184 67 72 18259697 10.1007/s00066-008-1807-5 (Pubitemid 351231656)
6. J. Dunst J. Debus V. Rudat 2008 Neoadjuvant capecitabine combined with standard radiotherapy in patients with locally advanced rectal cancer: mature results of a phase II trial Strahlenther Onkol 184 450 6 19016023 10.1007/s00066-008-1751-4
7. J. Füller D. Guderian C. Köhler 2008 Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer Strahlenther Onkol 184 206 11 18398585 10.1007/s00066-008-1728-3 (Pubitemid 351508127)
8. D. Georg P. Georg M. Hillbrand 2008 Assessment of improved organ at risk sparing for advanced cervix carcinoma utilizing precision radiotherapy techniques Strahlenther Onkol 184 586 91 19016017 10.1007/s00066-008-1872-9
9. J.P. Gerad T. Conroy F. Bonnetain 2006 Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 J Clin Oncol 24 4620 5 10.1200/JCO.2006.06.7629 (Pubitemid 46630960)
10. A. Hartley K.F. Ho C. McConkey 2005 Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: analysis of phase II/III trials Br J Radiol 78 934 8 16177017 10.1259/bjr/86650067 1:STN:280:DC%2BD2MrgsVCktg%3D%3D (Pubitemid 41582245)
11. K. Horisberger A. Treschl S. Mai 2009 Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a Phase II MARGIT trial Int J Radiat Oncol Biol Phys 74 1487 93 19131187 10.1016/j.ijrobp.2008.10.014 1:CAS:528:DC%2BD1MXoslGhtrw%3D
12. N. Janjan V. Khoo J. Abbruzzese 1999 Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer; The M.D. Anderson Cancer Center Experience Int J Radiat Oncol Biol Phys 44 1027 38 10421535 10.1016/S0360-3016(99)00099-1 1:STN:280:DyaK1Mzksl2jsQ%3D%3D (Pubitemid 29342903)
13. T. Juninger Hossfeld R. Sauer 1999 Adjuvante Therapie bei Kolon- und Rektumkarzinom Dtsch Ärztebl 96 698 700
14. K. Junker 2004 Therapieinduzierte morphologische Veränderungen bösartiger Lungentumoren Pathologe 25 475 80 15375632 10.1007/s00292-004- 0719-0 1:STN:280:DC%2BD2crotVajsg%3D%3D (Pubitemid 40022471)
15. M. Kaminsky-Forrett T. Conroy E. Luporsi 1998 Prognostic implication of downstaging following preoperative radiation therapy for operable T3-T4 rectal cancer Int J Radiat Oncol Biol Phys 42 935 41 9869213 10.1016/S0360-3016(98) 00345-9 1:STN:280:DyaK1M%2FosVGmug%3D%3D (Pubitemid 29004132)
16. E. Kapiteijn C.A.M. Marijnen I.D. Nagtegaal 2001 Preoperatve radiotherapy, combined with total meorectal excision for resectable cancer N Engl J Med 345 638 46 11547717 10.1056/NEJMoa010580 1:STN:280: DC%2BD3Mvps1ektw%3D%3D
17. E.I. Kaplan P. Meier 1958 Non-parametric estimation from incomplete observation J Am Stat Assoc 53 457 81 10.2307/2281868
18. N. Mantel 1994 evaluation of survival data and two new rank order statistics arising in its consideration Cancer Chemother Rep 73 163 70
19. A.L. Martling T. Holm T.E. Rutqvist 2000 Effect of surgical training programme on outcome of rectal cancer in the country of Stockholm. Stockholm Colorectal Cancer Study Group, Basingstoke Bowel Cancer Research Project Lancet 356 93 6 10963244 10.1016/S0140-6736(00)02469-7 1:STN:280:DC%2BD3cvjtVensQ%3D%3D (Pubitemid 30438509)
20. V. Milani M. Pazos R.D. Issels 2008 Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer Strahlenther Onko. 184 163 168 10.1007/s00066-008-1731-8 (Pubitemid 351365779)
21. A.C. Müller U. Ganswindt M. Bamberg 2007 Risk of second malignancies after prostate irradiation? Strahlenther Onkol 183 605 9 17960335 10.1007/s00066-007-1786-y (Pubitemid 350124275)
22. H.C. Rischke F. Momm M. Henke 2007 Does radiation prevent 5-fluorouracil-induced colitis in the early phase of radiochemotherapy? A case report and literature review Strahlenther Onkol 183 459 63 17680227 10.1007/s00066-007-1655-8 (Pubitemid 47230516)
23. C. Roedel W. Hohenberger R. Sauer 1998 Adjuvante und neoadjuvante Therapie des Rektumkarzinoms Strahlenther Onkol 174 497 504 10.1007/BF03038981
24. C. Roedel P. Martus T. Papadoupolus 2005 Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer J Clin Oncol 34 8688 96 10.1200/JCO.2005.02.1329 (Pubitemid 46211512)
25. C. Roedel R. Sauer R. Fietkau 2009 The role of magnetic resonance imaging to select patients for preoperative treatment in rectal cancer Strahlenther Onkol 185 488 92 10.1007/s00066-009-2043-3
26. R. Sauer H. Becker W. Hohenberger 2004 Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 1731 40 15496622 10.1056/NEJMoa040694 1:CAS:528:DC%2BD2cXovFSksbo%3D (Pubitemid 39383208)
27. W. Schmiegel A. [. Reinacher-Schick 2008 Update S3-guideline.,colorectal cancer" 2008 Z Gastroenterol 46 799 840 18759205 10.1055/s-2008-1027726 1:CAS:528:DC%2BD1cXhtFKltLbP
28. Schwedish Rectal Cancer Trial Group. 1997 Improved survival with preoperative radiotherapy in resectable rectal cancer N Engl J Med 336 980 7 10.1056/NEJM199704033361402 (Pubitemid 27152783)
29. M.H. Seegenschmiedt R. Sauer 1993 Systematik der akuten und chronischen Strahlenfolgen Strahlenther Onkol 169 83 98 8451729 1:STN:280: DyaK3s7pvVSitg%3D%3D
30. J. Shia J.G. Guillem H.G. Moore 2004 Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their asociation with long-term outcome Am J Surg Pathol 28 215 23 15043311 10.1097/00000478-200402000-00009 (Pubitemid 38124730)
31. Wittekind Ch, Klimpfinger M, Sobin LH. Union Internationale Contre le Cancer. Springer, Berlin 2004: 5-38.
32. H.A. Wolff J. Gaedcke K. Jung 2010 High-grade acute organ toxicity during preoperative radiochemotherapy as positive predictor for complete histopathological tumor regression in multimodal treatment of locally advanced rectal cancer Strahlenther Onkol 186 30 5 20082185 10.1007/s00066-009-2037-1