메뉴 건너뛰기




Volumn 8, Issue 9, 2013, Pages

EMMPRIN Promotes Angiogenesis, Proliferation, Invasion and Resistance to Sunitinib in Renal Cell Carcinoma, and Its Level Predicts Patient Outcome

Author keywords

[No Author keywords available]

Indexed keywords

CD147 ANTIGEN; FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOCARBOXYLATE TRANSPORTER 1; SMALL INTERFERING RNA; SUNITINIB; VASCULOTROPIN;

EID: 84884490529     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074313     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • doi:10.3322/caac.20138
    • Siegel R, Naishadham D, Jemal A, (2012) Cancer statistics, 2012. CA Cancer J Clin 62: 10-29. doi:10.3322/caac.20138. PubMed: 22237781.
    • (2012) CA Cancer J Clin , vol.62 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 2
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway
    • Pantuck AJ, Zeng G, Belldegrun AS, Figlin RA, (2003) Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin Cancer Res 9: 4641-4652. PubMed: 14581333.
    • (2003) Clin Cancer Res , vol.9 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 3
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • doi:10.1038/onc.2009.441
    • Semenza GL, (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29: 625-634. doi:10.1038/onc.2009.441. PubMed: 19946328.
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 4
    • 77955493600 scopus 로고    scopus 로고
    • EAU guidelines on renal cell carcinoma: the 2010 update
    • doi:10.1016/j.eururo.2010.06.032
    • Ljungberg B, Cowan NC, Hanbury DC, Hora M, Kuczyk MA, et al. (2010) EAU guidelines on renal cell carcinoma: the 2010 update. Eur Urol 58: 398-406. doi:10.1016/j.eururo.2010.06.032. PubMed: 20633979.
    • (2010) Eur Urol , vol.58 , pp. 398-406
    • Ljungberg, B.1    Cowan, N.C.2    Hanbury, D.C.3    Hora, M.4    Kuczyk, M.A.5
  • 5
    • 0028795147 scopus 로고
    • The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily
    • Biswas C, Zhang Y, DeCastro R, Guo H, Nakamura T, et al. (1995) The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res 55: 434-439. PubMed: 7812975.
    • (1995) Cancer Res , vol.55 , pp. 434-439
    • Biswas, C.1    Zhang, Y.2    DeCastro, R.3    Guo, H.4    Nakamura, T.5
  • 6
    • 0032487394 scopus 로고    scopus 로고
    • Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases
    • doi:10.1016/S0378-1119(98)00400-4
    • Guo H, Majmudar G, Jensen TC, Biswas C, Toole BP, et al. (1998) Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. Gene 220: 99-108. doi:10.1016/S0378-1119(98)00400-4. PubMed: 9767135.
    • (1998) Gene , vol.220 , pp. 99-108
    • Guo, H.1    Majmudar, G.2    Jensen, T.C.3    Biswas, C.4    Toole, B.P.5
  • 7
    • 0032520149 scopus 로고    scopus 로고
    • A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis
    • doi:10.1006/dbio.1997.8819
    • Igakura T, Kadomatsu K, Kaname T, Muramatsu H, Fan QW, et al. (1998) A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Dev Biol 194: 152-165. doi:10.1006/dbio.1997.8819. PubMed: 9501026.
    • (1998) Dev Biol , vol.194 , pp. 152-165
    • Igakura, T.1    Kadomatsu, K.2    Kaname, T.3    Muramatsu, H.4    Fan, Q.W.5
  • 8
    • 0027199009 scopus 로고
    • 5A11 antigen is a cell recognition molecule which is involved in neuronal-glial interactions in avian neural retina
    • doi:10.1002/aja.1001960406
    • Fadool JM, Linser PJ, (1993) 5A11 antigen is a cell recognition molecule which is involved in neuronal-glial interactions in avian neural retina. Dev Dyn 196: 252-262. doi:10.1002/aja.1001960406. PubMed: 8219348.
    • (1993) Dev Dyn , vol.196 , pp. 252-262
    • Fadool, J.M.1    Linser, P.J.2
  • 9
    • 15244344671 scopus 로고    scopus 로고
    • EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair
    • doi:10.1016/j.biochi.2004.09.023
    • Gabison EE, Hoang-Xuan T, Mauviel A, Menashi S, (2005) EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie 87: 361-368. doi:10.1016/j.biochi.2004.09.023. PubMed: 15781323.
    • (2005) Biochimie , vol.87 , pp. 361-368
    • Gabison, E.E.1    Hoang-Xuan, T.2    Mauviel, A.3    Menashi, S.4
  • 10
    • 33645072764 scopus 로고    scopus 로고
    • Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production
    • doi:10.1186/ar1778
    • Zhu P, Ding J, Zhou J, Dong WJ, Fan CM, et al. (2005) Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production. Arthritis Res Ther 7: R1023-R1033. doi:10.1186/ar1778. PubMed: 16207318.
    • (2005) Arthritis Res Ther , vol.7
    • Zhu, P.1    Ding, J.2    Zhou, J.3    Dong, W.J.4    Fan, C.M.5
  • 11
    • 33745075529 scopus 로고    scopus 로고
    • Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression
    • doi:10.1111/j.1440-1827.2006.01972.x
    • Nabeshima K, Iwasaki H, Koga K, Hojo H, Suzumiya J, et al. (2006) Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol Int 56: 359-367. doi:10.1111/j.1440-1827.2006.01972.x. PubMed: 16792544.
    • (2006) Pathol Int , vol.56 , pp. 359-367
    • Nabeshima, K.1    Iwasaki, H.2    Koga, K.3    Hojo, H.4    Suzumiya, J.5
  • 12
    • 33747187532 scopus 로고    scopus 로고
    • Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters
    • doi:10.1097/01.pgp.0000189244.57145.84
    • Jin JS, Yao CW, Loh SH, Cheng MF, Hsieh DS, et al. (2006) Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. Int J Gynecol Pathol 25: 140-146. doi:10.1097/01.pgp.0000189244.57145.84. PubMed: 16633062.
    • (2006) Int J Gynecol Pathol , vol.25 , pp. 140-146
    • Jin, J.S.1    Yao, C.W.2    Loh, S.H.3    Cheng, M.F.4    Hsieh, D.S.5
  • 13
    • 0033851302 scopus 로고    scopus 로고
    • Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas
    • doi:10.1002/1097-0215(20001001)88:1
    • Sameshima T, Nabeshima K, Toole BP, Yokogami K, Okada Y, et al. (2000) Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas. Int J Cancer 88: 21-27. doi:10.1002/1097-0215(20001001)88:1. PubMed: 10962435.
    • (2000) Int J Cancer , vol.88 , pp. 21-27
    • Sameshima, T.1    Nabeshima, K.2    Toole, B.P.3    Yokogami, K.4    Okada, Y.5
  • 14
    • 33751026616 scopus 로고    scopus 로고
    • Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis
    • doi:10.1038/sj.bjc.6603425
    • Zheng HC, Takahashi H, Murai Y, Cui ZG, Nomoto K, et al. (2006) Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br J Cancer 95: 1371-1378. doi:10.1038/sj.bjc.6603425. PubMed: 17088917.
    • (2006) Br J Cancer , vol.95 , pp. 1371-1378
    • Zheng, H.C.1    Takahashi, H.2    Murai, Y.3    Cui, Z.G.4    Nomoto, K.5
  • 15
    • 0033986262 scopus 로고    scopus 로고
    • Expression of emmprin by oral squamous cell carcinoma
    • doi:10.1002/(SICI)1097-0215(20000201)85:3
    • Bordador LC, Li X, Toole B, Chen B, Regezi J, et al. (2000) Expression of emmprin by oral squamous cell carcinoma. Int J Cancer 85: 347-352. doi:10.1002/(SICI)1097-0215(20000201)85:3. PubMed: 10652425.
    • (2000) Int J Cancer , vol.85 , pp. 347-352
    • Bordador, L.C.1    Li, X.2    Toole, B.3    Chen, B.4    Regezi, J.5
  • 16
    • 0036605095 scopus 로고    scopus 로고
    • Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts
    • doi:10.1002/ijc.10390
    • Kanekura T, Chen X, Kanzaki T, (2002) Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer 99: 520-528. doi:10.1002/ijc.10390. PubMed: 11992541.
    • (2002) Int J Cancer , vol.99 , pp. 520-528
    • Kanekura, T.1    Chen, X.2    Kanzaki, T.3
  • 17
    • 65349118157 scopus 로고    scopus 로고
    • HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection
    • doi:10.1111/j.1365-2559.2009.03280.x
    • Li Y, Xu J, Chen L, Zhong WD, Zhang Z, et al. (2009) HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology 54: 677-687. doi:10.1111/j.1365-2559.2009.03280.x. PubMed: 19438743.
    • (2009) Histopathology , vol.54 , pp. 677-687
    • Li, Y.1    Xu, J.2    Chen, L.3    Zhong, W.D.4    Zhang, Z.5
  • 18
    • 33847716645 scopus 로고    scopus 로고
    • Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinoma
    • doi:10.1097/01.cej.0000236245.40619.c3
    • Zhang Q, Zhou J, Ku XM, Chen XG, Zhang L, et al. (2007) Expression of CD147 as a significantly unfavorable prognostic factor in hepatocellular carcinoma. Eur J Cancer Prev 16: 196-202. doi:10.1097/01.cej.0000236245.40619.c3. PubMed: 17415090.
    • (2007) Eur J Cancer Prev , vol.16 , pp. 196-202
    • Zhang, Q.1    Zhou, J.2    Ku, X.M.3    Chen, X.G.4    Zhang, L.5
  • 19
    • 51749095725 scopus 로고    scopus 로고
    • CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma
    • doi:10.1016/j.trsl.2008.07.005
    • Tan H, Ye K, Wang Z, Tang H, (2008) CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma. Transl Res 152: 143-149. doi:10.1016/j.trsl.2008.07.005. PubMed: 18774544.
    • (2008) Transl Res , vol.152 , pp. 143-149
    • Tan, H.1    Ye, K.2    Wang, Z.3    Tang, H.4
  • 20
    • 2542432100 scopus 로고    scopus 로고
    • Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells
    • doi:10.1158/1078-0432.CCR-03-0610
    • Reimers N, Zafrakas K, Assmann V, Egen C, Riethdorf L, et al. (2004) Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells. Clin Cancer Res 10: 3422-3428. doi:10.1158/1078-0432.CCR-03-0610. PubMed: 15161697.
    • (2004) Clin Cancer Res , vol.10 , pp. 3422-3428
    • Reimers, N.1    Zafrakas, K.2    Assmann, V.3    Egen, C.4    Riethdorf, L.5
  • 21
    • 68849132734 scopus 로고    scopus 로고
    • CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value
    • doi:10.1080/07357900802709167
    • Liang YX, He HC, Han ZD, Bi XC, Dai QS, et al. (2009) CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value. Cancer Invest 27: 788-793. doi:10.1080/07357900802709167. PubMed: 19548138.
    • (2009) Cancer Invest , vol.27 , pp. 788-793
    • Liang, Y.X.1    He, H.C.2    Han, Z.D.3    Bi, X.C.4    Dai, Q.S.5
  • 22
    • 23244451640 scopus 로고    scopus 로고
    • Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK
    • Hagemann T, Wilson J, Kulbe H, Li NF, Leinster DA, et al. (2005) Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK. J Immunol 175: 1197-1205. PubMed: 16002723.
    • (2005) J Immunol , vol.175 , pp. 1197-1205
    • Hagemann, T.1    Wilson, J.2    Kulbe, H.3    Li, N.F.4    Leinster, D.A.5
  • 23
    • 17144422889 scopus 로고    scopus 로고
    • Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases
    • Tang Y, Nakada MT, Kesavan P, McCabe F, Millar H, et al. (2005) Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases. Cancer Res 65: 3193-3199. PubMed: 15833850.
    • (2005) Cancer Res , vol.65 , pp. 3193-3199
    • Tang, Y.1    Nakada, M.T.2    Kesavan, P.3    McCabe, F.4    Millar, H.5
  • 24
    • 84907601958 scopus 로고    scopus 로고
    • Microvessel area of immature vessels is a prognostic factor in renal cell carcinoma
    • PubMed: 23944647
    • Sato M, Nakai Y, Nakata W, Yoshida T, Hatano K, et al. (2013) Microvessel area of immature vessels is a prognostic factor in renal cell carcinoma. Int J Urol. PubMed: 23944647.
    • (2013) Int J Urol
    • Sato, M.1    Nakai, Y.2    Nakata, W.3    Yoshida, T.4    Hatano, K.5
  • 25
    • 0018637122 scopus 로고
    • Characterization of an established cell line from human renal carcinoma
    • Matsuda M, Osafune M, Nakano E, Kotake T, Sonoda T, et al. (1979) Characterization of an established cell line from human renal carcinoma. Cancer Res 39: 4694-4699. PubMed: 40693.
    • (1979) Cancer Res , vol.39 , pp. 4694-4699
    • Matsuda, M.1    Osafune, M.2    Nakano, E.3    Kotake, T.4    Sonoda, T.5
  • 26
    • 0032443309 scopus 로고    scopus 로고
    • Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38
    • doi:10.1016/S0014-5793(98)01474-4
    • Lim M, Martinez T, Jablons D, Cameron R, Guo H, et al. (1998) Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38. FEBS Lett 441: 88-92. doi:10.1016/S0014-5793(98)01474-4. PubMed: 9877171.
    • (1998) FEBS Lett , vol.441 , pp. 88-92
    • Lim, M.1    Martinez, T.2    Jablons, D.3    Cameron, R.4    Guo, H.5
  • 27
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • doi:10.1093/jnci/82.1.4
    • Folkman J, (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6. doi:10.1093/jnci/82.1.4. PubMed: 1688381.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 28
    • 0030058408 scopus 로고    scopus 로고
    • Quantitative microvessel density. A staging and prognostic marker for human prostatic carcinoma
    • doi:10.1002/(SICI)1097-0142(19960715)78:2
    • Brawer MK, (1996) Quantitative microvessel density. A staging and prognostic marker for human prostatic carcinoma. Cancer 78: 345-349. doi:10.1002/(SICI)1097-0142(19960715)78:2. PubMed: 8674015.
    • (1996) Cancer , vol.78 , pp. 345-349
    • Brawer, M.K.1
  • 29
    • 0029087133 scopus 로고
    • Microvessel density and vessel invasion in lymph-node-negative breast cancer: effect on recurrence-free survival
    • doi:10.1002/ijc.2910620203
    • Obermair A, Kurz C, Czerwenka K, Thoma M, Kaider A, et al. (1995) Microvessel density and vessel invasion in lymph-node-negative breast cancer: effect on recurrence-free survival. Int J Cancer 62: 126-131. doi:10.1002/ijc.2910620203. PubMed: 7622284.
    • (1995) Int J Cancer , vol.62 , pp. 126-131
    • Obermair, A.1    Kurz, C.2    Czerwenka, K.3    Thoma, M.4    Kaider, A.5
  • 31
    • 0029024310 scopus 로고
    • Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer
    • doi:10.1016/S0022-5347(01)67230-6
    • Jaeger TM, Weidner N, Chew K, Moore DH, Kerschmann RL, et al. (1995) Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer. J Urol 154: 69-71. doi:10.1016/S0022-5347(01)67230-6. PubMed: 7539869.
    • (1995) J Urol , vol.154 , pp. 69-71
    • Jaeger, T.M.1    Weidner, N.2    Chew, K.3    Moore, D.H.4    Kerschmann, R.L.5
  • 32
    • 84861445963 scopus 로고    scopus 로고
    • Role of emmprin in endometrial cancer
    • doi:10.1186/1471-2407-12-191
    • Nakamura K, Kodama J, Hongo A, Hiramatsu Y, (2012) Role of emmprin in endometrial cancer. BMC Cancer 12: 191. doi:10.1186/1471-2407-12-191. PubMed: 22640183.
    • (2012) BMC Cancer , vol.12 , pp. 191
    • Nakamura, K.1    Kodama, J.2    Hongo, A.3    Hiramatsu, Y.4
  • 33
    • 79960587072 scopus 로고    scopus 로고
    • Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer
    • doi:10.1186/1471-2407-11-312
    • Pértega-Gomes N, Vizcaíno JR, Miranda-Gonçalves V, Pinheiro C, Silva J, et al. (2011) Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer 11: 312. doi:10.1186/1471-2407-11-312. PubMed: 21787388.
    • (2011) BMC Cancer , vol.11 , pp. 312
    • Pértega-Gomes, N.1    Vizcaíno, J.R.2    Miranda-Gonçalves, V.3    Pinheiro, C.4    Silva, J.5
  • 34
    • 0031398915 scopus 로고    scopus 로고
    • Prognostic significance of microscopic vascularity for clear cell renal cell carcinoma
    • doi:10.1046/j.1464-410X.1997.00374.x
    • Delahunt B, Bethwaite PB, Thornton A, (1997) Prognostic significance of microscopic vascularity for clear cell renal cell carcinoma. Br J Urol 80: 401-404. doi:10.1046/j.1464-410X.1997.00374.x. PubMed: 9313657.
    • (1997) Br J Urol , vol.80 , pp. 401-404
    • Delahunt, B.1    Bethwaite, P.B.2    Thornton, A.3
  • 35
    • 0031977118 scopus 로고    scopus 로고
    • Evaluation of microvessel density by computerised image analysis in human renal cell carcinoma. Correlation to pT category, nuclear grade, proliferative activity and occurrence of metastasis
    • doi:10.1007/s004320050147
    • Herbst C, Kosmehl H, Stiller KJ, Berndt A, Eiselt M, et al. (1998) Evaluation of microvessel density by computerised image analysis in human renal cell carcinoma. Correlation to pT category, nuclear grade, proliferative activity and occurrence of metastasis. J Cancer Res Clin Oncol 124: 141-147. doi:10.1007/s004320050147. PubMed: 9619739.
    • (1998) J Cancer Res Clin Oncol , vol.124 , pp. 141-147
    • Herbst, C.1    Kosmehl, H.2    Stiller, K.J.3    Berndt, A.4    Eiselt, M.5
  • 36
    • 0034533927 scopus 로고    scopus 로고
    • Quantification of angiogenesis by a computerized image analysis system in renal cell carcinoma
    • Lee JS, Jung JJ, Kim J, (2000) Quantification of angiogenesis by a computerized image analysis system in renal cell carcinoma. Anal Quant Cytol Histol 22: 469-474. PubMed: 11147301.
    • (2000) Anal Quant Cytol Histol , vol.22 , pp. 469-474
    • Lee, J.S.1    Jung, J.J.2    Kim, J.3
  • 37
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • Liotta LA, Kleinerman J, Saidel GM, (1974) Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 34: 997-1004. PubMed: 4841969.
    • (1974) Cancer Res , vol.34 , pp. 997-1004
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 38
    • 0029127219 scopus 로고
    • Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors
    • doi:10.1007/BF00666038
    • Weidner N, (1995) Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36: 169-180. doi:10.1007/BF00666038. PubMed: 8534865.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 169-180
    • Weidner, N.1
  • 39
    • 0032564411 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C induces angiogenesis in vivo
    • doi:10.1073/pnas.95.24.14389
    • Cao Y, Linden P, Farnebo J, Cao R, Eriksson A, et al. (1998) Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci U S A 95: 14389-14394. doi:10.1073/pnas.95.24.14389. PubMed: 9826710.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14389-14394
    • Cao, Y.1    Linden, P.2    Farnebo, J.3    Cao, R.4    Eriksson, A.5
  • 40
    • 67449097902 scopus 로고    scopus 로고
    • Antiangiogenesis research is booming, as questions and studies proliferate
    • doi:10.1093/jnci/djp150
    • Brower V, (2009) Antiangiogenesis research is booming, as questions and studies proliferate. J Natl Cancer Inst 101: 780-781. doi:10.1093/jnci/djp150. PubMed: 19470957.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 780-781
    • Brower, V.1
  • 41
    • 33846559124 scopus 로고    scopus 로고
    • Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis
    • doi:10.1073/pnas.0607542104
    • Dorrell MI, Aguilar E, Scheppke L, Barnett FH, Friedlander M, (2007) Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci U S A 104: 967-972. doi:10.1073/pnas.0607542104. PubMed: 17210921.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 967-972
    • Dorrell, M.I.1    Aguilar, E.2    Scheppke, L.3    Barnett, F.H.4    Friedlander, M.5
  • 42
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • doi:10.1016/j.ccr.2005.09.005
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D, (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8: 299-309. doi:10.1016/j.ccr.2005.09.005. PubMed: 16226705.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 43
    • 67449132021 scopus 로고    scopus 로고
    • How well do angiogenesis inhibitors work? Biomarkers of response prove elusive
    • doi:10.1093/jnci/djp171
    • Brower V, (2009) How well do angiogenesis inhibitors work? Biomarkers of response prove elusive. J Natl Cancer Inst 101: 846-847. doi:10.1093/jnci/djp171. PubMed: 19509354.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 846-847
    • Brower, V.1
  • 44
    • 33845799113 scopus 로고    scopus 로고
    • A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma
    • doi:10.1158/0008-5472.CAN-06-1536
    • Chen X, Lin J, Kanekura T, Su J, Lin W, et al. (2006) A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res 66: 11323-11330. doi:10.1158/0008-5472.CAN-06-1536. PubMed: 17145878.
    • (2006) Cancer Res , vol.66 , pp. 11323-11330
    • Chen, X.1    Lin, J.2    Kanekura, T.3    Su, J.4    Lin, W.5
  • 45
    • 84867395350 scopus 로고    scopus 로고
    • Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumors
    • doi:10.1007/s00428-012-1302-3
    • Fukuoka M, Hamasaki M, Koga K, Hayashi H, Aoki M, et al. (2012) Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumors. Virchows Arch 461: 457-466. doi:10.1007/s00428-012-1302-3. PubMed: 22926487.
    • (2012) Virchows Arch , vol.461 , pp. 457-466
    • Fukuoka, M.1    Hamasaki, M.2    Koga, K.3    Hayashi, H.4    Aoki, M.5
  • 46
    • 2542473135 scopus 로고    scopus 로고
    • Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis
    • doi:10.1186/1471-230X-3-19
    • Huynh H, Nguyen TT, Chow KH, Tan PH, Soo KC, et al. (2003) Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol 3: 19. doi:10.1186/1471-230X-3-19. PubMed: 12906713.
    • (2003) BMC Gastroenterol , vol.3 , pp. 19
    • Huynh, H.1    Nguyen, T.T.2    Chow, K.H.3    Tan, P.H.4    Soo, K.C.5
  • 47
    • 0037478612 scopus 로고    scopus 로고
    • Regulation of multidrug resistance in cancer cells by hyaluronan
    • doi:10.1074/jbc.C300173200
    • Misra S, Ghatak S, Zoltan-Jones A, Toole BP, (2003) Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem 278: 25285-25288. doi:10.1074/jbc.C300173200. PubMed: 12738783.
    • (2003) J Biol Chem , vol.278 , pp. 25285-25288
    • Misra, S.1    Ghatak, S.2    Zoltan-Jones, A.3    Toole, B.P.4
  • 48
    • 1242338794 scopus 로고    scopus 로고
    • Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production
    • doi:10.1158/0008-5472.CAN-03-2832
    • Marieb EA, Zoltan-Jones A, Li R, Misra S, Ghatak S, et al. (2004) Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer Res 64: 1229-1232. doi:10.1158/0008-5472.CAN-03-2832. PubMed: 14983875.
    • (2004) Cancer Res , vol.64 , pp. 1229-1232
    • Marieb, E.A.1    Zoltan-Jones, A.2    Li, R.3    Misra, S.4    Ghatak, S.5
  • 49
    • 77952969188 scopus 로고    scopus 로고
    • RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro
    • doi:10.1186/1756-9966-29-61
    • Wang B, Xu YF, He BS, Pan YQ, Zhang LR, et al. (2010) RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro. J Exp Clin Cancer Res 29: 61. doi:10.1186/1756-9966-29-61. PubMed: 20525232.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 61
    • Wang, B.1    Xu, Y.F.2    He, B.S.3    Pan, Y.Q.4    Zhang, L.R.5
  • 50
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • doi:10.1056/NEJMoa065044
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, et al. (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356: 115-124. doi:10.1056/NEJMoa065044. PubMed: 17215529.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.